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The map label for this gene is livH [H]

Identifier: 91782151

GI number: 91782151

Start: 864381

End: 866039

Strand: Reverse

Name: livH [H]

Synonym: Bxe_A3684

Alternate gene names: 91782151

Gene position: 866039-864381 (Counterclockwise)

Preceding gene: 91782152

Following gene: 91782150

Centisome position: 17.69

GC content: 67.27

Gene sequence:

>1659_bases
ATGGCGTCCTCATTCCTGACATCCACACGACGGTTCGCACAACGATTCGCCCGGCGGCTCGCACCGCGCATCGGCGGCAT
GGCGCTCGTGCTCTTCGCCGGCGCGCCGCTGGCGGCCTTCGCACTGACCCCGGCCGATGTGGCGCCGCTTGCCGGCGACG
ACTTCGATGCGAAATCCGCGGCCATCGACAAACTGATCGCCAATCACGACAAGGAGTCGATGGCGGTACTGAAGGCCCTG
TCCGAAGACAGCGCGCTCGCCACCGACTCGGGCGCCGTGCTGCTGCAGGACGGCGACACCGCGAAGGACGCGGTCACCGG
CAAGACCGTCGCCGCGGGCGACGCCCAGCCGGTCACGCTGAACAATCTGCTGCGCTCGAAAGTGGCGGGCGCACTGTCCG
GCCTGCAACTCGATTCGCCAGACAGGGCAACGCGCGAAGCCGCGATCACCTCGTTGCTGCAGAACCCGGATCCGTCCATC
AAACCGCTCGTCGATGCGGCTCGCGCGAAGGAAACCGATCCCGCGTTGAAGAAGCGCCTCGACACGCTGTGGGCCATGAC
GGCGCTGCACGACGCCGATCCGGCCAAGCGCCTCGAAGCCGTGCAACTGGTGGCCGCCCGGCACGACCTCGACATGAACG
AACTGCTGCGGCCGCTCATCGCGAAGAAGCCGGACGGCACCTTCGTGGAAGCCGACGACCGCGTGCGCGCCGCCGCGCAA
AGCGGCATCGACGAACTCGACGCCATCCAGCGCCGCAGCCAGATCGCCGGCACGCTGTTCGCAGGCCTGTCGCTCGGCAG
CGTGCTGCTGCTCGCCGCGCTGGGCCTCGCCATCACCTACGGGCTGATCGGCGTGATCAACATGGCGCACGGCGAATTCC
TGATGATCGGCGCGTACGCCACCTACGTGGTGCAGAACCTCTTTCAGCGCTTCGCACCCGGCGCGTTCGACTGGTATCCG
CTGCTGGCGGTGCCGGCGTCGTTCGCGGCGGCCGGCATCGTCGGCATCGTGCTCGAACGGCTGGTGCTGAAGCATCTGTA
CGGCCGCCCGCTCGAAACGCTGCTGACCACTTTCGGCGTCAGCCTGATCCTGATTCAGGCGACCCGCATGCTGTTCGGCG
CGCAGAACGTGCAGGTGGTCAACCCGGCGTGGATGAGCGGCGGCGTGACGGTGCTGCCCAATCTGATCCTGCCGTACAAC
CGGCTGGCGATTCTCGCGTTCTCGCTGATCGTGGTCGGCATTGCGTGGGCCGTGCTCACGAAGACGCGTCTCGGTCTCTT
CGTGCGCGCCGTCACGCAGAACCGGCGCATGGCGGCCTGCGTCGGCGTGAAGACCGCGCGGGTCGACTCGTATGCGTTCG
CGTTCGGCGCGGGCATAGCCGGTTTGGGCGGCTGTGCGCTCTCGCAGATCGGCAACGTCGGACCGGACCTCGGCCAGAGC
TACATCATCGATTCGTTCATGGCCGTGGTGCTGGGTGGCGTCGGTCAGTTGGCCGGCACGGTGATCGGCGGCTTCGGCCT
CGGACTCGTCAGCAAGGCAATTGAGCCGTTCTGGGGCGCGGTGCTCGCCAAGATCGCGGTGCTCGTGCTGATCGTGTTGT
TCATCCAGAAGCGTCCGCAGGGCATGTTCGCCCTCAAGGGCCGTAGCGCGGAGGCATGA

Upstream 100 bases:

>100_bases
TTCCCGACGGTACGACTTTCGCGCGCAGCAACCCGACGGCGCAACTGCGGCGCGTGCCCACATACCGCGCCGCCCCGCCG
GTTTTCCTTCAAGGGCCACT

Downstream 100 bases:

>100_bases
GATGACGTCTGCAACTTCATCGGCTCACGTCGGCGCAAGCGGCGGCGCCCTGCCCGGCCGCGACGCGCAAGCGGGTTTCG
CGCTCGGCCTGCCGCCGCGT

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MASSFLTSTRRFAQRFARRLAPRIGGMALVLFAGAPLAAFALTPADVAPLAGDDFDAKSAAIDKLIANHDKESMAVLKAL
SEDSALATDSGAVLLQDGDTAKDAVTGKTVAAGDAQPVTLNNLLRSKVAGALSGLQLDSPDRATREAAITSLLQNPDPSI
KPLVDAARAKETDPALKKRLDTLWAMTALHDADPAKRLEAVQLVAARHDLDMNELLRPLIAKKPDGTFVEADDRVRAAAQ
SGIDELDAIQRRSQIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLFQRFAPGAFDWYP
LLAVPASFAAAGIVGIVLERLVLKHLYGRPLETLLTTFGVSLILIQATRMLFGAQNVQVVNPAWMSGGVTVLPNLILPYN
RLAILAFSLIVVGIAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQS
YIIDSFMAVVLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA

Sequences:

>Translated_552_residues
MASSFLTSTRRFAQRFARRLAPRIGGMALVLFAGAPLAAFALTPADVAPLAGDDFDAKSAAIDKLIANHDKESMAVLKAL
SEDSALATDSGAVLLQDGDTAKDAVTGKTVAAGDAQPVTLNNLLRSKVAGALSGLQLDSPDRATREAAITSLLQNPDPSI
KPLVDAARAKETDPALKKRLDTLWAMTALHDADPAKRLEAVQLVAARHDLDMNELLRPLIAKKPDGTFVEADDRVRAAAQ
SGIDELDAIQRRSQIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLFQRFAPGAFDWYP
LLAVPASFAAAGIVGIVLERLVLKHLYGRPLETLLTTFGVSLILIQATRMLFGAQNVQVVNPAWMSGGVTVLPNLILPYN
RLAILAFSLIVVGIAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQS
YIIDSFMAVVLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA
>Mature_551_residues
ASSFLTSTRRFAQRFARRLAPRIGGMALVLFAGAPLAAFALTPADVAPLAGDDFDAKSAAIDKLIANHDKESMAVLKALS
EDSALATDSGAVLLQDGDTAKDAVTGKTVAAGDAQPVTLNNLLRSKVAGALSGLQLDSPDRATREAAITSLLQNPDPSIK
PLVDAARAKETDPALKKRLDTLWAMTALHDADPAKRLEAVQLVAARHDLDMNELLRPLIAKKPDGTFVEADDRVRAAAQS
GIDELDAIQRRSQIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQNLFQRFAPGAFDWYPL
LAVPASFAAAGIVGIVLERLVLKHLYGRPLETLLTTFGVSLILIQATRMLFGAQNVQVVNPAWMSGGVTVLPNLILPYNR
LAILAFSLIVVGIAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQSY
IIDSFMAVVLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQGMFALKGRSAEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=300, Percent_Identity=28, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 57985; Mature: 57854

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSFLTSTRRFAQRFARRLAPRIGGMALVLFAGAPLAAFALTPADVAPLAGDDFDAKSA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHCCCCCCCCCCHHHH
AIDKLIANHDKESMAVLKALSEDSALATDSGAVLLQDGDTAKDAVTGKTVAAGDAQPVTL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCCEEECCCCCCCHH
NNLLRSKVAGALSGLQLDSPDRATREAAITSLLQNPDPSIKPLVDAARAKETDPALKKRL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
DTLWAMTALHDADPAKRLEAVQLVAARHDLDMNELLRPLIAKKPDGTFVEADDRVRAAAQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCCHHHHHHHH
SGIDELDAIQRRSQIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
TYVVQNLFQRFAPGAFDWYPLLAVPASFAAAGIVGIVLERLVLKHLYGRPLETLLTTFGV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SLILIQATRMLFGAQNVQVVNPAWMSGGVTVLPNLILPYNRLAILAFSLIVVGIAWAVLT
HHHHHHHHHHHHCCCCCEEECCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQS
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHH
YIIDSFMAVVLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GMFALKGRSAEA
CEEEECCCCCCC
>Mature Secondary Structure 
ASSFLTSTRRFAQRFARRLAPRIGGMALVLFAGAPLAAFALTPADVAPLAGDDFDAKSA
CCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHCCCCHHCCCCCCCCCCHHHH
AIDKLIANHDKESMAVLKALSEDSALATDSGAVLLQDGDTAKDAVTGKTVAAGDAQPVTL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCCEEECCCCCCCHH
NNLLRSKVAGALSGLQLDSPDRATREAAITSLLQNPDPSIKPLVDAARAKETDPALKKRL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHH
DTLWAMTALHDADPAKRLEAVQLVAARHDLDMNELLRPLIAKKPDGTFVEADDRVRAAAQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEECCCHHHHHHHH
SGIDELDAIQRRSQIAGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
TYVVQNLFQRFAPGAFDWYPLLAVPASFAAAGIVGIVLERLVLKHLYGRPLETLLTTFGV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SLILIQATRMLFGAQNVQVVNPAWMSGGVTVLPNLILPYNRLAILAFSLIVVGIAWAVLT
HHHHHHHHHHHHCCCCCEEECCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
KTRLGLFVRAVTQNRRMAACVGVKTARVDSYAFAFGAGIAGLGGCALSQIGNVGPDLGQS
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHH
YIIDSFMAVVLGGVGQLAGTVIGGFGLGLVSKAIEPFWGAVLAKIAVLVLIVLFIQKRPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GMFALKGRSAEA
CEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]