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The map label for this gene is pyrB [H]

Identifier: 91782036

GI number: 91782036

Start: 736152

End: 737177

Strand: Direct

Name: pyrB [H]

Synonym: Bxe_A3808

Alternate gene names: 91782036

Gene position: 736152-737177 (Clockwise)

Preceding gene: 91782035

Following gene: 91782037

Centisome position: 15.04

GC content: 62.87

Gene sequence:

>1026_bases
ATGAACACCGCCACCCAGGCTCCCAAGGATTCCGCCGACAGCGCCACCGAGCGCTTCCGTTATGGCTTCCTGAAGGGCAA
CCCGCAGCTCACGAAAAACGGCGAGCTGAAACATCTGTTGTCGATCGAGGGTTTGCCGAAGGCGATCGTCAATCACATTC
TCGACACCGCCGACCAGTTCGTCAGCGTGACCGATCGCGAAGTGAAGAAGGTGCCGCTGCTGCGCGGCAAGTCGGTGTTC
AATCTGTTCTTCGAGAACTCGACGCGCACCCGCACCACTTTCGAGATCGCCGCGACGCGTCTTTCTGCGGACGTGCTCAA
TCTGAACATCAACGCGTCGTCGACCAGCAAGGGCGAATCGCTGCTCGACACGATCAACAACCTCTCGGCGATGCACGCCG
ATATGTTCGTCGTGCGCCACGCATCGAGCGGCGCGCCGTATCTGATCGCCCAGCATTGCGCGCCGCACGTGCACGTGATC
AATGCCGGCGACGGCCGTCATGCGCACCCTACGCAGGGGCTGCTCGACATGTACACGATCCGCCACTACAAGAAGGATTT
CACCAAGCTGCGCGTGGCGATCGTCGGCGATATTCTGCATTCGCGGGTCGCGCGCTCGGACATCCATGCGCTGACCACGC
TCGGCGTGCCGGAAGTGCGCGCGATCGGTCCGCGCACGCTGCTGCCGGGCGGCCTCGAACAGATGGGCGTGCGCGTGTTC
CACAATCTCGACGAAGGCCTGAAGGACGTCGACGTGATCATCATGCTGCGTCTGCAGAACGAACGGATGAGCGGCGCGTT
GCTGCCGTCGGCGCAGGAGTACTTCAAGAGCTGGGGCTTGACGCCCGAGCGTCTCGCGCTCGCCGCGCCAGAGGCGATCG
TGATGCACCCGGGCCCGATGAATCGCGGCGTCGAAATCGATTCGCAGGTGGCCGACGGACCGCAGTCGGTGATTCTGAAT
CAGGTGACCTTCGGTATCGCCGTGCGCATGGCGGTGATGGGGATCGTGGCCGGCAATCACGACTGA

Upstream 100 bases:

>100_bases
CCGCTCACCGCAACGTCGCGCGAATGCCAGCCCGGCATCGTCACACGCAGTCCGCTCGACACCGGTCACGTTGAAGCCCG
TATTTGAAGCAGGTATACCC

Downstream 100 bases:

>100_bases
TCCCGCAGGCGGCAAGCGGCGTCACGCGACAAGCGTCACGGCACCGCGAAAGCACAGTGCGAACACGCGGCTTGGCACGC
GCAACGCAGCTGAACACCAG

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNTATQAPKDSADSATERFRYGFLKGNPQLTKNGELKHLLSIEGLPKAIVNHILDTADQFVSVTDREVKKVPLLRGKSVF
NLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGESLLDTINNLSAMHADMFVVRHASSGAPYLIAQHCAPHVHVI
NAGDGRHAHPTQGLLDMYTIRHYKKDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVRVF
HNLDEGLKDVDVIIMLRLQNERMSGALLPSAQEYFKSWGLTPERLALAAPEAIVMHPGPMNRGVEIDSQVADGPQSVILN
QVTFGIAVRMAVMGIVAGNHD

Sequences:

>Translated_341_residues
MNTATQAPKDSADSATERFRYGFLKGNPQLTKNGELKHLLSIEGLPKAIVNHILDTADQFVSVTDREVKKVPLLRGKSVF
NLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGESLLDTINNLSAMHADMFVVRHASSGAPYLIAQHCAPHVHVI
NAGDGRHAHPTQGLLDMYTIRHYKKDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVRVF
HNLDEGLKDVDVIIMLRLQNERMSGALLPSAQEYFKSWGLTPERLALAAPEAIVMHPGPMNRGVEIDSQVADGPQSVILN
QVTFGIAVRMAVMGIVAGNHD
>Mature_341_residues
MNTATQAPKDSADSATERFRYGFLKGNPQLTKNGELKHLLSIEGLPKAIVNHILDTADQFVSVTDREVKKVPLLRGKSVF
NLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGESLLDTINNLSAMHADMFVVRHASSGAPYLIAQHCAPHVHVI
NAGDGRHAHPTQGLLDMYTIRHYKKDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVRVF
HNLDEGLKDVDVIIMLRLQNERMSGALLPSAQEYFKSWGLTPERLALAAPEAIVMHPGPMNRGVEIDSQVADGPQSVILN
QVTFGIAVRMAVMGIVAGNHD

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=312, Percent_Identity=35.2564102564103, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI2367364, Length=309, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=333, Percent_Identity=32.1321321321321, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322331, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642586, Length=320, Percent_Identity=34.0625, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 37256; Mature: 37256

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTATQAPKDSADSATERFRYGFLKGNPQLTKNGELKHLLSIEGLPKAIVNHILDTADQF
CCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHH
VSVTDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGES
HHHCCHHHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHEEEEEEEEECCCCCCCHHH
LLDTINNLSAMHADMFVVRHASSGAPYLIAQHCAPHVHVINAGDGRHAHPTQGLLDMYTI
HHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHH
RHYKKDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVRVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHH
HNLDEGLKDVDVIIMLRLQNERMSGALLPSAQEYFKSWGLTPERLALAAPEAIVMHPGPM
HHHHHCHHCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCEEEECCCCC
NRGVEIDSQVADGPQSVILNQVTFGIAVRMAVMGIVAGNHD
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTATQAPKDSADSATERFRYGFLKGNPQLTKNGELKHLLSIEGLPKAIVNHILDTADQF
CCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHH
VSVTDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGES
HHHCCHHHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHEEEEEEEEECCCCCCCHHH
LLDTINNLSAMHADMFVVRHASSGAPYLIAQHCAPHVHVINAGDGRHAHPTQGLLDMYTI
HHHHHHHHHHHHHHEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHH
RHYKKDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVRVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHH
HNLDEGLKDVDVIIMLRLQNERMSGALLPSAQEYFKSWGLTPERLALAAPEAIVMHPGPM
HHHHHCHHCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCEEEECCCCC
NRGVEIDSQVADGPQSVILNQVTFGIAVRMAVMGIVAGNHD
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA