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The map label for this gene is ilvA [H]

Identifier: 91781791

GI number: 91781791

Start: 450764

End: 452371

Strand: Reverse

Name: ilvA [H]

Synonym: Bxe_A4054

Alternate gene names: 91781791

Gene position: 452371-450764 (Counterclockwise)

Preceding gene: 91781811

Following gene: 91781790

Centisome position: 9.24

GC content: 63.93

Gene sequence:

>1608_bases
ATGCATAAGCCGAAGGCCTTGGCGCACACCGTTGGCGCTATCATTGACCCTTTCCGGTCTCACACAGCGCTCCGCGCCAC
CCGCATGGCCTCCCACGACTACCTGAAGAAAACCCTGACCGCGCGCGTCTACGACGTCGCCCGCGAGACCGAACTCGAAC
GCGCGCCGAATCTGTCTGCACGTCTGCGCAATCCGGTCTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAG
GTGCGCGGCGCGTACAACAAGATGGCGCATATTCCGGCCGAGGCGCTGGAACGCGGGGTGATCACCGCGTCGGCGGGCAA
TCATGCGCAGGGCGTCGCGCTGTCGGCCGCGCGCATGGGCGTGAAGGCGATCATCGTGGTGCCGGTCACCACGCCGCAGG
TGAAGGTCGATGCAGTGCGAGCACACGGCGGCCCGACCGTCGAAGTGGTGCAGTTCGGCGAATCGTATAGCGACGCGTAT
GGCCATGCGGTGAAACTGCAGGAAGAGCGCGACCTGACCTTCGTGCATCCGTTCGACGATCCGTACGTGATCGCCGGACA
GGGCACGGTGGCAATGGAGATCCTGAGCCAGCACCAGGGGCCTATTCACGCGATCTTCGTGCCGATCGGCGGCGGCGGAC
TCGCGGCAGGCGTGGCCGCGTATGTGAAATCGGTGCGGCCCGAGATCAAGGTGATCGGCGTGCAGACCGATGATTCGTGC
GCGATGGCCGCATCGCTGAAAGCCGGCGAGCGGGTCACGCTGAACGAAGTCGGCCTGTTCTCGGACGGCACGGCGGTGAA
ACTGGTCGGCGAAGAAACCTTCCGCCTCTGCCGCGAATATCTCGACGACGTGCTGCTCGTGGACACCGACGCGCTATGCG
CCGCCATCAAGGACGTGTTCCAGGACACCCGCAGCGTGCTGGAACCCGCCGGCTCGCTCGCGGTGGCCGGGGCGAAACAG
TATGCGGAGCGCGAAGGCATCGAGAACCAGACGCTGATCGCGATCACATCGGGCGCGAACATGAACTTCGACCGCATGCG
CTTCGTGGCCGAGCGCGCCGAAGTCGGCGAAGCGCGTGAAGCCGTGTTCGCCGTGACGATCCCCGAAGAGCGCGGCAGTT
TCCGGCGTTTCTGCGAACTGGTGGGCACGCGCAGCGTCACCGAGTTCAACTACCGGATTGCGGACGCGAATTCCGCCCAT
ATCTTCGTGGGCGTGCAGATCAGGAATCGCAGCGAATCCGCGCAGATCGCGGGGGCGTTCGAAGCGCACGGCTTCGCCAC
CGTCGATCTGACTTTCGACGAACTGTCCAAGCAGCACATCCGTTACATGGTAGGCGGCCGCTCGCCTCTGGCGCACGACG
AACGGCTGTTCCGCTTCGAGTTTCCCGAACGTCCGGGCGCGCTGATGAAATTCCTTTCGTCGATGGCGCCGAACTGGAAT
ATCAGCCTGTTCCACTATCGCAACCAGGGCGCGGACTATAGCTCGATTCTGGTCGGCATCCAGGTGCCGGAGAGCGAGGA
TGCGGCGTTCGACCAGTTTCTCGCCACGCTCGGCTATCCGAACTGGGAAGAGACGCGCAACCCGGTGTATCGCCTGTTTC
TCGCTTGA

Upstream 100 bases:

>100_bases
GCGACCGGACTTTGGCCACTTTCATGGCGAATCGCGTGACAAACCCCTACGCCCGATTGACCGACCGAACGGTCGGGCGA
GGCTTTGCGGCACGGCTTGG

Downstream 100 bases:

>100_bases
TTAACCTTAACCGCACCTGGGACTGAAACGCGCAGATGGCTCTTTCGCTTGTCGACAAACTGGTGGTGGCAATCTCGTCG
CGCGCGCTGTTCGACTTCGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MHKPKALAHTVGAIIDPFRSHTALRATRMASHDYLKKTLTARVYDVARETELERAPNLSARLRNPVYLKREDNQPVFSFK
VRGAYNKMAHIPAEALERGVITASAGNHAQGVALSAARMGVKAIIVVPVTTPQVKVDAVRAHGGPTVEVVQFGESYSDAY
GHAVKLQEERDLTFVHPFDDPYVIAGQGTVAMEILSQHQGPIHAIFVPIGGGGLAAGVAAYVKSVRPEIKVIGVQTDDSC
AMAASLKAGERVTLNEVGLFSDGTAVKLVGEETFRLCREYLDDVLLVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKQ
YAEREGIENQTLIAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGTRSVTEFNYRIADANSAH
IFVGVQIRNRSESAQIAGAFEAHGFATVDLTFDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPNWN
ISLFHYRNQGADYSSILVGIQVPESEDAAFDQFLATLGYPNWEETRNPVYRLFLA

Sequences:

>Translated_535_residues
MHKPKALAHTVGAIIDPFRSHTALRATRMASHDYLKKTLTARVYDVARETELERAPNLSARLRNPVYLKREDNQPVFSFK
VRGAYNKMAHIPAEALERGVITASAGNHAQGVALSAARMGVKAIIVVPVTTPQVKVDAVRAHGGPTVEVVQFGESYSDAY
GHAVKLQEERDLTFVHPFDDPYVIAGQGTVAMEILSQHQGPIHAIFVPIGGGGLAAGVAAYVKSVRPEIKVIGVQTDDSC
AMAASLKAGERVTLNEVGLFSDGTAVKLVGEETFRLCREYLDDVLLVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKQ
YAEREGIENQTLIAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGTRSVTEFNYRIADANSAH
IFVGVQIRNRSESAQIAGAFEAHGFATVDLTFDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPNWN
ISLFHYRNQGADYSSILVGIQVPESEDAAFDQFLATLGYPNWEETRNPVYRLFLA
>Mature_535_residues
MHKPKALAHTVGAIIDPFRSHTALRATRMASHDYLKKTLTARVYDVARETELERAPNLSARLRNPVYLKREDNQPVFSFK
VRGAYNKMAHIPAEALERGVITASAGNHAQGVALSAARMGVKAIIVVPVTTPQVKVDAVRAHGGPTVEVVQFGESYSDAY
GHAVKLQEERDLTFVHPFDDPYVIAGQGTVAMEILSQHQGPIHAIFVPIGGGGLAAGVAAYVKSVRPEIKVIGVQTDDSC
AMAASLKAGERVTLNEVGLFSDGTAVKLVGEETFRLCREYLDDVLLVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKQ
YAEREGIENQTLIAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGTRSVTEFNYRIADANSAH
IFVGVQIRNRSESAQIAGAFEAHGFATVDLTFDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPNWN
ISLFHYRNQGADYSSILVGIQVPESEDAAFDQFLATLGYPNWEETRNPVYRLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=298, Percent_Identity=33.2214765100671, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI33469958, Length=318, Percent_Identity=28.9308176100629, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI19923959, Length=307, Percent_Identity=28.0130293159609, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=53.1746031746032, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=37.2990353697749, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=321, Percent_Identity=28.6604361370716, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=386, Percent_Identity=29.2746113989637, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=254, Percent_Identity=31.496062992126, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320930, Length=535, Percent_Identity=46.7289719626168, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=33.8815789473684, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=26.7657992565056, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=383, Percent_Identity=27.4151436031332, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=26.2745098039216, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 58704; Mature: 58704

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKPKALAHTVGAIIDPFRSHTALRATRMASHDYLKKTLTARVYDVARETELERAPNLSA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLRNPVYLKREDNQPVFSFKVRGAYNKMAHIPAEALERGVITASAGNHAQGVALSAARMG
HCCCCEEEEECCCCCEEEEEECCCHHHHHCCCHHHHHCCEEEECCCCCCCCEEEHHHHCC
VKAIIVVPVTTPQVKVDAVRAHGGPTVEVVQFGESYSDAYGHAVKLQEERDLTFVHPFDD
EEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCEEEECCCCC
PYVIAGQGTVAMEILSQHQGPIHAIFVPIGGGGLAAGVAAYVKSVRPEIKVIGVQTDDSC
CEEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCH
AMAASLKAGERVTLNEVGLFSDGTAVKLVGEETFRLCREYLDDVLLVDTDALCAAIKDVF
HHHHHCCCCCEEEEECCCEECCCCEEEEECHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
QDTRSVLEPAGSLAVAGAKQYAEREGIENQTLIAITSGANMNFDRMRFVAERAEVGEARE
HHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AVFAVTIPEERGSFRRFCELVGTRSVTEFNYRIADANSAHIFVGVQIRNRSESAQIAGAF
EEEEEEECHHCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEE
EAHGFATVDLTFDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPNWN
ECCCEEEEEEEHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
ISLFHYRNQGADYSSILVGIQVPESEDAAFDQFLATLGYPNWEETRNPVYRLFLA
EEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEEC
>Mature Secondary Structure
MHKPKALAHTVGAIIDPFRSHTALRATRMASHDYLKKTLTARVYDVARETELERAPNLSA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLRNPVYLKREDNQPVFSFKVRGAYNKMAHIPAEALERGVITASAGNHAQGVALSAARMG
HCCCCEEEEECCCCCEEEEEECCCHHHHHCCCHHHHHCCEEEECCCCCCCCEEEHHHHCC
VKAIIVVPVTTPQVKVDAVRAHGGPTVEVVQFGESYSDAYGHAVKLQEERDLTFVHPFDD
EEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCEEEECCCCC
PYVIAGQGTVAMEILSQHQGPIHAIFVPIGGGGLAAGVAAYVKSVRPEIKVIGVQTDDSC
CEEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCH
AMAASLKAGERVTLNEVGLFSDGTAVKLVGEETFRLCREYLDDVLLVDTDALCAAIKDVF
HHHHHCCCCCEEEEECCCEECCCCEEEEECHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
QDTRSVLEPAGSLAVAGAKQYAEREGIENQTLIAITSGANMNFDRMRFVAERAEVGEARE
HHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AVFAVTIPEERGSFRRFCELVGTRSVTEFNYRIADANSAHIFVGVQIRNRSESAQIAGAF
EEEEEEECHHCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEE
EAHGFATVDLTFDELSKQHIRYMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPNWN
ECCCEEEEEEEHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
ISLFHYRNQGADYSSILVGIQVPESEDAAFDQFLATLGYPNWEETRNPVYRLFLA
EEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA