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The map label for this gene is thlA [H]

Identifier: 91781591

GI number: 91781591

Start: 240168

End: 241376

Strand: Reverse

Name: thlA [H]

Synonym: Bxe_A4255

Alternate gene names: 91781591

Gene position: 241376-240168 (Counterclockwise)

Preceding gene: 91781592

Following gene: 91781590

Centisome position: 4.93

GC content: 65.92

Gene sequence:

>1209_bases
ATGAGTGAGACACACATGAGCGGGACAAAAGCTGATCCGATCGTCATCGTGGGCGTGGCCCGCACGCCGATGGCGGCATT
CCAGGGCGACTTCGCCACGCTGAGCGCGCCGCAATTGGGTTCGGTGGCAATCCAGGCGGCCGTGCAGCGCGCCGGCCTTA
AACCCGAACAGATCGACGAAGTGGTGATGGGTTGCGTGCTGCCCGCCGGCCTCGGCCAGGCGCCCGCGCGTCAGGCCGCG
CTCGGCGCCGGCTTGCCGCTCGCCACCGGCAGCACCACGGTGAACAAGATGTGCGGCTCAGGCATGCGCGCGGCCATGTT
CGCGCACGACATGCTCGCCGCGGGTTCCGTCGACGTGATCGTTGCGGGCGGCATGGAAAGCATGACGAACGCGCCGTATC
TGCTGCCCAAAGCGCGGGCGGGAATGCGCATGGGCCACGGTCAGGTGATCGACCACATGTTCTACGACGGTCTCGAAGAC
GCCTATGAAAAAGGCCGTCTGATGGGCTCCTTCGCCGAGGAATGCGCGGCTTCGTTCGACTTCACGCGCGAGGCGCAGGA
CGCGTTCGCCGTCGAGTCGCTCGCTCGTGCTAAGCGTGCGAACGAGGACGGTTCGTTCGCCTGGGAAATCGCGCCGGTGA
AAGTGGAGAGCCGCAAGGGCGAAGTCACCATCGATCGCGACGAACAGCCGTTCAAAGCGAACATCGAGAAGATTCCGACG
CTCAAGCCCGCGTTCAGCAAAACCGGCACCGTGACGGCGGCGAACTCGTCGTCGATTTCCGACGGCGCGGCCGCGCTCGT
CATGATGCGCGAGTCGACGGCGAAGCGCCTGGGCGTCCAGCCGATTGCGCGCGTGGTCGGCCACTCGACCCTCGCGCAGG
AACCGGCGAAGTTCACCACCGCGCCGGTCGGCGCGATTCGCAAGCTGTTCGAGAAGAACGGCTGGCGCGCCGACGAAGTC
GATCTGTTTGAAGTCAACGAAGCCTTTGCTGTCGTGACGATGGCCGCCATGAAGGAGCACCATCTGCCGCACGAGAAGGT
CAACGTGAACGGCGGCGCCTGTGCGCTCGGCCACCCGATCGGCGCGTCGGGCGCGCGCATTCTCGTCACGCTGATCGGCG
CGCTGAAAAAGCGCGGCGGCAAGCGCGGCGTCGCGACGCTGTGTATCGGCGGCGGCGAAGCGACGGCAATGGGTATCGAA
CTCGTGTAA

Upstream 100 bases:

>100_bases
GGCGGCGCACACAACGCGGACAACGACGTGGTGGCCGCCGACGCGGCGCAGCTCGGCGACGTGCCGGCCATTGTCGAAGG
CGTCATCAAGGAGCTTAAAC

Downstream 100 bases:

>100_bases
CGCGCGTTTTCGCGGCGCTCTGTTTTGATGGCTTGAGGTGTTCGATGAAGACTGTGTTGATCGTCGGTGCGTCGCGTGGC
ATTGGCCAGGAGTTTGTGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSETHMSGTKADPIVIVGVARTPMAAFQGDFATLSAPQLGSVAIQAAVQRAGLKPEQIDEVVMGCVLPAGLGQAPARQAA
LGAGLPLATGSTTVNKMCGSGMRAAMFAHDMLAAGSVDVIVAGGMESMTNAPYLLPKARAGMRMGHGQVIDHMFYDGLED
AYEKGRLMGSFAEECAASFDFTREAQDAFAVESLARAKRANEDGSFAWEIAPVKVESRKGEVTIDRDEQPFKANIEKIPT
LKPAFSKTGTVTAANSSSISDGAAALVMMRESTAKRLGVQPIARVVGHSTLAQEPAKFTTAPVGAIRKLFEKNGWRADEV
DLFEVNEAFAVVTMAAMKEHHLPHEKVNVNGGACALGHPIGASGARILVTLIGALKKRGGKRGVATLCIGGGEATAMGIE
LV

Sequences:

>Translated_402_residues
MSETHMSGTKADPIVIVGVARTPMAAFQGDFATLSAPQLGSVAIQAAVQRAGLKPEQIDEVVMGCVLPAGLGQAPARQAA
LGAGLPLATGSTTVNKMCGSGMRAAMFAHDMLAAGSVDVIVAGGMESMTNAPYLLPKARAGMRMGHGQVIDHMFYDGLED
AYEKGRLMGSFAEECAASFDFTREAQDAFAVESLARAKRANEDGSFAWEIAPVKVESRKGEVTIDRDEQPFKANIEKIPT
LKPAFSKTGTVTAANSSSISDGAAALVMMRESTAKRLGVQPIARVVGHSTLAQEPAKFTTAPVGAIRKLFEKNGWRADEV
DLFEVNEAFAVVTMAAMKEHHLPHEKVNVNGGACALGHPIGASGARILVTLIGALKKRGGKRGVATLCIGGGEATAMGIE
LV
>Mature_401_residues
SETHMSGTKADPIVIVGVARTPMAAFQGDFATLSAPQLGSVAIQAAVQRAGLKPEQIDEVVMGCVLPAGLGQAPARQAAL
GAGLPLATGSTTVNKMCGSGMRAAMFAHDMLAAGSVDVIVAGGMESMTNAPYLLPKARAGMRMGHGQVIDHMFYDGLEDA
YEKGRLMGSFAEECAASFDFTREAQDAFAVESLARAKRANEDGSFAWEIAPVKVESRKGEVTIDRDEQPFKANIEKIPTL
KPAFSKTGTVTAANSSSISDGAAALVMMRESTAKRLGVQPIARVVGHSTLAQEPAKFTTAPVGAIRKLFEKNGWRADEVD
LFEVNEAFAVVTMAAMKEHHLPHEKVNVNGGACALGHPIGASGARILVTLIGALKKRGGKRGVATLCIGGGEATAMGIEL
V

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=45.5223880597015, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=45.29262086514, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=36.2467866323907, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=35.8974358974359, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI4504327, Length=439, Percent_Identity=31.6628701594533, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI194353979, Length=388, Percent_Identity=28.3505154639175, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=43.8144329896907, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1788554, Length=389, Percent_Identity=49.6143958868895, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI1787663, Length=392, Percent_Identity=37.2448979591837, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=36.6336633663366, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=30.2663438256659, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=44.6153846153846, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=41.8181818181818, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=39.7435897435897, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=34.6835443037975, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=33.0166270783848, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.7236180904523, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=31.9899244332494, Blast_Score=179, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=44.987146529563, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=45.4314720812183, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=35.3689567430025, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=32.541567695962, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41977; Mature: 41846

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETHMSGTKADPIVIVGVARTPMAAFQGDFATLSAPQLGSVAIQAAVQRAGLKPEQIDE
CCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
VVMGCVLPAGLGQAPARQAALGAGLPLATGSTTVNKMCGSGMRAAMFAHDMLAAGSVDVI
HHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCEEEE
VAGGMESMTNAPYLLPKARAGMRMGHGQVIDHMFYDGLEDAYEKGRLMGSFAEECAASFD
EECCHHHHCCCCEECCCHHCCCCCCCHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHCC
FTREAQDAFAVESLARAKRANEDGSFAWEIAPVKVESRKGEVTIDRDEQPFKANIEKIPT
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEECCCCCCHHCCHHHCCC
LKPAFSKTGTVTAANSSSISDGAAALVMMRESTAKRLGVQPIARVVGHSTLAQEPAKFTT
CCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCHHHHHHHHCCHHHHCCCCHHCC
APVGAIRKLFEKNGWRADEVDLFEVNEAFAVVTMAAMKEHHLPHEKVNVNGGACALGHPI
CCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCC
GASGARILVTLIGALKKRGGKRGVATLCIGGGEATAMGIELV
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure 
SETHMSGTKADPIVIVGVARTPMAAFQGDFATLSAPQLGSVAIQAAVQRAGLKPEQIDE
CCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
VVMGCVLPAGLGQAPARQAALGAGLPLATGSTTVNKMCGSGMRAAMFAHDMLAAGSVDVI
HHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCEEEE
VAGGMESMTNAPYLLPKARAGMRMGHGQVIDHMFYDGLEDAYEKGRLMGSFAEECAASFD
EECCHHHHCCCCEECCCHHCCCCCCCHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHCC
FTREAQDAFAVESLARAKRANEDGSFAWEIAPVKVESRKGEVTIDRDEQPFKANIEKIPT
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEECCCCCCHHCCHHHCCC
LKPAFSKTGTVTAANSSSISDGAAALVMMRESTAKRLGVQPIARVVGHSTLAQEPAKFTT
CCCCCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCHHHHHHHHCCHHHHCCCCHHCC
APVGAIRKLFEKNGWRADEVDLFEVNEAFAVVTMAAMKEHHLPHEKVNVNGGACALGHPI
CCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCC
GASGARILVTLIGALKKRGGKRGVATLCIGGGEATAMGIELV
CCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]