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The map label for this gene is livM [H]

Identifier: 91785752

GI number: 91785752

Start: 4825047

End: 4826018

Strand: Reverse

Name: livM [H]

Synonym: Bxe_A0021

Alternate gene names: 91785752

Gene position: 4826018-4825047 (Counterclockwise)

Preceding gene: 91785753

Following gene: 91785751

Centisome position: 98.57

GC content: 64.2

Gene sequence:

>972_bases
ATGCAGAGAAAAGTGCTCTACGGTCTGCTGCTGATCGTGCTTCTCGCGGTGCCCGTGCTCGGCATCTATCCGCTCTTCGT
GATGAAGGTGATGTGCTTCGCGTTGTTCGCGGCGGCGTTCAATCTGCTGATCGGCTATACCGGATTGCTGTCGTTCGGCC
ACGCCATGTTTCTCGCCTCGGCGGGCTATGTCACGGGCTACGCGATGCAGACGCTCGGCTTCTCGCCGGAGCTCGGCGTG
CTCGCCGGCACGGCGGCGGCCACCTTGCTCGGGCTGATTGTGGGCATCTTCGCGATTCGCCGCCAGGGCATCTACTTTGC
GATGGTCACGCTGGCGCTCGCGCAAATGGTCTACTTCGTATTCCTGCAGGCGCCGTTCACGCATGGAGAGGACGGTCTGC
AAGGCGTGCCGCGCGGCAAGCTGTTCGGCGTGCTGGATCTCTCGTCCGACGTGGCGTTGTACTTCGTCGTGCTCGCCGTG
ATGGTGCTGGCTTTCCTGCTGATCGTGCGGATCGTGCATTCGCCGTTCGGACAGGTGCTGGTGGCGATCAAGGAGAACGA
ACCGCGGGCGGTGTCGCTCGGCTACGATACGGATCGCTTCAAGCTGCTCGCCTTCATTCTGTCGGCGGGAATCGCGGGTC
TCGCGGGGTCGCTCAAGGTGCTGGTGCAAGGGTTCGAAACATTGAGCGACGCGTACTGGACCATGTCGGGCCTCGTGATC
CTGATGACGCTCGTCGGCGGCATGGGCACGCTGTTCGGACCGTTGCTCGGCGCGGCGTTGATCGTCGCGCTCGAGGACCG
GCTGGGCGATTTCGGCGCGGCGCTCGCGTCGTCGACGGGCGTGGAGTGGTTCCGCTCGCTGGGGGAATCGGTGACCATCG
TGACCGGCATCATCTTCATTGCGTGCGTGCTGGCGTTCAGGCGCGGCATTGTCGGCGAGATCGTCGCGCGAGTGCGGCCG
TTGCGGGCCTGA

Upstream 100 bases:

>100_bases
CGCGCGTGTTTTACCCGGAAGCGTCGGCGACCGTCGTCTTCGTGATCATGGCGCTCGTGTTGCTGGTGCGCCCGGCGGGT
CTCTTCGGCAAGGAAAAATG

Downstream 100 bases:

>100_bases
CGCGCCGTGAAATATGCAATTGCTTCGGCGTCCGATATAGTGTGGCGGCCTTGATGCGGTGAGGCCGGAGCGCGGCGTCG
TGCGGCTTCGCCGAGGCGCC

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MQRKVLYGLLLIVLLAVPVLGIYPLFVMKVMCFALFAAAFNLLIGYTGLLSFGHAMFLASAGYVTGYAMQTLGFSPELGV
LAGTAAATLLGLIVGIFAIRRQGIYFAMVTLALAQMVYFVFLQAPFTHGEDGLQGVPRGKLFGVLDLSSDVALYFVVLAV
MVLAFLLIVRIVHSPFGQVLVAIKENEPRAVSLGYDTDRFKLLAFILSAGIAGLAGSLKVLVQGFETLSDAYWTMSGLVI
LMTLVGGMGTLFGPLLGAALIVALEDRLGDFGAALASSTGVEWFRSLGESVTIVTGIIFIACVLAFRRGIVGEIVARVRP
LRA

Sequences:

>Translated_323_residues
MQRKVLYGLLLIVLLAVPVLGIYPLFVMKVMCFALFAAAFNLLIGYTGLLSFGHAMFLASAGYVTGYAMQTLGFSPELGV
LAGTAAATLLGLIVGIFAIRRQGIYFAMVTLALAQMVYFVFLQAPFTHGEDGLQGVPRGKLFGVLDLSSDVALYFVVLAV
MVLAFLLIVRIVHSPFGQVLVAIKENEPRAVSLGYDTDRFKLLAFILSAGIAGLAGSLKVLVQGFETLSDAYWTMSGLVI
LMTLVGGMGTLFGPLLGAALIVALEDRLGDFGAALASSTGVEWFRSLGESVTIVTGIIFIACVLAFRRGIVGEIVARVRP
LRA
>Mature_323_residues
MQRKVLYGLLLIVLLAVPVLGIYPLFVMKVMCFALFAAAFNLLIGYTGLLSFGHAMFLASAGYVTGYAMQTLGFSPELGV
LAGTAAATLLGLIVGIFAIRRQGIYFAMVTLALAQMVYFVFLQAPFTHGEDGLQGVPRGKLFGVLDLSSDVALYFVVLAV
MVLAFLLIVRIVHSPFGQVLVAIKENEPRAVSLGYDTDRFKLLAFILSAGIAGLAGSLKVLVQGFETLSDAYWTMSGLVI
LMTLVGGMGTLFGPLLGAALIVALEDRLGDFGAALASSTGVEWFRSLGESVTIVTGIIFIACVLAFRRGIVGEIVARVRP
LRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=271, Percent_Identity=29.520295202952, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 34359; Mature: 34359

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKVLYGLLLIVLLAVPVLGIYPLFVMKVMCFALFAAAFNLLIGYTGLLSFGHAMFLAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQTLGFSPELGVLAGTAAATLLGLIVGIFAIRRQGIYFAMVTLALAQMVYFV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FLQAPFTHGEDGLQGVPRGKLFGVLDLSSDVALYFVVLAVMVLAFLLIVRIVHSPFGQVL
HHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRAVSLGYDTDRFKLLAFILSAGIAGLAGSLKVLVQGFETLSDAYWTMSGLVI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLLGAALIVALEDRLGDFGAALASSTGVEWFRSLGESVTIVTGIIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHH
ACVLAFRRGIVGEIVARVRPLRA
HHHHHHHHCHHHHHHHHHHCCCC
>Mature Secondary Structure
MQRKVLYGLLLIVLLAVPVLGIYPLFVMKVMCFALFAAAFNLLIGYTGLLSFGHAMFLAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQTLGFSPELGVLAGTAAATLLGLIVGIFAIRRQGIYFAMVTLALAQMVYFV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FLQAPFTHGEDGLQGVPRGKLFGVLDLSSDVALYFVVLAVMVLAFLLIVRIVHSPFGQVL
HHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRAVSLGYDTDRFKLLAFILSAGIAGLAGSLKVLVQGFETLSDAYWTMSGLVI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLLGAALIVALEDRLGDFGAALASSTGVEWFRSLGESVTIVTGIIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHH
ACVLAFRRGIVGEIVARVRPLRA
HHHHHHHHCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]