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The map label for this gene is guaA [H]

Identifier: 89898235

GI number: 89898235

Start: 502180

End: 503718

Strand: Direct

Name: guaA [H]

Synonym: CF0428

Alternate gene names: 89898235

Gene position: 502180-503718 (Clockwise)

Preceding gene: 89898234

Following gene: 89898236

Centisome position: 43.06

GC content: 37.82

Gene sequence:

>1539_bases
TTGAGTAAGATTCTTATTCTTGATTTTGGCTCTCAATATACGAATGTTTTAGCCAAAAAGATACGCTTACTTTCCGTATT
TTGTGAGGTACTTCCTTGGAATACACCTCTAGAAGACATTCTTCAAGAGTCTCCTTCAGGTCTAATTTTTTCTGGAGGGC
CTCATTCTGTTTATCAGGAGAATAGTCCAAAAGTTGATAGAGAAATCTATAACGCTAACATCCCTATACTTGGGGTATGT
TATGGTATGCAACTTATCGCTAGAGATTTTGGAAGTGAGGTAAGGGGAGGAGAGAATGAGTTTGGCTATACCCCTATAGT
TTTTTATCCGGGAAAACTTTTTCAAGGCCTTGTGGATAAGGACGCTTTTCATACTGAAATTCGTATGAGTCATTGCGACT
CTGTTACAGTCCCTCCTAAAGATTTTTTCATTACTGCAAGTTCACAACATTGTCCTGTTGCAGCCATAGAATACCCTGAG
AAAAAACTTTTCGGTCTCCAATTTCATCCGGAAGTTTCAGATTCTCAAGGAATAGGTGATACAATTTTATCAAATTTTGT
TAAGCATATCTGTCGGGCTTCGGAAACTTGGAAAATTGAGACAATAGAAAAACAACTTATTCAAAGGATCAAAGAACAAG
TAGGAGAAAAGGAACGTGTATTACTAGGCTTGTCTGGAGGGGTAGACTCTTCTGTTTTAGCTGTTTTACTTCATAATGCC
TTGGGTGATCGTTTATCGTGTGTCTTTGTTGATACGGGGCTATTGAGGAAAAATGAAGTTGAAGAGGTTAAACAGCAATT
TTTATCTCTAGGGCTAGAGATAATAGTGGAAGATGCTTCTGAAACATTTTTCTACGAGTTATCCGGAATACAGGATCCCG
AACAGAAACGTAAAATCATTGGATCTACCTTTATTGAAGTTTTTGATAAAGTATCTAAAAACCTTGAGGTTCAGTGGTTG
GCTCAAGGAACTATTTATTCCGATGTTATTGAATCGGCAAAATCTTGTGATGCAACGCAAGTAATTAAATCTCACCATAA
TGTTGGCGGACTTCCAGAAAAATTAAATCTGAAACTTTTAGAACCTTTGCGTTTTCTTTTTAAGGATGAAGTTAGAGCTT
TGGGCAAAGTTTTGGGCTTACCAGAAGTCTTTATATCCCGACACCCCTTTCCTGGCCCTGGTTTAGGAGTCAGAGTTCTT
GGAGAAATCCGTAAAGAATATGTAGAAATAGTAAAACATGCTGATAGTATCTTTATTGAAGAACTAAAAAAAGCTAATTT
ATACGACAAGGTTAGCCAAGCATTTGCTGTTTTCTTACCAGTAAAGTCGGTTGCTGTAAAAGGGGATTGTCGTCATTATG
GCTATACGATAGCTTTACGTGCAGTAGAGTCTTCTGATTTCATGACAGCATGCTGGTCGCCCCTATCTAGAGAATTTCTT
AACCGTTGTTCATCACGCATTATTAACGAAATCCCAGAAGTTAGCAGAGTGGTTTACGATATTTCCGATAAACCTCCAGC
AACTATTGAATGGGAATAG

Upstream 100 bases:

>100_bases
ATTACTCATTCTGGAAGAACAGAAAGTCACATTCATAATCTGCAACATATTCAACAAGCTCCAAATTACCTAGTCTCTAA
ATAATAAGAGGTATTCTATT

Downstream 100 bases:

>100_bases
GATTGGGCACAAAAAATAAGATATGATTGATAAGAAGCTTTTTTTTATTGCTGAAAGGTTATCACAGTTGTCCTTCGATC
TGGACGATAATAGGCCTTGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQENSPKVDREIYNANIPILGVC
YGMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDKDAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPE
KKLFGLQFHPEVSDSQGIGDTILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKIIGSTFIEVFDKVSKNLEVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVL
GEIRKEYVEIVKHADSIFIEELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFL
NRCSSRIINEIPEVSRVVYDISDKPPATIEWE

Sequences:

>Translated_512_residues
MSKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQENSPKVDREIYNANIPILGVC
YGMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDKDAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPE
KKLFGLQFHPEVSDSQGIGDTILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKIIGSTFIEVFDKVSKNLEVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVL
GEIRKEYVEIVKHADSIFIEELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFL
NRCSSRIINEIPEVSRVVYDISDKPPATIEWE
>Mature_511_residues
SKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQENSPKVDREIYNANIPILGVCY
GMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDKDAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPEK
KLFGLQFHPEVSDSQGIGDTILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNAL
GDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKIIGSTFIEVFDKVSKNLEVQWLA
QGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVLG
EIRKEYVEIVKHADSIFIEELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFLN
RCSSRIINEIPEVSRVVYDISDKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=34.7826086956522, Blast_Score=278, Evalue=6e-75,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=53.5508637236084, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=34.9040139616056, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=34.9040139616056, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=34.5549738219895, Blast_Score=267, Evalue=8e-72,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=47.9768786127168, Blast_Score=495, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=35.6363636363636, Blast_Score=273, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57420; Mature: 57288

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQE
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCCCCCC
NSPKVDREIYNANIPILGVCYGMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDK
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEEECHHHHHHHHCC
DAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPEKKLFGLQFHPEVSDSQGIGD
CHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHCCEEECCCCCCCCCCCH
TILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
LGDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKII
HCCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCCHHHHHHHH
GSTFIEVFDKVSKNLEVQWLAQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLL
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHH
EPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVLGEIRKEYVEIVKHADSIFIE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFL
HHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
NRCSSRIINEIPEVSRVVYDISDKPPATIEWE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEDILQESPSGLIFSGGPHSVYQE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCCCCCC
NSPKVDREIYNANIPILGVCYGMQLIARDFGSEVRGGENEFGYTPIVFYPGKLFQGLVDK
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEEECHHHHHHHHCC
DAFHTEIRMSHCDSVTVPPKDFFITASSQHCPVAAIEYPEKKLFGLQFHPEVSDSQGIGD
CHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHCCEEECCCCCCCCCCCH
TILSNFVKHICRASETWKIETIEKQLIQRIKEQVGEKERVLLGLSGGVDSSVLAVLLHNA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
LGDRLSCVFVDTGLLRKNEVEEVKQQFLSLGLEIIVEDASETFFYELSGIQDPEQKRKII
HCCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHEEEECCCCEEEEEECCCCCHHHHHHHH
GSTFIEVFDKVSKNLEVQWLAQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLL
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHH
EPLRFLFKDEVRALGKVLGLPEVFISRHPFPGPGLGVRVLGEIRKEYVEIVKHADSIFIE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ELKKANLYDKVSQAFAVFLPVKSVAVKGDCRHYGYTIALRAVESSDFMTACWSPLSREFL
HHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
NRCSSRIINEIPEVSRVVYDISDKPPATIEWE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]