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The map label for this gene is adk

Identifier: 89898281

GI number: 89898281

Start: 561164

End: 561805

Strand: Direct

Name: adk

Synonym: CF0474

Alternate gene names: 89898281

Gene position: 561164-561805 (Clockwise)

Preceding gene: 89898276

Following gene: 89898282

Centisome position: 48.12

GC content: 37.69

Gene sequence:

>642_bases
ATGTTAAAGAATATTTTTTATATCATTATGGGCCCTCCAGGATCTGGAAAGGGAACACAATCGCAATGTCTTGCTGAAAA
ATTGGGATTACCACATATCAGTTCGGGAAATCTTTTGCGATCTGCTATAAAAGCATCCACTCCTTTAGGAATCAAAGCAT
CGGAATACATAGATGAGGGGCAGCTAGTTCCAAATGGTCTTGTTTGGGAAATTGTACAAGAAACTCTAAACAAGTCAGAA
TGTTTATCAGGATGTATTATTGATGGTTTCCCCAGAACTTTAGATCAGGCAGTTCTTTTGCATGATTTTTTGGTAAAAGC
TAATGCTGATTACCGAGTGATACAATTAGACGTTGCTGATGAAGAAATTATTCGCAGAATCTACTCCCGATTTATTTGTC
CTTCATGTAATTTCGTCTATAATCAGAGTCAGGGTTTTAGAGAATGTCCTACGTGTCATAGTGAGTTAGTCCGTCGTTCT
GATGATACCCTCGAGGTTATTCAGAAGAGGCTGGAAAGTTATAAGAATACTACGGCTTCTGTAATTGACTATTATGCAGA
TTTAGGGAAACTCACATGTGTTCCTGCTGAAAAATCTCCTGATGAGGTTTTCCAAAGTATCTTGGCTTGTATAGAAGATT
AA

Upstream 100 bases:

>100_bases
TTTCATAGAATATACTTCTTTGATGCTATTTACAGCATCAGAGATGAACTTCTGAATTTATATAGGCGTCTTTTTTGTAG
GCGAATTTTCGACTATTGTT

Downstream 100 bases:

>100_bases
GCTTTGCTCTCCTTTTAGGCGTTTTAAAAGCAATTTTTTGATGTAGATAAGAAAGATGAAACATTATCAACTTTATGCGC
CTGTTTCTGACCTCTCATCT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MLKNIFYIIMGPPGSGKGTQSQCLAEKLGLPHISSGNLLRSAIKASTPLGIKASEYIDEGQLVPNGLVWEIVQETLNKSE
CLSGCIIDGFPRTLDQAVLLHDFLVKANADYRVIQLDVADEEIIRRIYSRFICPSCNFVYNQSQGFRECPTCHSELVRRS
DDTLEVIQKRLESYKNTTASVIDYYADLGKLTCVPAEKSPDEVFQSILACIED

Sequences:

>Translated_213_residues
MLKNIFYIIMGPPGSGKGTQSQCLAEKLGLPHISSGNLLRSAIKASTPLGIKASEYIDEGQLVPNGLVWEIVQETLNKSE
CLSGCIIDGFPRTLDQAVLLHDFLVKANADYRVIQLDVADEEIIRRIYSRFICPSCNFVYNQSQGFRECPTCHSELVRRS
DDTLEVIQKRLESYKNTTASVIDYYADLGKLTCVPAEKSPDEVFQSILACIED
>Mature_213_residues
MLKNIFYIIMGPPGSGKGTQSQCLAEKLGLPHISSGNLLRSAIKASTPLGIKASEYIDEGQLVPNGLVWEIVQETLNKSE
CLSGCIIDGFPRTLDQAVLLHDFLVKANADYRVIQLDVADEEIIRRIYSRFICPSCNFVYNQSQGFRECPTCHSELVRRS
DDTLEVIQKRLESYKNTTASVIDYYADLGKLTCVPAEKSPDEVFQSILACIED

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=35.5140186915888, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=35.5140186915888, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI19923437, Length=190, Percent_Identity=36.3157894736842, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI310110345, Length=191, Percent_Identity=37.17277486911, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832003, Length=191, Percent_Identity=37.17277486911, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI8051579, Length=191, Percent_Identity=37.17277486911, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI53832001, Length=191, Percent_Identity=37.17277486911, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502011, Length=206, Percent_Identity=31.5533980582524, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=31.7757009345794, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=31.7757009345794, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI7706497, Length=214, Percent_Identity=29.9065420560748, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI22749187, Length=207, Percent_Identity=27.0531400966184, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786680, Length=183, Percent_Identity=39.344262295082, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=203, Percent_Identity=33.9901477832512, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=34.2857142857143, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17537943, Length=210, Percent_Identity=28.0952380952381, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=25.4807692307692, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=34.4339622641509, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=37.0731707317073, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=37.5, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=35.2380952380952, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=35.2380952380952, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=25.8536585365854, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=25.8536585365854, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLFF (Q254P2)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_515391.1
- ProteinModelPortal:   Q254P2
- SMR:   Q254P2
- STRING:   Q254P2
- GeneID:   3958651
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0474
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   FQSILAC
- ProtClustDB:   PRK00279
- BioCyc:   CFEL264202:CF0474-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 23712; Mature: 23712

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNIFYIIMGPPGSGKGTQSQCLAEKLGLPHISSGNLLRSAIKASTPLGIKASEYIDEG
CCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCC
QLVPNGLVWEIVQETLNKSECLSGCIIDGFPRTLDQAVLLHDFLVKANADYRVIQLDVAD
CCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
EEIIRRIYSRFICPSCNFVYNQSQGFRECPTCHSELVRRSDDTLEVIQKRLESYKNTTAS
HHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCHHHH
VIDYYADLGKLTCVPAEKSPDEVFQSILACIED
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNIFYIIMGPPGSGKGTQSQCLAEKLGLPHISSGNLLRSAIKASTPLGIKASEYIDEG
CCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCC
QLVPNGLVWEIVQETLNKSECLSGCIIDGFPRTLDQAVLLHDFLVKANADYRVIQLDVAD
CCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
EEIIRRIYSRFICPSCNFVYNQSQGFRECPTCHSELVRRSDDTLEVIQKRLESYKNTTAS
HHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCHHHH
VIDYYADLGKLTCVPAEKSPDEVFQSILACIED
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA