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The map label for this gene is proC [H]

Identifier: 91781863

GI number: 91781863

Start: 537637

End: 538452

Strand: Reverse

Name: proC [H]

Synonym: Bxe_A3982

Alternate gene names: 91781863

Gene position: 538452-537637 (Counterclockwise)

Preceding gene: 91781864

Following gene: 91781856

Centisome position: 11.0

GC content: 67.52

Gene sequence:

>816_bases
ATGAAAATTGCTTTTATCGGCGGTGGCAACATGGCCGCCGCGTTGATCGGCGGCCTCATCAAACGTGGCGTCGCAGCCGC
TGACCTCTACGCAATCGATCCCAACGAAGAGGCGCGCAAACGCAATGAGCAGCAGTTCGGCATCCGGACCGGCGCCGCCG
CGGATGCCGCGCTGGCCGCGTACGACGCCGTCGTGCTGGCGGTGAAGCCGCAGATCCTGAAGAGCGTCGCCGAGGCGGTG
GCGCCGCATCTGAACGCGTCGCAACTGGTCGTGAGCATCGTCGCCGGTATTCGCATGGGCGACATGTCGCGCTGGCTGAA
CGGTCACAGCCGTATCGTGCGCGTCATGCCCAATACGCCGGCGTTGATCGGCATGGGCGTGACCGGTCTCGTGGCAACCG
GCAGCGTGGACGAAGCGGGCCGCGCGCTCGCGTCGCAACTGCTGGGCGCAGTCGGCGAAACGGTCTGGTTCGACGACGAA
GCGAAGATCGACGCCGTCACCGCAATCTCGGGCAGCGGGCCCGCCTACGTGTTCTATTTCATCGAAGCGTTGCAGGAAGC
CGCCCGCCAGCTCGGCATGGATGAAGCGCAGGGCCGTGCGCTCGCCGTCGCGACCTTCACCGGCGCGGCGCAACTGGCGG
CGAATTCCGACGAGCCGCCGGGCGTGCTGCGCGAACGCGTGACGTCGAAGGGCGGCACCACGGCGGCGGCGCTGGCGTCG
TTCGACGCGAGCGGCATCAAGGATGCGATCGTGCGCGGCGCGCTCGCGGCCAATGCCCGTGCGCGGGAAATGGGCGACGA
ATTCGGCAAGCAGTAA

Upstream 100 bases:

>100_bases
CGTAGGCACCGCGATCTTCGGCGCGCGAGATTACTCTAACTGAGCTTCGCGAACCTTTTCAGGCTCCGTTGGCTCTTCAC
GGCACTTCATCCGGAACATC

Downstream 100 bases:

>100_bases
GCGCGCAGGCAGCACAGTAGGACTGAACGCCGCGGCGCTTCGATTCAGGCCGCCGCGGCGTTAGTGATGAAGCACCGCAA
AGCCGGCGCAAAGCCGGCGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKIAFIGGGNMAAALIGGLIKRGVAAADLYAIDPNEEARKRNEQQFGIRTGAAADAALAAYDAVVLAVKPQILKSVAEAV
APHLNASQLVVSIVAGIRMGDMSRWLNGHSRIVRVMPNTPALIGMGVTGLVATGSVDEAGRALASQLLGAVGETVWFDDE
AKIDAVTAISGSGPAYVFYFIEALQEAARQLGMDEAQGRALAVATFTGAAQLAANSDEPPGVLRERVTSKGGTTAAALAS
FDASGIKDAIVRGALAANARAREMGDEFGKQ

Sequences:

>Translated_271_residues
MKIAFIGGGNMAAALIGGLIKRGVAAADLYAIDPNEEARKRNEQQFGIRTGAAADAALAAYDAVVLAVKPQILKSVAEAV
APHLNASQLVVSIVAGIRMGDMSRWLNGHSRIVRVMPNTPALIGMGVTGLVATGSVDEAGRALASQLLGAVGETVWFDDE
AKIDAVTAISGSGPAYVFYFIEALQEAARQLGMDEAQGRALAVATFTGAAQLAANSDEPPGVLRERVTSKGGTTAAALAS
FDASGIKDAIVRGALAANARAREMGDEFGKQ
>Mature_271_residues
MKIAFIGGGNMAAALIGGLIKRGVAAADLYAIDPNEEARKRNEQQFGIRTGAAADAALAAYDAVVLAVKPQILKSVAEAV
APHLNASQLVVSIVAGIRMGDMSRWLNGHSRIVRVMPNTPALIGMGVTGLVATGSVDEAGRALASQLLGAVGETVWFDDE
AKIDAVTAISGSGPAYVFYFIEALQEAARQLGMDEAQGRALAVATFTGAAQLAANSDEPPGVLRERVTSKGGTTAAALAS
FDASGIKDAIVRGALAANARAREMGDEFGKQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=32.2097378277154, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=31.7343173431734, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=31.7343173431734, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=29.520295202952, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=34.8148148148148, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=35.9259259259259, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=29.3286219081272, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=227, Percent_Identity=29.5154185022026, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.8490566037736, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=30.4347826086957, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=38.4615384615385, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27820; Mature: 27820

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAAADLYAIDPNEEARKRNEQQFGIRTGAAADAALAA
CEEEEECCCHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHCCHHHHCCCCCCHHHHHHHH
YDAVVLAVKPQILKSVAEAVAPHLNASQLVVSIVAGIRMGDMSRWLNGHSRIVRVMPNTP
HHHHHEEECHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCC
ALIGMGVTGLVATGSVDEAGRALASQLLGAVGETVWFDDEAKIDAVTAISGSGPAYVFYF
CEEECCCHHEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEALQEAARQLGMDEAQGRALAVATFTGAAQLAANSDEPPGVLRERVTSKGGTTAAALAS
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHH
FDASGIKDAIVRGALAANARAREMGDEFGKQ
CCCCHHHHHHHHHHHHHCHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAAADLYAIDPNEEARKRNEQQFGIRTGAAADAALAA
CEEEEECCCHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHCCHHHHCCCCCCHHHHHHHH
YDAVVLAVKPQILKSVAEAVAPHLNASQLVVSIVAGIRMGDMSRWLNGHSRIVRVMPNTP
HHHHHEEECHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCC
ALIGMGVTGLVATGSVDEAGRALASQLLGAVGETVWFDDEAKIDAVTAISGSGPAYVFYF
CEEECCCHHEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCCHHHHH
IEALQEAARQLGMDEAQGRALAVATFTGAAQLAANSDEPPGVLRERVTSKGGTTAAALAS
HHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHH
FDASGIKDAIVRGALAANARAREMGDEFGKQ
CCCCHHHHHHHHHHHHHCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]