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The map label for this gene is atoB [H]

Identifier: 91211518

GI number: 91211518

Start: 2462412

End: 2463596

Strand: Direct

Name: atoB [H]

Synonym: UTI89_C2506

Alternate gene names: 91211518

Gene position: 2462412-2463596 (Clockwise)

Preceding gene: 91211517

Following gene: 91211525

Centisome position: 48.61

GC content: 53.33

Gene sequence:

>1185_bases
ATGAAAAATTGTGTCATCGTCAGTGCGGTACGTACTGCTATCGGTAGTTTTAACGGTTCACTCGCTTCCACCAGCGCCAT
CGACCTGGGGGCGACAGTAATTAAAGCCGCCATTGAACGTGCAAAAATCGATTCACTACACGTTGATGAAGTGATTATGG
GTAACGTGTTGCAAGCCGGACTGGGGCAAAATCCGGCACGTCAGGCGCTGCTAAAAAGCGGACTGGCTGAAACGGTGTGC
GGATTCACGGTCAATAAAGTGTGTGGTTCGGGTCTTAAAAGTGTGGCGCTTGCCGCCCAGGCAATTCAGGCAGGTCAGGC
GCAGAGCATTGTGGCGGGGGGTATGGAAAATATGAGTTTAGCGCCCTACTTACTCGATGCAAAAGCACGCTCTGGTTATC
GTCTTGGAGACGGACAGGTTTATGACGTAATCCTGCGCGATGGTCTGATGTGCGCCACCCATGGTTATCATATGGGGATT
ACCGCCGAAAACGTGGCTAAAGAGTACGGAATTACCCGTGAAATGCAGGATGAACTGGCGCTACATTCACAGCGTAAAGC
GGCAGCCGCAATTGAGTCCGGTGCTTTTACAGCCGAAATCGTCCCGGTAAATGTTGTCACTCGGAAGAAAACCTTCGTCT
TCAGTCAAGACGAATTCCCGAAAGCGGATTCTACGGCTGAAGCGTTAGGCGCATTGCGCCCGGCCTTCGATAAAGCAGGA
ACAGTCACCGCCGGGAACGCGTCTGGCATTAACGACGGTGCTGCCGCTCTGGTGATTATGGAAGAATCTTCGGCGCTGGC
AGCAGGCCTTACCCCCCTGGCTCGCATTAAAAGTTATGCCAGCGGTGGCGTGCCCCCCGCATTGATGGGTATGGGGCCAG
TACCTGCCACGCAAAAAGCGTTACAACTGGCGGGGCTGCAACTGGCGGATATTGATCTCATTGAGGCTAATGAAGCATTT
GCTGCACAGTTCCTTGCCGTTGGGAAAACCCTGGGCTTTGAGCCTGAGAAAGTGAATGTCAACGGCGGGGCCATCGCGCT
GGGGCATCCTATCGGTGCCAGTGGTGCTCGTATTCTGGTCACACTATTACATGCAATGCAGGCACGCGATAAAACGCTGG
GGCTGGCAACACTGTGCATTGGTGGCGGCCAGGGAATTGCGATGGTGATTGAACGATTGAATTAA

Upstream 100 bases:

>100_bases
CATGGGCTATTGCATCACTGCCCTGCTCTTCTCCGGCGTCATTTTCGTCATTGGTTTAACGCTGTTCTGACGGCAACCCT
ACAGACAGAAGGAATATAAA

Downstream 100 bases:

>100_bases
CATGTAAAAACGCCCGATAGCGAAAGTCATCGGGCGTTTTCTTGAACATTGACAGTAAAGATAACCTCATTAATCACCAG
TCAAAACTTTTCACCAGCGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKADSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESSALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFEPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Sequences:

>Translated_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKADSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESSALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFEPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
>Mature_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKADSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMEESSALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFEPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=54.3589743589744, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=42.9292929292929, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=44.4444444444444, Blast_Score=301, Evalue=6e-82,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=41.3965087281795, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=32.9411764705882, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=32.5757575757576, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=98.4771573604061, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=57.9081632653061, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.5445544554455, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=42.962962962963, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=35.4609929078014, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=46.0559796437659, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=43.5114503816794, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=42.8934010152284, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=33.6633663366337, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.6291079812207, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.7236180904523, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=37.5314861460957, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=52.5380710659898, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.5648854961832, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=43.1122448979592, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.5294117647059, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40366; Mature: 40366

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELA
CCEEEECCCCCCCCCCCCCEEEEHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKADSTAEALGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
TVTAGNASGINDGAAALVIMEESSALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCCHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFEPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELA
CCEEEECCCCCCCCCCCCCEEEEHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNVVTRKKTFVFSQDEFPKADSTAEALGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCC
TVTAGNASGINDGAAALVIMEESSALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCCHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFEPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]