Click here to switch to the map view.

The map label for this gene is lcrD [H]

Identifier: 89898355

GI number: 89898355

Start: 644525

End: 646654

Strand: Direct

Name: lcrD [H]

Synonym: CF0548

Alternate gene names: 89898355

Gene position: 644525-646654 (Clockwise)

Preceding gene: 89898354

Following gene: 89898356

Centisome position: 55.27

GC content: 40.52

Gene sequence:

>2130_bases
ATGAACAAGCTACTCAATTTTGTCAGTAGAACCTTTGGGGGAGATGCCGCCCTAAATATGATCAATAAATCGAGTGATCT
CATCCTTGCCTTATGGATGATTGGTGTCGTTTTAATGATCATCTTGCCCCTACCTCCGACTATTGTCGACTTGATGATCA
CGATCAATTTGGCTGTTTCAGTCTTCCTGTTAATGGTAGCTTTATATATCCCCAGTGCTCTGCAATTATCAGTTTTCCCG
TCCCTACTCTTAATTACAACAATGTTTCGCTTAGGAATTAACATTTCTTCCTCGAGACAGATTCTTCTCAAAGCTTATGC
AGGTCACGTTATTCAAGCTTTCGGAGACTTCGTTGTTGGAGGGAATTACGTTGTCGGATTTATTATCTTTTTAATCATTA
CAATTATTCAATTTATTGTTGTTACCAAAGGTGCTGAGCGTGTTGCTGAGGTTGCTGCGAGATTTAGATTAGACGCTATG
CCTGGTAAACAAATGGCTATTGACGCTGATTTGCGTGCAGGCATGATTGATGCGCAACAAGCTCGCGATAAACGAGGCAT
GATTCAAAAGGAAAGTGAACTTTATGGAGCCATGGACGGTGCCATGAAGTTCATTAAAGGGGACGTTATTGCAGGTATCG
TGATCTCCTTGATTAACATCGTTGGTGGTTTGACTATCGGTGTAGCTATGCATGGCATGGACTTGGCTCAAGCTGCTCAC
GTGTATACTCTTTTATCTATCGGTGACGGATTAGTTTCTCAGATTCCTTCGCTCCTCATCTCTTTAACTGCTGGTATCGT
TACAACTCGAGTTTCTAGTGATAAAAACACGAACTTGGGTAAAGAGATTTCCTCTCAATTAGTTAAAGAACCTAGAGCCT
TGCTCCTAGCCTCTGCAGCAACTTTAGGTGTGGGCTTCTTTAAAGGATTCCCTCTGTGGTCATTCTCAATTCTATCTTTT
ATCTTTGGTCTTCTTGGAGTTATTCTTCTCGCTAAGAAAAATAGCACAGCTAAAAAGGGGGCTTCCGGTGCATCGACAAC
AGTCGGAGCTGCTGCAGATGGCGCCGCTACAGCTGGAGACAATCCTGACGACTACTCTCTTACTCTGCCGGTAATTTTAG
AATTAGGAAAAGACCTCTCTGCTCTAATTCAGCATAGAACGAAATCAGGCCAAAGCTTCATTGACGATATGATCCCTAAA
ATGCGTCAAGCTTTATATCAAGATATTGGTATTCGTTATCCAGGAATTCATGTACGTACCGACTCTCCTTCCTTAGAAGG
TTTCGATTACATGATCCTTCTTAACGAAGTTCCTTATGTTCGAGGAAAAATTCCTCCGCACCACGTCTTGACTAATGAAG
TAGAGGAAAATCTTAAGAGATACAATCTTCCTTTCATTACGTATAAAAATGCTGCAGGCTTACCTTCTGCATGGGTTAGT
GAGGATGCTAAAACCATTTTAGAAAAAGCAGCCATTAAGTACTGGACTCCTTTAGAGGTGATCATTCTTCATTTATCTTA
CTTCTTCCACAGAAGCTCTCAAGAGTTCTTAGGAATTCAAGAAGTACGCTCTATGATTGAATTTATGGAACGTTCGTTCC
CAGATCTTGTTAAGGAAGTCACGCGACTTATTCCTCTACAAAAACTTACTGAAATTTTCAAACGTTTGGTACAAGAGCAA
ATTTCTATTAAAGATTTGCGCACCATTTTAGAATCCTTAAGTGAGTGGGCTCAGACAGAAAAAGATACCGTATTGCTTAC
CGAGTACGTACGTTCCTCTCTCAAACTCTATATTAGCTTTAAATTTTCTCAAGGGCAGTCAGCAATTTCTGTCTATTTAT
TAGATCCAGAAATCGAAGAGATGATCCGTGGAGCAATTAAGCAAACTTCTGCAGGATCTTATCTTGCTTTAGATCCAGAT
TCTGTAAACCTCATCTTAAAATCTATGAGGAATACGATCACGCCAACACCTCCAGGAGGTCAACCCCCTGTGCTGTTGAC
AGCAATTGACGTAAGACGATATGTAAGAAAATTAATAGAGACAGAATTCCCTGATATTGCTGTGATTTCTTATCAAGAGA
TTCTCCCAGAGATTCGTATCCAGCCATTAGGAAGAATTCAGATTTTCTAA

Upstream 100 bases:

>100_bases
AATCGACTTATGAAGCTATTGGAGAAATCCTTCTCTACATCACTTCTCTTAATGCTCAAAATCCTAACAACAAAAACATT
AACCAACACGATAATCTATA

Downstream 100 bases:

>100_bases
GTATCTGTCGATTCTTAAAGAGGATATATGTCAGCATCCGGAGGAGCTGGGGGCTTAGGAGGCTCACAAGCTGTTGACGT
TGCACAAGTGCAAGCTGCGG

Product: type III secretory flagellar biosynthesis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MNKLLNFVSRTFGGDAALNMINKSSDLILALWMIGVVLMIILPLPPTIVDLMITINLAVSVFLLMVALYIPSALQLSVFP
SLLLITTMFRLGINISSSRQILLKAYAGHVIQAFGDFVVGGNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAM
PGKQMAIDADLRAGMIDAQQARDKRGMIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLTIGVAMHGMDLAQAAH
VYTLLSIGDGLVSQIPSLLISLTAGIVTTRVSSDKNTNLGKEISSQLVKEPRALLLASAATLGVGFFKGFPLWSFSILSF
IFGLLGVILLAKKNSTAKKGASGASTTVGAAADGAATAGDNPDDYSLTLPVILELGKDLSALIQHRTKSGQSFIDDMIPK
MRQALYQDIGIRYPGIHVRTDSPSLEGFDYMILLNEVPYVRGKIPPHHVLTNEVEENLKRYNLPFITYKNAAGLPSAWVS
EDAKTILEKAAIKYWTPLEVIILHLSYFFHRSSQEFLGIQEVRSMIEFMERSFPDLVKEVTRLIPLQKLTEIFKRLVQEQ
ISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISFKFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSYLALDPD
SVNLILKSMRNTITPTPPGGQPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEILPEIRIQPLGRIQIF

Sequences:

>Translated_709_residues
MNKLLNFVSRTFGGDAALNMINKSSDLILALWMIGVVLMIILPLPPTIVDLMITINLAVSVFLLMVALYIPSALQLSVFP
SLLLITTMFRLGINISSSRQILLKAYAGHVIQAFGDFVVGGNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAM
PGKQMAIDADLRAGMIDAQQARDKRGMIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLTIGVAMHGMDLAQAAH
VYTLLSIGDGLVSQIPSLLISLTAGIVTTRVSSDKNTNLGKEISSQLVKEPRALLLASAATLGVGFFKGFPLWSFSILSF
IFGLLGVILLAKKNSTAKKGASGASTTVGAAADGAATAGDNPDDYSLTLPVILELGKDLSALIQHRTKSGQSFIDDMIPK
MRQALYQDIGIRYPGIHVRTDSPSLEGFDYMILLNEVPYVRGKIPPHHVLTNEVEENLKRYNLPFITYKNAAGLPSAWVS
EDAKTILEKAAIKYWTPLEVIILHLSYFFHRSSQEFLGIQEVRSMIEFMERSFPDLVKEVTRLIPLQKLTEIFKRLVQEQ
ISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISFKFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSYLALDPD
SVNLILKSMRNTITPTPPGGQPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEILPEIRIQPLGRIQIF
>Mature_709_residues
MNKLLNFVSRTFGGDAALNMINKSSDLILALWMIGVVLMIILPLPPTIVDLMITINLAVSVFLLMVALYIPSALQLSVFP
SLLLITTMFRLGINISSSRQILLKAYAGHVIQAFGDFVVGGNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAM
PGKQMAIDADLRAGMIDAQQARDKRGMIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLTIGVAMHGMDLAQAAH
VYTLLSIGDGLVSQIPSLLISLTAGIVTTRVSSDKNTNLGKEISSQLVKEPRALLLASAATLGVGFFKGFPLWSFSILSF
IFGLLGVILLAKKNSTAKKGASGASTTVGAAADGAATAGDNPDDYSLTLPVILELGKDLSALIQHRTKSGQSFIDDMIPK
MRQALYQDIGIRYPGIHVRTDSPSLEGFDYMILLNEVPYVRGKIPPHHVLTNEVEENLKRYNLPFITYKNAAGLPSAWVS
EDAKTILEKAAIKYWTPLEVIILHLSYFFHRSSQEFLGIQEVRSMIEFMERSFPDLVKEVTRLIPLQKLTEIFKRLVQEQ
ISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISFKFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSYLALDPD
SVNLILKSMRNTITPTPPGGQPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEILPEIRIQPLGRIQIF

Specific function: Could be involved in the secretion of the yop virulence proteins [H]

COG id: COG4789

COG function: function code U; Type III secretory pathway, component EscV

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=667, Percent_Identity=35.9820089955022, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001712
- InterPro:   IPR006302 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 78023; Mature: 78023

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLLNFVSRTFGGDAALNMINKSSDLILALWMIGVVLMIILPLPPTIVDLMITINLAVS
CCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VFLLMVALYIPSALQLSVFPSLLLITTMFRLGINISSSRQILLKAYAGHVIQAFGDFVVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAMPGKQMAIDADLRAGMIDAQQ
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCCCHHH
ARDKRGMIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLTIGVAMHGMDLAQAAH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VYTLLSIGDGLVSQIPSLLISLTAGIVTTRVSSDKNTNLGKEISSQLVKEPRALLLASAA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
TLGVGFFKGFPLWSFSILSFIFGLLGVILLAKKNSTAKKGASGASTTVGAAADGAATAGD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
NPDDYSLTLPVILELGKDLSALIQHRTKSGQSFIDDMIPKMRQALYQDIGIRYPGIHVRT
CCCCCEEHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
DSPSLEGFDYMILLNEVPYVRGKIPPHHVLTNEVEENLKRYNLPFITYKNAAGLPSAWVS
CCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
EDAKTILEKAAIKYWTPLEVIILHLSYFFHRSSQEFLGIQEVRSMIEFMERSFPDLVKEV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHH
TRLIPLQKLTEIFKRLVQEQISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISF
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEE
KFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSYLALDPDSVNLILKSMRNTITPTPPGG
EECCCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
QPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEILPEIRIQPLGRIQIF
CCCEEEEHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MNKLLNFVSRTFGGDAALNMINKSSDLILALWMIGVVLMIILPLPPTIVDLMITINLAVS
CCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VFLLMVALYIPSALQLSVFPSLLLITTMFRLGINISSSRQILLKAYAGHVIQAFGDFVVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GNYVVGFIIFLIITIIQFIVVTKGAERVAEVAARFRLDAMPGKQMAIDADLRAGMIDAQQ
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCCCHHH
ARDKRGMIQKESELYGAMDGAMKFIKGDVIAGIVISLINIVGGLTIGVAMHGMDLAQAAH
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
VYTLLSIGDGLVSQIPSLLISLTAGIVTTRVSSDKNTNLGKEISSQLVKEPRALLLASAA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
TLGVGFFKGFPLWSFSILSFIFGLLGVILLAKKNSTAKKGASGASTTVGAAADGAATAGD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
NPDDYSLTLPVILELGKDLSALIQHRTKSGQSFIDDMIPKMRQALYQDIGIRYPGIHVRT
CCCCCEEHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
DSPSLEGFDYMILLNEVPYVRGKIPPHHVLTNEVEENLKRYNLPFITYKNAAGLPSAWVS
CCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
EDAKTILEKAAIKYWTPLEVIILHLSYFFHRSSQEFLGIQEVRSMIEFMERSFPDLVKEV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHHH
TRLIPLQKLTEIFKRLVQEQISIKDLRTILESLSEWAQTEKDTVLLTEYVRSSLKLYISF
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEE
KFSQGQSAISVYLLDPEIEEMIRGAIKQTSAGSYLALDPDSVNLILKSMRNTITPTPPGG
EECCCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
QPPVLLTAIDVRRYVRKLIETEFPDIAVISYQEILPEIRIQPLGRIQIF
CCCEEEEHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11402007 [H]