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The map label for this gene is hisI [H]

Identifier: 91785374

GI number: 91785374

Start: 4432914

End: 4433324

Strand: Reverse

Name: hisI [H]

Synonym: Bxe_A0405

Alternate gene names: 91785374

Gene position: 4433324-4432914 (Counterclockwise)

Preceding gene: 91785375

Following gene: 91785373

Centisome position: 90.55

GC content: 60.34

Gene sequence:

>411_bases
GTGGTGAATCCCTCGGCAGTCAATTGGCTCGACAAGGTCAGGTGGGACGCGAACGGCCTCGTGCCGGTGATCGCGCAGGA
AGCGTCGACGAACGACGTGCTGATGTTCGCGTGGATGAACCGCGAAGCGTTGGCGAAAACCGTCGAAACAGGCCGCGCGG
TGTATTTCTCGCGCTCGCGTCAGCGCCTGTGGTTCAAGGGTGAAGAGTCCGGCCACGTGCAGCATGTGCACGAAGTGCGG
CTCGATTGCGACGAAGACGTCGTGCTGCTGAAAGTGGAGCAGGTGTCGGGCATTGCCTGCCATACCGGCCGCCACTCGTG
CTTTTTCCAGAAATTCGAAGGCTCGGTGGAAGATGGCGACTGGGTTGCCGTCGACGCCGTGCTGAAAGACCCCGAACAGA
TCTACAAATGA

Upstream 100 bases:

>100_bases
GACGCGGTACTCGCCGCGAGCATTTTCCACTACGGCGAACACACCGTGGGCGAGGCCAAGCGCTTCATGGCCGATCAGGG
CATTTCGGTGAGGTTGTGAC

Downstream 100 bases:

>100_bases
CGCAATCCACGCAAACCACGCCGTCCAACGCCGCGTCCACCACCGACACGCTGCTGCGCCTCGCGGCGATCATCGACAGC
CGCAAGGGCGGCGATCCGGA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MVNPSAVNWLDKVRWDANGLVPVIAQEASTNDVLMFAWMNREALAKTVETGRAVYFSRSRQRLWFKGEESGHVQHVHEVR
LDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGSVEDGDWVAVDAVLKDPEQIYK

Sequences:

>Translated_136_residues
MVNPSAVNWLDKVRWDANGLVPVIAQEASTNDVLMFAWMNREALAKTVETGRAVYFSRSRQRLWFKGEESGHVQHVHEVR
LDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGSVEDGDWVAVDAVLKDPEQIYK
>Mature_136_residues
MVNPSAVNWLDKVRWDANGLVPVIAQEASTNDVLMFAWMNREALAKTVETGRAVYFSRSRQRLWFKGEESGHVQHVHEVR
LDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGSVEDGDWVAVDAVLKDPEQIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=47.8260869565217, Blast_Score=97, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=107, Percent_Identity=35.5140186915888, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15477; Mature: 15477

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNPSAVNWLDKVRWDANGLVPVIAQEASTNDVLMFAWMNREALAKTVETGRAVYFSRSR
CCCCHHHHHHHHHEECCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCC
QRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGSVEDGD
CEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEHHHHCCCCCCCC
WVAVDAVLKDPEQIYK
EEEEEHHHCCHHHHCC
>Mature Secondary Structure
MVNPSAVNWLDKVRWDANGLVPVIAQEASTNDVLMFAWMNREALAKTVETGRAVYFSRSR
CCCCHHHHHHHHHEECCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHCCCEEEEECCC
QRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGSVEDGD
CEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEHHHHCCCCCCCC
WVAVDAVLKDPEQIYK
EEEEEHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA