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The map label for this gene is alr

Identifier: 91786104

GI number: 91786104

Start: 211279

End: 212373

Strand: Direct

Name: alr

Synonym: Bpro_0193

Alternate gene names: 91786104

Gene position: 211279-212373 (Clockwise)

Preceding gene: 91786099

Following gene: 91786105

Centisome position: 4.06

GC content: 68.22

Gene sequence:

>1095_bases
ATGCCACGTCCCATCCTTGCCACCATCCACCGACCGGCGCTCGCCCACAACCTCGCGCGCGCCCGCAGCGCCGCGCCTGA
CGCCCGGGTCTGGGCGGTCGTCAAGGCCAATGCCTACGGCCATGGCATTGAACACGTCTTTGACGGCCTGCGCAGTGCCG
ACGGATTTGCGCTGCTGGATCTGGCGGAGGCGCGGCGCCTGCGCGCGCTCGACTGGCGCGGCCCCATCCTGCTGCTGGAA
GGCTGCTTCGAGGCGCGCGACCTGGAGTTGTGTTCGCGCCTGAGCCTGTGGCATGTCATCCATTGCAACGAGCAGATCGA
CATGCTGGCCGCGCACAAGACCCAGGTTCCGCATCGCGTGTTCCTGAAAATGAACTCCGGCATGAACCGCCTGGGCTTGC
GGCCCGAGCGCTTTCGCGCCGCCTGGACGCGTCTGAATGCGCTGCCGCAGGTTGACGAGATTTCGCTGATGACGCATTTC
TCGGACGCCGACGGCCCGAAGGGCATCGCGGCGCAACTCCGCGCATTTGATGCCGTGACGCATGACCTGCCCGGCGAGCG
CTCGTTGAGCAACAGCGCGGGTGTGCTGCGCCATGGCGATGAACTGGCGGCCCGCTCCGACTGGGTGCGGCCCGGCATTG
TGGTCTACGGCAGTGCGCCCGACTTCCCGGAGCACAGCGCCGCCGACTGGGGGCTGCAGCCGACCATGACGCTGTCGTCC
CGCATCATTGGCGTGCAGGAGCTGGCGGCCGGCGACACGGTGGGCTATGGCTCCAGTTTCACCGCCGATGGCCCGCTGCG
CATCGGTGTGGTCGCCTGCGGTTATGCCGACGGCTACCCGCGCCACTGCAGCACGGGCACGCCGGTGCTGGTAAACGGCG
TGCGCACTCGCATGGTCGGGCGCGTCAGCATGGACATGATCACGGTCGACCTGACGCCGGTACCGGACGCCGGGATGGGG
GCGGAGGTGACCTTGTGGGGCCGGTCTTCGGGCGGTGCCGTGCTGCCCATTGACGAAGTGGCGCAAACCGCCGGAACCGT
GGGGTATGAGCTGATGTGCGCGGTGGCGCCGCGCGTTCCGGTGATGACTGAGTGA

Upstream 100 bases:

>100_bases
GTCAGAATCCGGAAAGACCTTTAACCGGCGCTTTGACTACCGCAGCCAGCGCCACCTTGTCCACCAAGTCACGTTATTTC
ACCCACTACCTGTTTGCTTC

Downstream 100 bases:

>100_bases
ATGTCATTGGCTGGAATGTGCGCCTGGTATTCATCTGAGAATTGTCAGATTCACCTGCGATGGTTGCAATGCACATCTTG
TGGATATCTTGTGCGATTGA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MPRPILATIHRPALAHNLARARSAAPDARVWAVVKANAYGHGIEHVFDGLRSADGFALLDLAEARRLRALDWRGPILLLE
GCFEARDLELCSRLSLWHVIHCNEQIDMLAAHKTQVPHRVFLKMNSGMNRLGLRPERFRAAWTRLNALPQVDEISLMTHF
SDADGPKGIAAQLRAFDAVTHDLPGERSLSNSAGVLRHGDELAARSDWVRPGIVVYGSAPDFPEHSAADWGLQPTMTLSS
RIIGVQELAAGDTVGYGSSFTADGPLRIGVVACGYADGYPRHCSTGTPVLVNGVRTRMVGRVSMDMITVDLTPVPDAGMG
AEVTLWGRSSGGAVLPIDEVAQTAGTVGYELMCAVAPRVPVMTE

Sequences:

>Translated_364_residues
MPRPILATIHRPALAHNLARARSAAPDARVWAVVKANAYGHGIEHVFDGLRSADGFALLDLAEARRLRALDWRGPILLLE
GCFEARDLELCSRLSLWHVIHCNEQIDMLAAHKTQVPHRVFLKMNSGMNRLGLRPERFRAAWTRLNALPQVDEISLMTHF
SDADGPKGIAAQLRAFDAVTHDLPGERSLSNSAGVLRHGDELAARSDWVRPGIVVYGSAPDFPEHSAADWGLQPTMTLSS
RIIGVQELAAGDTVGYGSSFTADGPLRIGVVACGYADGYPRHCSTGTPVLVNGVRTRMVGRVSMDMITVDLTPVPDAGMG
AEVTLWGRSSGGAVLPIDEVAQTAGTVGYELMCAVAPRVPVMTE
>Mature_363_residues
PRPILATIHRPALAHNLARARSAAPDARVWAVVKANAYGHGIEHVFDGLRSADGFALLDLAEARRLRALDWRGPILLLEG
CFEARDLELCSRLSLWHVIHCNEQIDMLAAHKTQVPHRVFLKMNSGMNRLGLRPERFRAAWTRLNALPQVDEISLMTHFS
DADGPKGIAAQLRAFDAVTHDLPGERSLSNSAGVLRHGDELAARSDWVRPGIVVYGSAPDFPEHSAADWGLQPTMTLSSR
IIGVQELAAGDTVGYGSSFTADGPLRIGVVACGYADGYPRHCSTGTPVLVNGVRTRMVGRVSMDMITVDLTPVPDAGMGA
EVTLWGRSSGGAVLPIDEVAQTAGTVGYELMCAVAPRVPVMTE

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=363, Percent_Identity=53.168044077135, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790487, Length=354, Percent_Identity=42.9378531073446, Blast_Score=267, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_POLSJ (Q12H34)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547056.1
- ProteinModelPortal:   Q12H34
- SMR:   Q12H34
- STRING:   Q12H34
- GeneID:   4011851
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0193
- NMPDR:   fig|296591.1.peg.3441
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   WGKQVLA
- PhylomeDB:   Q12H34
- ProtClustDB:   CLSK951002
- BioCyc:   PSP296591:BPRO_0193-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39246; Mature: 39115

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPILATIHRPALAHNLARARSAAPDARVWAVVKANAYGHGIEHVFDGLRSADGFALLD
CCCCEEHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEE
LAEARRLRALDWRGPILLLEGCFEARDLELCSRLSLWHVIHCNEQIDMLAAHKTQVPHRV
HHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEE
FLKMNSGMNRLGLRPERFRAAWTRLNALPQVDEISLMTHFSDADGPKGIAAQLRAFDAVT
EEEECCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
HDLPGERSLSNSAGVLRHGDELAARSDWVRPGIVVYGSAPDFPEHSAADWGLQPTMTLSS
HCCCCCCCCCCCCCCEECCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHH
RIIGVQELAAGDTVGYGSSFTADGPLRIGVVACGYADGYPRHCSTGTPVLVNGVRTRMVG
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCHHHHHHH
RVSMDMITVDLTPVPDAGMGAEVTLWGRSSGGAVLPIDEVAQTAGTVGYELMCAVAPRVP
EEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCCCEEEEEECCCCC
VMTE
CCCC
>Mature Secondary Structure 
PRPILATIHRPALAHNLARARSAAPDARVWAVVKANAYGHGIEHVFDGLRSADGFALLD
CCCEEHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEE
LAEARRLRALDWRGPILLLEGCFEARDLELCSRLSLWHVIHCNEQIDMLAAHKTQVPHRV
HHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEE
FLKMNSGMNRLGLRPERFRAAWTRLNALPQVDEISLMTHFSDADGPKGIAAQLRAFDAVT
EEEECCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
HDLPGERSLSNSAGVLRHGDELAARSDWVRPGIVVYGSAPDFPEHSAADWGLQPTMTLSS
HCCCCCCCCCCCCCCEECCHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHH
RIIGVQELAAGDTVGYGSSFTADGPLRIGVVACGYADGYPRHCSTGTPVLVNGVRTRMVG
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCHHHHHHH
RVSMDMITVDLTPVPDAGMGAEVTLWGRSSGGAVLPIDEVAQTAGTVGYELMCAVAPRVP
EEEEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCCCEEEEEECCCCC
VMTE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA