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The map label for this gene is odhL [H]

Identifier: 91782999

GI number: 91782999

Start: 1839264

End: 1840694

Strand: Direct

Name: odhL [H]

Synonym: Bxe_A2810

Alternate gene names: 91782999

Gene position: 1839264-1840694 (Clockwise)

Preceding gene: 91782998

Following gene: 91783000

Centisome position: 37.57

GC content: 61.57

Gene sequence:

>1431_bases
ATGTCCAAAGAATTTGACGTCGTCGTGATCGGCGCAGGCCCTGGTGGTTATATCGCCGCCATCCGCGCAGCGCAGCTCGG
CAAGACCGTCGCATGTATCGAAAAATGGAAGAACCCGGCCGGCGCGCTGAAGCTCGGCGGCACGTGTCTGAACGTGGGTT
GCATTCCGTCGAAGGCGCTGCTCGCGTCGTCGGAAGAATTTGAGAACGCGTCGCATCACCTCGCTGACCACGGCATCTCC
GTGGAAAACGTGAAGGTCGATATCGCGAAGATGATGGCCCGCAAAGAAGGCATCGTCGAGAAGATGACGAAGGGCATCGA
ATTCCTGTTCCGCAAGAACAAGATCACGTGGCTCAAGGGCCACGGCAAGTTCACCGGCAAGACGGACGCCGGCGTGCAGA
TCGAAGTGAGCGGCGAGGGTGAAACGGAAACGGTCACGGCAAAGAACGTGATCATCGCCACGGGTTCGAAGGCACGCCAT
CTGCCGAACATTCCGGTCGACAACAGGATCGTCGCCGACAACGAAGGCGCGCTGAGCTTCGAATCCACGCCGAAAAAGCT
GGCTGTGATCGGCGCTGGCGTGATCGGTCTGGAACTGGGTTCGGTGTGGCGCCGTCTGGGCGCGGAAGTGACCGTGCTCG
AAGCGCTGCCGGAATTCCTCGGCGCGGCCGACCAGGCGCTCGCGAAAGAAGCGGCCAAGCAGTTCAAGAAGCAGGGTCTG
GACATCCACGTCGGCGTGAAGGTCGGCGAAGTGAAGACGACCGACAGCGGCGTGACGATCGCCTACACGGACAAGGACGG
CAACGCGCAGACGCTCGAAGCCGATCGCCTGATCGTGTCGATCGGCCGCGTGCCGAACACCGACAATCTCGGCCTCGAAG
CGATCGGCCTGAAGGCGAACGAGCGCGGCTTCATCGACGTGGACGAGCATTGCGCGACGGCGGTGCCGAACGTGTACGCG
ATCGGCGACGTGGTGCGTGGCCCGATGCTCGCGCACAAGGCGGAAGACGAAGGCGTACTGGTCGCTGAAATCATCGACGG
TCAGAAGCCGCATATCGACTACAACTGCATTCCGTGGGTGATCTACACCGAACCGGAAATCGCGTGGGTCGGCAAGACGG
AACAGCAGCTGAAGGCTGAAGGCCGCGAGATCAAGACGGGCCAGTTCCCGTTCATGGCGAACGGCCGCGCACTCGGCATC
AACAAGGCAGATGGTTTCGTCAAGATGATCGCCGACGCGAAGACCGACGAACTGCTCGGCGTGCACATCATCTCGGCGAA
CGCATCGGACCTGATCGCGGAAGCCGTGGTGGCGATGGAATTCAAGGCGGCTTCGGAAGACATCGGCCGCATTTGCCATC
CGCACCCGTCGCTGTCGGAAGTCATGCGCGAGGCGGCACTCGCTGTCGACAAGCGCGCGCTGAACATGTAA

Upstream 100 bases:

>100_bases
AAGCAACGGGTAAGCATCACGTCTTTCGCATTCCGCAGTACAGGAACGGCGCGCGCCGCGAAGCGTGGCCGCGCGCCGTT
CCGCCATCAAAAGGATTGTC

Downstream 100 bases:

>100_bases
TCACGCGCACGCCTGACTGACAGTACTCCGGCATTACCACAAAGGCGGGCGGGTTCACTCCCTCCCGCCTTTCTATTTGC
AGCACAACATGAACGTCACC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENASHHLADHGIS
VENVKVDIAKMMARKEGIVEKMTKGIEFLFRKNKITWLKGHGKFTGKTDAGVQIEVSGEGETETVTAKNVIIATGSKARH
LPNIPVDNRIVADNEGALSFESTPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPEFLGAADQALAKEAAKQFKKQGL
DIHVGVKVGEVKTTDSGVTIAYTDKDGNAQTLEADRLIVSIGRVPNTDNLGLEAIGLKANERGFIDVDEHCATAVPNVYA
IGDVVRGPMLAHKAEDEGVLVAEIIDGQKPHIDYNCIPWVIYTEPEIAWVGKTEQQLKAEGREIKTGQFPFMANGRALGI
NKADGFVKMIADAKTDELLGVHIISANASDLIAEAVVAMEFKAASEDIGRICHPHPSLSEVMREAALAVDKRALNM

Sequences:

>Translated_476_residues
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENASHHLADHGIS
VENVKVDIAKMMARKEGIVEKMTKGIEFLFRKNKITWLKGHGKFTGKTDAGVQIEVSGEGETETVTAKNVIIATGSKARH
LPNIPVDNRIVADNEGALSFESTPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPEFLGAADQALAKEAAKQFKKQGL
DIHVGVKVGEVKTTDSGVTIAYTDKDGNAQTLEADRLIVSIGRVPNTDNLGLEAIGLKANERGFIDVDEHCATAVPNVYA
IGDVVRGPMLAHKAEDEGVLVAEIIDGQKPHIDYNCIPWVIYTEPEIAWVGKTEQQLKAEGREIKTGQFPFMANGRALGI
NKADGFVKMIADAKTDELLGVHIISANASDLIAEAVVAMEFKAASEDIGRICHPHPSLSEVMREAALAVDKRALNM
>Mature_475_residues
SKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENASHHLADHGISV
ENVKVDIAKMMARKEGIVEKMTKGIEFLFRKNKITWLKGHGKFTGKTDAGVQIEVSGEGETETVTAKNVIIATGSKARHL
PNIPVDNRIVADNEGALSFESTPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPEFLGAADQALAKEAAKQFKKQGLD
IHVGVKVGEVKTTDSGVTIAYTDKDGNAQTLEADRLIVSIGRVPNTDNLGLEAIGLKANERGFIDVDEHCATAVPNVYAI
GDVVRGPMLAHKAEDEGVLVAEIIDGQKPHIDYNCIPWVIYTEPEIAWVGKTEQQLKAEGREIKTGQFPFMANGRALGIN
KADGFVKMIADAKTDELLGVHIISANASDLIAEAVVAMEFKAASEDIGRICHPHPSLSEVMREAALAVDKRALNM

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=47.96573875803, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=29.3617021276596, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI33519430, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI33519428, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI33519426, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI148277071, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI148277065, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=27.6371308016878, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=26.0869565217391, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=25.0549450549451, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=39.5299145299145, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI87082354, Length=475, Percent_Identity=30.9473684210526, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789915, Length=466, Percent_Identity=30.68669527897, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87081717, Length=467, Percent_Identity=28.051391862955, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=49.4669509594883, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17557007, Length=494, Percent_Identity=28.7449392712551, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=27.7661795407098, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=464, Percent_Identity=28.2327586206897, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=464, Percent_Identity=28.2327586206897, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17559934, Length=192, Percent_Identity=30.2083333333333, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=45.4356846473029, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=29.979035639413, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325166, Length=476, Percent_Identity=27.7310924369748, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=50, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=25.7142857142857, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50733; Mature: 50602

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKAL
CCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEECCCCCHHH
LASSEEFENASHHLADHGISVENVKVDIAKMMARKEGIVEKMTKGIEFLFRKNKITWLKG
HCCCHHHCCHHHHHHHCCCEEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGKFTGKTDAGVQIEVSGEGETETVTAKNVIIATGSKARHLPNIPVDNRIVADNEGALSF
CCEECCCCCCCEEEEECCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEEECCCCCEEE
ESTPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPEFLGAADQALAKEAAKQFKKQGL
CCCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
DIHVGVKVGEVKTTDSGVTIAYTDKDGNAQTLEADRLIVSIGRVPNTDNLGLEAIGLKAN
EEEEEEEECCEEECCCCEEEEEECCCCCCEEEECCEEEEEECCCCCCCCCCEEEEEEECC
ERGFIDVDEHCATAVPNVYAIGDVVRGPMLAHKAEDEGVLVAEIIDGQKPHIDYNCIPWV
CCCCEECHHHHHHHCCCCEEEHHHHCCCHHEECCCCCCEEEEEECCCCCCCCCCCCEEEE
IYTEPEIAWVGKTEQQLKAEGREIKTGQFPFMANGRALGINKADGFVKMIADAKTDELLG
EEECCCEEEECCCHHHHHHCCCEEECCCCCEEECCEEEECCCCCCCEEEECCCCCCCEEE
VHIISANASDLIAEAVVAMEFKAASEDIGRICHPHPSLSEVMREAALAVDKRALNM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKAL
CCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEECCCCCHHH
LASSEEFENASHHLADHGISVENVKVDIAKMMARKEGIVEKMTKGIEFLFRKNKITWLKG
HCCCHHHCCHHHHHHHCCCEEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGKFTGKTDAGVQIEVSGEGETETVTAKNVIIATGSKARHLPNIPVDNRIVADNEGALSF
CCEECCCCCCCEEEEECCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEEECCCCCEEE
ESTPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPEFLGAADQALAKEAAKQFKKQGL
CCCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
DIHVGVKVGEVKTTDSGVTIAYTDKDGNAQTLEADRLIVSIGRVPNTDNLGLEAIGLKAN
EEEEEEEECCEEECCCCEEEEEECCCCCCEEEECCEEEEEECCCCCCCCCCEEEEEEECC
ERGFIDVDEHCATAVPNVYAIGDVVRGPMLAHKAEDEGVLVAEIIDGQKPHIDYNCIPWV
CCCCEECHHHHHHHCCCCEEEHHHHCCCHHEECCCCCCEEEEEECCCCCCCCCCCCEEEE
IYTEPEIAWVGKTEQQLKAEGREIKTGQFPFMANGRALGINKADGFVKMIADAKTDELLG
EEECCCEEEECCCHHHHHHCCCEEECCCCCEEECCEEEECCCCCCCEEEECCCCCCCEEE
VHIISANASDLIAEAVVAMEFKAASEDIGRICHPHPSLSEVMREAALAVDKRALNM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8867378 [H]