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The map label for this gene is ahcY [H]

Identifier: 91785599

GI number: 91785599

Start: 4655967

End: 4657388

Strand: Reverse

Name: ahcY [H]

Synonym: Bxe_A0178

Alternate gene names: 91785599

Gene position: 4657388-4655967 (Counterclockwise)

Preceding gene: 91785600

Following gene: 91785598

Centisome position: 95.13

GC content: 61.25

Gene sequence:

>1422_bases
ATGAACGCCGCAGTTATCGATTCCAAAAATTCCCAGGATTTCATTGTTGCCGACATGTCGCTTGCCGACTGGGGCCGCAA
GGAACTGAACATCGCCGAGACGGAAATGCCCGGCCTCGTGCAAACGCGTGAAGAGTACAAGGTGCAGCAGCCGCTGAAGG
GCGCGCGCATCGCAGGTTCGCTGCACATGACGATCCAGACCGGCGTGCTGATCGAGACGCTGACGGCGCTCGGCGCCGAC
GTGCGCTGGGCCTCGTGCAACATCTTCTCGACCCAGGATCATGCCGCCGCGGCAATCGCCAAGGCCGGCACGCCGGTGTT
CGCATTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATTTTCGAATGGCCGAACGGCGAGTTCGCCA
ACATGATCCTCGACGACGGCGGCGACGCCACGTTGCTGCTGATCCTCGGCTCGAAGGCCGAGAAAGACCGTTCGGTGATC
TCGAAGCCGACCAACGAGGAAGAAGTCGCGCTGTACAAGTCGATCGAGCGCCATCTGGACGCCGACCCGACGTGGTACTC
CACGCGCCTTGCGCACATCAAGGGCGTGACCGAAGAAACCACGACCGGCGTGCACCGTCTGTATCAGATGGAAAAAGAAG
GCCGCCTGCCGTTCCCTGCGATCAACGTCAACGACTCGGTCACCAAGTCGAAGTTCGACAACCTGTATGGCTGCCGTGAG
TCGCTGGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGATCGCCGTGGTCGCCGGTTACGGCGACGT
GGGCAAGGGCTGCGCGCAATCGCTGCGCGGTTTGGGCGCCACCGTGTGGGTCACCGAAATCGATCCGATCTGCGCATTGC
AGGCGGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCGGCGGACAAGGCCGACATCTTCGTGACGGCGACCGGC
AACTACCACGTGATCGGCCACGACCACATGAAGGCGATGCGTCACAACGCGATTGTCTGCAACATCGGTCACTTCGACTC
GGAAATCGACGTTGCGTCGACCCGTCAGTACCAGTGGGACAACATCAAGCCGCAAGTCGACCACATCATTTTCCCGGACG
GCAAGCGCGTGATCCTGCTGGCTGAAGGCCGCCTCGTGAATCTGGGTTGCGCGACGGGCCACCCGTCGTTCGTGATGTCG
AACTCGTTCACGAACCAGACGCTCGCGCAGATCGAACTGTTCACGCAAGGCAACAAGTACGAGAACAAGGTGTACGTGCT
GCCGAAGCATCTGGACGAAAAGGTCGCACGCCTGCATCTGGCGCGCATCGGCGCGAACCTGACCGTGCTGTCGGACGAGC
AGGCCGGCTACATCGGCGTCGACAAGAACGGCCCGTTCAAGCCGAACCACTACCGCTATTAA

Upstream 100 bases:

>100_bases
TTCAATCGGAGGGCCCGGATGCGCATAGCGCTTTCCCATCCACCGCATCGAACCGCGCTCACGTCAAATTTCTAGTCAAT
TTCTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
GCGCGCCGCGAGCGGTTGAGCAGCATGACAGTTTGACGACAGGGCGGCGCATCATGCGCCGCTTTGTTCGCCATGACCGC
CTCCGCCCGTTCTGTACGCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNAAVIDSKNSQDFIVADMSLADWGRKELNIAETEMPGLVQTREEYKVQQPLKGARIAGSLHMTIQTGVLIETLTALGAD
VRWASCNIFSTQDHAAAAIAKAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIERHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWDNIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTQGNKYENKVYVLPKHLDEKVARLHLARIGANLTVLSDEQAGYIGVDKNGPFKPNHYRY

Sequences:

>Translated_473_residues
MNAAVIDSKNSQDFIVADMSLADWGRKELNIAETEMPGLVQTREEYKVQQPLKGARIAGSLHMTIQTGVLIETLTALGAD
VRWASCNIFSTQDHAAAAIAKAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIERHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWDNIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTQGNKYENKVYVLPKHLDEKVARLHLARIGANLTVLSDEQAGYIGVDKNGPFKPNHYRY
>Mature_473_residues
MNAAVIDSKNSQDFIVADMSLADWGRKELNIAETEMPGLVQTREEYKVQQPLKGARIAGSLHMTIQTGVLIETLTALGAD
VRWASCNIFSTQDHAAAAIAKAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
SKPTNEEEVALYKSIERHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWDNIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTQGNKYENKVYVLPKHLDEKVARLHLARIGANLTVLSDEQAGYIGVDKNGPFKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.7402597402597, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=59.5454545454545, Blast_Score=494, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=50.6382978723404, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=50.6382978723404, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=50.6382978723404, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=50.6382978723404, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=50.4255319148936, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=60, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=57.5569358178054, Blast_Score=511, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=60.3896103896104, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.3184713375796, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.8933901918977, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.7863247863248, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52310; Mature: 52310

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAVIDSKNSQDFIVADMSLADWGRKELNIAETEMPGLVQTREEYKVQQPLKGARIAGS
CCCEEECCCCCCCEEEEECCHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCEEECE
LHMTIQTGVLIETLTALGADVRWASCNIFSTQDHAAAAIAKAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVISKPTNEEEVALYKSIERHLD
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
ADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWD
EEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTQGNKY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ENKVYVLPKHLDEKVARLHLARIGANLTVLSDEQAGYIGVDKNGPFKPNHYRY
CCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAAVIDSKNSQDFIVADMSLADWGRKELNIAETEMPGLVQTREEYKVQQPLKGARIAGS
CCCEEECCCCCCCEEEEECCHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCEEECE
LHMTIQTGVLIETLTALGADVRWASCNIFSTQDHAAAAIAKAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVISKPTNEEEVALYKSIERHLD
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
ADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWD
EEEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTQGNKY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ENKVYVLPKHLDEKVARLHLARIGANLTVLSDEQAGYIGVDKNGPFKPNHYRY
CCEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA