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The map label for this gene is hemC [H]

Identifier: 89898473

GI number: 89898473

Start: 770319

End: 771050

Strand: Direct

Name: hemC [H]

Synonym: CF0666

Alternate gene names: 89898473

Gene position: 770319-771050 (Clockwise)

Preceding gene: 89898472

Following gene: 89898474

Centisome position: 66.05

GC content: 42.49

Gene sequence:

>732_bases
ATGCTATCCGATTGTTACACTGATCCCTTTCTCTCTGATTTTTGCTTAGGCAGACGCCCTCTACGCATAGCTTCTAGAAA
ATCCACCCTAGCCAAGGCTCAGGTATATGAATGTGTTCGGCTTCTTCGCTCATGGTTCCCCAAACTTTGGATTCAAATAC
AAACAGTCAATACCCAGGGAGACAAGGATAAAACAACCCCCTTACGTCTTATAGAAAATTCCCAATTTTTCACAGATGCC
GTTGATAAGCTTGTTCTTTCCGGCAACAGCCATTTGGCTGTACACTCTGCTAAAGACCTTCCGAATCCTCCGGTCACCAC
TATTATTGCCATAACCCAAGGTTTAGATCCTGCGGATCTTTTAGTATATGGGAACCGCTACCTATGGAAACGTTTTCCAA
AAAATCCTAAACTAGGAAGCTCTTCTTTGCGTCGTGAAGAAATACTAAAAAAACTATTTCCTGCAGGGAAAATTCTCCAT
ATTCGCGGAACTATAGAAGAAAGATTGGAGCAACTGGAAAGCGGAAAATATGACGCTATTATTGTTGCAAAAGCGGCAGC
ACTCCGACTACACTTGAAATTACCGTACACAGAAGAGCTCCCCCCTCCCTACCATCCTCTTCAAGGACGTTTAAGCGTTA
CCGCAGCAAAAAACATAGAATCTTGGAAAAAGCTTCTATACCCTTTGAACACTTCAGACATCACTCAAGAAAATACCTTG
AGCCTCATTTAA

Upstream 100 bases:

>100_bases
ATGGGTTTTGAAGGAGCTGTTATTCCTGAGGGACAAATCTTGGGTTTATCCTATGAAATTAAAGATCTCTTAGATATTCG
AGGGGTGAAAACTATAAAAG

Downstream 100 bases:

>100_bases
TCTAAAAACATGACTTGCTTCTACTTTTACAATGATTTTAATAATAGAAATTAAAATCTATCCTTGATTACTGAAAACAA
ACTCCTCATACATTAATAAG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLSDCYTDPFLSDFCLGRRPLRIASRKSTLAKAQVYECVRLLRSWFPKLWIQIQTVNTQGDKDKTTPLRLIENSQFFTDA
VDKLVLSGNSHLAVHSAKDLPNPPVTTIIAITQGLDPADLLVYGNRYLWKRFPKNPKLGSSSLRREEILKKLFPAGKILH
IRGTIEERLEQLESGKYDAIIVAKAAALRLHLKLPYTEELPPPYHPLQGRLSVTAAKNIESWKKLLYPLNTSDITQENTL
SLI

Sequences:

>Translated_243_residues
MLSDCYTDPFLSDFCLGRRPLRIASRKSTLAKAQVYECVRLLRSWFPKLWIQIQTVNTQGDKDKTTPLRLIENSQFFTDA
VDKLVLSGNSHLAVHSAKDLPNPPVTTIIAITQGLDPADLLVYGNRYLWKRFPKNPKLGSSSLRREEILKKLFPAGKILH
IRGTIEERLEQLESGKYDAIIVAKAAALRLHLKLPYTEELPPPYHPLQGRLSVTAAKNIESWKKLLYPLNTSDITQENTL
SLI
>Mature_243_residues
MLSDCYTDPFLSDFCLGRRPLRIASRKSTLAKAQVYECVRLLRSWFPKLWIQIQTVNTQGDKDKTTPLRLIENSQFFTDA
VDKLVLSGNSHLAVHSAKDLPNPPVTTIIAITQGLDPADLLVYGNRYLWKRFPKNPKLGSSSLRREEILKKLFPAGKILH
IRGTIEERLEQLESGKYDAIIVAKAAALRLHLKLPYTEELPPPYHPLQGRLSVTAAKNIESWKKLLYPLNTSDITQENTL
SLI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=178, Percent_Identity=35.3932584269663, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI66933009, Length=178, Percent_Identity=35.3932584269663, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI48994974, Length=215, Percent_Identity=32.093023255814, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319996, Length=225, Percent_Identity=30.2222222222222, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130425, Length=219, Percent_Identity=30.1369863013699, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417 [H]

Pfam domain/function: PF01379 Porphobil_deam [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 27559; Mature: 27559

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDCYTDPFLSDFCLGRRPLRIASRKSTLAKAQVYECVRLLRSWFPKLWIQIQTVNTQG
CCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
DKDKTTPLRLIENSQFFTDAVDKLVLSGNSHLAVHSAKDLPNPPVTTIIAITQGLDPADL
CCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHHE
LVYGNRYLWKRFPKNPKLGSSSLRREEILKKLFPAGKILHIRGTIEERLEQLESGKYDAI
EEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEE
IVAKAAALRLHLKLPYTEELPPPYHPLQGRLSVTAAKNIESWKKLLYPLNTSDITQENTL
EEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCE
SLI
ECC
>Mature Secondary Structure
MLSDCYTDPFLSDFCLGRRPLRIASRKSTLAKAQVYECVRLLRSWFPKLWIQIQTVNTQG
CCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
DKDKTTPLRLIENSQFFTDAVDKLVLSGNSHLAVHSAKDLPNPPVTTIIAITQGLDPADL
CCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHHE
LVYGNRYLWKRFPKNPKLGSSSLRREEILKKLFPAGKILHIRGTIEERLEQLESGKYDAI
EEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEE
IVAKAAALRLHLKLPYTEELPPPYHPLQGRLSVTAAKNIESWKKLLYPLNTSDITQENTL
EEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCE
SLI
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]