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The map label for this gene is purM [H]

Identifier: 91781909

GI number: 91781909

Start: 591828

End: 592895

Strand: Direct

Name: purM [H]

Synonym: Bxe_A3936

Alternate gene names: 91781909

Gene position: 591828-592895 (Clockwise)

Preceding gene: 91781908

Following gene: 91781912

Centisome position: 12.09

GC content: 64.04

Gene sequence:

>1068_bases
ATGAATCAACCGAAATCCGCCCCGAATTCAACTGATTCGGCCCAAGGTTTGTCGTATCGCGACGCCGGCGTGGACATCGA
CGCGGGCGACGCCCTTGTCGACGCAATCAAGCCGTTTGCCAGAAAGACGATGCGCGACGGCGTGCTGGGTGGCATCGGCG
GGTTTGGCGCGCTGTTCGAAGTGCCGAAGAAGTACAAGGAGCCGGTGCTGGTGTCCGGCACCGACGGCGTCGGCACCAAG
CTGCGTCTCGCCTTTCAGCTGAACAAACACGACACCGTGGGCCAGGATCTGGTGGCGATGAGCGTGAACGACATTCTCGT
GCAGGGCGCGGAGCCGCTGTTCTTCCTGGACTACTTCGCCTGCGGCAAGCTGGACGTCGGCACGGCGGCCACGGTCGTGA
AGGGTATCGCATACGGCTGCGAACTGTCGGGTTGCGCGTTGATCGGCGGCGAGACGGCGGAAATGCCGGGCATGTACCCG
GACGGCGAATACGATCTGGCGGGTTTCGCGGTCGGCGCGGTGGAAAAGAGCAAGATTATCGACGGCAGCACGATCGCCCC
CGGCGACGTGGTGCTGGGCCTGGCTTCGAGCGGCATTCATTCGAACGGGTTTTCGCTGGTGCGCAAGATCATCGAGCGTG
CGCAGCCTGATCTGAACGCGGACTTCGACGGCCGCTCGCTTGCCGACGCGTTGATGGCGCCCACGCATATCTATGTGAAG
CCGCTGCTGGCGCTGATGCAGCAGATCGCCGTGAAGGGCATGGCGCACATCACGGGCGGCGGGCTGGTCGAGAACATTCC
GCGCGTGTTGCGTGAAGGCCTGACGGCTGAGCTGGATCATCGCGGCTGGCCGTTGCCGCCGCTGTTCTCGTGGCTGCAAA
AGCACGGCGGCGTGGCGGACGCGGAAATGCACCGCGTGTTCAACTGCGGTATCGGCATGGCCGTGGTGGTGTCGGCCGCG
GATGCCGATGCGGCAATCGGTCTGCTGTCCGCAGCCGGCGAGCAGGTCTGGAAGATCGGCGTGATTCGCGAAAGTGCGGC
CGGTGAGGCTCAGACCGTAGTGATCTAA

Upstream 100 bases:

>100_bases
TAAAATCCTGAGGTCGTTCGAAGCGTAAGTACCTGTTTTAATTGCGATTTTCTACTTTTCCCAGTATCATCTCATTTTAC
CGACCTTCGAGCTCGTCCTC

Downstream 100 bases:

>100_bases
AAGCTTGTCAGACCGCGCGGCGTGCGGTTAGCCGGCGCCGCGCGGGTTTGAAGCTTCAACGCATCAGAGTTTCAAAGCGT
CAAAGTTTCAAAGCAACGCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNQPKSAPNSTDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTMRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LRLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAYGCELSGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSTIAPGDVVLGLASSGIHSNGFSLVRKIIERAQPDLNADFDGRSLADALMAPTHIYVK
PLLALMQQIAVKGMAHITGGGLVENIPRVLREGLTAELDHRGWPLPPLFSWLQKHGGVADAEMHRVFNCGIGMAVVVSAA
DADAAIGLLSAAGEQVWKIGVIRESAAGEAQTVVI

Sequences:

>Translated_355_residues
MNQPKSAPNSTDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTMRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LRLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAYGCELSGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSTIAPGDVVLGLASSGIHSNGFSLVRKIIERAQPDLNADFDGRSLADALMAPTHIYVK
PLLALMQQIAVKGMAHITGGGLVENIPRVLREGLTAELDHRGWPLPPLFSWLQKHGGVADAEMHRVFNCGIGMAVVVSAA
DADAAIGLLSAAGEQVWKIGVIRESAAGEAQTVVI
>Mature_355_residues
MNQPKSAPNSTDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTMRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTK
LRLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVGTAATVVKGIAYGCELSGCALIGGETAEMPGMYP
DGEYDLAGFAVGAVEKSKIIDGSTIAPGDVVLGLASSGIHSNGFSLVRKIIERAQPDLNADFDGRSLADALMAPTHIYVK
PLLALMQQIAVKGMAHITGGGLVENIPRVLREGLTAELDHRGWPLPPLFSWLQKHGGVADAEMHRVFNCGIGMAVVVSAA
DADAAIGLLSAAGEQVWKIGVIRESAAGEAQTVVI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=363, Percent_Identity=51.5151515151515, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI209869995, Length=363, Percent_Identity=51.5151515151515, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI209869993, Length=363, Percent_Identity=51.5151515151515, Blast_Score=358, Evalue=5e-99,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=60.2941176470588, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=43.731778425656, Blast_Score=254, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=48.8372093023256, Blast_Score=322, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24582400, Length=317, Percent_Identity=45.7413249211356, Blast_Score=247, Evalue=7e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37015; Mature: 37015

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPKSAPNSTDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTMRDGVLGGIGGFGALFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
VPKKYKEPVLVSGTDGVGTKLRLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFA
HHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHH
CGKLDVGTAATVVKGIAYGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKII
CCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCC
DGSTIAPGDVVLGLASSGIHSNGFSLVRKIIERAQPDLNADFDGRSLADALMAPTHIYVK
CCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLALMQQIAVKGMAHITGGGLVENIPRVLREGLTAELDHRGWPLPPLFSWLQKHGGVAD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCCCH
AEMHRVFNCGIGMAVVVSAADADAAIGLLSAAGEQVWKIGVIRESAAGEAQTVVI
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCHHHEEEEEEECCCCCCCEEEEC
>Mature Secondary Structure
MNQPKSAPNSTDSAQGLSYRDAGVDIDAGDALVDAIKPFARKTMRDGVLGGIGGFGALFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
VPKKYKEPVLVSGTDGVGTKLRLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFA
HHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHH
CGKLDVGTAATVVKGIAYGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKII
CCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCC
DGSTIAPGDVVLGLASSGIHSNGFSLVRKIIERAQPDLNADFDGRSLADALMAPTHIYVK
CCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLALMQQIAVKGMAHITGGGLVENIPRVLREGLTAELDHRGWPLPPLFSWLQKHGGVAD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCCCH
AEMHRVFNCGIGMAVVVSAADADAAIGLLSAAGEQVWKIGVIRESAAGEAQTVVI
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCHHHEEEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA