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The map label for this gene is thiC [H]

Identifier: 91785950

GI number: 91785950

Start: 39663

End: 41579

Strand: Direct

Name: thiC [H]

Synonym: Bpro_0037

Alternate gene names: 91785950

Gene position: 39663-41579 (Clockwise)

Preceding gene: 91785949

Following gene: 91785951

Centisome position: 0.76

GC content: 63.17

Gene sequence:

>1917_bases
ATGGCCAAAACCCGCCTCACCGTTGACACCAACGACCTCGCAAGCCGTATCACGCGCGCGCCTTTTCCCGGTTCCGCCAA
AATTTATATCGAGGGTTCGCGCCCCGACATCCGCGTGCCGTTTCGCGAGGTCACGCTGACCGACACGATGGTGCACGAGG
GGGCGGGCGAGCCGCGCCGCGAAGCCAATCCGCCGCTGCGCCTGTATGACGCCTCGGGCGTCTACACCGACCCGGCGTCG
CCGATCGACATCACGCGCGGCTTGCCGCCTTTGCGCGGCGCCTGGATCAATGAGCGCGCCGACACCGAAGCGCTGCCCGG
CATCAGCAGCGCCTATGGCCGCGAGCGCCTGAACGACCCGGCGCTGGCCGCCCTGCGCATGGCGCATGCGCCCGTGCCGC
GCCGCGCCAAGGCCGGTGCCAACGTCTCGCAAATGCATTACGCCCGCAAAGGCATCATCACGCCGGAGATGGAATACATC
GCGGTGCGCGAAAACCTGGTGCGCGCGCAGCTGGCCGAGCGCCTGGCGACCGAGCGCATGCCGAAGAAAGGGCACTCCTT
CAACGCCTCGATTCCGGAACAGATCACCGCTGAATTTGTGCGTGATGAAGTGGCGCGCGGCCGCGCCGTGATTCCGAACA
ACATCAACCACCCCGAGAGCGAGCCGATGATCATCGGCCGCAATTTCCTGATCAAGGTCAATGCCAACATCGGCAACTCG
GCCGTGACGTCTTCCATCGAGGAAGAGGTGGACAAGCTGGTCTGGTCGATCCGCTGGGGCGCCGACACCGTGATGGACCT
GTCGACCGGCGAGAACATCCACGAGACGCGCGAATGGATTCTGCGCAACTCGCCGGTGCCGATCGGCACGGTGCCGATTT
ACCAGGCGCTGGAAAAAGTCAACGGCAAGGCCGAAGACCTGACCTGGGAAATCTTCCGCGACACGCTGATCGAGCAGGCC
GAGCAGGGCGTGGACTACTTCACCATCCACGCCGGTGTGCGCCTGGCCTATGTGCCGCTGACCGCCAACCGCCTGACGGG
CATCGTCTCGCGCGGCGGCTCCATCATGGCCAAGTGGTGTTTGTCGCACCACAAGGAAAGCTTTTTGTACGAGCGCTTTG
ACGAGATCTGCGAGATCATGAAGGCCTACGACGTGTGCTTCTCGCTGGGCGACGGTCTGCGGCCCGGCTCGATTGCCGAT
GCCAATGACGAAGCGCAGTTTGCCGAGCTGCACACGCTGGGCGAACTCACGCAGATCGCCTGGAAACATGATGTGCAGGT
GATGATCGAAGGCCCTGGCCATGTGCCGCTGCAGCTGGTGAAGGAAAACGTCGACAAGCAGCTCGAGGCTTGTTTTGAGG
CGCCGTTCTACACGCTGGGCCCGCTGATCACCGACATCTCGCCGGGCTACGACCATATTTCTTCCGCGATGGGCGCGGCC
AACATCGGCTGGTATGGCACAGCCATGCTCTGCTACGTGACGCCGAAGGAGCACCTCGGGCTGCCAAACCGCGACGACGT
GAAGCAGGGCCTGATCGCCTACAAGATTGCGGCCCACGCGGGCGACCTGGCCAAGGGCTACCCGGGCGCGCAGATGTGGG
ACAACGCGGTGTCCAAGGCGCGCTTCGAGTTCCGCTGGGAAGACCAGTTCCGCCTGGCGATCGACCCGGACACGGCCATG
GCCTACCACGACGAAACCCTGCCGAAGGAAAACGCCAAGGTGGCGCATTTCTGTTCGATGTGCGGACCGAAGTTCTGTTC
GATGAAGATCTCGCAGGAAGTGCGCGAGTTTGCAAGGCTCAATCCGGCCAGCACCACGCTGGCCGCGCCGGGCGTGATTG
CGATCAAGCAGATCGACAGCGGATTCGAGGAAAAGGCGAAAGAGTTTCGTGAAGGTGGCAGTGAGATTTATTCTTGA

Upstream 100 bases:

>100_bases
CCCGCGTAGGGAACAAGGCACTTGGCTCCGGCACTCCGCAGAGGAACTCCCGGCTCCCCAGGCAGGCACCCCACCTTCTG
GACTTTCTGGAGCAAAAGCC

Downstream 100 bases:

>100_bases
TGATTTCGCCCCCGGTTTATCTCCTCTCCCTCTGGGAGAGGATTAAGGTGAGGGCTCCCTGGGCCCGAAATTAAATGAAG
TTGTTTCTTTTCATGTGCCG

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MAKTRLTVDTNDLASRITRAPFPGSAKIYIEGSRPDIRVPFREVTLTDTMVHEGAGEPRREANPPLRLYDASGVYTDPAS
PIDITRGLPPLRGAWINERADTEALPGISSAYGRERLNDPALAALRMAHAPVPRRAKAGANVSQMHYARKGIITPEMEYI
AVRENLVRAQLAERLATERMPKKGHSFNASIPEQITAEFVRDEVARGRAVIPNNINHPESEPMIIGRNFLIKVNANIGNS
AVTSSIEEEVDKLVWSIRWGADTVMDLSTGENIHETREWILRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQA
EQGVDYFTIHAGVRLAYVPLTANRLTGIVSRGGSIMAKWCLSHHKESFLYERFDEICEIMKAYDVCFSLGDGLRPGSIAD
ANDEAQFAELHTLGELTQIAWKHDVQVMIEGPGHVPLQLVKENVDKQLEACFEAPFYTLGPLITDISPGYDHISSAMGAA
NIGWYGTAMLCYVTPKEHLGLPNRDDVKQGLIAYKIAAHAGDLAKGYPGAQMWDNAVSKARFEFRWEDQFRLAIDPDTAM
AYHDETLPKENAKVAHFCSMCGPKFCSMKISQEVREFARLNPASTTLAAPGVIAIKQIDSGFEEKAKEFREGGSEIYS

Sequences:

>Translated_638_residues
MAKTRLTVDTNDLASRITRAPFPGSAKIYIEGSRPDIRVPFREVTLTDTMVHEGAGEPRREANPPLRLYDASGVYTDPAS
PIDITRGLPPLRGAWINERADTEALPGISSAYGRERLNDPALAALRMAHAPVPRRAKAGANVSQMHYARKGIITPEMEYI
AVRENLVRAQLAERLATERMPKKGHSFNASIPEQITAEFVRDEVARGRAVIPNNINHPESEPMIIGRNFLIKVNANIGNS
AVTSSIEEEVDKLVWSIRWGADTVMDLSTGENIHETREWILRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQA
EQGVDYFTIHAGVRLAYVPLTANRLTGIVSRGGSIMAKWCLSHHKESFLYERFDEICEIMKAYDVCFSLGDGLRPGSIAD
ANDEAQFAELHTLGELTQIAWKHDVQVMIEGPGHVPLQLVKENVDKQLEACFEAPFYTLGPLITDISPGYDHISSAMGAA
NIGWYGTAMLCYVTPKEHLGLPNRDDVKQGLIAYKIAAHAGDLAKGYPGAQMWDNAVSKARFEFRWEDQFRLAIDPDTAM
AYHDETLPKENAKVAHFCSMCGPKFCSMKISQEVREFARLNPASTTLAAPGVIAIKQIDSGFEEKAKEFREGGSEIYS
>Mature_637_residues
AKTRLTVDTNDLASRITRAPFPGSAKIYIEGSRPDIRVPFREVTLTDTMVHEGAGEPRREANPPLRLYDASGVYTDPASP
IDITRGLPPLRGAWINERADTEALPGISSAYGRERLNDPALAALRMAHAPVPRRAKAGANVSQMHYARKGIITPEMEYIA
VRENLVRAQLAERLATERMPKKGHSFNASIPEQITAEFVRDEVARGRAVIPNNINHPESEPMIIGRNFLIKVNANIGNSA
VTSSIEEEVDKLVWSIRWGADTVMDLSTGENIHETREWILRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAE
QGVDYFTIHAGVRLAYVPLTANRLTGIVSRGGSIMAKWCLSHHKESFLYERFDEICEIMKAYDVCFSLGDGLRPGSIADA
NDEAQFAELHTLGELTQIAWKHDVQVMIEGPGHVPLQLVKENVDKQLEACFEAPFYTLGPLITDISPGYDHISSAMGAAN
IGWYGTAMLCYVTPKEHLGLPNRDDVKQGLIAYKIAAHAGDLAKGYPGAQMWDNAVSKARFEFRWEDQFRLAIDPDTAMA
YHDETLPKENAKVAHFCSMCGPKFCSMKISQEVREFARLNPASTTLAAPGVIAIKQIDSGFEEKAKEFREGGSEIYS

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=616, Percent_Identity=69.3181818181818, Blast_Score=892, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 70744; Mature: 70613

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTRLTVDTNDLASRITRAPFPGSAKIYIEGSRPDIRVPFREVTLTDTMVHEGAGEPRR
CCCCEEEECCHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHEEEHHHHHHCCCCCCHH
EANPPLRLYDASGVYTDPASPIDITRGLPPLRGAWINERADTEALPGISSAYGRERLNDP
HCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCH
ALAALRMAHAPVPRRAKAGANVSQMHYARKGIITPEMEYIAVRENLVRAQLAERLATERM
HHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PKKGHSFNASIPEQITAEFVRDEVARGRAVIPNNINHPESEPMIIGRNFLIKVNANIGNS
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEEEEEECCCCCH
AVTSSIEEEVDKLVWSIRWGADTVMDLSTGENIHETREWILRNSPVPIGTVPIYQALEKV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLAYVPLTANRLTGIVSRGGSIMAKWC
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEHHHHHHHHHCCCHHHHHHH
LSHHKESFLYERFDEICEIMKAYDVCFSLGDGLRPGSIADANDEAQFAELHTLGELTQIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WKHDVQVMIEGPGHVPLQLVKENVDKQLEACFEAPFYTLGPLITDISPGYDHISSAMGAA
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCC
NIGWYGTAMLCYVTPKEHLGLPNRDDVKQGLIAYKIAAHAGDLAKGYPGAQMWDNAVSKA
CCCCEEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHC
RFEFRWEDQFRLAIDPDTAMAYHDETLPKENAKVAHFCSMCGPKFCSMKISQEVREFARL
EEEEEECCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NPASTTLAAPGVIAIKQIDSGFEEKAKEFREGGSEIYS
CCCCHHHCCCCEEEEHHHCCCHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
AKTRLTVDTNDLASRITRAPFPGSAKIYIEGSRPDIRVPFREVTLTDTMVHEGAGEPRR
CCCEEEECCHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHEEEHHHHHHCCCCCCHH
EANPPLRLYDASGVYTDPASPIDITRGLPPLRGAWINERADTEALPGISSAYGRERLNDP
HCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCH
ALAALRMAHAPVPRRAKAGANVSQMHYARKGIITPEMEYIAVRENLVRAQLAERLATERM
HHHHHHHHCCCCCCHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PKKGHSFNASIPEQITAEFVRDEVARGRAVIPNNINHPESEPMIIGRNFLIKVNANIGNS
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEECCEEEEEEECCCCCH
AVTSSIEEEVDKLVWSIRWGADTVMDLSTGENIHETREWILRNSPVPIGTVPIYQALEKV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLAYVPLTANRLTGIVSRGGSIMAKWC
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEHHHHHHHHHCCCHHHHHHH
LSHHKESFLYERFDEICEIMKAYDVCFSLGDGLRPGSIADANDEAQFAELHTLGELTQIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
WKHDVQVMIEGPGHVPLQLVKENVDKQLEACFEAPFYTLGPLITDISPGYDHISSAMGAA
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCC
NIGWYGTAMLCYVTPKEHLGLPNRDDVKQGLIAYKIAAHAGDLAKGYPGAQMWDNAVSKA
CCCCEEEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHC
RFEFRWEDQFRLAIDPDTAMAYHDETLPKENAKVAHFCSMCGPKFCSMKISQEVREFARL
EEEEEECCCEEEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NPASTTLAAPGVIAIKQIDSGFEEKAKEFREGGSEIYS
CCCCHHHCCCCEEEEHHHCCCHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA