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The map label for this gene is pth [H]

Identifier: 91781711

GI number: 91781711

Start: 361676

End: 362278

Strand: Reverse

Name: pth [H]

Synonym: Bxe_A4135

Alternate gene names: 91781711

Gene position: 362278-361676 (Counterclockwise)

Preceding gene: 91781712

Following gene: 91781710

Centisome position: 7.4

GC content: 63.85

Gene sequence:

>603_bases
ATGATCAAGCTGATCGTCGGCCTCGGCAATCCGGGCGCCGAATACACCGCGACGCGCCACAACGCCGGCTTCTGGCTGGT
CGATCAACTGGCCCGCGAAGCAGGCACGACGTTGCGCGACGAGCGGCGTTTCCACGGTTTCTACGCCAAGGCACGGCTTC
ACGGCGAGGAGGTGCACTTGCTGGAGCCGCAGACGTATATGAACCGCTCGGGCCAGTCGGTCGTGGCGCTTGCACAGTTC
TTCAAGATTCTTCCCGACGAAATTCTGGTCGCGCACGACGAACTCGACATGCCGCCCGGCAGCGTCAAGTTGAAACTGGG
CGGTGGCAGCGGCGGCCATAATGGGCTCAAGGACATCACCGCGCATCTGTCGTCGCAGCAATACTGGCGGTTGCGGATCG
GCATCGGGCATCCGCGTGACCTGATTCCCGAGAGCGCGCGCGCCGGCGCCAGGCCGGACGTCGCCAACTACGTGCTGAAA
CCGCCGCGGCGGGAAGAGCAGGATGTGATCGATGCATCGATCGAGCGCGCACTCGCCGTGATGCCGCAAGTCATCAAGGG
CGAGCTCGAGCGCGCGATGATGCAACTGCATCGCAATCCGTAG

Upstream 100 bases:

>100_bases
CGGTCGATGTGACCCGCCGAGGTTCGCCCCGGCGGGTTTTTTTTCGGTTTTTTTCGGTTCGGCCGCGTTCGGCTTCCGGG
CCAGATGGACCTACGCAATC

Downstream 100 bases:

>100_bases
GCGGCGCCTCTGCCGGAACCGGGCTGCCGTGCCGCCATCGACCGTAACTTTCCTGCTTGGGAGAATCGCTTGAGCCGTTA
TTGGAGTGACATCGTTCACC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDEILVAHDELDMPPGSVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLIPESARAGARPDVANYVLK
PPRREEQDVIDASIERALAVMPQVIKGELERAMMQLHRNP

Sequences:

>Translated_200_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDEILVAHDELDMPPGSVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLIPESARAGARPDVANYVLK
PPRREEQDVIDASIERALAVMPQVIKGELERAMMQLHRNP
>Mature_200_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGTTLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALAQF
FKILPDEILVAHDELDMPPGSVKLKLGGGSGGHNGLKDITAHLSSQQYWRLRIGIGHPRDLIPESARAGARPDVANYVLK
PPRREEQDVIDASIERALAVMPQVIKGELERAMMQLHRNP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=176, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=52.2842639593909, Blast_Score=173, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22268; Mature: 22268

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGTTLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCEEEE
LEPQTYMNRSGQSVVALAQFFKILPDEILVAHDELDMPPGSVKLKLGGGSGGHNGLKDIT
ECCHHHHCCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGARPDVANYVLKPPRREEQDVIDASIERALAV
HHHCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
MPQVIKGELERAMMQLHRNP
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGTTLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCEEEE
LEPQTYMNRSGQSVVALAQFFKILPDEILVAHDELDMPPGSVKLKLGGGSGGHNGLKDIT
ECCHHHHCCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGARPDVANYVLKPPRREEQDVIDASIERALAV
HHHCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHH
MPQVIKGELERAMMQLHRNP
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA