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The map label for this gene is ctaB

Identifier: 91781684

GI number: 91781684

Start: 333288

End: 334193

Strand: Direct

Name: ctaB

Synonym: Bxe_A4162

Alternate gene names: 91781684

Gene position: 333288-334193 (Clockwise)

Preceding gene: 91781683

Following gene: 91781685

Centisome position: 6.81

GC content: 63.69

Gene sequence:

>906_bases
ATGGACAGCACAACACTTTCCCAAACGCCCGGTAGCCGGGTCTCCCAGTACATCGCCCTGACGAAGCCGCGCGTCACGCA
ACTCGCCGTGTTCTGCGCAGTCATCGGCATGTTCCTGTCGACGCCCGGCATGGTGCCGTGGACTCCGCTGATCGGCGGCA
CGGTCGGCATCTGGTTGCTGGCCGGCGCGGCGTTCGCCATCAATTGCCTCGTCGAACAGAAAATCGACGCGAAGATGCGC
CGCACCTCGTGGCGTCCATCCGCGCGCGGCGAAATCACCACCGCGCAGATTCTGCTGTTCTCGGCCGTGCTCGGCGGCCT
CGGCATGTGGACGCTGTACACGTTCGCCAATCCGCTCACCATGTGGCTCACACTGGCCACGTTCGTGGGCTATGCGGTCA
TCTATACGCTGCTGCTCAAGCCTGCCACGCCGCAGAACATCGTGATCGGCGGCGCCTCGGGCGCCATGCCGCCGGCGCTC
GGTTGGGCGGCGGTCACCGGCCATGTGCCGGGCGACGCGTGGATTCTGGTGCTGATCATCTTCGTGTGGACGCCGCCGCA
TTTCTGGGCGCTCGCGCTGTATCGCCGCAAAGACTACGAAAACGCCGGCCTGCCTATGCTGCCGAACACGCACGGCGAGA
AGTACACGCGCCTGCATATTCTGCTGTACACGGTCATCCTGTTCGCGGTCACCATGATGCCCTTCATCTCCGGCATGAGC
GGCGTGGTGTACCTCGCGGCGGCCGTGCTGCTGGGCGCCTTGTTCCTTGCCTATGCGTGGAAGATCTATCGGGAGTACTC
GGACGATCTGGCGCGCAAGACTTTCCGTTATTCGATCGTCTATCTCTCGCTGCTGTTTGCGGCGCTGCTGATCGACCACT
ATGCGCGCGTCCTGATCGGCGCGTAA

Upstream 100 bases:

>100_bases
CCTGCTGCTTCTGCTCGTTATGTTAAACTTTCGGATCGCTTATAGCCGTCCCGGCCGCGCCGTGTTCCCAGCGCGCGATG
CCGCGCCAGCGTGACTCCAC

Downstream 100 bases:

>100_bases
TACCATGCTCAAAAACCGCTTCGCGCGTACGGCGCGTGCTGCCGTGATAGCCTGCGCGCTCGGCGGCGCCTTGCTGGTGG
CGGGCTGCGGCAAGCAGCCG

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLLAGAAFAINCLVEQKIDAKMR
RTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLTMWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPAL
GWAAVTGHVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
GVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIGA

Sequences:

>Translated_301_residues
MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLLAGAAFAINCLVEQKIDAKMR
RTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLTMWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPAL
GWAAVTGHVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
GVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIGA
>Mature_301_residues
MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLLAGAAFAINCLVEQKIDAKMR
RTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLTMWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPAL
GWAAVTGHVPGDAWILVLIIFVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
GVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=35.4166666666667, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71998235, Length=286, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6325085, Length=280, Percent_Identity=31.0714285714286, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=30.9859154929577, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_BURXL (Q146A1)

Other databases:

- EMBL:   CP000270
- RefSeq:   YP_556890.1
- GeneID:   4001876
- GenomeReviews:   CP000270_GR
- KEGG:   bxe:Bxe_A4162
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33059; Mature: 33059

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x129ec8fc)-; HASH(0x14a4d7b4)-; HASH(0x1511370c)-; HASH(0x145513a8)-; HASH(0x146ae428)-; HASH(0x15652ab0)-; HASH(0x150950c0)-; HASH(0x151f6130)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLL
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AGAAFAINCLVEQKIDAKMRRTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGHVPGDAWILVLII
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
FVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
A
H
>Mature Secondary Structure
MDSTTLSQTPGSRVSQYIALTKPRVTQLAVFCAVIGMFLSTPGMVPWTPLIGGTVGIWLL
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AGAAFAINCLVEQKIDAKMRRTSWRPSARGEITTAQILLFSAVLGGLGMWTLYTFANPLT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWLTLATFVGYAVIYTLLLKPATPQNIVIGGASGAMPPALGWAAVTGHVPGDAWILVLII
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHH
FVWTPPHFWALALYRRKDYENAGLPMLPNTHGEKYTRLHILLYTVILFAVTMMPFISGMS
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GVVYLAAAVLLGALFLAYAWKIYREYSDDLARKTFRYSIVYLSLLFAALLIDHYARVLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
A
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA