Click here to switch to the map view.

The map label for this gene is imdH [H]

Identifier: 89898234

GI number: 89898234

Start: 501087

End: 502163

Strand: Direct

Name: imdH [H]

Synonym: CF0427

Alternate gene names: 89898234

Gene position: 501087-502163 (Clockwise)

Preceding gene: 89898233

Following gene: 89898235

Centisome position: 42.97

GC content: 43.18

Gene sequence:

>1077_bases
ATGCGTGAAGCCTTGACTTTTGATGATGTTTTATTAGTTCCTCAATATTCTGAAGTTCTTCCTGGAGAAGCTTGCTTATC
TGCTTCTGTTTCGGAATCTTTGGATCTAGCTATCCCTATTTTATCTGCAGCAATGGATTCTGTTACAGAATTATCTATGG
CTATAGCTATGGCTGAAGCTGGGGGACTTGGAGTTATCCATAAAAATATGGATTTGGATGAACAAGTTAGTATGGTAAAA
CACATAAAATCACAAGCCTCTTCTCTGGCTGTGGGGTGTTCCGTAGGCATTGGTCAACAAGGTTTGCAAAGAGCCGATGT
TTTAGTTGAGGCTGGTGTAGATGCCGTAGTTGTAGACACTGCTCATGGACACTCAAGATTGGTTCTCGATACCGCAAAAA
CCCTTAAAAAGCATTATCCTTCGGTGACTCTTATTGTGGGAAATATTGTCTCAAGAGAGGCAGCTCTTTGTTTAGGAGAA
ATTGGCGTGGATGCTGTGAAGGTGGGTATTGGTCCAGGATCTATATGCACAACGCGGATCATCTCAGGTGTAGGATTACC
CCAATTAACAGCTGTTATGGATGTTTCTGAGGCATTGCGTGATTCTTCCGTTCGAGTCATTGCTGATGGAGGAATGCGCT
ATTCTGGCGATATAGTTAAAGCTCTTGCTGCTGGAGCGCACTGCGTTATGCTAGGTAGCATGCTAGCAGGAACGAATGAA
GCACCAGGAGAAATAGTTCATGTTAATGAGCAAGCTTACAAGATGTATCGAGGTATGGGCTCTCTAGGCGCCATGAAAAG
GGGTAGCGCTGAGCGCTATTTTCAAGAACATAACGCCAAGAAATTTGTTCCAGAGGGTGTTGAGGGGCTTGTTCCTTACA
AAGGCTCTCTTCATGATGTGCTTTATCAAATCCTAGGAGGGATTCGATCTGGTATGGGCTATGTAGGGGCCCGTAATTTG
GAAGAATTGCGGAAGAATGCTGTATTTGCACGCATTACTCATTCTGGAAGAACAGAAAGTCACATTCATAATCTGCAACA
TATTCAACAAGCTCCAAATTACCTAGTCTCTAAATAA

Upstream 100 bases:

>100_bases
GGTTGGTTCCTATCGACCTCTTTTGTGTTTGGTGCCGATGAGAAGAATAAATTTCTCAATCAGGCGTTACTCTTAATCGT
TTTCCTTTATTGAGAAGCAC

Downstream 100 bases:

>100_bases
TAAGAGGTATTCTATTTTGAGTAAGATTCTTATTCTTGATTTTGGCTCTCAATATACGAATGTTTTAGCCAAAAAGATAC
GCTTACTTTCCGTATTTTGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MREALTFDDVLLVPQYSEVLPGEACLSASVSESLDLAIPILSAAMDSVTELSMAIAMAEAGGLGVIHKNMDLDEQVSMVK
HIKSQASSLAVGCSVGIGQQGLQRADVLVEAGVDAVVVDTAHGHSRLVLDTAKTLKKHYPSVTLIVGNIVSREAALCLGE
IGVDAVKVGIGPGSICTTRIISGVGLPQLTAVMDVSEALRDSSVRVIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTNE
APGEIVHVNEQAYKMYRGMGSLGAMKRGSAERYFQEHNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYVGARNL
EELRKNAVFARITHSGRTESHIHNLQHIQQAPNYLVSK

Sequences:

>Translated_358_residues
MREALTFDDVLLVPQYSEVLPGEACLSASVSESLDLAIPILSAAMDSVTELSMAIAMAEAGGLGVIHKNMDLDEQVSMVK
HIKSQASSLAVGCSVGIGQQGLQRADVLVEAGVDAVVVDTAHGHSRLVLDTAKTLKKHYPSVTLIVGNIVSREAALCLGE
IGVDAVKVGIGPGSICTTRIISGVGLPQLTAVMDVSEALRDSSVRVIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTNE
APGEIVHVNEQAYKMYRGMGSLGAMKRGSAERYFQEHNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYVGARNL
EELRKNAVFARITHSGRTESHIHNLQHIQQAPNYLVSK
>Mature_358_residues
MREALTFDDVLLVPQYSEVLPGEACLSASVSESLDLAIPILSAAMDSVTELSMAIAMAEAGGLGVIHKNMDLDEQVSMVK
HIKSQASSLAVGCSVGIGQQGLQRADVLVEAGVDAVVVDTAHGHSRLVLDTAKTLKKHYPSVTLIVGNIVSREAALCLGE
IGVDAVKVGIGPGSICTTRIISGVGLPQLTAVMDVSEALRDSSVRVIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTNE
APGEIVHVNEQAYKMYRGMGSLGAMKRGSAERYFQEHNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYVGARNL
EELRKNAVFARITHSGRTESHIHNLQHIQQAPNYLVSK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=341, Percent_Identity=35.7771260997067, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI50541954, Length=337, Percent_Identity=36.2017804154303, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI50541952, Length=337, Percent_Identity=36.2017804154303, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI50541948, Length=337, Percent_Identity=36.2017804154303, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI50541956, Length=337, Percent_Identity=36.4985163204748, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI66933016, Length=275, Percent_Identity=40.7272727272727, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI217035150, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI217035146, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI217035148, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI217035152, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI156616279, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI34328928, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI34328930, Length=275, Percent_Identity=39.2727272727273, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788855, Length=253, Percent_Identity=54.5454545454545, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI1786293, Length=351, Percent_Identity=34.4729344729345, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17560440, Length=342, Percent_Identity=33.6257309941521, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994385, Length=270, Percent_Identity=35.1851851851852, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71994389, Length=192, Percent_Identity=40.1041666666667, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322012, Length=333, Percent_Identity=33.6336336336336, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323585, Length=317, Percent_Identity=33.7539432176656, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323464, Length=273, Percent_Identity=35.8974358974359, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319352, Length=185, Percent_Identity=31.3513513513514, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319353, Length=129, Percent_Identity=37.984496124031, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571163, Length=351, Percent_Identity=35.3276353276353, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24641071, Length=351, Percent_Identity=35.3276353276353, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24641073, Length=351, Percent_Identity=35.3276353276353, Blast_Score=184, Evalue=6e-47,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 37839; Mature: 37839

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREALTFDDVLLVPQYSEVLPGEACLSASVSESLDLAIPILSAAMDSVTELSMAIAMAEA
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLGVIHKNMDLDEQVSMVKHIKSQASSLAVGCSVGIGQQGLQRADVLVEAGVDAVVVDT
CCCEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
AHGHSRLVLDTAKTLKKHYPSVTLIVGNIVSREAALCLGEIGVDAVKVGIGPGSICTTRI
CCCCCEEEHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
ISGVGLPQLTAVMDVSEALRDSSVRVIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTNE
HHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHCCHHHHHHHHHHCCCCC
APGEIVHVNEQAYKMYRGMGSLGAMKRGSAERYFQEHNAKKFVPEGVEGLVPYKGSLHDV
CCCCEEEECHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
LYQILGGIRSGMGYVGARNLEELRKNAVFARITHSGRTESHIHNLQHIQQAPNYLVSK
HHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MREALTFDDVLLVPQYSEVLPGEACLSASVSESLDLAIPILSAAMDSVTELSMAIAMAEA
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLGVIHKNMDLDEQVSMVKHIKSQASSLAVGCSVGIGQQGLQRADVLVEAGVDAVVVDT
CCCEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
AHGHSRLVLDTAKTLKKHYPSVTLIVGNIVSREAALCLGEIGVDAVKVGIGPGSICTTRI
CCCCCEEEHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
ISGVGLPQLTAVMDVSEALRDSSVRVIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTNE
HHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHCCHHHHHHHHHHCCCCC
APGEIVHVNEQAYKMYRGMGSLGAMKRGSAERYFQEHNAKKFVPEGVEGLVPYKGSLHDV
CCCCEEEECHHHHHHHHCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
LYQILGGIRSGMGYVGARNLEELRKNAVFARITHSGRTESHIHNLQHIQQAPNYLVSK
HHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961392; 9403685; 10758003 [H]