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The map label for this gene is acsA1 [H]

Identifier: 91786031

GI number: 91786031

Start: 121916

End: 124006

Strand: Direct

Name: acsA1 [H]

Synonym: Bpro_0120

Alternate gene names: 91786031

Gene position: 121916-124006 (Clockwise)

Preceding gene: 91786027

Following gene: 91786032

Centisome position: 2.34

GC content: 62.55

Gene sequence:

>2091_bases
ATGAGCGCACCCTTTACTCCCCAAATACGCCTCTACCAGGACTGGTTGAAGGCCACGCGCGGCCTGTCCTTTGACAGCTA
TGACGCACTGTGGCGTTGGTCGGTGACCGACCTGGAGGCCTTCTGGCAAAGCATCTGGGACTATTTTGAGTTGCAATCGC
CGACGCCGCACACAGCGGTGCTGGCCGACCGGCGCATGCCTGGTGCCCGGTGGTTTCCGGGCGCCCAGGTCAACTATGCG
CGGCAGGTCCTGCGGCACGTGGACAAGGCCCACGCCGCAGGTTTCCCCGCGCTTGTCAACCACAACGAAAAAAGCCTTGC
CAGCGGCCAGCACCGCGAACTGAGCTGGCCTGCTCTGCGCCAGCAGGTCGCGTCACTGGCACTGCACCTGAAGGCCCAAG
GTGTGGAGCCGGGCGACCGCGTGGCCGCCTATTTACCCAACATTCCCGAGGCCATGGTGGCTTTCCTGGCCGTGGTCAGC
ATAGGCGGCGTCTGGAGCATTTGCGCGCCCGACATGGGCACCCACGCCGTGCTGGACCGCTTCAAACAGATCGAACCCAA
GGTGCTGATTGCCTGTGACGGCGTGCGCTATGGCGGGCGCGATTTTGACCGCACGGCTGTGCTGGCGGAGCTGCGCGCCG
CGCTGCCCAGCCTGCAGCATGTGATCGTTCATGAGAATCTTGGCAGCACAAATTCAATAGCCGACAGCACCCTTCTCGAA
AGCGCGACGGCCCGAAATGATGCGCAAACTGCGGCGTTTGAACCGCTCTGGCTGCCGTTTGACCATCCGCTGTGGATTGT
CTATTCCAGCGGCACCACCGGCCTGCCCAAGCCCATCGTGCATGGCCACGGCGGCACGCAACTGGTAGCGCTGGCGTTGA
AGACCCTGCACAACGACATCGGTTGCAGCTACGAGGCCAACAGCTGGGGCGAGCGCTACCACTGGTACAGCTCCACCGGC
TGGGTGATGTGGAACGCGCAGCTGAGCGGCCTGCTCAACGGCACCACCTGCTGCCTGTTTGACGGCAACCCCGGCGGCAG
CAAGGACAAACCCGACTGGACCACGCTCTGGCGCTTTGCGGCCGACCTTGACGTGACGTTTTTCGGCGCCGGTGCCGCCT
TCTTTGCCAATTGCATGAAGGCGGGGGTTGAGCTGGCGGAATGCGGCGATCTGACAAGGATAAGGGCACTCGGCAGCACC
GGTTCGCCGCTGAGCGAAGACACGCAGCGATGGGGGACGCAGCAATTCCGCAAGCTCCATGCCGTTCGCTCTGAGCCTGT
CAAAGAGCCCTTCGACCTTGCTCAGGACCGGCTTCGACAAGCTCAGCCCGAACGGGAAGATATCTGGTGGTGCAACATCT
CCGGCGGAACGGACTTCGCCGGCGCTTTCATCGGCGGCAACCGCGAATTGCCGCTGGTCCCCGGCGAGATGCAGTGCCGC
CTGCTCGGCTGCGCGGTCGAGGCCTGGAACGAGCAGGGCCAACCTGTCATCAATGAAGTGGGCGAATTGGTCTGTACGCA
GCCCCTGCCGTCCATGCCTCTGTACTTCGTCGGCGATGAGGGCAACCAGCGCTACCTCTCCAGCTACTTCGACATATACC
CCAATGTCTGGCGGCATGGCGACTGGCTCAAGATTGGCGCCAACGGCGGTTGCGTGATATACGGCCGCAGCGATGCCACC
ATCAACCGCCACGGCCTGCGCATGGGCACCAGCGAGCTGTACAGCGCGATAGAGGCGCTGCCCGAGGTGCTGGACTCGAT
GGTGGTGGACCTGGAGTATCTGGGCCGCGAAAGCTACATGCCGCTGTTTGTGGTGCTGCGCGAGGGTGTCGCGCTCGACG
ACGCCCTGAAAGCCCGTTTGAATGGTGCGATCAAAACCGCGTTGTCGCCGCGCTTTGTACCCGATGCCATTTTTCAGGTG
CCCGAAATACCGCGCACTCTGTCGGGCAAAAAACAGGAGCTGCCAATCAAGAAACTGTTGCTGGGGCAACCGATCGAGAA
GGTGGTGAACCGGGACGCGATGGCCAACCCGGATTGCCTCGCATGGTATGTTCAGTTCTCGCAAAACTACCTTGCCGAAA
GGGGCGCATGA

Upstream 100 bases:

>100_bases
TGCGGCGAATATTAGCACGATTGTGCGAAATTGCAAATCACGCACTTCATGAGGCGTGCTGACCCTTCTCACGTCAAGGT
CGTGGCGTTAAGCTTGCACC

Downstream 100 bases:

>100_bases
ATCGACGAATGATGGGGGCGGCCGCCCTCGCTGTCCTTGGCCTGCTCACTGCATGCGCGACCGGACCCGCCTCCGCTCCC
CCGGCCGACGTGCCAGCAGC

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSAPFTPQIRLYQDWLKATRGLSFDSYDALWRWSVTDLEAFWQSIWDYFELQSPTPHTAVLADRRMPGARWFPGAQVNYA
RQVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALRQQVASLALHLKAQGVEPGDRVAAYLPNIPEAMVAFLAVVS
IGGVWSICAPDMGTHAVLDRFKQIEPKVLIACDGVRYGGRDFDRTAVLAELRAALPSLQHVIVHENLGSTNSIADSTLLE
SATARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHNDIGCSYEANSWGERYHWYSSTG
WVMWNAQLSGLLNGTTCCLFDGNPGGSKDKPDWTTLWRFAADLDVTFFGAGAAFFANCMKAGVELAECGDLTRIRALGST
GSPLSEDTQRWGTQQFRKLHAVRSEPVKEPFDLAQDRLRQAQPEREDIWWCNISGGTDFAGAFIGGNRELPLVPGEMQCR
LLGCAVEAWNEQGQPVINEVGELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHGDWLKIGANGGCVIYGRSDAT
INRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYMPLFVVLREGVALDDALKARLNGAIKTALSPRFVPDAIFQV
PEIPRTLSGKKQELPIKKLLLGQPIEKVVNRDAMANPDCLAWYVQFSQNYLAERGA

Sequences:

>Translated_696_residues
MSAPFTPQIRLYQDWLKATRGLSFDSYDALWRWSVTDLEAFWQSIWDYFELQSPTPHTAVLADRRMPGARWFPGAQVNYA
RQVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALRQQVASLALHLKAQGVEPGDRVAAYLPNIPEAMVAFLAVVS
IGGVWSICAPDMGTHAVLDRFKQIEPKVLIACDGVRYGGRDFDRTAVLAELRAALPSLQHVIVHENLGSTNSIADSTLLE
SATARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHNDIGCSYEANSWGERYHWYSSTG
WVMWNAQLSGLLNGTTCCLFDGNPGGSKDKPDWTTLWRFAADLDVTFFGAGAAFFANCMKAGVELAECGDLTRIRALGST
GSPLSEDTQRWGTQQFRKLHAVRSEPVKEPFDLAQDRLRQAQPEREDIWWCNISGGTDFAGAFIGGNRELPLVPGEMQCR
LLGCAVEAWNEQGQPVINEVGELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHGDWLKIGANGGCVIYGRSDAT
INRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYMPLFVVLREGVALDDALKARLNGAIKTALSPRFVPDAIFQV
PEIPRTLSGKKQELPIKKLLLGQPIEKVVNRDAMANPDCLAWYVQFSQNYLAERGA
>Mature_695_residues
SAPFTPQIRLYQDWLKATRGLSFDSYDALWRWSVTDLEAFWQSIWDYFELQSPTPHTAVLADRRMPGARWFPGAQVNYAR
QVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALRQQVASLALHLKAQGVEPGDRVAAYLPNIPEAMVAFLAVVSI
GGVWSICAPDMGTHAVLDRFKQIEPKVLIACDGVRYGGRDFDRTAVLAELRAALPSLQHVIVHENLGSTNSIADSTLLES
ATARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHNDIGCSYEANSWGERYHWYSSTGW
VMWNAQLSGLLNGTTCCLFDGNPGGSKDKPDWTTLWRFAADLDVTFFGAGAAFFANCMKAGVELAECGDLTRIRALGSTG
SPLSEDTQRWGTQQFRKLHAVRSEPVKEPFDLAQDRLRQAQPEREDIWWCNISGGTDFAGAFIGGNRELPLVPGEMQCRL
LGCAVEAWNEQGQPVINEVGELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHGDWLKIGANGGCVIYGRSDATI
NRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYMPLFVVLREGVALDDALKARLNGAIKTALSPRFVPDAIFQVP
EIPRTLSGKKQELPIKKLLLGQPIEKVVNRDAMANPDCLAWYVQFSQNYLAERGA

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=686, Percent_Identity=34.2565597667638, Blast_Score=391, Evalue=1e-108,
Organism=Homo sapiens, GI28416953, Length=677, Percent_Identity=26.4401772525849, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI8923896, Length=699, Percent_Identity=25.7510729613734, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI253970489, Length=712, Percent_Identity=25.2808988764045, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI13375727, Length=657, Percent_Identity=25.5707762557078, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1790505, Length=684, Percent_Identity=25.1461988304094, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1786529, Length=652, Percent_Identity=25.4601226993865, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17569507, Length=678, Percent_Identity=30.8259587020649, Blast_Score=341, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI71982997, Length=674, Percent_Identity=23.8872403560831, Blast_Score=142, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71983001, Length=674, Percent_Identity=23.8872403560831, Blast_Score=142, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319264, Length=631, Percent_Identity=24.8811410459588, Blast_Score=154, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6323182, Length=689, Percent_Identity=23.6574746008708, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24667955, Length=663, Percent_Identity=24.4343891402715, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI62472339, Length=568, Percent_Identity=25.5281690140845, Blast_Score=152, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24667959, Length=535, Percent_Identity=24.4859813084112, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355225, Length=654, Percent_Identity=23.7003058103976, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 77115; Mature: 76984

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPFTPQIRLYQDWLKATRGLSFDSYDALWRWSVTDLEAFWQSIWDYFELQSPTPHTAV
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCEE
LADRRMPGARWFPGAQVNYARQVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCCCCCCCCCHHHH
QQVASLALHLKAQGVEPGDRVAAYLPNIPEAMVAFLAVVSIGGVWSICAPDMGTHAVLDR
HHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
FKQIEPKVLIACDGVRYGGRDFDRTAVLAELRAALPSLQHVIVHENLGSTNSIADSTLLE
HHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHH
SATARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHNDI
HHHCCCCCHHHCCCCEECCCCCCEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
GCSYEANSWGERYHWYSSTGWVMWNAQLSGLLNGTTCCLFDGNPGGSKDKPDWTTLWRFA
CCCCCCCCCCCCEEEECCCCEEEECCEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
ADLDVTFFGAGAAFFANCMKAGVELAECGDLTRIRALGSTGSPLSEDTQRWGTQQFRKLH
HCCCEEEECCCHHHHHHHHHHCCCHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AVRSEPVKEPFDLAQDRLRQAQPEREDIWWCNISGGTDFAGAFIGGNRELPLVPGEMQCR
HHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCHHHEE
LLGCAVEAWNEQGQPVINEVGELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHG
EHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCEEEECCCCCHHHHHHHHHHCCHHHCCC
DWLKIGANGGCVIYGRSDATINRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYM
CEEEECCCCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLFVVLREGVALDDALKARLNGAIKTALSPRFVPDAIFQVPEIPRTLSGKKQELPIKKLL
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHCCCCCCCCHHHHH
LGQPIEKVVNRDAMANPDCLAWYVQFSQNYLAERGA
HCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPFTPQIRLYQDWLKATRGLSFDSYDALWRWSVTDLEAFWQSIWDYFELQSPTPHTAV
CCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCEE
LADRRMPGARWFPGAQVNYARQVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCCCCCCCCCHHHH
QQVASLALHLKAQGVEPGDRVAAYLPNIPEAMVAFLAVVSIGGVWSICAPDMGTHAVLDR
HHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
FKQIEPKVLIACDGVRYGGRDFDRTAVLAELRAALPSLQHVIVHENLGSTNSIADSTLLE
HHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHH
SATARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHNDI
HHHCCCCCHHHCCCCEECCCCCCEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
GCSYEANSWGERYHWYSSTGWVMWNAQLSGLLNGTTCCLFDGNPGGSKDKPDWTTLWRFA
CCCCCCCCCCCCEEEECCCCEEEECCEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHH
ADLDVTFFGAGAAFFANCMKAGVELAECGDLTRIRALGSTGSPLSEDTQRWGTQQFRKLH
HCCCEEEECCCHHHHHHHHHHCCCHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AVRSEPVKEPFDLAQDRLRQAQPEREDIWWCNISGGTDFAGAFIGGNRELPLVPGEMQCR
HHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCHHHEE
LLGCAVEAWNEQGQPVINEVGELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHG
EHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCEEEECCCCCHHHHHHHHHHCCHHHCCC
DWLKIGANGGCVIYGRSDATINRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYM
CEEEECCCCCEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLFVVLREGVALDDALKARLNGAIKTALSPRFVPDAIFQVPEIPRTLSGKKQELPIKKLL
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHCCCCCCCCHHHHH
LGQPIEKVVNRDAMANPDCLAWYVQFSQNYLAERGA
HCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]