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The map label for this gene is ispD [H]

Identifier: 91783504

GI number: 91783504

Start: 2357576

End: 2358289

Strand: Direct

Name: ispD [H]

Synonym: Bxe_A2312

Alternate gene names: 91783504

Gene position: 2357576-2358289 (Clockwise)

Preceding gene: 91783499

Following gene: 91783505

Centisome position: 48.15

GC content: 66.67

Gene sequence:

>714_bases
GTGACTTCCCGTCTATTTGCCCTGATTCCGTGCGCAGGCACCGGCAGCCGTTCCGGCGCCGCGATGCCCAAACAATATCG
CACTGTCGCCGGCCGCGACATGTTGCATTTTTCGCTGGCGGCATTCGACGCCTGCAGCGAGTTTGCGCAAACCCTCGTCG
TGATCGCCCCTGATGACGCCCATTTCGACGCGCGCCGCTTCGGCGGCTTGCGTTTTGCCGTGCGCCGCAGCGGCGGAGCC
TCGCGCCAGGCGTCGGTGCTCAATGGCCTGCACGCGCTTGCCGAGTTCGGCGCCCATGACGACGACTGGGTACTCGTGCA
CGATGCGGCGCGTCCCGGCATCACGCCTGCGCTGATCCGCACGCTGGTCGGCGCGCTGAAGGACGACACGGTAGGCGGCA
TCATGGCGTTGCCCGTGGCGGACACGCTCAAACGCATCGACGCGAATTCGGCCGACGGCCGGATCGCCCGCACCGAGGCG
CGCGACGGCTTGTGGCAGGCGCAGACGCCGCAGATGTTCCGCATCGGCATGTTGCGCGCGGCGATCCTGCGCGCGCAGGC
CGACGGTCACGACCTGACCGACGAAGCGAGCGCGATCGAATGGTTGGGTCACGCGCCGAAACTGGTGCAGGGCAGCTTGC
GCAACTTCAAGGTGACTTATCCGGAAGACTTCGATCTGGCCGAAGCCATTCTGAGCCGGCCAGCGGTTTCGTGA

Upstream 100 bases:

>100_bases
GGCTCACACGTGACCGGCAAGTTTACGCGCGTCGGGGCGTGGATGCGAAGGACCTATTATAAAATCCGTCCTTTACTTTG
ACTTCGCGGCATCCGCACTC

Downstream 100 bases:

>100_bases
CGGGCGACTTCAAATTTAATGAGCGGACTTGAGGACTTGACGCATATGGATTTCAGAATTGGGCAAGGGTACGACGTGCA
TGCGCTGGTGCCGGGACGTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTSRLFALIPCAGTGSRSGAAMPKQYRTVAGRDMLHFSLAAFDACSEFAQTLVVIAPDDAHFDARRFGGLRFAVRRSGGA
SRQASVLNGLHALAEFGAHDDDWVLVHDAARPGITPALIRTLVGALKDDTVGGIMALPVADTLKRIDANSADGRIARTEA
RDGLWQAQTPQMFRIGMLRAAILRAQADGHDLTDEASAIEWLGHAPKLVQGSLRNFKVTYPEDFDLAEAILSRPAVS

Sequences:

>Translated_237_residues
MTSRLFALIPCAGTGSRSGAAMPKQYRTVAGRDMLHFSLAAFDACSEFAQTLVVIAPDDAHFDARRFGGLRFAVRRSGGA
SRQASVLNGLHALAEFGAHDDDWVLVHDAARPGITPALIRTLVGALKDDTVGGIMALPVADTLKRIDANSADGRIARTEA
RDGLWQAQTPQMFRIGMLRAAILRAQADGHDLTDEASAIEWLGHAPKLVQGSLRNFKVTYPEDFDLAEAILSRPAVS
>Mature_236_residues
TSRLFALIPCAGTGSRSGAAMPKQYRTVAGRDMLHFSLAAFDACSEFAQTLVVIAPDDAHFDARRFGGLRFAVRRSGGAS
RQASVLNGLHALAEFGAHDDDWVLVHDAARPGITPALIRTLVGALKDDTVGGIMALPVADTLKRIDANSADGRIARTEAR
DGLWQAQTPQMFRIGMLRAAILRAQADGHDLTDEASAIEWLGHAPKLVQGSLRNFKVTYPEDFDLAEAILSRPAVS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=238, Percent_Identity=26.0504201680672, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1789104, Length=229, Percent_Identity=39.7379912663755, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25448; Mature: 25317

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLFALIPCAGTGSRSGAAMPKQYRTVAGRDMLHFSLAAFDACSEFAQTLVVIAPDDA
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFGGLRFAVRRSGGASRQASVLNGLHALAEFGAHDDDWVLVHDAARPGITPALIR
CCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLVGALKDDTVGGIMALPVADTLKRIDANSADGRIARTEARDGLWQAQTPQMFRIGMLRA
HHHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCCEEECHHHCCCCCCCCCHHHHHHHHHH
AILRAQADGHDLTDEASAIEWLGHAPKLVQGSLRNFKVTYPEDFDLAEAILSRPAVS
HHHHHCCCCCCCCCHHHHHHHHCCCCHHHHCCHHCEEEECCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TSRLFALIPCAGTGSRSGAAMPKQYRTVAGRDMLHFSLAAFDACSEFAQTLVVIAPDDA
CCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFGGLRFAVRRSGGASRQASVLNGLHALAEFGAHDDDWVLVHDAARPGITPALIR
CCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLVGALKDDTVGGIMALPVADTLKRIDANSADGRIARTEARDGLWQAQTPQMFRIGMLRA
HHHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCCEEECHHHCCCCCCCCCHHHHHHHHHH
AILRAQADGHDLTDEASAIEWLGHAPKLVQGSLRNFKVTYPEDFDLAEAILSRPAVS
HHHHHCCCCCCCCCHHHHHHHHCCCCHHHHCCHHCEEEECCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA