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The map label for this gene is lysC [H]

Identifier: 91784171

GI number: 91784171

Start: 3108921

End: 3110171

Strand: Reverse

Name: lysC [H]

Synonym: Bxe_A1630

Alternate gene names: 91784171

Gene position: 3110171-3108921 (Counterclockwise)

Preceding gene: 91784172

Following gene: 91784170

Centisome position: 63.53

GC content: 61.07

Gene sequence:

>1251_bases
ATGGCACTCATCGTACACAAATACGGCGGCACCTCGATGGGCTCGGTCGAGCGCATCAAGAACGTCGCCAGGCGCGTCGC
GAAATGGCACAAGGCTGGCCACAAGATGGTCGTCGTGCCGTCGGCGATGTCCGGCGAAACCAACCGTTTGCTCGGTCTCG
CGAAAGAAATCACGGCTCAGCCGAGCCCGCGCGAACTCGACATGATCGCCGCTACGGGCGAGCAGGTCAGCTCCGGACTG
CTCGCCATCGCGCTGCAGGAAGCCGGCGTCGACGCGGTCAGCTACGCCGGCTGGCAAGTGCCGGTCAAAACGGATAGCGC
ATTCACGAAAGCGCGTATCAGCGAAATCGACGGCGAGCGCGTGCTGCGCGATCTCGACGCGGGCAAGGTGGTGGTGATCA
CCGGCTTCCAGGGTATCGATCCTGACGGCAATATCACCACGCTCGGCCGTGGCGGCTCGGATACGTCGGCGGTCGCGGTC
GCGGCTGCGCTGAAGGCCGATGAGTGCCTGATCTACACGGACGTCGACGGTGTGTACACGACCGACCCGCGCGTGGTGGA
AGAAGCGCGCCGGCTCGATCGCGTGACGTTCGAAGAAATGCTGGAAATGGCAAGCCTGGGTTCGAAGGTGCTGCAGATCC
GCTCGGTGGAATTCGCCGGCAAATATCAGGTGAAGACGCGTGTGCTGTCGAGCCTGACCGATCCGCTGATACCGCTCGAC
GCTGAAATGAAGTCGGGCACCCTGATTACTTTTGAAGAAGACGAGACCATGGAAAAAGCAGTCATCTCGGGTATCGCGTT
TCAGCGCGATGAAGCTCGTATCGCCGTGATGGGTGTGCCCGACAAGCCGGGCATCGCGTATCAGATTCTCGGCCCGGTGG
CGGACGCGAATATCGACGTCGACATGATCATTCAGAACCAGAGCGTGGATGGTAAAACGGCGTTCACGTTCACGGTCGGC
CGTGGCGACTATCAGCGCGCTATGGACATCCTCACGGGACAGGTGAAGGGCCACGTGCAGGCCGAGCAGGTGCTGGGCGA
TCCGAAGGTGTCGAAGGTGTCGGTGGTCGGCGTCGGCATGCGCTCGCACGTCGGTATCGCGAGCACCATGTTCCGCACGC
TGTCGGAAGAGGGCATCAACATCCAGATGATCTCGACCTCCGAAATCAAGATCTCGGTATTGATCGACGAGAAGTACATG
GAGCTCGCCGTACGCGCGCTTCATAAAGCGTTCGAACTGGATCAGGCGTGA

Upstream 100 bases:

>100_bases
CCACACATTTTGCCGTCGTTCACAAGACGTTGCGCTCCTGTGCTTTTGTGCGGTCGTCTCCAGCGCGCCAGCGCGGTTTC
TCTTCCAGTTCAGAACGACA

Downstream 100 bases:

>100_bases
GTAAAGTTGGGCAACGGAGTGGACAGGAGCGCTCCGTTTGTTTTGCGTGGTCGACGTGAATAAATTGCGTCATTGATGAC
AAAACTGGCACAAAAAATGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MALIVHKYGGTSMGSVERIKNVARRVAKWHKAGHKMVVVPSAMSGETNRLLGLAKEITAQPSPRELDMIAATGEQVSSGL
LAIALQEAGVDAVSYAGWQVPVKTDSAFTKARISEIDGERVLRDLDAGKVVVITGFQGIDPDGNITTLGRGGSDTSAVAV
AAALKADECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIPLD
AEMKSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTAFTFTVG
RGDYQRAMDILTGQVKGHVQAEQVLGDPKVSKVSVVGVGMRSHVGIASTMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA

Sequences:

>Translated_416_residues
MALIVHKYGGTSMGSVERIKNVARRVAKWHKAGHKMVVVPSAMSGETNRLLGLAKEITAQPSPRELDMIAATGEQVSSGL
LAIALQEAGVDAVSYAGWQVPVKTDSAFTKARISEIDGERVLRDLDAGKVVVITGFQGIDPDGNITTLGRGGSDTSAVAV
AAALKADECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIPLD
AEMKSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTAFTFTVG
RGDYQRAMDILTGQVKGHVQAEQVLGDPKVSKVSVVGVGMRSHVGIASTMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA
>Mature_415_residues
ALIVHKYGGTSMGSVERIKNVARRVAKWHKAGHKMVVVPSAMSGETNRLLGLAKEITAQPSPRELDMIAATGEQVSSGLL
AIALQEAGVDAVSYAGWQVPVKTDSAFTKARISEIDGERVLRDLDAGKVVVITGFQGIDPDGNITTLGRGGSDTSAVAVA
AALKADECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIPLDA
EMKSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDVDMIIQNQSVDGKTAFTFTVGR
GDYQRAMDILTGQVKGHVQAEQVLGDPKVSKVSVVGVGMRSHVGIASTMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKAFELDQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=301, Percent_Identity=32.890365448505, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790455, Length=382, Percent_Identity=29.0575916230367, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790376, Length=280, Percent_Identity=26.0714285714286, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=404, Percent_Identity=28.4653465346535, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44800; Mature: 44669

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSVERIKNVARRVAKWHKAGHKMVVVPSAMSGETNRLLGLAKEITAQ
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIAATGEQVSSGLLAIALQEAGVDAVSYAGWQVPVKTDSAFTKARISEIDGER
CCCCCEEEEEECCHHHHCCEEEEEEECCCCCEEEECCEEEEECCCCHHHHHHHHHCCHHH
VLRDLDAGKVVVITGFQGIDPDGNITTLGRGGSDTSAVAVAAALKADECLIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIPLD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
AEMKSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDV
CCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTAFTFTVGRGDYQRAMDILTGQVKGHVQAEQVLGDPKVSKVSVVGVGM
EEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEHHHHCCCCCCCEEEEEEECH
RSHVGIASTMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSVERIKNVARRVAKWHKAGHKMVVVPSAMSGETNRLLGLAKEITAQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIAATGEQVSSGLLAIALQEAGVDAVSYAGWQVPVKTDSAFTKARISEIDGER
CCCCCEEEEEECCHHHHCCEEEEEEECCCCCEEEECCEEEEECCCCHHHHHHHHHCCHHH
VLRDLDAGKVVVITGFQGIDPDGNITTLGRGGSDTSAVAVAAALKADECLIYTDVDGVYT
HHHHCCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIPLD
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
AEMKSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANIDV
CCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTAFTFTVGRGDYQRAMDILTGQVKGHVQAEQVLGDPKVSKVSVVGVGM
EEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEHHHHCCCCCCCEEEEEEECH
RSHVGIASTMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]