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The map label for this gene is mvaB [H]

Identifier: 91781575

GI number: 91781575

Start: 224738

End: 225667

Strand: Reverse

Name: mvaB [H]

Synonym: Bxe_A4270

Alternate gene names: 91781575

Gene position: 225667-224738 (Counterclockwise)

Preceding gene: 91781576

Following gene: 91781574

Centisome position: 4.61

GC content: 64.73

Gene sequence:

>930_bases
ATGGCCCTACCCCAGCAAGTGAAAATCGTCGAAGTCGGTCCGCGTGACGGACTGCAGAACGAAAAAGAATTCGTGCCCAC
CGCGACCAAGATCGAGCTGATCAACCGGTTGTCGGCGGCGGGCTTCCGTAACGTCGAGGCCGCTTCGTTCGTGTCGCCGA
AATGGGTGCCGCAAATGGCGGACGGCGCCGACGTGATGGCCGGTATCGAACGGCGCCCCGGCACGATCTACTCGGTGCTG
ACGCCCAACCTGCGCGGCTTCGAGGGCGCGCTCGCCGCGCGTGCCGACGAGATCGTGATTTTCGGCGCCGCCAGCGAAGC
GTTCTCGCAGAAGAACATCAATTGCAGCATCGCGGAAAGCATCGGCCGGTTCGCGCCCGTCGCGCAGGCGGCCAAGGAGC
ACGGCGTGCGGATTCGCGGCAGCGTCTCTTGCGCGCTGGGCTGTCCGTATCAGGGTGAAGTGCCGGTGGCGTCGGTGGTG
GACGTCGTCGAGCGCTTCGCCGCGCTCGGCTGCGACGAAATCGATATCGCCGATACGATCGGTGTGGGCACGCCCAAGCG
CACGCGTGAAGTGTTCGAAGCGGTCACGCGGGTGTTTCCGCGCGAACGCCTGTCGGGCCACTTCCACGATACCTATGGTC
AGGCACTCGCCAATATCTACGCGGCGTTGCTGGAAGGCATCGAGATCTATCACGCGTCGGTGGCGGGCCTCGGCGGCTGT
CCGTATGCGAAGGGCGCGACCGGCAACGTCGCAACCGAAGACGTGCTGTATCTGATGAACGGCCTCGGCATCGAAACCGG
CATCGATCTCGCGCAAGTCGTCGCGATCGGCGATTTCATCTCGACCTCGATCGGCCGGCCCAATGTGTCGCGCGCCGGTA
AAGCGCTGCTCGCCAAAGCGCGCAGCGAAGCAGCGGCGAACTGCGTCTGA

Upstream 100 bases:

>100_bases
TGGCGGAGTGGTGAATCTGGAACGCGGATACTGAACACAGCCAATCCCATTGAAGGAGCGCCGCCACGCGCGGCGTCAAC
GAGTTGCATGGAGACAGATC

Downstream 100 bases:

>100_bases
CGCCGGCCCGGCGCATGCGCCCGGCACTCATGCCAACTGTCATGCCAACACTCAGGACCTGAAACGATGACGGACCACGC
TTCTCCCGAAACCGACGATC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMADGADVMAGIERRPGTIYSVL
TPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAESIGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVV
DVVERFAALGCDEIDIADTIGVGTPKRTREVFEAVTRVFPRERLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC
PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAKARSEAAANCV

Sequences:

>Translated_309_residues
MALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMADGADVMAGIERRPGTIYSVL
TPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAESIGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVV
DVVERFAALGCDEIDIADTIGVGTPKRTREVFEAVTRVFPRERLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC
PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAKARSEAAANCV
>Mature_308_residues
ALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMADGADVMAGIERRPGTIYSVLT
PNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAESIGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVVD
VVERFAALGCDEIDIADTIGVGTPKRTREVFEAVTRVFPRERLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGCP
YAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAKARSEAAANCV

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=56.3139931740614, Blast_Score=347, Evalue=6e-96,
Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=55.2901023890785, Blast_Score=347, Evalue=6e-96,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=56.3139931740614, Blast_Score=347, Evalue=6e-96,
Organism=Homo sapiens, GI260654708, Length=293, Percent_Identity=39.2491467576792, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17510563, Length=296, Percent_Identity=49.6621621621622, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=57.3883161512027, Blast_Score=358, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32532; Mature: 32401

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMA
CCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
DGADVMAGIERRPGTIYSVLTPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCCEEEEECCHHHHHHCCCCCHHHHH
IGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVVDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPKRTREVFEAVTRVFPRERLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC
CCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAKA
CCCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RSEAAANCV
HHHHHCCCC
>Mature Secondary Structure 
ALPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAASFVSPKWVPQMA
CCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
DGADVMAGIERRPGTIYSVLTPNLRGFEGALAARADEIVIFGAASEAFSQKNINCSIAES
CCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCCEEEEECCHHHHHHCCCCCHHHHH
IGRFAPVAQAAKEHGVRIRGSVSCALGCPYQGEVPVASVVDVVERFAALGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPKRTREVFEAVTRVFPRERLSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGGC
CCCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYLMNGLGIETGIDLAQVVAIGDFISTSIGRPNVSRAGKALLAKA
CCCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RSEAAANCV
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]