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The map label for this gene is rnc [H]

Identifier: 91784707

GI number: 91784707

Start: 3694388

End: 3695674

Strand: Reverse

Name: rnc [H]

Synonym: Bxe_A1085

Alternate gene names: 91784707

Gene position: 3695674-3694388 (Counterclockwise)

Preceding gene: 91784708

Following gene: 91784706

Centisome position: 75.49

GC content: 65.97

Gene sequence:

>1287_bases
ATGCCCCTATCTCCGTTGGAAAGCCGTCTGCGCTACGAATTTCGCAATGCGGAATTGCTGCGCCAGGCTTTAACGCACCG
CAGTCACAGTTCCACGCATAACGAACGGCTCGAATTTCTTGGCGACTCCGTTCTGAATTGCGCGGTGGCTGCGCTTTTGT
TCCAACGCTTCGGCAAACTGGACGAGGGTGACCTGTCGCGCGTCCGTGCCAATCTGGTCAAACAGCAGTCGCTCTACGAA
ATTGCTCAGGCCCTCAATATTTCGGAGGGCTTGCGGCTGGGCGAAGGCGAGTTGCGCAGCGGCGGCTTCCGCCGCCCCTC
GATCCTCGCTGACACGCTCGAAGCCGTGCTGGGCGCGGTGTTCCTCGACGGCGGCTTCGAGGCCGCCCAAACGGTCATCA
AGCGTCTTTACGTGCCGATTCTCGATCACATCGACCCGCGCACGCTTGGCAAGGACGCCAAGACGCTGCTCCAGGAGTAT
TTGCAGGGCCACAAGATCGCGCTGCCTACTTACACGGTCGTGGCTACACATGGTGCGGCGCACAATCAGCAATTCGAAGT
CGAATGCACGGTGCCGAAGCTGGAGGTGAAAGTCTCCGGCTCCGGCGCGAGCCGGCGCGCCGCGGAGCAGGCGGCCGCCA
AGAAAGCGCTCGACGAGGTCATGGCCGCGGCGCCCGCTATGGTCGCCAAACCCAAGCGCTCGAAAAGTGCCCGCGCGGCG
AAGAACGTCGAGCCGGAGATCGTGCCCGGCGTCACTGGCGTGCAAGCCGCGCTGGATTTGCGCAGCCCGGATCGCAAGAG
CGAGCGTGGAGCGGGGCGCGGTGAAGCCCGCGCGGCGGCCACGGCCGAGCCGGCAGGCGAGCGCCCCATGCTGGGCCTCG
CAGCCGCACCGTTGGCCGTGATTCGCGCCGCGCACGTGGAGTACAGCGGGCAGGACAAAGCCGAACGCGCCGACAAGGCC
GAGAAAGCAGAGAAGCCGGCCGCCCACACGGGCGACAGGTCCACGGATAAAGCCGGAGCGGCAGCGGCGGATAAACCCGC
CGAGAAGTCCGCTGAAAAACCCGATACAAAGCCTGCGGACGCGAAAACGACCGAAACCAGAGCGGCCGAAGCCAAAGTGG
CCGAAGCCAAACCGGAAGCCGCTGCCGCGCGCGGCGTCGACAAACTTCGCAACCGCGAGGCCACGCCTGGCGCAGCCGCG
CCTGCAGCGGGCGCAGCCGCGCCGACCGAACACGAACCCGGCGTAGCCGACGCGGTGCAAACGCGCGTCGCCGACGCGGG
CCATTGA

Upstream 100 bases:

>100_bases
ACGCTACTTTAAAATCCTGCGGTAACCTCGCTTCACCACGCTTTTTCCGCTGGCCGTCCCGCGTTTTCGCCGGGTCAGGC
GCCCGCGTTATACTCTGCCC

Downstream 100 bases:

>100_bases
TTGCCATCGGCGCGCCCATTGCGCGTGTCGATCTGAACTTGCCGTAGCCCGAATATGAACGCTCCCACTCCCACTGGTTT
TCGCTGCGGCATGGTCGCGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MPLSPLESRLRYEFRNAELLRQALTHRSHSSTHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISEGLRLGEGELRSGGFRRPSILADTLEAVLGAVFLDGGFEAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLEVKVSGSGASRRAAEQAAAKKALDEVMAAAPAMVAKPKRSKSARAA
KNVEPEIVPGVTGVQAALDLRSPDRKSERGAGRGEARAAATAEPAGERPMLGLAAAPLAVIRAAHVEYSGQDKAERADKA
EKAEKPAAHTGDRSTDKAGAAAADKPAEKSAEKPDTKPADAKTTETRAAEAKVAEAKPEAAAARGVDKLRNREATPGAAA
PAAGAAAPTEHEPGVADAVQTRVADAGH

Sequences:

>Translated_428_residues
MPLSPLESRLRYEFRNAELLRQALTHRSHSSTHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISEGLRLGEGELRSGGFRRPSILADTLEAVLGAVFLDGGFEAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLEVKVSGSGASRRAAEQAAAKKALDEVMAAAPAMVAKPKRSKSARAA
KNVEPEIVPGVTGVQAALDLRSPDRKSERGAGRGEARAAATAEPAGERPMLGLAAAPLAVIRAAHVEYSGQDKAERADKA
EKAEKPAAHTGDRSTDKAGAAAADKPAEKSAEKPDTKPADAKTTETRAAEAKVAEAKPEAAAARGVDKLRNREATPGAAA
PAAGAAAPTEHEPGVADAVQTRVADAGH
>Mature_427_residues
PLSPLESRLRYEFRNAELLRQALTHRSHSSTHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYEI
AQALNISEGLRLGEGELRSGGFRRPSILADTLEAVLGAVFLDGGFEAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLEVKVSGSGASRRAAEQAAAKKALDEVMAAAPAMVAKPKRSKSARAAK
NVEPEIVPGVTGVQAALDLRSPDRKSERGAGRGEARAAATAEPAGERPMLGLAAAPLAVIRAAHVEYSGQDKAERADKAE
KAEKPAAHTGDRSTDKAGAAAADKPAEKSAEKPDTKPADAKTTETRAAEAKVAEAKPEAAAARGVDKLRNREATPGAAAP
AAGAAAPTEHEPGVADAVQTRVADAGH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=28.6343612334802, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=28.6343612334802, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=52.9126213592233, Blast_Score=218, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=30.4568527918782, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=30.4568527918782, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137682, Length=227, Percent_Identity=29.0748898678414, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 45146; Mature: 45015

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSPLESRLRYEFRNAELLRQALTHRSHSSTHNERLEFLGDSVLNCAVAALLFQRFGKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADTLEAVLGAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLEVKVSGSGASRRAAEQAAAKKALDEVMAAAPAMVAKPKRSKSARAA
CCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
KNVEPEIVPGVTGVQAALDLRSPDRKSERGAGRGEARAAATAEPAGERPMLGLAAAPLAV
HCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
IRAAHVEYSGQDKAERADKAEKAEKPAAHTGDRSTDKAGAAAADKPAEKSAEKPDTKPAD
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
AKTTETRAAEAKVAEAKPEAAAARGVDKLRNREATPGAAAPAAGAAAPTEHEPGVADAVQ
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TRVADAGH
HHHHCCCC
>Mature Secondary Structure 
PLSPLESRLRYEFRNAELLRQALTHRSHSSTHNERLEFLGDSVLNCAVAALLFQRFGKL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADTLEAVLGAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQTVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLEVKVSGSGASRRAAEQAAAKKALDEVMAAAPAMVAKPKRSKSARAA
CCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
KNVEPEIVPGVTGVQAALDLRSPDRKSERGAGRGEARAAATAEPAGERPMLGLAAAPLAV
HCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
IRAAHVEYSGQDKAERADKAEKAEKPAAHTGDRSTDKAGAAAADKPAEKSAEKPDTKPAD
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
AKTTETRAAEAKVAEAKPEAAAARGVDKLRNREATPGAAAPAAGAAAPTEHEPGVADAVQ
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TRVADAGH
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]