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The map label for this gene is lhgO [H]

Identifier: 91781512

GI number: 91781512

Start: 153781

End: 154887

Strand: Direct

Name: lhgO [H]

Synonym: Bxe_A4334

Alternate gene names: 91781512

Gene position: 153781-154887 (Clockwise)

Preceding gene: 91781511

Following gene: 91781513

Centisome position: 3.14

GC content: 65.58

Gene sequence:

>1107_bases
ATGGACCAAATCGAATGTGTAGTGATCGGCGCTGGCGTGGTCGGTCTCGCGGTGGCGCGCGCGTTGGCTGCGCGCGGCCG
CGAAGTGATCGTGCTGGAAGCGGCGGAGGCGATCGGCGTGGGCACCAGCTCGCGCAACAGCGAGGTGATTCACGCGGGCA
TCTACTATCCGCGCGGCTCGCTCAAAGCGGCGCTTTGCGTGCGCGGCCGCGAGATGCTCTACGACTACTGCGTCGAGCGT
AAGGTGCCGCATTCGCGCTGCGGCAAATTACTGGTCGCCACCTCGCGCAACCAGATTCCCCAGCTCGAAAACATCATGGC
CAAAGGCCGCGACAACGGCGTGCTCGACCTGATGCGAATCACCGGCGACCAGGCGCAAGCCCTCGAACCCGCGCTCGAGT
GCGTCGAAGCGGTGTTCTCGCCGCAGACGGGCATCGTCGATAGTCATCAGTTCATGCTGGCGCTGCAGGGTGACGCCGAA
CGCGACGGCGCGGTGTGCGCGTTTCACGCGCCGGTGCAGGGGATCGAAGCGAGCAATGGCCGCTTCAACATCCAGGTGGG
CGGTGACGCGCCGACCACGATCAGCGCCGCCTGCGTGATCAACAGCGCCGGCCTGCAGGCGAATGCACTGGCCCGCAAGA
TTCGCGGACTCGACGCGCGGCATGTGCCGCCGCTCTATCTCGCGCGCGGCAACTACTTCAGCATCTCCGGGCGCGCGCCA
TTCAGCCGCCTGATTTACCCGATGCCGAATGAAGCCGGTCTCGGCGTGCATCTGACCATCGACCTGGGCGGGCAGGCGCG
TTTCGGTCCCGACGTCGAATGGGTCGATGCGATCAATTACGATGTCGATCCGCGTCGCGCGGAATCGTTTTACGCGGCGA
TTCGCGCCTATTGGCCCGCGCTTCCGGACAATGCATTGCAGCCCGCTTATGCGGGGATTCGTCCGAAGCTTTCCGGTCCC
GGCGAACCTGCCGCCGACTTCCTGATTCAAGGCCCGGCCGCGCACGGCGTACGTGGACTGGTGAATCTGTTCGGTATCGA
GTCGCCGGGATTGACGGCGTCGCTCGCCATCGCGCAGCGCGTGTGCGAACTGAGCGGCCGCGCGTAA

Upstream 100 bases:

>100_bases
TCGACAGCGCGCGGTGTACGGCACGCGTCGGACGCATCCTGTCTTCATCTTGATCGGGCGAACGAGGCAGCGCGCGGCGA
AGTCGGCCGCGTCAAGGGAC

Downstream 100 bases:

>100_bases
TTCGCGCGGTTCACGCGCCTCGCGTATCGCTGCGAGGTCACGGTAAGTGCCCGACTCGCGCGTAATCTCGCGCGTGATCG
ATCCGCATTGCGCGCGACCT

Product: putative FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MDQIECVVIGAGVVGLAVARALAARGREVIVLEAAEAIGVGTSSRNSEVIHAGIYYPRGSLKAALCVRGREMLYDYCVER
KVPHSRCGKLLVATSRNQIPQLENIMAKGRDNGVLDLMRITGDQAQALEPALECVEAVFSPQTGIVDSHQFMLALQGDAE
RDGAVCAFHAPVQGIEASNGRFNIQVGGDAPTTISAACVINSAGLQANALARKIRGLDARHVPPLYLARGNYFSISGRAP
FSRLIYPMPNEAGLGVHLTIDLGGQARFGPDVEWVDAINYDVDPRRAESFYAAIRAYWPALPDNALQPAYAGIRPKLSGP
GEPAADFLIQGPAAHGVRGLVNLFGIESPGLTASLAIAQRVCELSGRA

Sequences:

>Translated_368_residues
MDQIECVVIGAGVVGLAVARALAARGREVIVLEAAEAIGVGTSSRNSEVIHAGIYYPRGSLKAALCVRGREMLYDYCVER
KVPHSRCGKLLVATSRNQIPQLENIMAKGRDNGVLDLMRITGDQAQALEPALECVEAVFSPQTGIVDSHQFMLALQGDAE
RDGAVCAFHAPVQGIEASNGRFNIQVGGDAPTTISAACVINSAGLQANALARKIRGLDARHVPPLYLARGNYFSISGRAP
FSRLIYPMPNEAGLGVHLTIDLGGQARFGPDVEWVDAINYDVDPRRAESFYAAIRAYWPALPDNALQPAYAGIRPKLSGP
GEPAADFLIQGPAAHGVRGLVNLFGIESPGLTASLAIAQRVCELSGRA
>Mature_368_residues
MDQIECVVIGAGVVGLAVARALAARGREVIVLEAAEAIGVGTSSRNSEVIHAGIYYPRGSLKAALCVRGREMLYDYCVER
KVPHSRCGKLLVATSRNQIPQLENIMAKGRDNGVLDLMRITGDQAQALEPALECVEAVFSPQTGIVDSHQFMLALQGDAE
RDGAVCAFHAPVQGIEASNGRFNIQVGGDAPTTISAACVINSAGLQANALARKIRGLDARHVPPLYLARGNYFSISGRAP
FSRLIYPMPNEAGLGVHLTIDLGGQARFGPDVEWVDAINYDVDPRRAESFYAAIRAYWPALPDNALQPAYAGIRPKLSGP
GEPAADFLIQGPAAHGVRGLVNLFGIESPGLTASLAIAQRVCELSGRA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=273, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082148, Length=249, Percent_Identity=30.5220883534137, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17565764, Length=281, Percent_Identity=33.0960854092527, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585081, Length=400, Percent_Identity=30.75, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39047; Mature: 39047

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQIECVVIGAGVVGLAVARALAARGREVIVLEAAEAIGVGTSSRNSEVIHAGIYYPRGS
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKAALCVRGREMLYDYCVERKVPHSRCGKLLVATSRNQIPQLENIMAKGRDNGVLDLMRI
CCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEE
TGDQAQALEPALECVEAVFSPQTGIVDSHQFMLALQGDAERDGAVCAFHAPVQGIEASNG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
RFNIQVGGDAPTTISAACVINSAGLQANALARKIRGLDARHVPPLYLARGNYFSISGRAP
EEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCC
FSRLIYPMPNEAGLGVHLTIDLGGQARFGPDVEWVDAINYDVDPRRAESFYAAIRAYWPA
HHHCEECCCCCCCCEEEEEEEECCCCCCCCCCCEEHCCCCCCCHHHHHHHHHHHHHHCCC
LPDNALQPAYAGIRPKLSGPGEPAADFLIQGPAAHGVRGLVNLFGIESPGLTASLAIAQR
CCCCCCCCHHCCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VCELSGRA
HHHHCCCC
>Mature Secondary Structure
MDQIECVVIGAGVVGLAVARALAARGREVIVLEAAEAIGVGTSSRNSEVIHAGIYYPRGS
CCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKAALCVRGREMLYDYCVERKVPHSRCGKLLVATSRNQIPQLENIMAKGRDNGVLDLMRI
CCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEE
TGDQAQALEPALECVEAVFSPQTGIVDSHQFMLALQGDAERDGAVCAFHAPVQGIEASNG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
RFNIQVGGDAPTTISAACVINSAGLQANALARKIRGLDARHVPPLYLARGNYFSISGRAP
EEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCC
FSRLIYPMPNEAGLGVHLTIDLGGQARFGPDVEWVDAINYDVDPRRAESFYAAIRAYWPA
HHHCEECCCCCCCCEEEEEEEECCCCCCCCCCCEEHCCCCCCCHHHHHHHHHHHHHHCCC
LPDNALQPAYAGIRPKLSGPGEPAADFLIQGPAAHGVRGLVNLFGIESPGLTASLAIAQR
CCCCCCCCHHCCCCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VCELSGRA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]