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The map label for this gene is cytR [H]

Identifier: 91782159

GI number: 91782159

Start: 873680

End: 874651

Strand: Direct

Name: cytR [H]

Synonym: Bxe_A3676

Alternate gene names: 91782159

Gene position: 873680-874651 (Clockwise)

Preceding gene: 91782137

Following gene: 91782160

Centisome position: 17.85

GC content: 68.72

Gene sequence:

>972_bases
GTGGCCGAGCAGGCGGGCGTTTCGGTCGCCACCGTGTCGCGCGTGCTGAACGGTCACGAGAACGTGAGGCCAGCCACGCG
CGACAAGGTGCTCGCCGCCATCGACGCCAGCGGCTACCGCGTCAACGAACTTGCACGCAACCTGCGCACCGCCGAGAGCC
GCCTGCTGCTGACTATGGTGCCGGACGTCGGCAACCCGTTTTACGCGGAGATCGTGCGCGGCATCGACAGCGTGGCGCGT
CAGCACGGCTACTTCATGTTGCTGTGCGACACCGGCGCCGATCCGGGCCGCGAGCGCAGCTACTTCGATCTGCTGCGACG
CCGCCGCGCGGACGGCGCGATCTGTCTCGATCCGGCCACCATCCAGCAGGCGCTCGGCGAGGCCTCCGGCGCGCTGCCGT
GGGTTGCGTGCTGCGAGTTCGACCCGGCAATGGGCGTGCCGTACGTGGGCATCGACAACTACCGGGCCGCCGGCGACGCT
GTCCGGCACCTGCTCGCGCGCGGTCATCGCCGCATCGGCCTGATCAATTCCGATGTCGATTATCTGTACGCGCGCCAGCG
TCAGCAGGGCTATCTGGATGCGCTGACCGAAGCGGGCATCACGCCGGACGAACGCTGGCGCATGAACCTGAACAGCCTCG
ATTACGAAGCGGGCGCCTCGGCCGCGGCCACGCTGATGAATCAGCCGCAGGCGCCGGGCGCGATCTTCGCGGTTTCGGAC
ACGCTCGCGATCGGCGTGATCCACGGCTTGCGCAGCGTCGGCAAGCGCGTGCCCGACGATATCGCGGTGGTCGGCTTCGA
CGATATCTCGCTCGCCGCGCAGATCGATCCACCGCTCACCACCATCGCGCAGCCCATGCGCGAGCTGGGCGAAACCGCCG
CGCGCCTGTTGCTGCAGCGGCTCGCCAATCCGTTGGCGAATGTGCCGGGCGTCTTGTTGCCGCACCGGCTCGTGATTCGC
GGGAGCGCCTGA

Upstream 100 bases:

>100_bases
ATCGTCGTCCAGGAAAGCGTCGGCAGCGGTGCCCGCGGCGCATGCCCAGCCCGGCGGCCAGCCGTCGCGCGGCGCGGCCG
AAGGCCTGTCGATTGCCGGT

Downstream 100 bases:

>100_bases
GTCATGAGCCTCGCAATCCGCTTCGACGATATCCGCAAAGACTTCGGGCCCGTGCGCGTGCTGCACGGCGTGAGCTTCGA
ACTGGCGCCGGGCCGCATCT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAEQAGVSVATVSRVLNGHENVRPATRDKVLAAIDASGYRVNELARNLRTAESRLLLTMVPDVGNPFYAEIVRGIDSVAR
QHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATIQQALGEASGALPWVACCEFDPAMGVPYVGIDNYRAAGDA
VRHLLARGHRRIGLINSDVDYLYARQRQQGYLDALTEAGITPDERWRMNLNSLDYEAGASAAATLMNQPQAPGAIFAVSD
TLAIGVIHGLRSVGKRVPDDIAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANPLANVPGVLLPHRLVIR
GSA

Sequences:

>Translated_323_residues
MAEQAGVSVATVSRVLNGHENVRPATRDKVLAAIDASGYRVNELARNLRTAESRLLLTMVPDVGNPFYAEIVRGIDSVAR
QHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATIQQALGEASGALPWVACCEFDPAMGVPYVGIDNYRAAGDA
VRHLLARGHRRIGLINSDVDYLYARQRQQGYLDALTEAGITPDERWRMNLNSLDYEAGASAAATLMNQPQAPGAIFAVSD
TLAIGVIHGLRSVGKRVPDDIAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANPLANVPGVLLPHRLVIR
GSA
>Mature_322_residues
AEQAGVSVATVSRVLNGHENVRPATRDKVLAAIDASGYRVNELARNLRTAESRLLLTMVPDVGNPFYAEIVRGIDSVARQ
HGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPATIQQALGEASGALPWVACCEFDPAMGVPYVGIDNYRAAGDAV
RHLLARGHRRIGLINSDVDYLYARQRQQGYLDALTEAGITPDERWRMNLNSLDYEAGASAAATLMNQPQAPGAIFAVSDT
LAIGVIHGLRSVGKRVPDDIAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQRLANPLANVPGVLLPHRLVIRG
SA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=324, Percent_Identity=37.962962962963, Blast_Score=220, Evalue=9e-59,
Organism=Escherichia coli, GI1790194, Length=326, Percent_Identity=35.5828220858896, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1788474, Length=300, Percent_Identity=33.6666666666667, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1787948, Length=325, Percent_Identity=29.8461538461538, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI48994940, Length=307, Percent_Identity=31.5960912052117, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1789202, Length=317, Percent_Identity=31.5457413249211, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787906, Length=325, Percent_Identity=28, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1789068, Length=306, Percent_Identity=30.0653594771242, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=27.2151898734177, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786540, Length=326, Percent_Identity=30.9815950920245, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790715, Length=309, Percent_Identity=27.5080906148867, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789456, Length=335, Percent_Identity=25.6716417910448, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786268, Length=321, Percent_Identity=28.3489096573209, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34886; Mature: 34755

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQAGVSVATVSRVLNGHENVRPATRDKVLAAIDASGYRVNELARNLRTAESRLLLTMV
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHCEEEEEC
PDVGNPFYAEIVRGIDSVARQHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPAT
CCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEECHHH
IQQALGEASGALPWVACCEFDPAMGVPYVGIDNYRAAGDAVRHLLARGHRRIGLINSDVD
HHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHH
YLYARQRQQGYLDALTEAGITPDERWRMNLNSLDYEAGASAAATLMNQPQAPGAIFAVSD
HHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCCCCHHHHHHHCCCCCCCEEEEEHH
TLAIGVIHGLRSVGKRVPDDIAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQR
HHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LANPLANVPGVLLPHRLVIRGSA
HHHHHHCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
AEQAGVSVATVSRVLNGHENVRPATRDKVLAAIDASGYRVNELARNLRTAESRLLLTMV
CCCCCCHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHCEEEEEC
PDVGNPFYAEIVRGIDSVARQHGYFMLLCDTGADPGRERSYFDLLRRRRADGAICLDPAT
CCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEECHHH
IQQALGEASGALPWVACCEFDPAMGVPYVGIDNYRAAGDAVRHLLARGHRRIGLINSDVD
HHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHH
YLYARQRQQGYLDALTEAGITPDERWRMNLNSLDYEAGASAAATLMNQPQAPGAIFAVSD
HHHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCCCCCHHHHHHHCCCCCCCEEEEEHH
TLAIGVIHGLRSVGKRVPDDIAVVGFDDISLAAQIDPPLTTIAQPMRELGETAARLLLQR
HHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LANPLANVPGVLLPHRLVIRGSA
HHHHHHCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]