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The map label for this gene is fadA [H]

Identifier: 91781809

GI number: 91781809

Start: 475223

End: 476422

Strand: Direct

Name: fadA [H]

Synonym: Bxe_A4036

Alternate gene names: 91781809

Gene position: 475223-476422 (Clockwise)

Preceding gene: 91781808

Following gene: 91781810

Centisome position: 9.71

GC content: 66.0

Gene sequence:

>1200_bases
ATGGCAAAGCAATTGCAAGACGCATACATCGTCGCCGCGAGCCGCACGCCGATCGGCAAGGCGCCGCGCGGGATGTTCAG
GAACACGCGCCCGGACGAACTGCTGGTCCACGCGATCAGGTCGGCTGTGGCGCAAGTGCCCGGCCTCGACACCAAGGTGA
TCGAAGACGCGATCATCGGCTGCGCGATTCCGGAAGCGGAACAAGGCCTGAACGTGGCGCGCATGGGCGCGCTGCTGGCC
GGCCTGCCGAATACCGTCGGCGGTGTGACGGTGAACCGCTTCTGCGCGTCGGGCCTGACGGCGCTGGCGATGGCGGCGGA
CCGCATCCGCGTCGGCGAGTCGGACGCAATGATCGCGGGCGGCTGCGAATCCATGAGCATGGTGCCGATGATGGGCAACA
AGCCTTCCATGTCGCCGCATATCTTCGATCGCAATGAAGATATCGGCATCGCGTACGGCATGGGCCTCACGGCCGAGAAG
GTCGCCGAGCGCTGGAAGATCAGCCGCGAAGCGCAGGACGCGTTCTCGGTCGAATCGCACCGCCGCGCCATTGCCGCGCA
GCAAGCCGGCGAGTTCAACGACGAAATCGCCGCCTACACGATCACCGAACGCTTCCCCGATCTCGCCACCGGCGAAGTCC
GCGTGAAGACCCGCGAAGTCTCGCTCGACGAAGGTCCGCGCGCGGAAACCTCGCTCGAAGGTCTCGCCAAACTGCGCGCA
GTGTTCGCGAACAAGGGTTCGGTGACGGCGGGCAACAGCTCGCAGACCTCGGACGGCGCGGGCGCGCTGATCGTGGTGTC
GGAAAAGATGCTGAAGGAATTCAACCTGACGCCGCTCGCGCGTTTCGTCAGCTTCGCCGTGCGCGGCGTGCCGCCGGAGA
TCATGGGCATCGGTCCGAAGGAAGCGATTCCGGCCGCATTGAAGGCCGCCGGCCTGAAGATCGACGACCTGGACTGGATC
GAGCTGAACGAAGCGTTCGCCGCGCAATCGCTGGCGGTGATTCAGGACCTCGGTCTCGATCCGGCGAAGATCAACCCGCT
CGGCGGCGCGATCGCACTCGGCCACCCGCTGGGCGCAACGGGCGCGATTCGTGCGTCGACCGTGGTGCATGGTTTGCGCC
GCCGTAACTACAAGTACGGCATGGTGACGATGTGCGTCGGCACGGGCATGGGCGCGGCGGGCATCATCGAGCGCCTGTGA

Upstream 100 bases:

>100_bases
CGATCTGCTCGGCACGCAAAAGACGCAGGAACGGATCATGGGCATGCTGCAAACCGGCAAGCCGGTGCGCAACTGAGCGA
CGAGCCAATAGGAGATTCAA

Downstream 100 bases:

>100_bases
GCGTGATCGCCCCGCTGTTCAGCCCGGCGTTCGCTTCGGTCCACACGGCGAGCCTCGGGGCGCCCCCTTGGGGCGACCCG
TTAGGCACGCGCAACGGTTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGLTALAMAADRIRVGESDAMIAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAEK
VAERWKISREAQDAFSVESHRRAIAAQQAGEFNDEIAAYTITERFPDLATGEVRVKTREVSLDEGPRAETSLEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALIVVSEKMLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKIDDLDWI
ELNEAFAAQSLAVIQDLGLDPAKINPLGGAIALGHPLGATGAIRASTVVHGLRRRNYKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MAKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGLTALAMAADRIRVGESDAMIAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAEK
VAERWKISREAQDAFSVESHRRAIAAQQAGEFNDEIAAYTITERFPDLATGEVRVKTREVSLDEGPRAETSLEGLAKLRA
VFANKGSVTAGNSSQTSDGAGALIVVSEKMLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKIDDLDWI
ELNEAFAAQSLAVIQDLGLDPAKINPLGGAIALGHPLGATGAIRASTVVHGLRRRNYKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
AKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPGLDTKVIEDAIIGCAIPEAEQGLNVARMGALLAG
LPNTVGGVTVNRFCASGLTALAMAADRIRVGESDAMIAGGCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAEKV
AERWKISREAQDAFSVESHRRAIAAQQAGEFNDEIAAYTITERFPDLATGEVRVKTREVSLDEGPRAETSLEGLAKLRAV
FANKGSVTAGNSSQTSDGAGALIVVSEKMLKEFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKIDDLDWIE
LNEAFAAQSLAVIQDLGLDPAKINPLGGAIALGHPLGATGAIRASTVVHGLRRRNYKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.6428571428571, Blast_Score=294, Evalue=9e-80,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=38.8206388206388, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI148539872, Length=341, Percent_Identity=39.8826979472141, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=35.7142857142857, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=34.6938775510204, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=29.372197309417, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI19923233, Length=352, Percent_Identity=25.8522727272727, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=44.5255474452555, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.7810945273632, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.3940886699507, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=40.0990099009901, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1788683, Length=380, Percent_Identity=33.9473684210526, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=40.8977556109726, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=35.5555555555556, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=406, Percent_Identity=33.4975369458128, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=28.6783042394015, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=39.5522388059701, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=38.4803921568627, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=40.0990099009901, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17648125, Length=410, Percent_Identity=39.2682926829268, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.4963325183374, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=30.7692307692308, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42021; Mature: 41890

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPGLDTKVIEDAIIG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGLTALAMAADRIRVGESDAMIAG
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAEKVAERWKISREAQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRAIAAQQAGEFNDEIAAYTITERFPDLATGEVRVKTREVSLDEGPRAETSLEGLAKLRA
HHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALIVVSEKMLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCH
EAIPAALKAAGLKIDDLDWIELNEAFAAQSLAVIQDLGLDPAKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCC
GAIRASTVVHGLRRRNYKYGMVTMCVGTGMGAAGIIERL
CHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
AKQLQDAYIVAASRTPIGKAPRGMFRNTRPDELLVHAIRSAVAQVPGLDTKVIEDAIIG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGLTALAMAADRIRVGESDAMIAG
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEC
GCESMSMVPMMGNKPSMSPHIFDRNEDIGIAYGMGLTAEKVAERWKISREAQDAFSVESH
CCCCCEECCCCCCCCCCCCCEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRAIAAQQAGEFNDEIAAYTITERFPDLATGEVRVKTREVSLDEGPRAETSLEGLAKLRA
HHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGAGALIVVSEKMLKEFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCH
EAIPAALKAAGLKIDDLDWIELNEAFAAQSLAVIQDLGLDPAKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCC
GAIRASTVVHGLRRRNYKYGMVTMCVGTGMGAAGIIERL
CHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]