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The map label for this gene is degS [H]

Identifier: 91786205

GI number: 91786205

Start: 308808

End: 310040

Strand: Reverse

Name: degS [H]

Synonym: Bpro_0294

Alternate gene names: 91786205

Gene position: 310040-308808 (Counterclockwise)

Preceding gene: 91786218

Following gene: 91786204

Centisome position: 5.96

GC content: 66.99

Gene sequence:

>1233_bases
ATGGTTGAAGACACCCTCCTGCCCGACATGCGTGGCCTCGCTCTTGGGCAAGCCGTGCCGGCCCACCTTCCGGCCGCCGG
GCAGGTGGTCTGGCGCGACAAGCTCTCGCAGTTGCTGGAATCCACCGGAGAAGGGATTTTTGGCATCGACATGGACGGCC
GCTGTACCTTCATCAACCGGGCCGGGGCCGAACAGCTGGGCTGGCTGCCTGCCGAGGTGCTGGGCCACAACATGCACGAA
CTGGCGCACCACTCCCATGCCGGCGGCGCGCACTACCCCGAGCATCTGTGCCCCATCTTCAACGCCTTCCGCAAGGCCCT
GCCCTGCCGCATTGACACCGAGCTGTTCTGGCGCAAAAACGGCAGTGCGTTTGCGGTGGAATATTCCTCCTACCCGATCG
TCGAAGGCGGCGTGGTCCAGGGCGCAGTCGTCACGTTCGTGGACATCTCGGCGCGGCGGCAGGCGGAAGACGCGCTGCGG
CAGGCCCATGCCGTACTGGAGCAGCGCGTCAGTGAGCGCACCCAGGCTTTGTCGGAAGCCCTGGAGCAGCTGCGCGAACT
CACGGCCTACACCCACAGCGTGCGCGAAGACGAGCGCACCCGCATCGCACGCGAGGTGCATGACGAGCTGGGCAGCCTGC
TGGTCGCGCTGAAGATGGACGTGGGCTGGCTCGACAAGCGCCTGGGCGAGCAACAGCAGCGCAGCCTGGACGAAGCCCAG
TCCATGCGCGAGCGCATGCGCAGCAAATGCCAGAACATGGGCCGCCTGATTGAGGCCGCCGTCGACAACGTGGGCCGCAT
CATCACCGACCTGCGCCCCAGCATTCTGGACCACCAGGGCCTGTGGGCCGCGCTGGACTGGCAGGCGCATGAATTCGTGC
TGTCTGCCGAACTGGCCCTGGACTGGCAGATGGACGTGGCCGGCGCCGCGCCGCTGCCGGAGCAGGCGGCCATCGGCATC
TTCCGCATCTTCCAGGAAATGCTCAGCAATGTGGGCCGCCACGCGCAGGCCAGCCGCGTCGCCATCACCATCCAGGCCAC
GCCCCGGGACATCAGCATCGCGGTGCGGGACAACGGCAAGGGTGCCGAGGCCGCCGCCTTTGAAGCGGCCAACGCGTACG
GCGTGATGGGCATGCGCGAGCGGGCGCGCCACCTCGGCGGCACGCTGGACATCTCAAGCCAGATCGGCCATGGCGCCCTG
TTTAACCTCCGCATTCCGCTCTCAAATCAGTAA

Upstream 100 bases:

>100_bases
GGTGGCCTCGGCCATACGGGCGGGTCAATGCACCACTATGGCACCAATACAGGGCCTGTTTTTGCACCAATCTGGGCACG
ATGCTTGCTATTAGGAGTGC

Downstream 100 bases:

>100_bases
CCTTAACAAAGCTGCTTGCCCACCATGAACACCGTGAAAATCCTGATCGGCGACGACCACCGCATCGTGCGCGAAGGCCT
GAAACAGGTGCTGGCCGATG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVEDTLLPDMRGLALGQAVPAHLPAAGQVVWRDKLSQLLESTGEGIFGIDMDGRCTFINRAGAEQLGWLPAEVLGHNMHE
LAHHSHAGGAHYPEHLCPIFNAFRKALPCRIDTELFWRKNGSAFAVEYSSYPIVEGGVVQGAVVTFVDISARRQAEDALR
QAHAVLEQRVSERTQALSEALEQLRELTAYTHSVREDERTRIAREVHDELGSLLVALKMDVGWLDKRLGEQQQRSLDEAQ
SMRERMRSKCQNMGRLIEAAVDNVGRIITDLRPSILDHQGLWAALDWQAHEFVLSAELALDWQMDVAGAAPLPEQAAIGI
FRIFQEMLSNVGRHAQASRVAITIQATPRDISIAVRDNGKGAEAAAFEAANAYGVMGMRERARHLGGTLDISSQIGHGAL
FNLRIPLSNQ

Sequences:

>Translated_410_residues
MVEDTLLPDMRGLALGQAVPAHLPAAGQVVWRDKLSQLLESTGEGIFGIDMDGRCTFINRAGAEQLGWLPAEVLGHNMHE
LAHHSHAGGAHYPEHLCPIFNAFRKALPCRIDTELFWRKNGSAFAVEYSSYPIVEGGVVQGAVVTFVDISARRQAEDALR
QAHAVLEQRVSERTQALSEALEQLRELTAYTHSVREDERTRIAREVHDELGSLLVALKMDVGWLDKRLGEQQQRSLDEAQ
SMRERMRSKCQNMGRLIEAAVDNVGRIITDLRPSILDHQGLWAALDWQAHEFVLSAELALDWQMDVAGAAPLPEQAAIGI
FRIFQEMLSNVGRHAQASRVAITIQATPRDISIAVRDNGKGAEAAAFEAANAYGVMGMRERARHLGGTLDISSQIGHGAL
FNLRIPLSNQ
>Mature_410_residues
MVEDTLLPDMRGLALGQAVPAHLPAAGQVVWRDKLSQLLESTGEGIFGIDMDGRCTFINRAGAEQLGWLPAEVLGHNMHE
LAHHSHAGGAHYPEHLCPIFNAFRKALPCRIDTELFWRKNGSAFAVEYSSYPIVEGGVVQGAVVTFVDISARRQAEDALR
QAHAVLEQRVSERTQALSEALEQLRELTAYTHSVREDERTRIAREVHDELGSLLVALKMDVGWLDKRLGEQQQRSLDEAQ
SMRERMRSKCQNMGRLIEAAVDNVGRIITDLRPSILDHQGLWAALDWQAHEFVLSAELALDWQMDVAGAAPLPEQAAIGI
FRIFQEMLSNVGRHAQASRVAITIQATPRDISIAVRDNGKGAEAAAFEAANAYGVMGMRERARHLGGTLDISSQIGHGAL
FNLRIPLSNQ

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=295, Percent_Identity=27.4576271186441, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082311, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788812, Length=210, Percent_Identity=29.0476190476191, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45233; Mature: 45233

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEDTLLPDMRGLALGQAVPAHLPAAGQVVWRDKLSQLLESTGEGIFGIDMDGRCTFINR
CCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEC
AGAEQLGWLPAEVLGHNMHELAHHSHAGGAHYPEHLCPIFNAFRKALPCRIDTELFWRKN
CCCHHHCCCCHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECC
GSAFAVEYSSYPIVEGGVVQGAVVTFVDISARRQAEDALRQAHAVLEQRVSERTQALSEA
CCEEEEEECCCCCCCCCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQLRELTAYTHSVREDERTRIAREVHDELGSLLVALKMDVGWLDKRLGEQQQRSLDEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHH
SMRERMRSKCQNMGRLIEAAVDNVGRIITDLRPSILDHQGLWAALDWQAHEFVLSAELAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEECCCHHHHEEEHHHEE
DWQMDVAGAAPLPEQAAIGIFRIFQEMLSNVGRHAQASRVAITIQATPRDISIAVRDNGK
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCCC
GAEAAAFEAANAYGVMGMRERARHLGGTLDISSQIGHGALFNLRIPLSNQ
CCCHHHHHHCCHHCCCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MVEDTLLPDMRGLALGQAVPAHLPAAGQVVWRDKLSQLLESTGEGIFGIDMDGRCTFINR
CCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEC
AGAEQLGWLPAEVLGHNMHELAHHSHAGGAHYPEHLCPIFNAFRKALPCRIDTELFWRKN
CCCHHHCCCCHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECC
GSAFAVEYSSYPIVEGGVVQGAVVTFVDISARRQAEDALRQAHAVLEQRVSERTQALSEA
CCEEEEEECCCCCCCCCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEQLRELTAYTHSVREDERTRIAREVHDELGSLLVALKMDVGWLDKRLGEQQQRSLDEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHH
SMRERMRSKCQNMGRLIEAAVDNVGRIITDLRPSILDHQGLWAALDWQAHEFVLSAELAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEECCCHHHHEEEHHHEE
DWQMDVAGAAPLPEQAAIGIFRIFQEMLSNVGRHAQASRVAITIQATPRDISIAVRDNGK
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCCC
GAEAAAFEAANAYGVMGMRERARHLGGTLDISSQIGHGALFNLRIPLSNQ
CCCHHHHHHCCHHCCCCHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]