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The map label for this gene is trxA3 [H]

Identifier: 89898731

GI number: 89898731

Start: 1067887

End: 1068195

Strand: Direct

Name: trxA3 [H]

Synonym: CF0924

Alternate gene names: 89898731

Gene position: 1067887-1068195 (Clockwise)

Preceding gene: 89898691

Following gene: 89898737

Centisome position: 91.57

GC content: 38.51

Gene sequence:

>309_bases
ATGGTCAAAGTCGTATCTGCTGAAAATTTCGATTCCTTCATTGCCTCAGGCCTAGTGCTTATAGACTTTTTTGCTGAATG
GTGTGGTCCTTGCAAAATGCTTTCCCCCGTCTTGGACAGCCTTGCAACAGAAATGCCTGCGGTACTCATTGGAAAAGTAA
ATATCGATGATCATCCTGCACCCGCAGAAAAGTACGGCGTTTCTTCGATTCCAACTTTAATTTTATTTAAAGATGGGAAA
GAAGTAGATCGTGTAGTTGGATTAAAAGATAAAGATTCTTTAATTAAGTTGATTAATCAATACGCTTAA

Upstream 100 bases:

>100_bases
CGCTAGATTCAGGTTCTAGTGAGCTTATGCTCGTGGAAGTTCAAGTCTTCTTAGCTGCAAGTAACATTCAAAACGCATAC
CCCGAACTTATTGGAGAATT

Downstream 100 bases:

>100_bases
CCTCCATTACGGATACAAGCACTTTGATTATTTTGTCGAACTGCTTCGAAAAGTACTACACCCACGGTTGTTGCCAAATT
TAGAGACCTGACTCCAGGTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MVKVVSAENFDSFIASGLVLIDFFAEWCGPCKMLSPVLDSLATEMPAVLIGKVNIDDHPAPAEKYGVSSIPTLILFKDGK
EVDRVVGLKDKDSLIKLINQYA

Sequences:

>Translated_102_residues
MVKVVSAENFDSFIASGLVLIDFFAEWCGPCKMLSPVLDSLATEMPAVLIGKVNIDDHPAPAEKYGVSSIPTLILFKDGK
EVDRVVGLKDKDSLIKLINQYA
>Mature_102_residues
MVKVVSAENFDSFIASGLVLIDFFAEWCGPCKMLSPVLDSLATEMPAVLIGKVNIDDHPAPAEKYGVSSIPTLILFKDGK
EVDRVVGLKDKDSLIKLINQYA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=77, Percent_Identity=48.0519480519481, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI224493972, Length=93, Percent_Identity=41.9354838709677, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI42794771, Length=93, Percent_Identity=41.9354838709677, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI21361657, Length=103, Percent_Identity=34.9514563106796, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI4758304, Length=109, Percent_Identity=34.8623853211009, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=43.8775510204082, Blast_Score=90, Evalue=3e-20,
Organism=Escherichia coli, GI1788936, Length=97, Percent_Identity=34.020618556701, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=88, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=37.8048780487805, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=98, Percent_Identity=32.6530612244898, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=84, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=70, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=90, Percent_Identity=30, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=102, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=50, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323072, Length=83, Percent_Identity=46.9879518072289, Blast_Score=85, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=35.2272727272727, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358065, Length=95, Percent_Identity=43.1578947368421, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=41.8604651162791, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=39.7590361445783, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24658597, Length=90, Percent_Identity=36.6666666666667, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=45.5696202531646, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=45.5696202531646, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859803, Length=98, Percent_Identity=38.7755102040816, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24664269, Length=99, Percent_Identity=35.3535353535354, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11098; Mature: 11098

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVVSAENFDSFIASGLVLIDFFAEWCGPCKMLSPVLDSLATEMPAVLIGKVNIDDHPA
CEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEEECCCCCCCC
PAEKYGVSSIPTLILFKDGKEVDRVVGLKDKDSLIKLINQYA
CHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKVVSAENFDSFIASGLVLIDFFAEWCGPCKMLSPVLDSLATEMPAVLIGKVNIDDHPA
CEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEEECCCCCCCC
PAEKYGVSSIPTLILFKDGKEVDRVVGLKDKDSLIKLINQYA
CHHHCCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8936321; 12682364 [H]