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The map label for this gene is hipA [H]

Identifier: 91786248

GI number: 91786248

Start: 358129

End: 359451

Strand: Reverse

Name: hipA [H]

Synonym: Bpro_0337

Alternate gene names: 91786248

Gene position: 359451-358129 (Counterclockwise)

Preceding gene: 91786249

Following gene: 91786247

Centisome position: 6.91

GC content: 62.96

Gene sequence:

>1323_bases
ATGGCGGCGCTCAACGCGTGGATGAATGGCGAATTCGTCGGTGCCTGGCAGGTCAACCGCGGAACCCACAACTTTTCGTA
CGCACCGTCATGGCTGGAGTCCGAGAAATCCCGGCCGCTGTCCCTGTCTCTGCCTCTCACCCGCACCCTGGAGATCAAGG
GGGAGGTCGTTGCGAACTATTTCGACAATTTGCTGCCTGACAACGACAAGATCCGCGAGCGCATCGGCCGGAGGTTCAGA
ACCAAGACGCTCGATGCCTTCGCCTTGCTGGAGGCCATCGGCCGTGACTGCGTCGGCGCCGTGCAGTTGCTTCCGGAAGG
AACGGTGCCCGACGGGTGGAACCACGTCGAGTGCGAGCCGTTGACCGAAGAACAGGTCGCCGACGCCCTTCGCGCCGTCC
CCGGCGACCCGGTTGCGCGCCAAGTGAATGAAGCCCCACCGTTCCGCATTTCCCTGGCGGGCGCCCAGGAAAAAACCGCC
TTCGTGCAGGTCGACGGCCAGTGGTGCAGGCCCCTCGGGGCCACCCCGAGCACTCATATCTTCAAGCTCCCACTCGGAGT
GATCGCCAACACGACCAGGGTGGAAATGTTCGACTCCGTCGAGAACGAATGGCTGTGCGCGCAGATCATCCAGGCGCTCG
GGCTGCCCATGGCGCACACTGAGATGGCCATGTTTGGCGACCAGCGCGCGCTGGTCGTGGAGCGCTTCGACCGGGGATGG
ATGAAGGAGGGGAAGTGGATTGCCCGGCTTCCCCAGGAAGACTTCTGCCAGGCGCTGGGCCTGCCTCCCCGTCTGAAGTA
CGAAGACGATGGGGGCCCGTCCGTCGCCGATGGCCTCAAGCTGCTGTCTGGCAGCGCGGACGCGCAAACGGACAGAACTG
CCTTCCAACTCGCCCAGTTGGCCTTCTGGCTCATGGCGGCGCCCGACGGTCATGCCAAGAACTTTTCGATCTTCCTGCGC
CAAGGCAATGCCTACGACATGACGCCACTGTACGACGTCCTGTCCGTGTGGCCCTATGTGGGCAAAGGCCGCGGGCAACT
GCATCTGCGCAACGCGCGTCTTGCCATGGCGCTGCGTTCAAAGAACACGCACTACGACATCCACACCATCCGCGCCCGCC
ATTGGCACGACCTTGCCATGAAGAACGGTGGCCCCTTCGTCTGGGAAGCGATGCTAGGCTTGGTTGATCGCGTCGTGCTG
GCCCTCGACACCGTCGAGGCACAACTGCCCCAGAGCTTTCCCGAACGCATCTGGGAACCGATCTCGCAAGGAATGCGAAG
TCAAGCGGAGAGATTTCTATCAGAGGCCGCCAACGTCTCCTGA

Upstream 100 bases:

>100_bases
CGTCGGACGCGCAAGCGCTGCGGGATGCGAATCCACACGCCGATGTCACAGCAACATCCAAGCGCAACTTCGTCATCCGG
CCTAAGAAAGGCTCGTGGTG

Downstream 100 bases:

>100_bases
TCGCGAAGAACGCAGCCTCCTCGCGGCCTTCTCAGCGGTAGCCAACAGTGCCTTGGCTTTCGATGCGCTTCGCAGTTGAG
CAAACGCCATGCGCTTTCCC

Product: HipA-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAALNAWMNGEFVGAWQVNRGTHNFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNDKIRERIGRRFR
TKTLDAFALLEAIGRDCVGAVQLLPEGTVPDGWNHVECEPLTEEQVADALRAVPGDPVARQVNEAPPFRISLAGAQEKTA
FVQVDGQWCRPLGATPSTHIFKLPLGVIANTTRVEMFDSVENEWLCAQIIQALGLPMAHTEMAMFGDQRALVVERFDRGW
MKEGKWIARLPQEDFCQALGLPPRLKYEDDGGPSVADGLKLLSGSADAQTDRTAFQLAQLAFWLMAAPDGHAKNFSIFLR
QGNAYDMTPLYDVLSVWPYVGKGRGQLHLRNARLAMALRSKNTHYDIHTIRARHWHDLAMKNGGPFVWEAMLGLVDRVVL
ALDTVEAQLPQSFPERIWEPISQGMRSQAERFLSEAANVS

Sequences:

>Translated_440_residues
MAALNAWMNGEFVGAWQVNRGTHNFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNDKIRERIGRRFR
TKTLDAFALLEAIGRDCVGAVQLLPEGTVPDGWNHVECEPLTEEQVADALRAVPGDPVARQVNEAPPFRISLAGAQEKTA
FVQVDGQWCRPLGATPSTHIFKLPLGVIANTTRVEMFDSVENEWLCAQIIQALGLPMAHTEMAMFGDQRALVVERFDRGW
MKEGKWIARLPQEDFCQALGLPPRLKYEDDGGPSVADGLKLLSGSADAQTDRTAFQLAQLAFWLMAAPDGHAKNFSIFLR
QGNAYDMTPLYDVLSVWPYVGKGRGQLHLRNARLAMALRSKNTHYDIHTIRARHWHDLAMKNGGPFVWEAMLGLVDRVVL
ALDTVEAQLPQSFPERIWEPISQGMRSQAERFLSEAANVS
>Mature_439_residues
AALNAWMNGEFVGAWQVNRGTHNFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANYFDNLLPDNDKIRERIGRRFRT
KTLDAFALLEAIGRDCVGAVQLLPEGTVPDGWNHVECEPLTEEQVADALRAVPGDPVARQVNEAPPFRISLAGAQEKTAF
VQVDGQWCRPLGATPSTHIFKLPLGVIANTTRVEMFDSVENEWLCAQIIQALGLPMAHTEMAMFGDQRALVVERFDRGWM
KEGKWIARLPQEDFCQALGLPPRLKYEDDGGPSVADGLKLLSGSADAQTDRTAFQLAQLAFWLMAAPDGHAKNFSIFLRQ
GNAYDMTPLYDVLSVWPYVGKGRGQLHLRNARLAMALRSKNTHYDIHTIRARHWHDLAMKNGGPFVWEAMLGLVDRVVLA
LDTVEAQLPQSFPERIWEPISQGMRSQAERFLSEAANVS

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=424, Percent_Identity=43.6320754716981, Blast_Score=325, Evalue=4e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49159; Mature: 49027

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALNAWMNGEFVGAWQVNRGTHNFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANY
CCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECHHHHHHH
FDNLLPDNDKIRERIGRRFRTKTLDAFALLEAIGRDCVGAVQLLPEGTVPDGWNHVECEP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
LTEEQVADALRAVPGDPVARQVNEAPPFRISLAGAQEKTAFVQVDGQWCRPLGATPSTHI
CCHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHCCCCCCCCCCEE
FKLPLGVIANTTRVEMFDSVENEWLCAQIIQALGLPMAHTEMAMFGDQRALVVERFDRGW
EEECHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCH
MKEGKWIARLPQEDFCQALGLPPRLKYEDDGGPSVADGLKLLSGSADAQTDRTAFQLAQL
HHCCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
AFWLMAAPDGHAKNFSIFLRQGNAYDMTPLYDVLSVWPYVGKGRGQLHLRNARLAMALRS
HHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEEECHHEEEHHHC
KNTHYDIHTIRARHWHDLAMKNGGPFVWEAMLGLVDRVVLALDTVEAQLPQSFPERIWEP
CCCEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ISQGMRSQAERFLSEAANVS
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AALNAWMNGEFVGAWQVNRGTHNFSYAPSWLESEKSRPLSLSLPLTRTLEIKGEVVANY
CCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCEEEEEECHHHHHHH
FDNLLPDNDKIRERIGRRFRTKTLDAFALLEAIGRDCVGAVQLLPEGTVPDGWNHVECEP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCC
LTEEQVADALRAVPGDPVARQVNEAPPFRISLAGAQEKTAFVQVDGQWCRPLGATPSTHI
CCHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHCCCCCCCCCCEE
FKLPLGVIANTTRVEMFDSVENEWLCAQIIQALGLPMAHTEMAMFGDQRALVVERFDRGW
EEECHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCH
MKEGKWIARLPQEDFCQALGLPPRLKYEDDGGPSVADGLKLLSGSADAQTDRTAFQLAQL
HHCCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
AFWLMAAPDGHAKNFSIFLRQGNAYDMTPLYDVLSVWPYVGKGRGQLHLRNARLAMALRS
HHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEEECHHEEEHHHC
KNTHYDIHTIRARHWHDLAMKNGGPFVWEAMLGLVDRVVLALDTVEAQLPQSFPERIWEP
CCCEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ISQGMRSQAERFLSEAANVS
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]