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The map label for this gene is tyrP [H]

Identifier: 89898033

GI number: 89898033

Start: 267946

End: 269133

Strand: Direct

Name: tyrP [H]

Synonym: CF0226

Alternate gene names: 89898033

Gene position: 267946-269133 (Clockwise)

Preceding gene: 89898032

Following gene: 89898034

Centisome position: 22.98

GC content: 39.81

Gene sequence:

>1188_bases
ATGTCTAGCAAGGTTTTAGGGGGCTCCCTCATTATTGCAGGGACCGCCATAGGTGCTGGGGTGTTAGCTGTCCCTATATT
AACAGCGCATGCAGGATTTTTACCTACGACTCTTCTCTATACCCTGTCGTGGTTATTCTCCATGGGATCTGGAATGTGCC
TTCTCGAGATTATGACCTGGTTTAAAGATAAACAACAGATCAACATGTTATCGATGGCCCAGTACACTCTAGGAGATGTG
GGCAAGATTTGCATGTGGCTTGTTTACTTGTTTCTATTTTACTCTCTACTTATTGCTTACTTTTGTGAGGGAGGCAATAT
ACTATTTCGTATTTTTGGTTGTCAGGGATTGGATATTCCTTGGATACGTCACGTAGCTCCTTTAGCTTTTGCTATTTTGA
TTTGTCCAGCTTTAATGATGGGAACAAAAATCGTGGACTACTGTAACCGCGTTTGTGTTGTCGGAATAGCTATTGCGTTT
GCTGCATTTTGTATTTTAGGAGTTTTATCCTTGAAACCAGAATTGCTTTTACGTGCTTCATGGATGCAATCTGTGAATGG
ATTGCCTATCTTATTCCTTTCCTTTGGCTTTCAAAGTGTGGTTCCCTCACTGTATTACTATATGAATAGGAACGTTAAAG
ATGTCAAAAAAGCTATAGTTATTGGTAGCTTTGTACCTTTAATCTTATACTTAATTTGGGAAGGTTTAGTTCTAGGGGTA
GTTCCCTTGGATTTTCTTATGAAAGCTAAAGAAAATGGTTACACAGCTGTGGAGGCGATGAAAAATTCGTTGCAATGCTC
TCTGTTTTATGTGGCCGGTGAATTCTTCGGCTTCTTTGCTTTGGTTTCTTCATTTTTAGGCGTGGCTTTGGGTGTTACGG
ACTTCCTTGCCGATGCTTGTCGATGGAACAAACAGAAACACAAGTTTGCTATTTTCTTTTTAACTGTTATGGTCCCTTTA
GCTTTATCAATGTGCTATCCTGAGATCGTTCTCAAATGTCTCAATTATGCTGGAGGGGTAGGCTCTGCTTTAATTATCGG
AGTTTTCCCTGTACTCATGGTCTGGAAAGGCCGTTACGGGAAAAAACGTTGTCATGAAAAACAAGTGCTTCCGGGTGGGA
AAATTGTTTTATTGCTAATGGTCGTGGTAATGGTAATTAATTTGGTGAGTCTTTATTATAAATTTTAA

Upstream 100 bases:

>100_bases
TTTAGCCAAATCTGTAACTGTTGAATAACACAAAAGATTAAGGTTTTATTTCTAAATAACTTTAAATCTGAAATATAAGA
CAAAATTCGAAAGGTTTGTT

Downstream 100 bases:

>100_bases
ATAAACAGCAGCATGTTTGTTAAGTTTTTAATTGTATGTGAGTATAGGAGGTAATATGGGACTATACGATCGTGATTACG
CGCAAGAATCTCGTTTGCCA

Product: tyrosine transport

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSSKVLGGSLIIAGTAIGAGVLAVPILTAHAGFLPTTLLYTLSWLFSMGSGMCLLEIMTWFKDKQQINMLSMAQYTLGDV
GKICMWLVYLFLFYSLLIAYFCEGGNILFRIFGCQGLDIPWIRHVAPLAFAILICPALMMGTKIVDYCNRVCVVGIAIAF
AAFCILGVLSLKPELLLRASWMQSVNGLPILFLSFGFQSVVPSLYYYMNRNVKDVKKAIVIGSFVPLILYLIWEGLVLGV
VPLDFLMKAKENGYTAVEAMKNSLQCSLFYVAGEFFGFFALVSSFLGVALGVTDFLADACRWNKQKHKFAIFFLTVMVPL
ALSMCYPEIVLKCLNYAGGVGSALIIGVFPVLMVWKGRYGKKRCHEKQVLPGGKIVLLLMVVVMVINLVSLYYKF

Sequences:

>Translated_395_residues
MSSKVLGGSLIIAGTAIGAGVLAVPILTAHAGFLPTTLLYTLSWLFSMGSGMCLLEIMTWFKDKQQINMLSMAQYTLGDV
GKICMWLVYLFLFYSLLIAYFCEGGNILFRIFGCQGLDIPWIRHVAPLAFAILICPALMMGTKIVDYCNRVCVVGIAIAF
AAFCILGVLSLKPELLLRASWMQSVNGLPILFLSFGFQSVVPSLYYYMNRNVKDVKKAIVIGSFVPLILYLIWEGLVLGV
VPLDFLMKAKENGYTAVEAMKNSLQCSLFYVAGEFFGFFALVSSFLGVALGVTDFLADACRWNKQKHKFAIFFLTVMVPL
ALSMCYPEIVLKCLNYAGGVGSALIIGVFPVLMVWKGRYGKKRCHEKQVLPGGKIVLLLMVVVMVINLVSLYYKF
>Mature_394_residues
SSKVLGGSLIIAGTAIGAGVLAVPILTAHAGFLPTTLLYTLSWLFSMGSGMCLLEIMTWFKDKQQINMLSMAQYTLGDVG
KICMWLVYLFLFYSLLIAYFCEGGNILFRIFGCQGLDIPWIRHVAPLAFAILICPALMMGTKIVDYCNRVCVVGIAIAFA
AFCILGVLSLKPELLLRASWMQSVNGLPILFLSFGFQSVVPSLYYYMNRNVKDVKKAIVIGSFVPLILYLIWEGLVLGVV
PLDFLMKAKENGYTAVEAMKNSLQCSLFYVAGEFFGFFALVSSFLGVALGVTDFLADACRWNKQKHKFAIFFLTVMVPLA
LSMCYPEIVLKCLNYAGGVGSALIIGVFPVLMVWKGRYGKKRCHEKQVLPGGKIVLLLMVVVMVINLVSLYYKF

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=387, Percent_Identity=29.4573643410853, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789552, Length=380, Percent_Identity=26.0526315789474, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790145, Length=385, Percent_Identity=23.6363636363636, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43655; Mature: 43523

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKVLGGSLIIAGTAIGAGVLAVPILTAHAGFLPTTLLYTLSWLFSMGSGMCLLEIMTW
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FKDKQQINMLSMAQYTLGDVGKICMWLVYLFLFYSLLIAYFCEGGNILFRIFGCQGLDIP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCH
WIRHVAPLAFAILICPALMMGTKIVDYCNRVCVVGIAIAFAAFCILGVLSLKPELLLRAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
WMQSVNGLPILFLSFGFQSVVPSLYYYMNRNVKDVKKAIVIGSFVPLILYLIWEGLVLGV
HHHHCCCCCHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLDFLMKAKENGYTAVEAMKNSLQCSLFYVAGEFFGFFALVSSFLGVALGVTDFLADAC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWNKQKHKFAIFFLTVMVPLALSMCYPEIVLKCLNYAGGVGSALIIGVFPVLMVWKGRYG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
KKRCHEKQVLPGGKIVLLLMVVVMVINLVSLYYKF
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]