| Definition | Burkholderia xenovorans LB400 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_007951 |
| Length | 4,895,836 |
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The map label for this gene is lvr [H]
Identifier: 91782465
GI number: 91782465
Start: 1212090
End: 1212839
Strand: Direct
Name: lvr [H]
Synonym: Bxe_A3366
Alternate gene names: 91782465
Gene position: 1212090-1212839 (Clockwise)
Preceding gene: 91782464
Following gene: 91782466
Centisome position: 24.76
GC content: 71.2
Gene sequence:
>750_bases ATGAGCACGGCCGACAGGAAAGTGGCGATCGTAACCGGCGCGGGCGGCGGCATTGGCGCGGCGGTATGTGCGCGGCTCGC GGCCGGCGGCTGGGCGGTCGTGCTCGCGGACCGCAGCGCCGGCACGACCGCCGAAGCCGAGGCGCGCTGCCGCGCGCTCG ATGCGCCGGCGGACACGTTCGCGGGCGACGTGACGGATGCGGACTACGTGCGTGAGCTGGTCGCGTTCGCGCTGCGCCGT CATGGGCGGCTCGACGCCTTCGTCGGCAACGCCGGGATCGCCGGGCAGGTCAAGCCGCTCGCAGACTATCCGGACGACGC GTTCGATCTCGTGATGAACGTGAACGTGCGCGGCATGTTCCTGTGCCTGAAGCATGGGATTCCGGCGTTGCGCGAGCGCG GCGGCAGCTTCGTCGCGACCGCGTCGACCTCGGCGATTCGCGGTCGCGCGAACCTGTCCGCGTATGTCGCGAGCAAGCAC GCGGTGCTCGGACTCGTGCGCAGCGCGGCGCTCGAATGCATGGGCAGCGGTGTGCGCGTGAACGCGGTACTGCCCGGTCC GATCCAGACGCCGATGATCGACGCGATCAACGACATGGCCGCGCAGCACGGCGGCGTCGCACGCGCCGCTCACGCGGCTT ACGGTCGCCCGGAAGACGTCGCGAACACGGTCGCGTTCCTGCTGTCGCCTGACGCGTCGCATATGAACGGCGCCGCGCTC GTGGTCGACGCGGGCAGCACCGTGGCGTGA
Upstream 100 bases:
>100_bases AGCGCGCACTTCATGACGTCGGACGTGTACGGCGGCGGCTTCGAAGTCGAGGATCGCCGGCTGCTGAAGCGCCTTTATCC CTGAACGGAGCGACGGGAAC
Downstream 100 bases:
>100_bases ACCTGAGCTGGCCTCGCCGTCAGAACAGGACGCCGGCCCACCCGACAACCGATAACAAACAAATATGGAGACTTGCGTGA TGGAATCGATCGCTCTCGCT
Product: Short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]
Number of amino acids: Translated: 249; Mature: 248
Protein sequence:
>249_residues MSTADRKVAIVTGAGGGIGAAVCARLAAGGWAVVLADRSAGTTAEAEARCRALDAPADTFAGDVTDADYVRELVAFALRR HGRLDAFVGNAGIAGQVKPLADYPDDAFDLVMNVNVRGMFLCLKHGIPALRERGGSFVATASTSAIRGRANLSAYVASKH AVLGLVRSAALECMGSGVRVNAVLPGPIQTPMIDAINDMAAQHGGVARAAHAAYGRPEDVANTVAFLLSPDASHMNGAAL VVDAGSTVA
Sequences:
>Translated_249_residues MSTADRKVAIVTGAGGGIGAAVCARLAAGGWAVVLADRSAGTTAEAEARCRALDAPADTFAGDVTDADYVRELVAFALRR HGRLDAFVGNAGIAGQVKPLADYPDDAFDLVMNVNVRGMFLCLKHGIPALRERGGSFVATASTSAIRGRANLSAYVASKH AVLGLVRSAALECMGSGVRVNAVLPGPIQTPMIDAINDMAAQHGGVARAAHAAYGRPEDVANTVAFLLSPDASHMNGAAL VVDAGSTVA >Mature_248_residues STADRKVAIVTGAGGGIGAAVCARLAAGGWAVVLADRSAGTTAEAEARCRALDAPADTFAGDVTDADYVRELVAFALRRH GRLDAFVGNAGIAGQVKPLADYPDDAFDLVMNVNVRGMFLCLKHGIPALRERGGSFVATASTSAIRGRANLSAYVASKHA VLGLVRSAALECMGSGVRVNAVLPGPIQTPMIDAINDMAAQHGGVARAAHAAYGRPEDVANTVAFLLSPDASHMNGAALV VDAGSTVA
Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=32.2314049586777, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=32.7935222672065, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=31.3253012048193, Blast_Score=92, Evalue=3e-19, Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=33.695652173913, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=30.0884955752212, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI31542939, Length=255, Percent_Identity=30.5882352941176, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI66933014, Length=263, Percent_Identity=26.9961977186312, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=3e-16, Organism=Homo sapiens, GI126723191, Length=178, Percent_Identity=32.0224719101124, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI223718074, Length=243, Percent_Identity=30.0411522633745, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI109715829, Length=235, Percent_Identity=27.2340425531915, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=26.8774703557312, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI4504505, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=30.3501945525292, Blast_Score=99, Evalue=3e-22, Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=31.9838056680162, Blast_Score=97, Evalue=7e-22, Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=34.5238095238095, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=30.7053941908714, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=29.8804780876494, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=27.7551020408163, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI1789378, Length=242, Percent_Identity=29.7520661157025, Blast_Score=80, Evalue=9e-17, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=28.1853281853282, Blast_Score=78, Evalue=7e-16, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=29.3172690763052, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1788891, Length=129, Percent_Identity=41.8604651162791, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1787526, Length=195, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=32.1138211382114, Blast_Score=112, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560676, Length=241, Percent_Identity=29.8755186721992, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=33.469387755102, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=31.0077519379845, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=33.1967213114754, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=31.0483870967742, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=27.9245283018868, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17544670, Length=258, Percent_Identity=28.6821705426357, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=29.3436293436293, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.5546558704453, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=29.3814432989691, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538182, Length=248, Percent_Identity=27.8225806451613, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=31.3008130081301, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.1187739463602, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17551412, Length=272, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17564282, Length=238, Percent_Identity=26.890756302521, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=25.7352941176471, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.996282527881, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=28.6821705426357, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=28.0769230769231, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17568967, Length=188, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=26.4367816091954, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=26.9230769230769, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=27.4131274131274, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=25.0965250965251, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI193203115, Length=232, Percent_Identity=26.2931034482759, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=25.8426966292135, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=26.5060240963855, Blast_Score=66, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=26, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=245, Percent_Identity=26.1224489795918, Blast_Score=66, Evalue=6e-12, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=34.412955465587, Blast_Score=116, Evalue=2e-26, Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=35.1351351351351, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=30.4526748971193, Blast_Score=115, Evalue=4e-26, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=36.7588932806324, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=33.976833976834, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=31.4516129032258, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=5e-19, Organism=Drosophila melanogaster, GI24644337, Length=248, Percent_Identity=34.2741935483871, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI17737361, Length=250, Percent_Identity=29.6, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=31.7460317460317, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24641232, Length=238, Percent_Identity=28.1512605042017, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24640492, Length=189, Percent_Identity=26.984126984127, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24648693, Length=249, Percent_Identity=28.5140562248996, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21355889, Length=249, Percent_Identity=28.5140562248996, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21358495, Length=211, Percent_Identity=27.0142180094787, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.-.-.- [C]
Molecular weight: Translated: 25294; Mature: 25163
Theoretical pI: Translated: 7.11; Mature: 7.11
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTADRKVAIVTGAGGGIGAAVCARLAAGGWAVVLADRSAGTTAEAEARCRALDAPADTF CCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHH AGDVTDADYVRELVAFALRRHGRLDAFVGNAGIAGQVKPLADYPDDAFDLVMNVNVRGMF CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCEE LCLKHGIPALRERGGSFVATASTSAIRGRANLSAYVASKHAVLGLVRSAALECMGSGVRV EEHHHCCHHHHHCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE NAVLPGPIQTPMIDAINDMAAQHGGVARAAHAAYGRPEDVANTVAFLLSPDASHMNGAAL EEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCEEE VVDAGSTVA EEECCCCCC >Mature Secondary Structure STADRKVAIVTGAGGGIGAAVCARLAAGGWAVVLADRSAGTTAEAEARCRALDAPADTF CCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHH AGDVTDADYVRELVAFALRRHGRLDAFVGNAGIAGQVKPLADYPDDAFDLVMNVNVRGMF CCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEECCCCCEE LCLKHGIPALRERGGSFVATASTSAIRGRANLSAYVASKHAVLGLVRSAALECMGSGVRV EEHHHCCHHHHHCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE NAVLPGPIQTPMIDAINDMAAQHGGVARAAHAAYGRPEDVANTVAFLLSPDASHMNGAAL EEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCEEE VVDAGSTVA EEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11388460; 10508066 [H]