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The map label for this gene is hisB [H]

Identifier: 91785379

GI number: 91785379

Start: 4436618

End: 4437205

Strand: Reverse

Name: hisB [H]

Synonym: Bxe_A0400

Alternate gene names: 91785379

Gene position: 4437205-4436618 (Counterclockwise)

Preceding gene: 91785380

Following gene: 91785378

Centisome position: 90.63

GC content: 60.54

Gene sequence:

>588_bases
ATGCGCCTTGCGGAAGTCGTTCGCAACACCAGCGAAACGCAGATCCGTGTGAAGATCAATCTGGACGGCACCGGTCAGCA
GAAGCTGGCCACCGGCGTGCCGTTTCTGGACCACATGCTCGACCAGATCGCGCGGCATGGATTGTTCGACCTCGAGATCG
AAGCGCATGGCGATCTGCATATCGACGACCATCACACGGTCGAAGACACCGGCATCACGCTCGGCCAGGCCGTCGCGAAA
GCGATCGGCGACAAGAAGGGCATCCGCCGTTACGGTCATTCTTACGTGCCGCTCGACGAAGCGCTGTCGCGCGTCGTGAT
CGATTTTTCCGGTCGTCCGGGGCTCGAATTCCATGTGCCGTTCACGCGCGCGCGCATCGGTACGTTCGACGTCGATCTGT
CCATCGAATTTTTCCGCGGCTTCGTCAATCACGCCGGCGTGACGCTGCATATCGACAACCTGCGCGGCCTGAACGCCCAT
CATCAGATGGAAACGGTGTTCAAGGCGTTCGGGCGTGCATTGCGCATGGCTACCGAACTGGACGAACGCGCGGCCGGACA
GATTCCGTCGACCAAGGGCAGCCTTTAA

Upstream 100 bases:

>100_bases
CCGCGCAAGCGCTTTTCCTCATCACGGGATAGCGCGCGCAGCCCTGCCGTTTTTCCATCCCACATACCTATCGCTTTCTA
GCCAGATTCGAGGAATTACC

Downstream 100 bases:

>100_bases
GCGCTCACCAGCCGGCTCATCGGCCTATTTACCTGGACCGGGACCGGCGCCGTTTGCGCTCGCGCCCGGTGTGCGATGGA
CATTCTGAAGTCGTTTATTT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRLAEVVRNTSETQIRVKINLDGTGQQKLATGVPFLDHMLDQIARHGLFDLEIEAHGDLHIDDHHTVEDTGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGLNAH
HQMETVFKAFGRALRMATELDERAAGQIPSTKGSL

Sequences:

>Translated_195_residues
MRLAEVVRNTSETQIRVKINLDGTGQQKLATGVPFLDHMLDQIARHGLFDLEIEAHGDLHIDDHHTVEDTGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGLNAH
HQMETVFKAFGRALRMATELDERAAGQIPSTKGSL
>Mature_195_residues
MRLAEVVRNTSETQIRVKINLDGTGQQKLATGVPFLDHMLDQIARHGLFDLEIEAHGDLHIDDHHTVEDTGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGLNAH
HQMETVFKAFGRALRMATELDERAAGQIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=52.0618556701031, Blast_Score=194, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=40.2777777777778, Blast_Score=158, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21628; Mature: 21628

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAEVVRNTSETQIRVKINLDGTGQQKLATGVPFLDHMLDQIARHGLFDLEIEAHGDLH
CCHHHHHCCCCCEEEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCEE
IDDHHTVEDTGITLGQAVAKAIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVP
ECCCCEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEEECCCCCCEEECC
FTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGLNAHHQMETVFKAFGRALRMATEL
HHHHCCCEEEEEEHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DERAAGQIPSTKGSL
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MRLAEVVRNTSETQIRVKINLDGTGQQKLATGVPFLDHMLDQIARHGLFDLEIEAHGDLH
CCHHHHHCCCCCEEEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCEE
IDDHHTVEDTGITLGQAVAKAIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVP
ECCCCEECCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEEECCCCCCEEECC
FTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGLNAHHQMETVFKAFGRALRMATEL
HHHHCCCEEEEEEHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DERAAGQIPSTKGSL
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA