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The map label for this gene is xseA [H]

Identifier: 89898503

GI number: 89898503

Start: 802616

End: 804283

Strand: Direct

Name: xseA [H]

Synonym: CF0696

Alternate gene names: 89898503

Gene position: 802616-804283 (Clockwise)

Preceding gene: 89898501

Following gene: 89898504

Centisome position: 68.82

GC content: 40.29

Gene sequence:

>1668_bases
ATGACAACTTCATCTCCTCCCCAAGCAGTCACGACGCTCACAGAATCTATAAAAAATCTTCTGGAGTCAAACTTTTGTCA
TGTTGTGGTCAAAGGAGAGTTAAGTAACGTCTCACTACAACCTAGCGGACACTTATATTTTGGAATTAAAGATAGCCGAT
CCTTCTTAAATGGGGCTTTTTTCCATTTTAAAAGTAAATATTTTGATCGTCGCCCTAAAGATGGCGATTCCGTAATCATT
CACGGCAAGCTCACGGTTTATGCCCCACGAGGTCAATATCAAATTGTAGCCCATGCTTTAGTCTATGCTGGAGAAGGAGA
CCTACTACAAAAATTTGAAGAGACAAAGAAACGCCTCGCTGCTGAGGGGTATTTTGCTCTAGAGAAAAAGCAAACACTAC
CCAATATTCCCCAAAGCATCGGTGTGATTACCAGCCCTACGGGGGCGGTAATCCAAGATATTTTGCGCGTTCTTTCCCGT
CGGTGCTATCAGTACAAAATCCTTATTTATCCTGTAACGGTTCAGGGAGCTACGGCTGCAAAAGAAATCTCACGAGCTAT
CGAAGAAATGAACAAAGAGAATCTTGCAGATGTTCTTATTCTAGCTCGTGGCGGCGGAAGCATCGAAGATCTTTGGGCTT
TCAATGAAGAGATCGTTGTCAAAGCCATAGATGCCAGCTCCATCCCCATTATTTCTGCTATAGGTCATGAAACGGACTAT
ACGTTATGTGATTTTGCTGCTGACGTACGTGCTCCCACGCCTTCTGCTGCTGCAGAAATCGTTTGCCAAAGTAGCGAACA
ACAAATTCAAGTATTTAAAAGTTATTTACGCTACCTGAACGCACATTCGCAACAGCTTCTTTCGGGAAAAATCAAACAAA
TTCAACAATGGAAGCGTTATTTAGACCACGTAGATTTTTTCCGTTCAGCGCATCAGTCTCTAGATTATCTTTGCTTATCT
GTAGAACGGTCAATTCAAACAAAACTTTCACAATACAAACAGCGCTATATGCAGTATGCACGCTGGTTGCAAAGTGATGT
TTTACAGAGAATGACTTACCGCCTTCATGATCTTTGGAAAATGATCGTACAGGCCTTCCACAATCGCCTGACTGCAGCAA
AGCATCTCTGTATGCAGAAGAAAAAAAATCTAACATTTCATAATACGCAGCAATTTATCCAGAAATTGGATCTTTGGAAA
CAACAACTCCATAGAGCTCTGACGCAACGTCTAGGATACTGTAGCCAATCTCTAACTCACCAACAAACATTATTAAAACA
TTTTACAATCAAATTAAATCAGCAGTTTACTAAGGGAAAACACACCTTGAATCTTTTACAGAAACGGCTGACGAGAACTT
TTGCCAATACAGTAGACGAACATAGAGAAAACTATGTTCGTTCTAGGGAAAACTTAATATTTTCCTTACATCACCTTGTA
GAAAGAAACCGAGAAAAATATTATACGCTTTCTAAGCAGCTTACCCTATTAAACCCTAAAAATGTTTTCAAACGTGGGTA
TGCTATGCTCTTTGACTTTAATGAAAATTTCGCTATCATTTCCGCAAAAAGCTTACACAAACACAGTTGTGTAAGGGTAC
GACTGCAGGACGGGGAAGCCACTCTTACTGTAACGGATATTCAGAATTTTGAAACTCAAGAGTCCTAA

Upstream 100 bases:

>100_bases
ACTATAGACACTGATTCACGATTCTTGCTAGTTTTCTACTAAGTAAGGTACTTTATTCTTCAAATAAATAGAACTTGAAA
CCTCCTGGAAATCTAAGGAT

Downstream 100 bases:

>100_bases
ATTATGGAAGAAATTCCCTTTGAAAATGCTATGGAAAGGTTGGAAGAGATCGTAGATCTTATGAATCAACCCTCAACGTC
TTTAGATTCTTCTTTAAAAC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTTSSPPQAVTTLTESIKNLLESNFCHVVVKGELSNVSLQPSGHLYFGIKDSRSFLNGAFFHFKSKYFDRRPKDGDSVII
HGKLTVYAPRGQYQIVAHALVYAGEGDLLQKFEETKKRLAAEGYFALEKKQTLPNIPQSIGVITSPTGAVIQDILRVLSR
RCYQYKILIYPVTVQGATAAKEISRAIEEMNKENLADVLILARGGGSIEDLWAFNEEIVVKAIDASSIPIISAIGHETDY
TLCDFAADVRAPTPSAAAEIVCQSSEQQIQVFKSYLRYLNAHSQQLLSGKIKQIQQWKRYLDHVDFFRSAHQSLDYLCLS
VERSIQTKLSQYKQRYMQYARWLQSDVLQRMTYRLHDLWKMIVQAFHNRLTAAKHLCMQKKKNLTFHNTQQFIQKLDLWK
QQLHRALTQRLGYCSQSLTHQQTLLKHFTIKLNQQFTKGKHTLNLLQKRLTRTFANTVDEHRENYVRSRENLIFSLHHLV
ERNREKYYTLSKQLTLLNPKNVFKRGYAMLFDFNENFAIISAKSLHKHSCVRVRLQDGEATLTVTDIQNFETQES

Sequences:

>Translated_555_residues
MTTSSPPQAVTTLTESIKNLLESNFCHVVVKGELSNVSLQPSGHLYFGIKDSRSFLNGAFFHFKSKYFDRRPKDGDSVII
HGKLTVYAPRGQYQIVAHALVYAGEGDLLQKFEETKKRLAAEGYFALEKKQTLPNIPQSIGVITSPTGAVIQDILRVLSR
RCYQYKILIYPVTVQGATAAKEISRAIEEMNKENLADVLILARGGGSIEDLWAFNEEIVVKAIDASSIPIISAIGHETDY
TLCDFAADVRAPTPSAAAEIVCQSSEQQIQVFKSYLRYLNAHSQQLLSGKIKQIQQWKRYLDHVDFFRSAHQSLDYLCLS
VERSIQTKLSQYKQRYMQYARWLQSDVLQRMTYRLHDLWKMIVQAFHNRLTAAKHLCMQKKKNLTFHNTQQFIQKLDLWK
QQLHRALTQRLGYCSQSLTHQQTLLKHFTIKLNQQFTKGKHTLNLLQKRLTRTFANTVDEHRENYVRSRENLIFSLHHLV
ERNREKYYTLSKQLTLLNPKNVFKRGYAMLFDFNENFAIISAKSLHKHSCVRVRLQDGEATLTVTDIQNFETQES
>Mature_554_residues
TTSSPPQAVTTLTESIKNLLESNFCHVVVKGELSNVSLQPSGHLYFGIKDSRSFLNGAFFHFKSKYFDRRPKDGDSVIIH
GKLTVYAPRGQYQIVAHALVYAGEGDLLQKFEETKKRLAAEGYFALEKKQTLPNIPQSIGVITSPTGAVIQDILRVLSRR
CYQYKILIYPVTVQGATAAKEISRAIEEMNKENLADVLILARGGGSIEDLWAFNEEIVVKAIDASSIPIISAIGHETDYT
LCDFAADVRAPTPSAAAEIVCQSSEQQIQVFKSYLRYLNAHSQQLLSGKIKQIQQWKRYLDHVDFFRSAHQSLDYLCLSV
ERSIQTKLSQYKQRYMQYARWLQSDVLQRMTYRLHDLWKMIVQAFHNRLTAAKHLCMQKKKNLTFHNTQQFIQKLDLWKQ
QLHRALTQRLGYCSQSLTHQQTLLKHFTIKLNQQFTKGKHTLNLLQKRLTRTFANTVDEHRENYVRSRENLIFSLHHLVE
RNREKYYTLSKQLTLLNPKNVFKRGYAMLFDFNENFAIISAKSLHKHSCVRVRLQDGEATLTVTDIQNFETQES

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=287, Percent_Identity=43.9024390243902, Blast_Score=257, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579 [H]

Pfam domain/function: PF02601 Exonuc_VII_L [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 64001; Mature: 63870

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSSPPQAVTTLTESIKNLLESNFCHVVVKGELSNVSLQPSGHLYFGIKDSRSFLNGAF
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCCCEEEEECCCHHHHHHHH
FHFKSKYFDRRPKDGDSVIIHGKLTVYAPRGQYQIVAHALVYAGEGDLLQKFEETKKRLA
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AEGYFALEKKQTLPNIPQSIGVITSPTGAVIQDILRVLSRRCYQYKILIYPVTVQGATAA
HCCHHEEEHHCCCCCCCHHCCCEECCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCHHH
KEISRAIEEMNKENLADVLILARGGGSIEDLWAFNEEIVVKAIDASSIPIISAIGHETDY
HHHHHHHHHHCCCCHHEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCEEHHCCCCCCC
TLCDFAADVRAPTPSAAAEIVCQSSEQQIQVFKSYLRYLNAHSQQLLSGKIKQIQQWKRY
HHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDHVDFFRSAHQSLDYLCLSVERSIQTKLSQYKQRYMQYARWLQSDVLQRMTYRLHDLWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVQAFHNRLTAAKHLCMQKKKNLTFHNTQQFIQKLDLWKQQLHRALTQRLGYCSQSLTH
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQTLLKHFTIKLNQQFTKGKHTLNLLQKRLTRTFANTVDEHRENYVRSRENLIFSLHHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERNREKYYTLSKQLTLLNPKNVFKRGYAMLFDFNENFAIISAKSLHKHSCVRVRLQDGEA
HCCCHHHEEHHHCEEEECHHHHHHCCCEEEEEECCCEEEEEECHHCCCCEEEEEEECCCE
TLTVTDIQNFETQES
EEEEEECCCCCCCCC
>Mature Secondary Structure 
TTSSPPQAVTTLTESIKNLLESNFCHVVVKGELSNVSLQPSGHLYFGIKDSRSFLNGAF
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCCCEEEEECCCHHHHHHHH
FHFKSKYFDRRPKDGDSVIIHGKLTVYAPRGQYQIVAHALVYAGEGDLLQKFEETKKRLA
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AEGYFALEKKQTLPNIPQSIGVITSPTGAVIQDILRVLSRRCYQYKILIYPVTVQGATAA
HCCHHEEEHHCCCCCCCHHCCCEECCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCHHH
KEISRAIEEMNKENLADVLILARGGGSIEDLWAFNEEIVVKAIDASSIPIISAIGHETDY
HHHHHHHHHHCCCCHHEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCEEHHCCCCCCC
TLCDFAADVRAPTPSAAAEIVCQSSEQQIQVFKSYLRYLNAHSQQLLSGKIKQIQQWKRY
HHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDHVDFFRSAHQSLDYLCLSVERSIQTKLSQYKQRYMQYARWLQSDVLQRMTYRLHDLWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVQAFHNRLTAAKHLCMQKKKNLTFHNTQQFIQKLDLWKQQLHRALTQRLGYCSQSLTH
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQTLLKHFTIKLNQQFTKGKHTLNLLQKRLTRTFANTVDEHRENYVRSRENLIFSLHHLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERNREKYYTLSKQLTLLNPKNVFKRGYAMLFDFNENFAIISAKSLHKHSCVRVRLQDGEA
HCCCHHHEEHHHCEEEECHHHHHHCCCEEEEEECCCEEEEEECHHCCCCEEEEEEECCCE
TLTVTDIQNFETQES
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]