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The map label for this gene is yddQ [H]

Identifier: 91785074

GI number: 91785074

Start: 4103867

End: 4104499

Strand: Reverse

Name: yddQ [H]

Synonym: Bxe_A0706

Alternate gene names: 91785074

Gene position: 4104499-4103867 (Counterclockwise)

Preceding gene: 91785076

Following gene: 91785072

Centisome position: 83.84

GC content: 67.61

Gene sequence:

>633_bases
ATGACCACACCGCGCCGTGCGCTGATCGTCATCGATGTGCAGAACGAATACGTGACCGGCGATCTGCCGATCGAATACCC
GGACGTGCAAAGCTCGCTCGCCAACATCGCCCGTGCGATGGATGCGGCGCGGGCGGCCGGCGTGCCGGTGGTGATCGTGC
AGAACTTCGCGCCGGCCGGCTCGCCGTTGTTCGCGCGCGGCAGCAATGGGGCGGAACTGCATCCGGTGGTGAGCGAGCGG
GCGCGCGATCATTACGTGGAGAAGTCCTTGCCGAGCGCCTTCACCGGGACCGATCTGGCCGGCTGGCTCGCCGCGCGCCA
GATCGATACGCTGACGGTCACCGGCTACATGACGCACAACTGCGACGCGTCGACCATCAACCACGCGGTTCACTCCGGGC
TTGCGGTCGAATTTCTGCACGACGCGACCGGCTCGGTGCCGTACGAGAACAGCGCGGGGTTCGCCAGCGCCGAGGAGATT
CACCGCGTGTTCAGCGTGGTGCTGCAATCGCGCTTCGCGGCGGTGGCGAGCACGGACGAGTGGATCGCGGCGGTGCAGGG
CGGGACGCCGCTGGCGCGCGGCAATATCTATGCGTCGAACCAGAAGGCGCGGGCCAGACGGGCCACGGCGTAA

Upstream 100 bases:

>100_bases
CAACTCGCCCGAAGCCCGGACCCGGACTGGACTGGACTGGACCAGCAGCCCGCGCGGCGCCCGCCATCCCCATCCCTTTA
CTCTACCGAGGAGTCTTGCC

Downstream 100 bases:

>100_bases
CTAGCCACCGGCTGTTCGCCGTGCATGCCCGTTGCGCAGCGCCGGGCTCAGCTTCAGCGCGTCGAACATGCCTTCCACCA
TCTGCACGGCGTGAGCGCCG

Product: putative isochorismatase hydrolase

Products: Nicotinate; pyrazinoic acid; NH3 [C]

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTTPRRALIVIDVQNEYVTGDLPIEYPDVQSSLANIARAMDAARAAGVPVVIVQNFAPAGSPLFARGSNGAELHPVVSER
ARDHYVEKSLPSAFTGTDLAGWLAARQIDTLTVTGYMTHNCDASTINHAVHSGLAVEFLHDATGSVPYENSAGFASAEEI
HRVFSVVLQSRFAAVASTDEWIAAVQGGTPLARGNIYASNQKARARRATA

Sequences:

>Translated_210_residues
MTTPRRALIVIDVQNEYVTGDLPIEYPDVQSSLANIARAMDAARAAGVPVVIVQNFAPAGSPLFARGSNGAELHPVVSER
ARDHYVEKSLPSAFTGTDLAGWLAARQIDTLTVTGYMTHNCDASTINHAVHSGLAVEFLHDATGSVPYENSAGFASAEEI
HRVFSVVLQSRFAAVASTDEWIAAVQGGTPLARGNIYASNQKARARRATA
>Mature_209_residues
TTPRRALIVIDVQNEYVTGDLPIEYPDVQSSLANIARAMDAARAAGVPVVIVQNFAPAGSPLFARGSNGAELHPVVSERA
RDHYVEKSLPSAFTGTDLAGWLAARQIDTLTVTGYMTHNCDASTINHAVHSGLAVEFLHDATGSVPYENSAGFASAEEIH
RVFSVVLQSRFAAVASTDEWIAAVQGGTPLARGNIYASNQKARARRATA

Specific function: NAD biosynthesis; nicotinamide to NaMN; first step. [C]

COG id: COG1335

COG function: function code Q; Amidases related to nicotinamidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismatase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000868 [H]

Pfam domain/function: PF00857 Isochorismatase [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 22317; Mature: 22186

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPRRALIVIDVQNEYVTGDLPIEYPDVQSSLANIARAMDAARAAGVPVVIVQNFAPAG
CCCCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SPLFARGSNGAELHPVVSERARDHYVEKSLPSAFTGTDLAGWLAARQIDTLTVTGYMTHN
CCEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEEEEECC
CDASTINHAVHSGLAVEFLHDATGSVPYENSAGFASAEEIHRVFSVVLQSRFAAVASTDE
CCHHHHHHHHHCCHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
WIAAVQGGTPLARGNIYASNQKARARRATA
HEEEECCCCCEECCCEEECCCHHHHHCCCC
>Mature Secondary Structure 
TTPRRALIVIDVQNEYVTGDLPIEYPDVQSSLANIARAMDAARAAGVPVVIVQNFAPAG
CCCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SPLFARGSNGAELHPVVSERARDHYVEKSLPSAFTGTDLAGWLAARQIDTLTVTGYMTHN
CCEEEECCCCCEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEEEEECC
CDASTINHAVHSGLAVEFLHDATGSVPYENSAGFASAEEIHRVFSVVLQSRFAAVASTDE
CCHHHHHHHHHCCHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
WIAAVQGGTPLARGNIYASNQKARARRATA
HEEEECCCCCEECCCEEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Nicotinamide; pyrazinamide; H2O [C]

Specific reaction: Nicotinamide + H2O = Nicotinate + NH3 pyrazinamide + H2O = pyrazinoic acid + NH3 [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]