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The map label for this gene is butA [H]

Identifier: 91783547

GI number: 91783547

Start: 2408949

End: 2409863

Strand: Direct

Name: butA [H]

Synonym: Bxe_A2268

Alternate gene names: 91783547

Gene position: 2408949-2409863 (Clockwise)

Preceding gene: 91783546

Following gene: 91783548

Centisome position: 49.2

GC content: 68.09

Gene sequence:

>915_bases
ATGACGTTCGAGTTCGCAGGCAAGGTGGCGGTGATCACCGGAGCGGCCAGCGGTTTCGGCCGCGCGTTTGCGCAGAAGGG
TGCGTCGCTCGGCATGAAGCTGGTGCTGGCCGACGTGAATCCCGGCGCGCTCGCGCAAACCGTCGAAGCGTTGCGCGCCG
GCGGCGCCGAAGCGATCGGCGTGCCGACCGACGTCGCCAGCGCGGCGCAGGTCGAAGCGCTCGCGCAAGCGGCGCTCGCT
GCCTACGGCAAGGTGCATCTGCTGTTCAACAACGCGGGCGTGGGCGCGGGCGGCTTCCTGTGGGAAAGCTCGGCGAACGA
CTGGTCGTGGGTATTCGGCGTGAACGTGATGGGCGTCGCGCACGGCGTGCGGGTGTTCACACCGATCATGCTGGCGCAGA
ACGAGCCGGCGCATATCGTCAACACGGCATCGGTCGCGGGTTTGTTGTCGCCGCCCGCAATGGGTATCTACAACGCGTCG
AAGCACGCCGTGGTGTCGCTCACCGAAACGCTGTATCACGACCTGCAACTGGCCCAGGCGGCCCAGTCGGCCCAGGCCGC
CCAGGCGGAAACGGCCGGCGCGCAGGTCGGCTGTTCGCTGCTGTGCCCGGCCTTTGTGCCGACCGGCATCGCCGATGCGG
AACGCGCGCGGCCCGCGGACCTGCGCAACGACAGCCGGCCGACCCGCTCGCAGATCGCCGCGGGCAAGCAATTGCAGCGC
GCGGTGCAGTCAGGCAAGCTGAGTGCCGACGATGTCGCCGGCATCACCTTCGAAGCGATCGCGGCGCGGCGTTTCTACGT
CGTCACGCATCCGGGCATCATGGCGACGGTGAAGTTGCGCCATGAAGACATCGAGCAGTTGCGCAATCCCACCGATCCGA
TGTCGCTGAAGCCGGAAGTGAAGGGCGCCGGCTAG

Upstream 100 bases:

>100_bases
CTCAAAGGCAAGAACTTCGGCAAGCAGCTCGTCAAGCTGATCTGAGCGTGGCGGCAACTGGGCGAATCCCACGAGACAAC
GGTCAACGCAAAGGAACCAC

Downstream 100 bases:

>100_bases
GCGAAGCGCTCATCGCAACGCCGGCGCCGCCGACACCGCGGCGCTGTTTTTCAAACCTTCGGCGCTCACGCGCTATCAGA
CGGACCATGCCGCTGAATCC

Product: hypothetical protein

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTFEFAGKVAVITGAASGFGRAFAQKGASLGMKLVLADVNPGALAQTVEALRAGGAEAIGVPTDVASAAQVEALAQAALA
AYGKVHLLFNNAGVGAGGFLWESSANDWSWVFGVNVMGVAHGVRVFTPIMLAQNEPAHIVNTASVAGLLSPPAMGIYNAS
KHAVVSLTETLYHDLQLAQAAQSAQAAQAETAGAQVGCSLLCPAFVPTGIADAERARPADLRNDSRPTRSQIAAGKQLQR
AVQSGKLSADDVAGITFEAIAARRFYVVTHPGIMATVKLRHEDIEQLRNPTDPMSLKPEVKGAG

Sequences:

>Translated_304_residues
MTFEFAGKVAVITGAASGFGRAFAQKGASLGMKLVLADVNPGALAQTVEALRAGGAEAIGVPTDVASAAQVEALAQAALA
AYGKVHLLFNNAGVGAGGFLWESSANDWSWVFGVNVMGVAHGVRVFTPIMLAQNEPAHIVNTASVAGLLSPPAMGIYNAS
KHAVVSLTETLYHDLQLAQAAQSAQAAQAETAGAQVGCSLLCPAFVPTGIADAERARPADLRNDSRPTRSQIAAGKQLQR
AVQSGKLSADDVAGITFEAIAARRFYVVTHPGIMATVKLRHEDIEQLRNPTDPMSLKPEVKGAG
>Mature_303_residues
TFEFAGKVAVITGAASGFGRAFAQKGASLGMKLVLADVNPGALAQTVEALRAGGAEAIGVPTDVASAAQVEALAQAALAA
YGKVHLLFNNAGVGAGGFLWESSANDWSWVFGVNVMGVAHGVRVFTPIMLAQNEPAHIVNTASVAGLLSPPAMGIYNASK
HAVVSLTETLYHDLQLAQAAQSAQAAQAETAGAQVGCSLLCPAFVPTGIADAERARPADLRNDSRPTRSQIAAGKQLQRA
VQSGKLSADDVAGITFEAIAARRFYVVTHPGIMATVKLRHEDIEQLRNPTDPMSLKPEVKGAG

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=204, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=30.8056872037915, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI25282469, Length=237, Percent_Identity=32.0675105485232, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI224922801, Length=168, Percent_Identity=32.7380952380952, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI40807363, Length=208, Percent_Identity=29.3269230769231, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI20149619, Length=209, Percent_Identity=27.7511961722488, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI210032110, Length=227, Percent_Identity=28.6343612334802, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI310128830, Length=245, Percent_Identity=25.3061224489796, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI310115468, Length=245, Percent_Identity=25.3061224489796, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI109715829, Length=177, Percent_Identity=27.683615819209, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI83715985, Length=182, Percent_Identity=32.967032967033, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=182, Percent_Identity=32.967032967033, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7706318, Length=166, Percent_Identity=26.5060240963855, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33667109, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI5031737, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=220, Percent_Identity=29.5454545454545, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=25.5639097744361, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787905, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789208, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=206, Percent_Identity=31.5533980582524, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=29.2452830188679, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=206, Percent_Identity=30.0970873786408, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=204, Percent_Identity=28.4313725490196, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=169, Percent_Identity=30.1775147928994, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=223, Percent_Identity=28.6995515695067, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=214, Percent_Identity=28.5046728971963, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=180, Percent_Identity=27.2222222222222, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=176, Percent_Identity=30.6818181818182, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581726, Length=215, Percent_Identity=28.8372093023256, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640492, Length=215, Percent_Identity=27.906976744186, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357041, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281364892, Length=174, Percent_Identity=32.7586206896552, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510726, Length=238, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=172, Percent_Identity=32.5581395348837, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=167, Percent_Identity=32.9341317365269, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644339, Length=174, Percent_Identity=32.7586206896552, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737361, Length=179, Percent_Identity=34.0782122905028, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355631, Length=178, Percent_Identity=28.6516853932584, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859837, Length=235, Percent_Identity=28.5106382978723, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648944, Length=188, Percent_Identity=30.8510638297872, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007238, Length=176, Percent_Identity=30.1136363636364, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007236, Length=176, Percent_Identity=30.1136363636364, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=169, Percent_Identity=31.3609467455621, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 31364; Mature: 31233

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEFAGKVAVITGAASGFGRAFAQKGASLGMKLVLADVNPGALAQTVEALRAGGAEAIG
CCEECCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCC
VPTDVASAAQVEALAQAALAAYGKVHLLFNNAGVGAGGFLWESSANDWSWVFGVNVMGVA
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCCCCCEEEECCCHHHHH
HGVRVFTPIMLAQNEPAHIVNTASVAGLLSPPAMGIYNASKHAVVSLTETLYHDLQLAQA
HHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
AQSAQAAQAETAGAQVGCSLLCPAFVPTGIADAERARPADLRNDSRPTRSQIAAGKQLQR
HHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVQSGKLSADDVAGITFEAIAARRFYVVTHPGIMATVKLRHEDIEQLRNPTDPMSLKPEV
HHHHCCCCCCHHCCCHHHHHHCEEEEEEECCCEEEEEEECHHHHHHHCCCCCCCCCCCCC
KGAG
CCCC
>Mature Secondary Structure 
TFEFAGKVAVITGAASGFGRAFAQKGASLGMKLVLADVNPGALAQTVEALRAGGAEAIG
CEECCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCC
VPTDVASAAQVEALAQAALAAYGKVHLLFNNAGVGAGGFLWESSANDWSWVFGVNVMGVA
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEECCCCCCCEEEECCCHHHHH
HGVRVFTPIMLAQNEPAHIVNTASVAGLLSPPAMGIYNASKHAVVSLTETLYHDLQLAQA
HHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
AQSAQAAQAETAGAQVGCSLLCPAFVPTGIADAERARPADLRNDSRPTRSQIAAGKQLQR
HHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVQSGKLSADDVAGITFEAIAARRFYVVTHPGIMATVKLRHEDIEQLRNPTDPMSLKPEV
HHHHCCCCCCHHCCCHHHHHHCEEEEEEECCCEEEEEEECHHHHHHHCCCCCCCCCCCCC
KGAG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA