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The map label for this gene is pyrC' [H]

Identifier: 91782037

GI number: 91782037

Start: 737297

End: 738577

Strand: Direct

Name: pyrC' [H]

Synonym: Bxe_A3807

Alternate gene names: 91782037

Gene position: 737297-738577 (Clockwise)

Preceding gene: 91782036

Following gene: 91782038

Centisome position: 15.06

GC content: 66.67

Gene sequence:

>1281_bases
ATGAAGATTCATATTCAAGGCGGCACGCTGATCGATCCGGCGGCGGGCACCGAACAGCAGCAGGACATTTTTATCGCGGC
GGGCAAGATCGCCGCCATCGGCAATGCGCCTGCGGATTTCAACGCGGACAAGACGATCGACGCCCAGGGCCTCCATGTCA
TGCCGGGTCTGGTCGATCTGTCCGCGCGTTTGCGCGAGCCGGGCTACGAACACAAGGCCACGCTCGAATCCGAAATGACC
GCGGCGCTCGCAGGTGGCGTGACGAGCCTCGTCTGTCCGCCGGACACCGATCCGACGCTCGATGAACCCGGCCTCGTCGA
GATGCTCAAGTTCCGCGCGCGCAATCTGAACCAGGCGCATGTGTATCCGCTCGGCGCGCTGACGGTCGGCCTCAAGGGGC
AGGTCATCACCGAGATGGTCGAGTTGACCGAAGCGGGCTGCATCGGCTTTTCGCAGGCCGACGTGCCTGTGGTCGATACG
CAGGTGCTGCTGCGCGCGCTGCAATACGCGAAGACCTACGGCTATACCGTGTGGCTGCGTCCGGTGGATGCGTATCTCGG
CAAGGGCGGCGTGGCCGCGAGCGGCGCGCTGGCGTCGCGGCTCGGGCTGTCGGGCGTGCCGGTATCGGCGGAAACCATCG
CACTGCACACCATCTTCGAACTGGTGCGCGTGACTGGCGCGCGGGTGCATCTGTCGCATGTGTCGTCGGCGGCGGGCATT
GCGTTGATGCGCGCGGCGAAGGCCGAGGGCTTGCCGGTATCGTGCGACGTCACGGTGAATCACGTGCACCTGATCGACCT
CGACATCGGCTACTTCGACGCGCAGTTCCGGCTCGATCCGCCGCTGCGCCAGCAGCGCGATCGCGAGGCGATCCGCGCGG
GTCTCGTCGACGGCACGATCGACGCGATCTGCTCCGACCACACGCCCGTGGACGACGACGAAAAGCTGCTGCCGTTCGCC
GAAGCGACGCCCGGCGCGACCGGACTGGAGCTGTTCCTGTCCTTGACGGTGAAGTGGGCGGACGAAGCGCGCGTGCCGCT
CGCCAAGGCGCTGAACCGCATCACCGCGGCGCCCGCCAAGGTGCTCGAACTGGACGCGGCAGGCCGTATCGCGGTGGGCG
GCGTGGCCGATCTGTGCGTGTTCGATCGCAACGCGCATTGGCGCGTTGAGCCGCGTGCGCTGAAGAGCCAGGGGCACAAC
ACGCCGTTCCTCGGCTACGAACTGCCGGCACGTGTGCACGCGACGATCGTGTCCGGTCACGTCGCATTCGAACAGCGCTG
A

Upstream 100 bases:

>100_bases
CGTCACGCGACAAGCGTCACGGCACCGCGAAAGCACAGTGCGAACACGCGGCTTGGCACGCGCAACGCAGCTGAACACCA
GGCTGAACATAAGGTAGCGC

Downstream 100 bases:

>100_bases
TGGCCGCGGCGTTGCCGCGCTTATTGTCCAGTAAATTGGCCGGCTTGCCGGCCAGTCAAGGAACGCCCCGACCATGAAGC
TCGCGTTACGCAAGGCCCGT

Product: dihydroorotase

Products: Allantoate; H+ [C]

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKIHIQGGTLIDPAAGTEQQQDIFIAAGKIAAIGNAPADFNADKTIDAQGLHVMPGLVDLSARLREPGYEHKATLESEMT
AALAGGVTSLVCPPDTDPTLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGQVITEMVELTEAGCIGFSQADVPVVDT
QVLLRALQYAKTYGYTVWLRPVDAYLGKGGVAASGALASRLGLSGVPVSAETIALHTIFELVRVTGARVHLSHVSSAAGI
ALMRAAKAEGLPVSCDVTVNHVHLIDLDIGYFDAQFRLDPPLRQQRDREAIRAGLVDGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELFLSLTVKWADEARVPLAKALNRITAAPAKVLELDAAGRIAVGGVADLCVFDRNAHWRVEPRALKSQGHN
TPFLGYELPARVHATIVSGHVAFEQR

Sequences:

>Translated_426_residues
MKIHIQGGTLIDPAAGTEQQQDIFIAAGKIAAIGNAPADFNADKTIDAQGLHVMPGLVDLSARLREPGYEHKATLESEMT
AALAGGVTSLVCPPDTDPTLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGQVITEMVELTEAGCIGFSQADVPVVDT
QVLLRALQYAKTYGYTVWLRPVDAYLGKGGVAASGALASRLGLSGVPVSAETIALHTIFELVRVTGARVHLSHVSSAAGI
ALMRAAKAEGLPVSCDVTVNHVHLIDLDIGYFDAQFRLDPPLRQQRDREAIRAGLVDGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELFLSLTVKWADEARVPLAKALNRITAAPAKVLELDAAGRIAVGGVADLCVFDRNAHWRVEPRALKSQGHN
TPFLGYELPARVHATIVSGHVAFEQR
>Mature_426_residues
MKIHIQGGTLIDPAAGTEQQQDIFIAAGKIAAIGNAPADFNADKTIDAQGLHVMPGLVDLSARLREPGYEHKATLESEMT
AALAGGVTSLVCPPDTDPTLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGQVITEMVELTEAGCIGFSQADVPVVDT
QVLLRALQYAKTYGYTVWLRPVDAYLGKGGVAASGALASRLGLSGVPVSAETIALHTIFELVRVTGARVHLSHVSSAAGI
ALMRAAKAEGLPVSCDVTVNHVHLIDLDIGYFDAQFRLDPPLRQQRDREAIRAGLVDGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLELFLSLTVKWADEARVPLAKALNRITAAPAKVLELDAAGRIAVGGVADLCVFDRNAHWRVEPRALKSQGHN
TPFLGYELPARVHATIVSGHVAFEQR

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=403, Percent_Identity=26.5508684863524, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=28.4090909090909, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87082175, Length=441, Percent_Identity=23.1292517006803, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=399, Percent_Identity=24.0601503759398, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=396, Percent_Identity=24.2424242424242, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=26.4705882352941, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18859883, Length=466, Percent_Identity=25.5364806866953, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.5 [C]

Molecular weight: Translated: 45291; Mature: 45291

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHIQGGTLIDPAAGTEQQQDIFIAAGKIAAIGNAPADFNADKTIDAQGLHVMPGLVDL
CEEEECCCCEECCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCEECCCCCEECCCHHHH
SARLREPGYEHKATLESEMTAALAGGVTSLVCPPDTDPTLDEPGLVEMLKFRARNLNQAH
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VYPLGALTVGLKGQVITEMVELTEAGCIGFSQADVPVVDTQVLLRALQYAKTYGYTVWLR
EEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHCCEEEEEE
PVDAYLGKGGVAASGALASRLGLSGVPVSAETIALHTIFELVRVTGARVHLSHVSSAAGI
EHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHH
ALMRAAKAEGLPVSCDVTVNHVHLIDLDIGYFDAQFRLDPPLRQQRDREAIRAGLVDGTI
HHHHHHCCCCCCEEEEEEEEEEEEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLELFLSLTVKWADEARVPLAKALNRITAAPAK
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEECCCCCCCHHHHHHHHHCCCHH
VLELDAAGRIAVGGVADLCVFDRNAHWRVEPRALKSQGHNTPFLGYELPARVHATIVSGH
EEEECCCCCEEECCCEEEEEECCCCCEEECHHHHHCCCCCCCEECEECCCEEEEEEEECE
VAFEQR
EEECCC
>Mature Secondary Structure
MKIHIQGGTLIDPAAGTEQQQDIFIAAGKIAAIGNAPADFNADKTIDAQGLHVMPGLVDL
CEEEECCCCEECCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCEECCCCCEECCCHHHH
SARLREPGYEHKATLESEMTAALAGGVTSLVCPPDTDPTLDEPGLVEMLKFRARNLNQAH
HHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VYPLGALTVGLKGQVITEMVELTEAGCIGFSQADVPVVDTQVLLRALQYAKTYGYTVWLR
EEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHCCEEEEEE
PVDAYLGKGGVAASGALASRLGLSGVPVSAETIALHTIFELVRVTGARVHLSHVSSAAGI
EHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHH
ALMRAAKAEGLPVSCDVTVNHVHLIDLDIGYFDAQFRLDPPLRQQRDREAIRAGLVDGTI
HHHHHHCCCCCCEEEEEEEEEEEEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCCCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLELFLSLTVKWADEARVPLAKALNRITAAPAK
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEECCCCCCCHHHHHHHHHCCCHH
VLELDAAGRIAVGGVADLCVFDRNAHWRVEPRALKSQGHNTPFLGYELPARVHATIVSGH
EEEECCCCCEEECCCEEEEEECCCCCEEECHHHHHCCCCCCCEECEECCCEEEEEEEECE
VAFEQR
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Allantoin; H2O [C]

Specific reaction: Allantoin + H2O --> Allantoate + H+ [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: Dithiothreitol; p-Chloromercuribenzene-sulphonic acid [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]