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The map label for this gene is zwf [H]

Identifier: 89898275

GI number: 89898275

Start: 555639

End: 557180

Strand: Direct

Name: zwf [H]

Synonym: CF0468

Alternate gene names: 89898275

Gene position: 555639-557180 (Clockwise)

Preceding gene: 89898274

Following gene: 89898276

Centisome position: 47.64

GC content: 40.27

Gene sequence:

>1542_bases
ATGGAAATGACGAGTCAAGAAAATAAAGATGGCGGGAGATCTCCACTTCCCTGTCCTCCCTGTGTAATGGTGATTTTCGG
TGCTACTGGAGATCTAACAGCACGCAAGTTATTTCCAGCATTGTATCATCTGATTAAAGATGGCAGGCTATCCGAAAATT
TTGTTTGTATAGGATTTGCTAGAAGAAAGAAAAGTCATGAGCAATTTCGAGAAGAAATGAAATTAGCCATACAGAATTTT
TCTCGTGCTCAGGAGATTGATATCCGCATCTGGGAAGAATTTGAATCTCGTATATTTTACCATGAGTCTAACTTCTCCTC
TCCCGAAGGCTATGACTCCTTGAGAGAGAGGCTGGAAGATATTGATAAAAAGTTTGGAACTCAAGGTAACCGGCTATTTT
ATTTATCAACACCTCCAGATTACTTCCCCGAGATTATCGAAAATATCAATAAGCATGGTCTTTTCTATCACGATCAAGGA
GAGGGAAAACCCTGGTCGCGGGTGATTATAGAAAAGCCTTTCGGTGTGGATTTGCAAAGCGCTCGGGTTCTGCAAAAGTA
CATAGATGATAATCTAGATGAAAAGTTTGTCTATCGTATAGATCACTATTTGGGGAAAGAAACCGTGCAAAACATCCTTA
CGATACGTTTTGCTAATACCCTATTCGAGTCTTGTTGGAATTCCCAATACATCGATCACGTGCAAATAAGCGTTAGCGAA
TCTATAGGCATAGGCACACGAGGGAACTTCTTTGAGAAATCAGGAATGCTTCGTGATATGGTACAAAACCATATGATGCA
GCTCCTGTGTTTATTAACCATGGAACCTCCTTCGATATTTAATTCTGAAGAGATAAAGAAAGAAAAGATCAAGGTGCTTA
AGAAAATACGCCCATTTTCTAAAGAAAGTATTGTTCGAGGTCAGTATGGCCCAGGAGAAGTGCAAGGGGTTTCTGTTCTT
GGTTATCGAGAAGAGGAAAATGTTTCTCCAGAGTCTTCAGTAGAGACTTTCGTGGCTCTAAAAATGTTTATAGACAACCC
CCGTTGGCTTGGGGTTCCTTTTTATCTTCGAGCAGGAAAGCGTCTTTCTAAACGTTCTACAGATATTTCTATTATCTTTA
AAAAGTCTTTCTCTACTCTATTTGAATCAGAATCATGCCCCGTATGCCCTTTAGAGAATGACCTTTTAATTATCCGTATA
CAGCCGGATGAAGGTGTAGCCTTGAAGTTCAATTGTAAAGTTCCCGGAATGAATAATATCGTGCGTCCTGTGAAAATGGA
TTTTCGCTATGATACCTACTTTAAAACGACTGCTCCAGAAGCTTATGAAAGACTACTTTGCGATTGTATTTTAGGTGATA
GGATCCTATTTACTTGCAGTGATGAAGTGATGGGGTCCTGGGAGCTCTTTACTCCGATTTTAAAGCAATGGGAGCAAGAT
TCTTCAGATGTCTTCTTCCCTAATTATGTTGCCGGATCTTCAGGCCCCAAAGAAGCTGAGGAATTACTACAGGCAGATGG
AAGGAATTGGCGTCCTCTGTAA

Upstream 100 bases:

>100_bases
TAGATGTGCGTGGGAAAATAAGAATGTTTCTCCGTAGTTACTTTTATTCCTTTTTGTTATCCTAAATGTTTTTAGCTATG
TCAAAGAGGTCCTAAGTACA

Downstream 100 bases:

>100_bases
TTTAACTTTATTATGAGATGTTTATGGCAACATTAGTTAACTTTAATGATACGAACAAACTACTCCTCACAAAAAAACCA
GAATTGTTTATTGATTTGGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MEMTSQENKDGGRSPLPCPPCVMVIFGATGDLTARKLFPALYHLIKDGRLSENFVCIGFARRKKSHEQFREEMKLAIQNF
SRAQEIDIRIWEEFESRIFYHESNFSSPEGYDSLRERLEDIDKKFGTQGNRLFYLSTPPDYFPEIIENINKHGLFYHDQG
EGKPWSRVIIEKPFGVDLQSARVLQKYIDDNLDEKFVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSE
SIGIGTRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPSIFNSEEIKKEKIKVLKKIRPFSKESIVRGQYGPGEVQGVSVL
GYREEENVSPESSVETFVALKMFIDNPRWLGVPFYLRAGKRLSKRSTDISIIFKKSFSTLFESESCPVCPLENDLLIIRI
QPDEGVALKFNCKVPGMNNIVRPVKMDFRYDTYFKTTAPEAYERLLCDCILGDRILFTCSDEVMGSWELFTPILKQWEQD
SSDVFFPNYVAGSSGPKEAEELLQADGRNWRPL

Sequences:

>Translated_513_residues
MEMTSQENKDGGRSPLPCPPCVMVIFGATGDLTARKLFPALYHLIKDGRLSENFVCIGFARRKKSHEQFREEMKLAIQNF
SRAQEIDIRIWEEFESRIFYHESNFSSPEGYDSLRERLEDIDKKFGTQGNRLFYLSTPPDYFPEIIENINKHGLFYHDQG
EGKPWSRVIIEKPFGVDLQSARVLQKYIDDNLDEKFVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSE
SIGIGTRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPSIFNSEEIKKEKIKVLKKIRPFSKESIVRGQYGPGEVQGVSVL
GYREEENVSPESSVETFVALKMFIDNPRWLGVPFYLRAGKRLSKRSTDISIIFKKSFSTLFESESCPVCPLENDLLIIRI
QPDEGVALKFNCKVPGMNNIVRPVKMDFRYDTYFKTTAPEAYERLLCDCILGDRILFTCSDEVMGSWELFTPILKQWEQD
SSDVFFPNYVAGSSGPKEAEELLQADGRNWRPL
>Mature_513_residues
MEMTSQENKDGGRSPLPCPPCVMVIFGATGDLTARKLFPALYHLIKDGRLSENFVCIGFARRKKSHEQFREEMKLAIQNF
SRAQEIDIRIWEEFESRIFYHESNFSSPEGYDSLRERLEDIDKKFGTQGNRLFYLSTPPDYFPEIIENINKHGLFYHDQG
EGKPWSRVIIEKPFGVDLQSARVLQKYIDDNLDEKFVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSE
SIGIGTRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPSIFNSEEIKKEKIKVLKKIRPFSKESIVRGQYGPGEVQGVSVL
GYREEENVSPESSVETFVALKMFIDNPRWLGVPFYLRAGKRLSKRSTDISIIFKKSFSTLFESESCPVCPLENDLLIIRI
QPDEGVALKFNCKVPGMNNIVRPVKMDFRYDTYFKTTAPEAYERLLCDCILGDRILFTCSDEVMGSWELFTPILKQWEQD
SSDVFFPNYVAGSSGPKEAEELLQADGRNWRPL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=35.655737704918, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=35.655737704918, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=28.9205702647658, Blast_Score=175, Evalue=9e-44,
Organism=Escherichia coli, GI1788158, Length=499, Percent_Identity=38.877755511022, Blast_Score=345, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=35.5691056910569, Blast_Score=322, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=487, Percent_Identity=38.8090349075975, Blast_Score=327, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=36.0824742268041, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24643352, Length=484, Percent_Identity=35.7438016528926, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI221513548, Length=480, Percent_Identity=27.7083333333333, Blast_Score=215, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 59298; Mature: 59298

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMTSQENKDGGRSPLPCPPCVMVIFGATGDLTARKLFPALYHLIKDGRLSENFVCIGFA
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEH
RRKKSHEQFREEMKLAIQNFSRAQEIDIRIWEEFESRIFYHESNFSSPEGYDSLRERLED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHH
IDKKFGTQGNRLFYLSTPPDYFPEIIENINKHGLFYHDQGEGKPWSRVIIEKPFGVDLQS
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHH
ARVLQKYIDDNLDEKFVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSE
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SIGIGTRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPSIFNSEEIKKEKIKVLKKIRPFS
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
KESIVRGQYGPGEVQGVSVLGYREEENVSPESSVETFVALKMFIDNPRWLGVPFYLRAGK
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHHCCC
RLSKRSTDISIIFKKSFSTLFESESCPVCPLENDLLIIRIQPDEGVALKFNCKVPGMNNI
HHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCC
VRPVKMDFRYDTYFKTTAPEAYERLLCDCILGDRILFTCSDEVMGSWELFTPILKQWEQD
CCCEEECEEECCEEECCCHHHHHHHHHHHHHCCEEEEEECHHHHCCHHHHHHHHHHHCCC
SSDVFFPNYVAGSSGPKEAEELLQADGRNWRPL
CCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEMTSQENKDGGRSPLPCPPCVMVIFGATGDLTARKLFPALYHLIKDGRLSENFVCIGFA
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEH
RRKKSHEQFREEMKLAIQNFSRAQEIDIRIWEEFESRIFYHESNFSSPEGYDSLRERLED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHH
IDKKFGTQGNRLFYLSTPPDYFPEIIENINKHGLFYHDQGEGKPWSRVIIEKPFGVDLQS
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCHHH
ARVLQKYIDDNLDEKFVYRIDHYLGKETVQNILTIRFANTLFESCWNSQYIDHVQISVSE
HHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
SIGIGTRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPSIFNSEEIKKEKIKVLKKIRPFS
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
KESIVRGQYGPGEVQGVSVLGYREEENVSPESSVETFVALKMFIDNPRWLGVPFYLRAGK
HHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHHCCC
RLSKRSTDISIIFKKSFSTLFESESCPVCPLENDLLIIRIQPDEGVALKFNCKVPGMNNI
HHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCC
VRPVKMDFRYDTYFKTTAPEAYERLLCDCILGDRILFTCSDEVMGSWELFTPILKQWEQD
CCCEEECEEECCEEECCCHHHHHHHHHHHHHCCEEEEEECHHHHCCHHHHHHHHHHHCCC
SSDVFFPNYVAGSSGPKEAEELLQADGRNWRPL
CCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]