| Definition | Escherichia coli UTI89 chromosome, complete genome. |
|---|---|
| Accession | NC_007946 |
| Length | 5,065,741 |
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The map label for this gene is patB [H]
Identifier: 91213925
GI number: 91213925
Start: 4881012
End: 4882190
Strand: Direct
Name: patB [H]
Synonym: UTI89_C4977
Alternate gene names: 91213925
Gene position: 4881012-4882190 (Clockwise)
Preceding gene: 91213919
Following gene: 91213926
Centisome position: 96.35
GC content: 40.46
Gene sequence:
>1179_bases ATGAAAGTTTATAATTTTGATAAAGTTATTTCACGCGACGGAACCTATAGCGCTAAATATAATAACAAGGGGCATGACAT CATTCCTCTGTCTGTAGCTGATATGGATATTCCTGTAGCTGATTTTATAGTTTCTGAATTATCTGTCGCAAATCAGAAAG GTATCTACGGTTATACATTATTAAGTGATGACTGGCAGCAAGTGGCAGCACAGTGGTATCAACGCCATTACTCGTGGAAG GTCAACCCTGAACACATTGTTTTTTGCCCACGGGTAGTACAGGCCGTCTCATTATTTATCCAGAACTTTACCCAACCGGG AGATGCTATTGTCAGCCTGACACCAGCCTATCATCCTATTAGTCATGCAGTTGAAGTCAACCATCGAGTATTGCTGGAAA GTGCGTTACTTTATCGTGACCACCACTATGAAATAGACTTTGCGGATCTCGAAGATAAGTTTAAAATGGCTTGTTGTTTC ATTCTAATATCGCCGCATAATCCAACAGGAACAATCTGGTCAGAAGACAATCTAAGGAAAATAGCTTCATTAGCAGAAAA ATATAATATTTTTATTATTTCTGATGATGTTCATGCAGACTTCAACTTCACCCAAAAACAACATCAAACAATTTCTTCTA TAAGCTCATACGTTGCACAAAACTCGTTTATTTGTACATCTCCAGCAAAAACTTTTAATATGGCCGGACTTGAAATCGCA AATATTGTTATTGCTAACGATAAATATCGTGAACAGTTTAAATTAGCTCTTATTGCAGCAGGTATCCATAATCCTGGTTA TTTCTCTGTTCCTGCATTTCTCTGTGCTTACCGCCATGGCGATTCTTGGTTAGCAGCATTAAAAGATTATTTGGTCGAAA ACAGGAGCTGGGTTCAATCATTCTGCCAAGCTCATTTTCCAGACTGGTTTGTCGCCTCTGGTGGCGGAACTTACATGTTG TGGATCGACTACCGGGCAATGAACATCAGCGAAGAGCAACTACGCCATTGGTTTGTCTCGCTCGCAGGTGTTGAGATGAG CTGGGGATCAGATTTTGGCGATGAAGGACTTGGTTTTTTCCGTGTGAACATAGCCACGCCGAGAAGCAATCTTACACAAG CATTTGAACGGATTTATCAGAGCATCCCCTTCACTACAGGAGTTTCCCTTCATGAATAA
Upstream 100 bases:
>100_bases ATATGCAAATTTTCATAATAACGAAAACAAAATACAGAATAACACTTCCTCCCTCGATATATTACGTTACCCTAACGATA AAATCGGGCGAGTAACAAAT
Downstream 100 bases:
>100_bases TAACAATACTCCAAGATCCCCAACTCTGGTGGAATCATTATTACCAATACTAGCGATGATACTATTGCTGGGATTTGGTT ATGCGGCATTCGATCTGCCA
Product: hypothetical protein
Products: NA
Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]
Number of amino acids: Translated: 392; Mature: 392
Protein sequence:
>392_residues MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE
Sequences:
>Translated_392_residues MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE >Mature_392_residues MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTLLSDDWQQVAAQWYQRHYSWK VNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPISHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCF ILISPHNPTGTIWSEDNLRKIASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQSFCQAHFPDWFVASGGGTYML WIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFFRVNIATPRSNLTQAFERIYQSIPFTTGVSLHE
Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]
COG id: COG1168
COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]
Homologues:
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=28.7917737789203, Blast_Score=197, Evalue=1e-51, Organism=Escherichia coli, GI1786816, Length=325, Percent_Identity=21.8461538461538, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1787710, Length=295, Percent_Identity=23.0508474576271, Blast_Score=67, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004839 - InterPro: IPR015424 - InterPro: IPR015421 - InterPro: IPR015422 [H]
Pfam domain/function: PF00155 Aminotran_1_2 [H]
EC number: =4.4.1.8 [H]
Molecular weight: Translated: 44634; Mature: 44634
Theoretical pI: Translated: 6.07; Mature: 6.07
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTL CCEECCHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE LSDDWQQVAAQWYQRHYSWKVNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPI ECCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH SHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCFILISPHNPTGTIWSEDNLRK HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHEEEEEEEEEECCCCCCCEECCCHHHH IASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA HHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCEEEE NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQS EEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH FCQAHFPDWFVASGGGTYMLWIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFF HHHHCCCCEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCCCEEE RVNIATPRSNLTQAFERIYQSIPFTTGVSLHE EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC >Mature Secondary Structure MKVYNFDKVISRDGTYSAKYNNKGHDIIPLSVADMDIPVADFIVSELSVANQKGIYGYTL CCEECCHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEE LSDDWQQVAAQWYQRHYSWKVNPEHIVFCPRVVQAVSLFIQNFTQPGDAIVSLTPAYHPI ECCHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH SHAVEVNHRVLLESALLYRDHHYEIDFADLEDKFKMACCFILISPHNPTGTIWSEDNLRK HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHEEEEEEEEEECCCCCCCEECCCHHHH IASLAEKYNIFIISDDVHADFNFTQKQHQTISSISSYVAQNSFICTSPAKTFNMAGLEIA HHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCEEEE NIVIANDKYREQFKLALIAAGIHNPGYFSVPAFLCAYRHGDSWLAALKDYLVENRSWVQS EEEEECCHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHH FCQAHFPDWFVASGGGTYMLWIDYRAMNISEEQLRHWFVSLAGVEMSWGSDFGDEGLGFF HHHHCCCCEEEECCCCEEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCCCEEE RVNIATPRSNLTQAFERIYQSIPFTTGVSLHE EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8497199; 9274030; 9384377 [H]