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The map label for this gene is nanT1 [H]

Identifier: 91781745

GI number: 91781745

Start: 398490

End: 399773

Strand: Direct

Name: nanT1 [H]

Synonym: Bxe_A4100

Alternate gene names: 91781745

Gene position: 398490-399773 (Clockwise)

Preceding gene: 91781742

Following gene: 91781746

Centisome position: 8.14

GC content: 64.95

Gene sequence:

>1284_bases
ATGTCGAGTTCGATCGACCTGGCAGTCGTAGTAGCGCGCCCGTATCGCGTGTTCATCGCCACATGGGCGGGCTGGATGCT
GGACGGTTTCGACAACGCCATCTACATCTACGTCATCGTGCCCGCGTTGACCGAGTTGCTGCCCAAAAGCGGCTTCGTGG
CCGATCACGCGCATATTGCACGGCTCGGCGGCTTGATGTTCAGCCTCTTCATGCTCGGCTGGGCCTGCTCGATGTTCTGG
GGCTGGTGCGCGGACCGATTCGGCCGCGTCCCTACCATGTGCGCGACCATCCTCATTTATTCGATCTTCACCGGCGCTTG
TGGGCTCGCGCCCGGCATCGTATCGTTCGCGATCTTCCGTTTCCTGACGGGTTTCGGCATAGGCGGCGAATGGGCCGCCG
GCGCGCCGCTGCTTCAGGAGTCGGTGCCAGAGCATCTGCGCGAGCGTTTGTCGGGCTGGCTGCACACCGGCACGCCGATC
GGCTTTCTGCTGGCTTCCGCCGCCGCGCTGGTGATTCTGCCGCTGGGCGGCTGGCGGGTTCTGTTTCTGATCGGCAGCGC
ACCCGCGTTGCTGACCATCTGGCTGCGGCTCGGCGTACCGGAGTCGCGCCGCTGGCAGGAACAGCGTCGCGTGCAGGGGC
CGCGTGCGCGTGTGCGCGACCTGTTCGCGCGCGACATGGCGCGCACCACGTGGTCGGCCGCGCTGATGATGACGTGCCTG
ATATTCGGCCTGTGGTCGTCGACCTTCTGGATTCCGACGCTCGTGATCACGTGGCAGCGCGCGGGCGGCGCATCCGTCGC
CGATGCGCAGTATCTGGGCTCGCTGAGCGGCTTGATCCTGAGCGTCGGCACGCTCGCCGGTTGCGTTGCGATGCCGTGGA
TCGTGCGCTGGATTCCGCGTCGTAAATCGGTCGCCAGCGTGTTCTTCTCCGGCGCGCTGATCTGCAATGTCGCCTCGTAC
TTCGGCATTGTGGTGTTGCTGAAAAGCCTGCCGCTATTCCTGATCACACTGCCGCTGCTCGGCTTCTTCACAAGCGGCGT
GTTCTCGCTGTTCACGATCTGGCTGCCCGAAATGTTTCCGACGATGCAGCGCGCGCTCGGTTCCGGATTCGCCTTCAGCT
TCGGCCGCGTCCTCGGCGCGGCGGGACCGTCGATTGTCGGCGCGCTCGCGGCGATGTTCGGTTCCTATCCGCTCGCGATC
ACCGCGGTTTCGCTGATCTATCTGGTCGGTCTGTTCTGCGTGAAGTGGGCGCCGGAAACCGCGCACCGGGCATTGCGGCA
GTGA

Upstream 100 bases:

>100_bases
CGTCCTCGCGCCGACAGCGTGCGCGTTGGCGAAATCATTGTCGACAAAAAACAGGCTGCGATACCCACGAACGCGGCGGA
CCGTGGATTCAGGAGACGAG

Downstream 100 bases:

>100_bases
CTCTATGTATTCCGAACGATCCGCGTCGCATGTTGACGGGCGTCCGCGACAATCGAAAATGAAGGAGCAAACCATGCAAC
ACGATAACCGGCAGGGCGGT

Product: major facilitator superfamily metabolite/H(+) symporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: Sialic acid permease 1 [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSSSIDLAVVVARPYRVFIATWAGWMLDGFDNAIYIYVIVPALTELLPKSGFVADHAHIARLGGLMFSLFMLGWACSMFW
GWCADRFGRVPTMCATILIYSIFTGACGLAPGIVSFAIFRFLTGFGIGGEWAAGAPLLQESVPEHLRERLSGWLHTGTPI
GFLLASAAALVILPLGGWRVLFLIGSAPALLTIWLRLGVPESRRWQEQRRVQGPRARVRDLFARDMARTTWSAALMMTCL
IFGLWSSTFWIPTLVITWQRAGGASVADAQYLGSLSGLILSVGTLAGCVAMPWIVRWIPRRKSVASVFFSGALICNVASY
FGIVVLLKSLPLFLITLPLLGFFTSGVFSLFTIWLPEMFPTMQRALGSGFAFSFGRVLGAAGPSIVGALAAMFGSYPLAI
TAVSLIYLVGLFCVKWAPETAHRALRQ

Sequences:

>Translated_427_residues
MSSSIDLAVVVARPYRVFIATWAGWMLDGFDNAIYIYVIVPALTELLPKSGFVADHAHIARLGGLMFSLFMLGWACSMFW
GWCADRFGRVPTMCATILIYSIFTGACGLAPGIVSFAIFRFLTGFGIGGEWAAGAPLLQESVPEHLRERLSGWLHTGTPI
GFLLASAAALVILPLGGWRVLFLIGSAPALLTIWLRLGVPESRRWQEQRRVQGPRARVRDLFARDMARTTWSAALMMTCL
IFGLWSSTFWIPTLVITWQRAGGASVADAQYLGSLSGLILSVGTLAGCVAMPWIVRWIPRRKSVASVFFSGALICNVASY
FGIVVLLKSLPLFLITLPLLGFFTSGVFSLFTIWLPEMFPTMQRALGSGFAFSFGRVLGAAGPSIVGALAAMFGSYPLAI
TAVSLIYLVGLFCVKWAPETAHRALRQ
>Mature_426_residues
SSSIDLAVVVARPYRVFIATWAGWMLDGFDNAIYIYVIVPALTELLPKSGFVADHAHIARLGGLMFSLFMLGWACSMFWG
WCADRFGRVPTMCATILIYSIFTGACGLAPGIVSFAIFRFLTGFGIGGEWAAGAPLLQESVPEHLRERLSGWLHTGTPIG
FLLASAAALVILPLGGWRVLFLIGSAPALLTIWLRLGVPESRRWQEQRRVQGPRARVRDLFARDMARTTWSAALMMTCLI
FGLWSSTFWIPTLVITWQRAGGASVADAQYLGSLSGLILSVGTLAGCVAMPWIVRWIPRRKSVASVFFSGALICNVASYF
GIVVLLKSLPLFLITLPLLGFFTSGVFSLFTIWLPEMFPTMQRALGSGFAFSFGRVLGAAGPSIVGALAAMFGSYPLAIT
AVSLIYLVGLFCVKWAPETAHRALRQ

Specific function: May be a sugar-cation symporter involved in sialic acid uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Sialic acid transporter (TC 2.A.1.12.1) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082231, Length=468, Percent_Identity=27.7777777777778, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI87082404, Length=386, Percent_Identity=26.6839378238342, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1790550, Length=395, Percent_Identity=23.0379746835443, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788292, Length=411, Percent_Identity=24.8175182481752, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32564663, Length=443, Percent_Identity=24.1534988713318, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742
- InterPro:   IPR005828 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 46480; Mature: 46348

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSIDLAVVVARPYRVFIATWAGWMLDGFDNAIYIYVIVPALTELLPKSGFVADHAHIA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHH
RLGGLMFSLFMLGWACSMFWGWCADRFGRVPTMCATILIYSIFTGACGLAPGIVSFAIFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTGFGIGGEWAAGAPLLQESVPEHLRERLSGWLHTGTPIGFLLASAAALVILPLGGWRV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCEE
LFLIGSAPALLTIWLRLGVPESRRWQEQRRVQGPRARVRDLFARDMARTTWSAALMMTCL
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFGLWSSTFWIPTLVITWQRAGGASVADAQYLGSLSGLILSVGTLAGCVAMPWIVRWIPR
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKSVASVFFSGALICNVASYFGIVVLLKSLPLFLITLPLLGFFTSGVFSLFTIWLPEMFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMQRALGSGFAFSFGRVLGAAGPSIVGALAAMFGSYPLAITAVSLIYLVGLFCVKWAPET
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
AHRALRQ
HHHHHCC
>Mature Secondary Structure 
SSSIDLAVVVARPYRVFIATWAGWMLDGFDNAIYIYVIVPALTELLPKSGFVADHAHIA
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHH
RLGGLMFSLFMLGWACSMFWGWCADRFGRVPTMCATILIYSIFTGACGLAPGIVSFAIFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTGFGIGGEWAAGAPLLQESVPEHLRERLSGWLHTGTPIGFLLASAAALVILPLGGWRV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCEE
LFLIGSAPALLTIWLRLGVPESRRWQEQRRVQGPRARVRDLFARDMARTTWSAALMMTCL
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFGLWSSTFWIPTLVITWQRAGGASVADAQYLGSLSGLILSVGTLAGCVAMPWIVRWIPR
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKSVASVFFSGALICNVASYFGIVVLLKSLPLFLITLPLLGFFTSGVFSLFTIWLPEMFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMQRALGSGFAFSFGRVLGAAGPSIVGALAAMFGSYPLAITAVSLIYLVGLFCVKWAPET
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
AHRALRQ
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]