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The map label for this gene is msrA [H]

Identifier: 91785042

GI number: 91785042

Start: 4064388

End: 4064936

Strand: Reverse

Name: msrA [H]

Synonym: Bxe_A0738

Alternate gene names: 91785042

Gene position: 4064936-4064388 (Counterclockwise)

Preceding gene: 91785044

Following gene: 91785038

Centisome position: 83.03

GC content: 59.56

Gene sequence:

>549_bases
ATGAATCAGACAGGCGAAGTCGCCACTCTCGGCGGCGGTTGTTTCTGGTGCCTTGAAGCGGTGTATCTGGGCGTCGAAGG
TGTGAACGCGGTGGAGTCGGGCTACGCGGGTGGTGAGGCCCGGCATCCGACTTATGAAGACGTGTGCGACGGCGAAACGG
GCCACGCGGAAGTCGTGAAGGTCGACTTCGATCCGGCGAAGATCAGCTATCGCGAGATTCTCGACATCTTCTTCGCGATC
CACGATCCGACGCAGTTGAACCGGCAGGGCAACGACGTCGGCACGCAATACCGCTCGGTGATCTTCACGCATTCCGACGC
GCAGCGGGAGATCGCGCTGCAGGCGATCCGCGAGATTGGCGAACAGCAGATCTACGACGGCCAGATCGTCACCCAGGTGT
TGCCGCTCAACGACAACTACTGGCCTGCCGAGGATTATCACCAGAACTATTTTGCGCACCATCCGAATCAGGGTTACTGC
TCGTTCGTGGTGGCGCCCAAGGTGGCGAAGTTTCGTCAGAAGTTTGCTCACCGGATCAAGGCGAGCTGA

Upstream 100 bases:

>100_bases
AGCGAAAAACCCGCTAAGCTGGAAAATCAGCGGGTGGAACGGGCGTTGCGGCGAAGCGTGGACCGGCATCGGCCGATTAT
GAGTTCAAGGAGCGGGCAGC

Downstream 100 bases:

>100_bases
CACGGCGAGCGGCTGGCCGACGCTCCCTCTCAAGCGTCGGAGTGAGGTGGGCTCCCGTCCCCGTCGGCCGGCGGGGGCTC
ATGTTCGTGCTCATGAACCA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MNQTGEVATLGGGCFWCLEAVYLGVEGVNAVESGYAGGEARHPTYEDVCDGETGHAEVVKVDFDPAKISYREILDIFFAI
HDPTQLNRQGNDVGTQYRSVIFTHSDAQREIALQAIREIGEQQIYDGQIVTQVLPLNDNYWPAEDYHQNYFAHHPNQGYC
SFVVAPKVAKFRQKFAHRIKAS

Sequences:

>Translated_182_residues
MNQTGEVATLGGGCFWCLEAVYLGVEGVNAVESGYAGGEARHPTYEDVCDGETGHAEVVKVDFDPAKISYREILDIFFAI
HDPTQLNRQGNDVGTQYRSVIFTHSDAQREIALQAIREIGEQQIYDGQIVTQVLPLNDNYWPAEDYHQNYFAHHPNQGYC
SFVVAPKVAKFRQKFAHRIKAS
>Mature_182_residues
MNQTGEVATLGGGCFWCLEAVYLGVEGVNAVESGYAGGEARHPTYEDVCDGETGHAEVVKVDFDPAKISYREILDIFFAI
HDPTQLNRQGNDVGTQYRSVIFTHSDAQREIALQAIREIGEQQIYDGQIVTQVLPLNDNYWPAEDYHQNYFAHHPNQGYC
SFVVAPKVAKFRQKFAHRIKAS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=43.75, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI208609995, Length=161, Percent_Identity=43.4782608695652, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=45.6140350877193, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=39.8692810457516, Blast_Score=119, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=32.8767123287671, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=41.4634146341463, Blast_Score=111, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24664627, Length=171, Percent_Identity=34.5029239766082, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664631, Length=171, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45553131, Length=159, Percent_Identity=33.9622641509434, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20398; Mature: 20398

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTGEVATLGGGCFWCLEAVYLGVEGVNAVESGYAGGEARHPTYEDVCDGETGHAEVVK
CCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VDFDPAKISYREILDIFFAIHDPTQLNRQGNDVGTQYRSVIFTHSDAQREIALQAIREIG
EECCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHH
EQQIYDGQIVTQVLPLNDNYWPAEDYHQNYFAHHPNQGYCSFVVAPKVAKFRQKFAHRIK
HHHCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHC
AS
CC
>Mature Secondary Structure
MNQTGEVATLGGGCFWCLEAVYLGVEGVNAVESGYAGGEARHPTYEDVCDGETGHAEVVK
CCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VDFDPAKISYREILDIFFAIHDPTQLNRQGNDVGTQYRSVIFTHSDAQREIALQAIREIG
EECCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHEEEECCCHHHHHHHHHHHHHH
EQQIYDGQIVTQVLPLNDNYWPAEDYHQNYFAHHPNQGYCSFVVAPKVAKFRQKFAHRIK
HHHCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHC
AS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]