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The map label for this gene is ybhO [H]

Identifier: 91785938

GI number: 91785938

Start: 24438

End: 25748

Strand: Reverse

Name: ybhO [H]

Synonym: Bpro_0025

Alternate gene names: 91785938

Gene position: 25748-24438 (Counterclockwise)

Preceding gene: 91785939

Following gene: 91785937

Centisome position: 0.5

GC content: 67.43

Gene sequence:

>1311_bases
ATGAGCCCCTGGATCAGCGGCAACCAGTTCCGCCTGCTTGAAAACGGCGAGGAGTATTTCCCGCGCGTCTTTGCCTGCAT
TGCCGCCGCTGAACGCGAGGTCGTGCTGGAAACCTTCATCCTGTTTGACGACAAGGTCGGCCAGGCGCTGCATGCCGCCC
TGCTGCAGGCGGCCACCCGCGGCGTGCAGATTGACATCACCGTTGACGGCTATGGCTCACCCGACCTGTCGCACGAATTC
ATTTCTGCACTGACCCAGGCCGGGGTGCGGGTTCATGTGTTTGACCCCGGCCCCAGGCTCTGGGGCTGGCGTACCAACCT
GTTTCGCCGCATGCACCGCAAGATCGTCGTGATTGATGGCCAGCGCGCCTTTGTCGGTGGCCTCAATTACTCGGCCGATC
ACCTGGCCGATTTCGGCCCCGCCGCCAAACAGGACTATGCGGTCGAAATTGAGGGCCCCATCGTCACCTTCATCCACGCC
TTTGTGCACCGGGCACTGGCGGCGGGCCAGCGCAATGCGCAGGACAGTCTGGCCGGCCGGCTGCGTGAGCGCCTGTCCAG
CCGCGCCCATTCGCTGGCCCGAAGCTGGGGGCTCGCCCCGCCAAGCCAGGCCGCGGCCGCTCCCGCCGGTGAAGCGGCGG
CCATCTTCGTGACGCGCGACAACCGCGAACACACCAACGACATCGAACGCCACTACCGCATCGCCATCCGCGTGGCCCGC
CAGCGCATCGTGATCGCCAATGCCTACTTCTTCCCCGGCTACCGCCTGCTCAAGGAGATGCGCAAGGCGGCGCGGCGCGG
TGTCGACGTGCGGCTCATCCTGCAGGGCGCGCCCGACATGCCCTTCGTCAAAACCGCCGCCAGCATGCTCTACCACCACC
TGCTGGAGGCCGGCGTGCAGATTTACGAGTATTGCGAGCGGCCGCTGCACGGCAAGGTCGCCGTGGCCGACGACGAATGG
GCCACCGTGGGCTCCAGCAACCTTGACCCGCTGAGCCTGTCGCTGAACCTGGAGGCCAACGTGGTCATCCGCGACCGCGC
CTTCAACCAGGTGCTCAGCGCACGGCTGGACCACCTGATGCAACACGGCTGCAAGCAGATCGGCCCCGGCGACCTGCAGG
AGTCGAGCGGCTGGCGCATCGTGCGCAGCTTTTTCCTGTTTCACCTGCTGCGCCGTTACCCGGCCTGGGCGGGCTGGCTG
CCCGCGCATGCGCCGCGCCTCACGCCTGCGCTGGCACCCGCCGACCCGACGGCGCACATCAGCACCGCGCAGGCAGACGC
CGTCCACCGCGCGGACCCGACCACCCCGTGA

Upstream 100 bases:

>100_bases
CGTGTGCCTTCGGCGTTGCGCTGCCCCTTTCACGAGGAAACGGGGCGGAACTTGCTCGGGGCGGCCCTTCGCTGCGTTCG
ATGGCACCTGTGGGAGGCTT

Downstream 100 bases:

>100_bases
GCCGTGAATGACCACCAGCCCCGACGCAGCCCGCCCCGCAGTCCCGGCCCCGCGGCGCAAGAGCCGGCATAAATTCACCG
GCAAAGCCTGGTGGCCATGG

Product: cardiolipin synthase 2

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSPWISGNQFRLLENGEEYFPRVFACIAAAEREVVLETFILFDDKVGQALHAALLQAATRGVQIDITVDGYGSPDLSHEF
ISALTQAGVRVHVFDPGPRLWGWRTNLFRRMHRKIVVIDGQRAFVGGLNYSADHLADFGPAAKQDYAVEIEGPIVTFIHA
FVHRALAAGQRNAQDSLAGRLRERLSSRAHSLARSWGLAPPSQAAAAPAGEAAAIFVTRDNREHTNDIERHYRIAIRVAR
QRIVIANAYFFPGYRLLKEMRKAARRGVDVRLILQGAPDMPFVKTAASMLYHHLLEAGVQIYEYCERPLHGKVAVADDEW
ATVGSSNLDPLSLSLNLEANVVIRDRAFNQVLSARLDHLMQHGCKQIGPGDLQESSGWRIVRSFFLFHLLRRYPAWAGWL
PAHAPRLTPALAPADPTAHISTAQADAVHRADPTTP

Sequences:

>Translated_436_residues
MSPWISGNQFRLLENGEEYFPRVFACIAAAEREVVLETFILFDDKVGQALHAALLQAATRGVQIDITVDGYGSPDLSHEF
ISALTQAGVRVHVFDPGPRLWGWRTNLFRRMHRKIVVIDGQRAFVGGLNYSADHLADFGPAAKQDYAVEIEGPIVTFIHA
FVHRALAAGQRNAQDSLAGRLRERLSSRAHSLARSWGLAPPSQAAAAPAGEAAAIFVTRDNREHTNDIERHYRIAIRVAR
QRIVIANAYFFPGYRLLKEMRKAARRGVDVRLILQGAPDMPFVKTAASMLYHHLLEAGVQIYEYCERPLHGKVAVADDEW
ATVGSSNLDPLSLSLNLEANVVIRDRAFNQVLSARLDHLMQHGCKQIGPGDLQESSGWRIVRSFFLFHLLRRYPAWAGWL
PAHAPRLTPALAPADPTAHISTAQADAVHRADPTTP
>Mature_435_residues
SPWISGNQFRLLENGEEYFPRVFACIAAAEREVVLETFILFDDKVGQALHAALLQAATRGVQIDITVDGYGSPDLSHEFI
SALTQAGVRVHVFDPGPRLWGWRTNLFRRMHRKIVVIDGQRAFVGGLNYSADHLADFGPAAKQDYAVEIEGPIVTFIHAF
VHRALAAGQRNAQDSLAGRLRERLSSRAHSLARSWGLAPPSQAAAAPAGEAAAIFVTRDNREHTNDIERHYRIAIRVARQ
RIVIANAYFFPGYRLLKEMRKAARRGVDVRLILQGAPDMPFVKTAASMLYHHLLEAGVQIYEYCERPLHGKVAVADDEWA
TVGSSNLDPLSLSLNLEANVVIRDRAFNQVLSARLDHLMQHGCKQIGPGDLQESSGWRIVRSFFLFHLLRRYPAWAGWLP
AHAPRLTPALAPADPTAHISTAQADAVHRADPTTP

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=414, Percent_Identity=53.8647342995169, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1787502, Length=372, Percent_Identity=26.6129032258064, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 48396; Mature: 48265

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPWISGNQFRLLENGEEYFPRVFACIAAAEREVVLETFILFDDKVGQALHAALLQAATR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
GVQIDITVDGYGSPDLSHEFISALTQAGVRVHVFDPGPRLWGWRTNLFRRMHRKIVVIDG
CEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEC
QRAFVGGLNYSADHLADFGPAAKQDYAVEIEGPIVTFIHAFVHRALAAGQRNAQDSLAGR
CEEEECCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRERLSSRAHSLARSWGLAPPSQAAAAPAGEAAAIFVTRDNREHTNDIERHYRIAIRVAR
HHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
QRIVIANAYFFPGYRLLKEMRKAARRGVDVRLILQGAPDMPFVKTAASMLYHHLLEAGVQ
HEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IYEYCERPLHGKVAVADDEWATVGSSNLDPLSLSLNLEANVVIRDRAFNQVLSARLDHLM
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECEEEEEEEHHHHHHHHHHHHHHHH
QHGCKQIGPGDLQESSGWRIVRSFFLFHLLRRYPAWAGWLPAHAPRLTPALAPADPTAHI
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
STAQADAVHRADPTTP
CCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SPWISGNQFRLLENGEEYFPRVFACIAAAEREVVLETFILFDDKVGQALHAALLQAATR
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
GVQIDITVDGYGSPDLSHEFISALTQAGVRVHVFDPGPRLWGWRTNLFRRMHRKIVVIDG
CEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEC
QRAFVGGLNYSADHLADFGPAAKQDYAVEIEGPIVTFIHAFVHRALAAGQRNAQDSLAGR
CEEEECCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRERLSSRAHSLARSWGLAPPSQAAAAPAGEAAAIFVTRDNREHTNDIERHYRIAIRVAR
HHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
QRIVIANAYFFPGYRLLKEMRKAARRGVDVRLILQGAPDMPFVKTAASMLYHHLLEAGVQ
HEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IYEYCERPLHGKVAVADDEWATVGSSNLDPLSLSLNLEANVVIRDRAFNQVLSARLDHLM
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECEEEEEEEHHHHHHHHHHHHHHHH
QHGCKQIGPGDLQESSGWRIVRSFFLFHLLRRYPAWAGWLPAHAPRLTPALAPADPTAHI
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
STAQADAVHRADPTTP
CCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]