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The map label for this gene is uvrD [H]

Identifier: 91783265

GI number: 91783265

Start: 2104394

End: 2105956

Strand: Direct

Name: uvrD [H]

Synonym: Bxe_A2560

Alternate gene names: 91783265

Gene position: 2104394-2105956 (Clockwise)

Preceding gene: 91783264

Following gene: 91783266

Centisome position: 42.98

GC content: 59.56

Gene sequence:

>1563_bases
TTGCGCGAGAATGAAGATCAATGGTGCGCCTACCAGGCGACGGGGAACTGTGTCATTTTGGCAGGCCCTGGCAGTGGTAA
GACGAAGACGATCACCATTAAGATCGCCCGACTTCTTGCTGAGGACGTCCGCAGACCGCGCCGCGTCGCGTGCATCACCT
ACAGCAATGCTTGCGTCGGTGAACTGCGATCACGGCTTACGAGACTCGGCGTGGGCGACAGCGATCGTCTCGTGCTTTCC
ACTGTTCACTCTTTTTGCCTGACGGAGTTGGTGTTCCCTTATGCCAAGATGGCGGGGCTCCAAATGCCGGATCCACTGGT
TGTGGCTTCACCAGCACAGGCAAGAGCGCTTTTCAGCGATGCCTATCGTGCGCAGTTGGGCGGGAACGCACCGGCGTGGT
TCCGCATGGCCTGCGACAGGCTACGGCGCACGATTCTGGACCGAGGAAGTGACGAATGGCGAGCGGGGTCGGCCCGGGAA
ACGATGGTAGTCGAGGCCTACGAAAATTTGCTTCTACAAAACGGCCTGATCGACTTCGACGGATTGGTCCTCGCCGGCCT
GCAGCTTGTTGAGAAGAACGAGTGGGTCCGGCATGCTATTCGGGCCAAGTATCCCGTGGTCGTGATCGACGAATATCAGG
ATCTCGGCGTGCCCCTGCACCGCATCGTGTTGGCGCTCCTTCAAGCGGGAGTTCGGATCATCGCTGTGGGTGATCCTGAC
CAGTCCATTTACGGGTTCACCGGTGCAAAGCCAGACCTGTTGACAGCGTTGGCTGGTCTCCAGCAGATGGAGTCCGTTAC
GCTCAAGTTGAATTACCGGTGCGCCGATAGAATCATCGCTGCCTCCAGGGCGCTCTTGCCCGAGCCAGCGGAGTTCCGTT
CCCATGATGGCCGGTCCGGCGAAATCCATATTCACCGTTTGGAGTGCAGCATTCGCGAGCAGGCGGACTATGCGCTCGGT
ACGCTGGTGCCAGCGTTGCTCGAGGCGAATCCGTCGTGGGCGCCGGGAGATATAGCGGTGTTATACCGCACGCTTAATGA
GGGCGCGCCGATTGCGGAGGCGGCAGATGCTCTTGGTCTGCAATACTTCCGTCTTGACAACGGCTCACCCATCAAGCGCA
CACGCGTGACCGAGTGGCTCACGGATGCGGCACGATGGTGTTCCGGGGGATGGCAGACCGGGGAAATCTCGCTCTCCCAA
CTCCTCAAAGCATGGCGACGGATGTACCGCTCGGTCACGCACGAGTCCGAGTTGCTGGCTACACGGAAGCGCTTGATTTC
GGCACTGTTCTCGCTTCGGGATAGTGCGCTCCCTTTACGCCGATGGCTCTTGGCATTGCGTCGCGACGTGCTGGATGAAT
TACTTGAACAAGAGCCTGGACTTGCCGATGAGAAAGACAACCTTGAAGAACTGACAGCGGCCGCGGGGGCAGGCGGCCCC
CTGCGGGCATTCACGGTGGAGATCTTCGGGAATCAGGGTAAGATGCCGCGCGTCAAACAAGATGAGAGCAGCGCGTCAAT
CTGGATGAGAGTACTGGCGTTGCGGCAGCGGTGGAGGGCGTAG

Upstream 100 bases:

>100_bases
TCGATGTATGCCCAACGTACATAAAGAAGGCTCTGAAGTATTTGAAAGCCAAACTGGCATGAGTACCTCGACACCTCTCT
ATCTCAAAGCTGCGGAAGAT

Downstream 100 bases:

>100_bases
CCCGGAACCGCTGCCGCAACGCCGCGCCGAGGAGTCCGCCCCGCTGCCGGGGTGCCTTGTCGGTGGTCGCGGTAAATCGG
GTATGAACAGCTCTTCCATG

Product: putative ATP-dependent DNA helicase, Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MRENEDQWCAYQATGNCVILAGPGSGKTKTITIKIARLLAEDVRRPRRVACITYSNACVGELRSRLTRLGVGDSDRLVLS
TVHSFCLTELVFPYAKMAGLQMPDPLVVASPAQARALFSDAYRAQLGGNAPAWFRMACDRLRRTILDRGSDEWRAGSARE
TMVVEAYENLLLQNGLIDFDGLVLAGLQLVEKNEWVRHAIRAKYPVVVIDEYQDLGVPLHRIVLALLQAGVRIIAVGDPD
QSIYGFTGAKPDLLTALAGLQQMESVTLKLNYRCADRIIAASRALLPEPAEFRSHDGRSGEIHIHRLECSIREQADYALG
TLVPALLEANPSWAPGDIAVLYRTLNEGAPIAEAADALGLQYFRLDNGSPIKRTRVTEWLTDAARWCSGGWQTGEISLSQ
LLKAWRRMYRSVTHESELLATRKRLISALFSLRDSALPLRRWLLALRRDVLDELLEQEPGLADEKDNLEELTAAAGAGGP
LRAFTVEIFGNQGKMPRVKQDESSASIWMRVLALRQRWRA

Sequences:

>Translated_520_residues
MRENEDQWCAYQATGNCVILAGPGSGKTKTITIKIARLLAEDVRRPRRVACITYSNACVGELRSRLTRLGVGDSDRLVLS
TVHSFCLTELVFPYAKMAGLQMPDPLVVASPAQARALFSDAYRAQLGGNAPAWFRMACDRLRRTILDRGSDEWRAGSARE
TMVVEAYENLLLQNGLIDFDGLVLAGLQLVEKNEWVRHAIRAKYPVVVIDEYQDLGVPLHRIVLALLQAGVRIIAVGDPD
QSIYGFTGAKPDLLTALAGLQQMESVTLKLNYRCADRIIAASRALLPEPAEFRSHDGRSGEIHIHRLECSIREQADYALG
TLVPALLEANPSWAPGDIAVLYRTLNEGAPIAEAADALGLQYFRLDNGSPIKRTRVTEWLTDAARWCSGGWQTGEISLSQ
LLKAWRRMYRSVTHESELLATRKRLISALFSLRDSALPLRRWLLALRRDVLDELLEQEPGLADEKDNLEELTAAAGAGGP
LRAFTVEIFGNQGKMPRVKQDESSASIWMRVLALRQRWRA
>Mature_520_residues
MRENEDQWCAYQATGNCVILAGPGSGKTKTITIKIARLLAEDVRRPRRVACITYSNACVGELRSRLTRLGVGDSDRLVLS
TVHSFCLTELVFPYAKMAGLQMPDPLVVASPAQARALFSDAYRAQLGGNAPAWFRMACDRLRRTILDRGSDEWRAGSARE
TMVVEAYENLLLQNGLIDFDGLVLAGLQLVEKNEWVRHAIRAKYPVVVIDEYQDLGVPLHRIVLALLQAGVRIIAVGDPD
QSIYGFTGAKPDLLTALAGLQQMESVTLKLNYRCADRIIAASRALLPEPAEFRSHDGRSGEIHIHRLECSIREQADYALG
TLVPALLEANPSWAPGDIAVLYRTLNEGAPIAEAADALGLQYFRLDNGSPIKRTRVTEWLTDAARWCSGGWQTGEISLSQ
LLKAWRRMYRSVTHESELLATRKRLISALFSLRDSALPLRRWLLALRRDVLDELLEQEPGLADEKDNLEELTAAAGAGGP
LRAFTVEIFGNQGKMPRVKQDESSASIWMRVLALRQRWRA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI48994965, Length=362, Percent_Identity=29.0055248618785, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI2367296, Length=298, Percent_Identity=25.1677852348993, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 57795; Mature: 57795

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRENEDQWCAYQATGNCVILAGPGSGKTKTITIKIARLLAEDVRRPRRVACITYSNACVG
CCCCCCCEEEEEECCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCHHHH
ELRSRLTRLGVGDSDRLVLSTVHSFCLTELVFPYAKMAGLQMPDPLVVASPAQARALFSD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
AYRAQLGGNAPAWFRMACDRLRRTILDRGSDEWRAGSARETMVVEAYENLLLQNGLIDFD
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GLVLAGLQLVEKNEWVRHAIRAKYPVVVIDEYQDLGVPLHRIVLALLQAGVRIIAVGDPD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCC
QSIYGFTGAKPDLLTALAGLQQMESVTLKLNYRCADRIIAASRALLPEPAEFRSHDGRSG
CCEEECCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
EIHIHRLECSIREQADYALGTLVPALLEANPSWAPGDIAVLYRTLNEGAPIAEAADALGL
CEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCE
QYFRLDNGSPIKRTRVTEWLTDAARWCSGGWQTGEISLSQLLKAWRRMYRSVTHESELLA
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRKRLISALFSLRDSALPLRRWLLALRRDVLDELLEQEPGLADEKDNLEELTAAAGAGGP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
LRAFTVEIFGNQGKMPRVKQDESSASIWMRVLALRQRWRA
CEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRENEDQWCAYQATGNCVILAGPGSGKTKTITIKIARLLAEDVRRPRRVACITYSNACVG
CCCCCCCEEEEEECCCEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCEEEEEEECCHHHH
ELRSRLTRLGVGDSDRLVLSTVHSFCLTELVFPYAKMAGLQMPDPLVVASPAQARALFSD
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
AYRAQLGGNAPAWFRMACDRLRRTILDRGSDEWRAGSARETMVVEAYENLLLQNGLIDFD
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GLVLAGLQLVEKNEWVRHAIRAKYPVVVIDEYQDLGVPLHRIVLALLQAGVRIIAVGDPD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCC
QSIYGFTGAKPDLLTALAGLQQMESVTLKLNYRCADRIIAASRALLPEPAEFRSHDGRSG
CCEEECCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
EIHIHRLECSIREQADYALGTLVPALLEANPSWAPGDIAVLYRTLNEGAPIAEAADALGL
CEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCE
QYFRLDNGSPIKRTRVTEWLTDAARWCSGGWQTGEISLSQLLKAWRRMYRSVTHESELLA
EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRKRLISALFSLRDSALPLRRWLLALRRDVLDELLEQEPGLADEKDNLEELTAAAGAGGP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
LRAFTVEIFGNQGKMPRVKQDESSASIWMRVLALRQRWRA
CEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8253782 [H]