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The map label for this gene is pepQ [H]

Identifier: 91785339

GI number: 91785339

Start: 4400228

End: 4402042

Strand: Reverse

Name: pepQ [H]

Synonym: Bxe_A0440

Alternate gene names: 91785339

Gene position: 4402042-4400228 (Counterclockwise)

Preceding gene: 91785340

Following gene: 91785338

Centisome position: 89.91

GC content: 66.34

Gene sequence:

>1815_bases
ATGAATGCCCGACTTCCCGAAACCTCCTCCATTCCCGAACGGCTCGCCACTTTGCGCAACGCAATGGCGCGCGAAGGCGT
CGCTGCCTATCTGGTGCCGTCCGCGGACCCACATCTGTCCGAGTATCTGCCAGGGCGCTGGCAAGGCCGGCAGTGGTTGT
CGGGCTTCACCGGCTCGGCCGGCACGCTGATCGTCACCGCGGATTTCGCGGGGGTCTGGACGGACAGCCGCTATTGGGAA
CAGGCCTACGCGCAACTGGCGGGAACCGGCGTTCAGTTGATGAAGATGACCGGCGGCCAGCAAACCGCGCCGCATTTCGA
ATGGCTCGCGCAGAACGTGCCGGCAGGCGGCACGGTCGGCGTGGACGGTGCCGTGCTCGGCGTGGCGGCGGCGCGGGCCT
TGAGCCAGGCGCTGAGCGCGCGCGGTGTGCAACTGCGCACCGACGTCGATCTGTTCGACGCGATCTGGCCGCAGCGTCCG
TCGCTGCCGGCGGCCGCCGTGTTCGAGCATGCCGCGCCGCACGCGAGCGTCGCCCGTTCGGACAAGCTCGCGCAGATTCG
CCGCGCAATGGCGGACAAGGGCGCGCAATGGCATTTCATCTCCACGCTCGACGATCTTGCCTGGCTGCTGAATCTGCGCG
GCGCCGACGTCAGCTACAACCCGGTATTCGTGGCGCACGCGCTGATCGGAGTCGATCACGCATCGCTCTTCGTCGCTGAC
GGCAAGGTGCCGCAGGCACTGGCCGAGGCGCTGGCGAAAGACAACATCAGCATCGAGCCGTATGCCAAAGCTGCGGACGC
GCTGGCCGCGCTGCCCGCCGGCAGCACGCTGCTGATCGACCCGCGCCGCATTACGTTCGGCTCGCTGCAATCCGTGCCGG
CCACGGTCAAGGTGATCGAGGCCGTCAATCCGTCCACCTTCTTCAAGTCGCGCAAGACCGCGGCGGAAGCCGGGCATGTG
CGCGAGACGATGGAACAGGACGGCGCGGCGCTGGCGGAATTTTTCGCCTGGTTCGAAGGCGCGTTGGGCCGCGAAACGAT
CACCGAACTCACTATCGACGAACGTTCGACGGCGGCTCGCGCGCGCCGGCCGGGTTTCGTGTCGCTGAGCTTTGCGACGA
TCGCCGGCTTCAACGCGAACGGCGCAATGCCGCATTACCGCGCCACTGAAGAATCGCACTCGGTGATCGAGGGCAACGGC
CTGTTGCTGATCGACTCCGGCGCGCAGTATCTGAGCGGCACGACCGACATCACCCGCGTGGTACCCGTCGGCACCATCAG
CGAAGAACAGCGGCGCGATTTCACGATCGTGCTCAAGGGCACGATGGCGCTTTCGCGCGCGCACTTTCCGCGCGGTATCC
GTTCGCCCATGCTCGACGCAATCGCCCGCGCGCCGATCTGGGAAGCCGGCGCTGATTACGGCCACGGCACCGGTCACGGC
GTGGGTTATTTCCTGAACGTGCACGAAGGCCCGCAGGTGATTTCGCACTATGCGCCGGCCGAACCGTGGACCGCGATGGA
AGAGGGCATGATCACCTCGGTCGAGCCGGGCATTTACCGTCCGGGCAAATGGGGCGTGCGGATTGAGAACCTCGTGCTGA
ACGTGCCAGCCGGCCAGACCGAGTTCGGCGACTTCCTCAAGTTCGAGACGTTGACGCTGTGCCCGATCGACACGCGTTGC
CTCGATCTGTCGCTGCTGCGCGAAGACGAACGCGCGTGGCTGAACGCGTATCACGAGACCGTGCGCACGCGCCTCGCGCC
GCACGTCTCGGGCGAGGCCAAAGCATGGCTGGAGTTGCGCACGCAACCCATCTGA

Upstream 100 bases:

>100_bases
GATACGCTCGAATGGCCGGTATGCACCGCCGTTGCGTTGATCGCCGTTGCCGTGACGGTCGGCTTGCTTTCCCGTCGATG
AATATTTGCAGGTGACTCCG

Downstream 100 bases:

>100_bases
TCGCAATCGGGAATCGGCTTACGGAGCGTGCATGGCCATCAAGGCAGTGGTATTCGATTTCGGCGGCGTGCTGATCGACT
GGAGCCCTGAGTATCTGTAT

Product: putative Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNARLPETSSIPERLATLRNAMAREGVAAYLVPSADPHLSEYLPGRWQGRQWLSGFTGSAGTLIVTADFAGVWTDSRYWE
QAYAQLAGTGVQLMKMTGGQQTAPHFEWLAQNVPAGGTVGVDGAVLGVAAARALSQALSARGVQLRTDVDLFDAIWPQRP
SLPAAAVFEHAAPHASVARSDKLAQIRRAMADKGAQWHFISTLDDLAWLLNLRGADVSYNPVFVAHALIGVDHASLFVAD
GKVPQALAEALAKDNISIEPYAKAADALAALPAGSTLLIDPRRITFGSLQSVPATVKVIEAVNPSTFFKSRKTAAEAGHV
RETMEQDGAALAEFFAWFEGALGRETITELTIDERSTAARARRPGFVSLSFATIAGFNANGAMPHYRATEESHSVIEGNG
LLLIDSGAQYLSGTTDITRVVPVGTISEEQRRDFTIVLKGTMALSRAHFPRGIRSPMLDAIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPWTAMEEGMITSVEPGIYRPGKWGVRIENLVLNVPAGQTEFGDFLKFETLTLCPIDTRC
LDLSLLREDERAWLNAYHETVRTRLAPHVSGEAKAWLELRTQPI

Sequences:

>Translated_604_residues
MNARLPETSSIPERLATLRNAMAREGVAAYLVPSADPHLSEYLPGRWQGRQWLSGFTGSAGTLIVTADFAGVWTDSRYWE
QAYAQLAGTGVQLMKMTGGQQTAPHFEWLAQNVPAGGTVGVDGAVLGVAAARALSQALSARGVQLRTDVDLFDAIWPQRP
SLPAAAVFEHAAPHASVARSDKLAQIRRAMADKGAQWHFISTLDDLAWLLNLRGADVSYNPVFVAHALIGVDHASLFVAD
GKVPQALAEALAKDNISIEPYAKAADALAALPAGSTLLIDPRRITFGSLQSVPATVKVIEAVNPSTFFKSRKTAAEAGHV
RETMEQDGAALAEFFAWFEGALGRETITELTIDERSTAARARRPGFVSLSFATIAGFNANGAMPHYRATEESHSVIEGNG
LLLIDSGAQYLSGTTDITRVVPVGTISEEQRRDFTIVLKGTMALSRAHFPRGIRSPMLDAIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPWTAMEEGMITSVEPGIYRPGKWGVRIENLVLNVPAGQTEFGDFLKFETLTLCPIDTRC
LDLSLLREDERAWLNAYHETVRTRLAPHVSGEAKAWLELRTQPI
>Mature_604_residues
MNARLPETSSIPERLATLRNAMAREGVAAYLVPSADPHLSEYLPGRWQGRQWLSGFTGSAGTLIVTADFAGVWTDSRYWE
QAYAQLAGTGVQLMKMTGGQQTAPHFEWLAQNVPAGGTVGVDGAVLGVAAARALSQALSARGVQLRTDVDLFDAIWPQRP
SLPAAAVFEHAAPHASVARSDKLAQIRRAMADKGAQWHFISTLDDLAWLLNLRGADVSYNPVFVAHALIGVDHASLFVAD
GKVPQALAEALAKDNISIEPYAKAADALAALPAGSTLLIDPRRITFGSLQSVPATVKVIEAVNPSTFFKSRKTAAEAGHV
RETMEQDGAALAEFFAWFEGALGRETITELTIDERSTAARARRPGFVSLSFATIAGFNANGAMPHYRATEESHSVIEGNG
LLLIDSGAQYLSGTTDITRVVPVGTISEEQRRDFTIVLKGTMALSRAHFPRGIRSPMLDAIARAPIWEAGADYGHGTGHG
VGYFLNVHEGPQVISHYAPAEPWTAMEEGMITSVEPGIYRPGKWGVRIENLVLNVPAGQTEFGDFLKFETLTLCPIDTRC
LDLSLLREDERAWLNAYHETVRTRLAPHVSGEAKAWLELRTQPI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=631, Percent_Identity=36.608557844691, Blast_Score=388, Evalue=1e-107,
Organism=Homo sapiens, GI264681565, Length=631, Percent_Identity=35.1822503961965, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI93141226, Length=607, Percent_Identity=33.2784184514003, Blast_Score=338, Evalue=8e-93,
Organism=Escherichia coli, GI1788728, Length=198, Percent_Identity=37.3737373737374, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=614, Percent_Identity=32.8990228013029, Blast_Score=314, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI25149105, Length=603, Percent_Identity=27.363184079602, Blast_Score=225, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6322999, Length=650, Percent_Identity=31.6923076923077, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17137632, Length=618, Percent_Identity=34.9514563106796, Blast_Score=338, Evalue=9e-93,
Organism=Drosophila melanogaster, GI161078230, Length=617, Percent_Identity=27.2285251215559, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21357287, Length=617, Percent_Identity=27.2285251215559, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65289; Mature: 65289

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARLPETSSIPERLATLRNAMAREGVAAYLVPSADPHLSEYLPGRWQGRQWLSGFTGSA
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCCCHHHHCCCCCCC
GTLIVTADFAGVWTDSRYWEQAYAQLAGTGVQLMKMTGGQQTAPHFEWLAQNVPAGGTVG
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCC
VDGAVLGVAAARALSQALSARGVQLRTDVDLFDAIWPQRPSLPAAAVFEHAAPHASVARS
CCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHH
DKLAQIRRAMADKGAQWHFISTLDDLAWLLNLRGADVSYNPVFVAHALIGVDHASLFVAD
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GKVPQALAEALAKDNISIEPYAKAADALAALPAGSTLLIDPRRITFGSLQSVPATVKVIE
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
AVNPSTFFKSRKTAAEAGHVRETMEQDGAALAEFFAWFEGALGRETITELTIDERSTAAR
HCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHEECCCHHHHHH
ARRPGFVSLSFATIAGFNANGAMPHYRATEESHSVIEGNGLLLIDSGAQYLSGTTDITRV
HCCCCEEEEEEHEEECCCCCCCCCCCCCCCCCCCEEECCCEEEECCCCHHHCCCCCCEEE
VPVGTISEEQRRDFTIVLKGTMALSRAHFPRGIRSPMLDAIARAPIWEAGADYGHGTGHG
EECCCCCHHHCCCEEEEEECHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPWTAMEEGMITSVEPGIYRPGKWGVRIENLVLNVPAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLKFETLTLCPIDTRCLDLSLLREDERAWLNAYHETVRTRLAPHVSGEAKAWLELR
CHHHHHEECEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
TQPI
CCCC
>Mature Secondary Structure
MNARLPETSSIPERLATLRNAMAREGVAAYLVPSADPHLSEYLPGRWQGRQWLSGFTGSA
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCCCHHHHCCCCCCC
GTLIVTADFAGVWTDSRYWEQAYAQLAGTGVQLMKMTGGQQTAPHFEWLAQNVPAGGTVG
CEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCC
VDGAVLGVAAARALSQALSARGVQLRTDVDLFDAIWPQRPSLPAAAVFEHAAPHASVARS
CCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHH
DKLAQIRRAMADKGAQWHFISTLDDLAWLLNLRGADVSYNPVFVAHALIGVDHASLFVAD
HHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GKVPQALAEALAKDNISIEPYAKAADALAALPAGSTLLIDPRRITFGSLQSVPATVKVIE
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
AVNPSTFFKSRKTAAEAGHVRETMEQDGAALAEFFAWFEGALGRETITELTIDERSTAAR
HCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHEECCCHHHHHH
ARRPGFVSLSFATIAGFNANGAMPHYRATEESHSVIEGNGLLLIDSGAQYLSGTTDITRV
HCCCCEEEEEEHEEECCCCCCCCCCCCCCCCCCCEEECCCEEEECCCCHHHCCCCCCEEE
VPVGTISEEQRRDFTIVLKGTMALSRAHFPRGIRSPMLDAIARAPIWEAGADYGHGTGHG
EECCCCCHHHCCCEEEEEECHHHHHHHHCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCC
VGYFLNVHEGPQVISHYAPAEPWTAMEEGMITSVEPGIYRPGKWGVRIENLVLNVPAGQT
EEEEEEECCCHHHHHHCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEEEEEEEECCCCCC
EFGDFLKFETLTLCPIDTRCLDLSLLREDERAWLNAYHETVRTRLAPHVSGEAKAWLELR
CHHHHHEECEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
TQPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]