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The map label for this gene is vat [H]

Identifier: 91786077

GI number: 91786077

Start: 179131

End: 181500

Strand: Direct

Name: vat [H]

Synonym: Bpro_0166

Alternate gene names: 91786077

Gene position: 179131-181500 (Clockwise)

Preceding gene: 91786075

Following gene: 91786083

Centisome position: 3.44

GC content: 65.61

Gene sequence:

>2370_bases
ATGAGCAAGCGTTCCGCGAGTGAGCAGCAGTGGCTGTTGTCTCCCGGCCTGAAAGAAGCGCCGGTGCTCGATCTCATGTG
CTCGCACTTTGTGCTGACCCTGGCAGCCCGCCAGGGCGCCAAGTTCAATGTACGGCGCGACCTCAACAGCCTGCTGTCGC
TCTCGGGGCGACACCTGGTCTGGCCGCTGCCGGCGATGCAGCGCCTGCGTGAATTCCTGGGGCGCCGCTGCAAGGACAAC
GAACTGTGGCGCGGCCACGAAACCCTGAGCGACGCCGAGTTCATGGCGCGCCACGGCGCCTGGCGTGGTCCGTATGAGGA
GGGCACGCTGTTCTTCTATCTCGATGAGCACGCCAAGGACCAGCCCAAGGATTTGCTGTCCGTGCTGGCCGCCACCGGCG
AGTGGCTGACGCACGCGCTGAAAAAGCAGTCCACGCTGGTGGAGAAAAACATTGATGCGCTGGCCAACCTGCTGCAACTC
AACCGGGCCGAGCGTGCGCTGCTGCTGTATGGAACCCTCGCGCGCTATCAGCGCGATCTTCGCTCGCTGCTGGTCGAGTT
CAAGGTCAGCAACGCACCCGAGGCTTACGCCGCCATCGCCGACGTGGCCGGCGTCAAGGCACCGGAGGTCGCCGAGGCAT
TGCGCGCCGGCTCGCGGCTCGAGCGCATTGGTATGGTCGAAAACCTGATTTCAGAGCACAACATCACGGACCTGGCCGAC
CTGATGAAGGTCAGCGAAAAGCTGCCGCCGGTGCTGATGCGCGAATACCGCGACCAGAACGAGCTGATGGCCGTCTTTAC
CCGGCCCGCTGCGCGCAGCAGCCTCGGCTTGGCGGACTTCGCCTTTGTGCAGGACGACGCCCAGGTGCTGGTGTCCCTGC
TGCGCAATGCGGTCGCCGCCCGGGAGCAGGGCGTCAATGTGCTGCTCTACGGGCCACCCGGCACCGGCAAGACCGAGCTG
GCCAAGGTGGTGGCGCATGCGGCCGGGCTGGACCTGTTCGAGGTCGAATATGCCGACCGCGACGGCAACTCGCTGAGCGG
GCGCGATCGCTACCGCTCCCTGCAGATCGCCCAGGTTTTCCTGAAGGGCAGCACGCACTCCGCCCTGCTGTTTGACGAGG
TGGAGGATGTGTTCCCGCCGATCTCCAGTGAAGCCGCGCAGTTCATGGCGCGCTCCGAACAGTTGCCGCCCGCCAGTGCG
GCCAACGGCTCGGTCAGCGGCAAGGCCTGGGTCAACCAGATCCTGGAGTCCAACGCGGTGCCCACGCTGTGGGTGACCAA
CCGCATCGAGCAGATCGATCCGGCCTTTCGCCGCCGTTTTGCCTACCACCTCGAGCTTCGCTCACCGCCGCCCGGTGCGC
GCGAGGGCGTGGTGCGCAAGACGCTGGAAGGCGTGCAGGTCAGCGAGGCGTTTGTGGAGAAGCTCACCGCGCGCAAGGGC
CTGACGCCGGCGCAGATACGCACGGCCGTGCGGTTTGCCCAGCTGGCCAGCGCGCCAGCGGACACGGTGGACGCCCAGGT
GGATGCCGAGGGGATGAAGGCCATGCTGGCGGGCGGCCGCCCGGCGCTGATGGAGTCCCTGATCGAGCGGCAGCTCAAGA
ACGCCGATGTCGCACTGGGCAATCCGGCGGAAGCGGCGGGCCGCCGCAGCGTGACGACCTACGACCTGGCGATGCTGCAT
GTCGAGTCCCGTTTTGAGGTGCCGCGCATCGTCGAGGCGCTGAAAAGCCGGGGCCACGGCTGCCTGTGTTTTTACGGCGC
CCCCGGCACGGGTAAAACTGCGCTGGCCGAACACATCGCCAAAACGCTGGACCAGGCGCTCATCATCAAGCAGGCCAGCG
ACCTGATGAGCAAGTATGTGGGTGAGACCGAGCAGAACATGGCGGCCATGTTCCGCGAGGCCGAAGCCGAGAAGGCCGTG
CTGCTGCTCGATGAGGCCGACAGCTTTCTGCAGGACAGGCGCGGCGCGCAGCGCACCTATGAGGTCACCGAGGTCAACGA
AATGCTGCAGGGCATGGAGCGCTATGCGGGCATCTTCATCTGCACCACCAACCTGATGGAAAGCCTGGACCAGGCCGCCT
TGCGGCGCTTTACCTTCAAGATCAAGTTCATGCCGCTGACGCGCGAGCAGCGCGAGAAGATGTTCGTGGTCGAGGCGCTG
GGCGGCGACGCCGCGCTGTTCACGGCGGCGCTGCAGGAGCGGCTGGGCAAGCTCTCACAGCTGTGCCCCGGTGACTTCGC
GGCCGTCAAACGCCAGACAGATATTCTGGGCGCGGTGTTCAGCCCTGACGAATTCATGAGTCAGCTCGAAGCCGAGCACC
GCATCAAGCCCGAAGTGCGCGAGTCGCGCAACATGGGCTTTTTGCACTGA

Upstream 100 bases:

>100_bases
CTTCAAGTAGCGTCTTCCATGATGCTTCAAGCTGCGTTATGGTGTGTCTTTAGAGCTGGGTTTGCGTCAAAGGTTTTTTT
TGCAAACTGGGGGTTTGTCC

Downstream 100 bases:

>100_bases
TCGGAATTTCAGAACTTGACAAGGCGGATGGTTTTGCGCGAGCCATTGCCCCTGTCGGTGACGGCCTGCACCCTGCGCGC
CCGGCAGCCGCCGGCACCGC

Product: AAA ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MSKRSASEQQWLLSPGLKEAPVLDLMCSHFVLTLAARQGAKFNVRRDLNSLLSLSGRHLVWPLPAMQRLREFLGRRCKDN
ELWRGHETLSDAEFMARHGAWRGPYEEGTLFFYLDEHAKDQPKDLLSVLAATGEWLTHALKKQSTLVEKNIDALANLLQL
NRAERALLLYGTLARYQRDLRSLLVEFKVSNAPEAYAAIADVAGVKAPEVAEALRAGSRLERIGMVENLISEHNITDLAD
LMKVSEKLPPVLMREYRDQNELMAVFTRPAARSSLGLADFAFVQDDAQVLVSLLRNAVAAREQGVNVLLYGPPGTGKTEL
AKVVAHAAGLDLFEVEYADRDGNSLSGRDRYRSLQIAQVFLKGSTHSALLFDEVEDVFPPISSEAAQFMARSEQLPPASA
ANGSVSGKAWVNQILESNAVPTLWVTNRIEQIDPAFRRRFAYHLELRSPPPGAREGVVRKTLEGVQVSEAFVEKLTARKG
LTPAQIRTAVRFAQLASAPADTVDAQVDAEGMKAMLAGGRPALMESLIERQLKNADVALGNPAEAAGRRSVTTYDLAMLH
VESRFEVPRIVEALKSRGHGCLCFYGAPGTGKTALAEHIAKTLDQALIIKQASDLMSKYVGETEQNMAAMFREAEAEKAV
LLLDEADSFLQDRRGAQRTYEVTEVNEMLQGMERYAGIFICTTNLMESLDQAALRRFTFKIKFMPLTREQREKMFVVEAL
GGDAALFTAALQERLGKLSQLCPGDFAAVKRQTDILGAVFSPDEFMSQLEAEHRIKPEVRESRNMGFLH

Sequences:

>Translated_789_residues
MSKRSASEQQWLLSPGLKEAPVLDLMCSHFVLTLAARQGAKFNVRRDLNSLLSLSGRHLVWPLPAMQRLREFLGRRCKDN
ELWRGHETLSDAEFMARHGAWRGPYEEGTLFFYLDEHAKDQPKDLLSVLAATGEWLTHALKKQSTLVEKNIDALANLLQL
NRAERALLLYGTLARYQRDLRSLLVEFKVSNAPEAYAAIADVAGVKAPEVAEALRAGSRLERIGMVENLISEHNITDLAD
LMKVSEKLPPVLMREYRDQNELMAVFTRPAARSSLGLADFAFVQDDAQVLVSLLRNAVAAREQGVNVLLYGPPGTGKTEL
AKVVAHAAGLDLFEVEYADRDGNSLSGRDRYRSLQIAQVFLKGSTHSALLFDEVEDVFPPISSEAAQFMARSEQLPPASA
ANGSVSGKAWVNQILESNAVPTLWVTNRIEQIDPAFRRRFAYHLELRSPPPGAREGVVRKTLEGVQVSEAFVEKLTARKG
LTPAQIRTAVRFAQLASAPADTVDAQVDAEGMKAMLAGGRPALMESLIERQLKNADVALGNPAEAAGRRSVTTYDLAMLH
VESRFEVPRIVEALKSRGHGCLCFYGAPGTGKTALAEHIAKTLDQALIIKQASDLMSKYVGETEQNMAAMFREAEAEKAV
LLLDEADSFLQDRRGAQRTYEVTEVNEMLQGMERYAGIFICTTNLMESLDQAALRRFTFKIKFMPLTREQREKMFVVEAL
GGDAALFTAALQERLGKLSQLCPGDFAAVKRQTDILGAVFSPDEFMSQLEAEHRIKPEVRESRNMGFLH
>Mature_788_residues
SKRSASEQQWLLSPGLKEAPVLDLMCSHFVLTLAARQGAKFNVRRDLNSLLSLSGRHLVWPLPAMQRLREFLGRRCKDNE
LWRGHETLSDAEFMARHGAWRGPYEEGTLFFYLDEHAKDQPKDLLSVLAATGEWLTHALKKQSTLVEKNIDALANLLQLN
RAERALLLYGTLARYQRDLRSLLVEFKVSNAPEAYAAIADVAGVKAPEVAEALRAGSRLERIGMVENLISEHNITDLADL
MKVSEKLPPVLMREYRDQNELMAVFTRPAARSSLGLADFAFVQDDAQVLVSLLRNAVAAREQGVNVLLYGPPGTGKTELA
KVVAHAAGLDLFEVEYADRDGNSLSGRDRYRSLQIAQVFLKGSTHSALLFDEVEDVFPPISSEAAQFMARSEQLPPASAA
NGSVSGKAWVNQILESNAVPTLWVTNRIEQIDPAFRRRFAYHLELRSPPPGAREGVVRKTLEGVQVSEAFVEKLTARKGL
TPAQIRTAVRFAQLASAPADTVDAQVDAEGMKAMLAGGRPALMESLIERQLKNADVALGNPAEAAGRRSVTTYDLAMLHV
ESRFEVPRIVEALKSRGHGCLCFYGAPGTGKTALAEHIAKTLDQALIIKQASDLMSKYVGETEQNMAAMFREAEAEKAVL
LLDEADSFLQDRRGAQRTYEVTEVNEMLQGMERYAGIFICTTNLMESLDQAALRRFTFKIKFMPLTREQREKMFVVEALG
GDAALFTAALQERLGKLSQLCPGDFAAVKRQTDILGAVFSPDEFMSQLEAEHRIKPEVRESRNMGFLH

Specific function: Seems To Act As An ATP-Dependent Zinc Metallopeptidase. Involved In The Degradation Of Sigma-32. Degrades Carboxy- Terminal-Tagged Cytoplasmic Proteins. These Proteins Are Tagged With An 11-Amino-Acid Nonpolar Destabilizing Tail VIa A Mechanism Involving

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family. CDC48 subfamily [H]

Homologues:

Organism=Homo sapiens, GI153792536, Length=195, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532375, Length=455, Percent_Identity=27.032967032967, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17531535, Length=446, Percent_Identity=27.1300448430493, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146157, Length=221, Percent_Identity=31.2217194570136, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320077, Length=449, Percent_Identity=27.8396436525612, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323429, Length=417, Percent_Identity=24.7002398081535, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324000, Length=177, Percent_Identity=31.0734463276836, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319554, Length=175, Percent_Identity=30.2857142857143, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320602, Length=155, Percent_Identity=30.3225806451613, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161076488, Length=433, Percent_Identity=26.0969976905312, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137560, Length=433, Percent_Identity=26.0969976905312, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076486, Length=433, Percent_Identity=26.0969976905312, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581396, Length=156, Percent_Identity=32.6923076923077, Blast_Score=70, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355121, Length=174, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR003593
- InterPro:   IPR005938
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR003338
- InterPro:   IPR004201 [H]

Pfam domain/function: PF00004 AAA; PF02933 CDC48_2; PF02359 CDC48_N [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 87437; Mature: 87306

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRSASEQQWLLSPGLKEAPVLDLMCSHFVLTLAARQGAKFNVRRDLNSLLSLSGRHLV
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCEEE
WPLPAMQRLREFLGRRCKDNELWRGHETLSDAEFMARHGAWRGPYEEGTLFFYLDEHAKD
ECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
QPKDLLSVLAATGEWLTHALKKQSTLVEKNIDALANLLQLNRAERALLLYGTLARYQRDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLLVEFKVSNAPEAYAAIADVAGVKAPEVAEALRAGSRLERIGMVENLISEHNITDLAD
HHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LMKVSEKLPPVLMREYRDQNELMAVFTRPAARSSLGLADFAFVQDDAQVLVSLLRNAVAA
HHHHHHHCCHHHHHHHCCCHHEEHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
REQGVNVLLYGPPGTGKTELAKVVAHAAGLDLFEVEYADRDGNSLSGRDRYRSLQIAQVF
HHCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
LKGSTHSALLFDEVEDVFPPISSEAAQFMARSEQLPPASAANGSVSGKAWVNQILESNAV
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PTLWVTNRIEQIDPAFRRRFAYHLELRSPPPGAREGVVRKTLEGVQVSEAFVEKLTARKG
CEEHHHHHHHHCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCC
LTPAQIRTAVRFAQLASAPADTVDAQVDAEGMKAMLAGGRPALMESLIERQLKNADVALG
CCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECC
NPAEAAGRRSVTTYDLAMLHVESRFEVPRIVEALKSRGHGCLCFYGAPGTGKTALAEHIA
CCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
KTLDQALIIKQASDLMSKYVGETEQNMAAMFREAEAEKAVLLLDEADSFLQDRRGAQRTY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCHHHH
EVTEVNEMLQGMERYAGIFICTTNLMESLDQAALRRFTFKIKFMPLTREQREKMFVVEAL
HHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHEEEEEEC
GGDAALFTAALQERLGKLSQLCPGDFAAVKRQTDILGAVFSPDEFMSQLEAEHRIKPEVR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCHHH
ESRNMGFLH
HCCCCCCCC
>Mature Secondary Structure 
SKRSASEQQWLLSPGLKEAPVLDLMCSHFVLTLAARQGAKFNVRRDLNSLLSLSGRHLV
CCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCEEE
WPLPAMQRLREFLGRRCKDNELWRGHETLSDAEFMARHGAWRGPYEEGTLFFYLDEHAKD
ECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
QPKDLLSVLAATGEWLTHALKKQSTLVEKNIDALANLLQLNRAERALLLYGTLARYQRDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLLVEFKVSNAPEAYAAIADVAGVKAPEVAEALRAGSRLERIGMVENLISEHNITDLAD
HHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LMKVSEKLPPVLMREYRDQNELMAVFTRPAARSSLGLADFAFVQDDAQVLVSLLRNAVAA
HHHHHHHCCHHHHHHHCCCHHEEHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
REQGVNVLLYGPPGTGKTELAKVVAHAAGLDLFEVEYADRDGNSLSGRDRYRSLQIAQVF
HHCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
LKGSTHSALLFDEVEDVFPPISSEAAQFMARSEQLPPASAANGSVSGKAWVNQILESNAV
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
PTLWVTNRIEQIDPAFRRRFAYHLELRSPPPGAREGVVRKTLEGVQVSEAFVEKLTARKG
CEEHHHHHHHHCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCC
LTPAQIRTAVRFAQLASAPADTVDAQVDAEGMKAMLAGGRPALMESLIERQLKNADVALG
CCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECC
NPAEAAGRRSVTTYDLAMLHVESRFEVPRIVEALKSRGHGCLCFYGAPGTGKTALAEHIA
CCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
KTLDQALIIKQASDLMSKYVGETEQNMAAMFREAEAEKAVLLLDEADSFLQDRRGAQRTY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCHHHH
EVTEVNEMLQGMERYAGIFICTTNLMESLDQAALRRFTFKIKFMPLTREQREKMFVVEAL
HHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHEEEEEEC
GGDAALFTAALQERLGKLSQLCPGDFAAVKRQTDILGAVFSPDEFMSQLEAEHRIKPEVR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCHHH
ESRNMGFLH
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9119075; 11029001; 10356978 [H]