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The map label for this gene is glmS [H]

Identifier: 89898032

GI number: 89898032

Start: 266044

End: 267873

Strand: Direct

Name: glmS [H]

Synonym: CF0225

Alternate gene names: 89898032

Gene position: 266044-267873 (Clockwise)

Preceding gene: 89898031

Following gene: 89898033

Centisome position: 22.81

GC content: 39.62

Gene sequence:

>1830_bases
ATGTGCGGAATATTCGGTTATCTAGGTTCTAAATTAGCTATTCCTGTAGTTTTAGATGGATTGGCTAAACTAGAGTATCG
TGGTTATGATTCCGCTGGATTGGCAGCAATTACATCGGGTCAATTGTTTGTAAGAAAAACCATCGGACGTGTCGATGAGC
TCAGAAATGCTTTAGAAACACATCAGATTCAGTCTTCATTAGCCATAGGTCATACGCGTTGGGCAACGCATGGCGTGCCT
ACGGTAAATAATGCTCATCCTCATGTGGATGAGAATGCTACCTGTGCTATTGTTCACAATGGGATTATTGAGAATTTTAA
AGAATTAAAGTCTTTACTTCTTTCTGAAGGCATTTCTTTTTCCTCAGATACAGACTCTGAGGTTATCGCGCAACTCTTTG
CTTTTCGTTATCAAGCTACTGGAGATTTCGTACATAGCTTTTCTTGGACTCTGTCTCAGCTTCAGGGCAGCTTTTCCTGC
GGGCTTATTCATAAAGATCATCCTTCAGTTCTTCTCTGTGCTTCTCAGGAAAGCCCGTTAATTATTGGCTTAGGGGATCA
AGAGCGGTTGATTGCTTCGGATACTCGTGCTTTCTTAAAATATACAAAGAATGTTCAAGCTTTAGCTTCCGGAGAACTAG
CTATTGTCAGTCTGGGCAATGAAGTCGAGACATACAATTTTGCATTAAAACGCATTCAGAAAGAAGTTCGTCAAGTTACT
TACACCGATGCAGATTCAGATAAGCAGGGGTATAGCTACTATATGCTTAAAGAAATTTATGAGCAGCCGGAAGTTTTCGA
ACGTCTTCTTCATAAATATCTAGACCCTCAAGGATATATTGGCGAGAAATTTTTAGAAGGCTTCTCTATAGAAGATTTTG
ATGAAATTTCTATAGTTGCTTGTGGTTCTTCTTACCACGCAGGCTTGTTAGCGAAGTACATTGTAGAATCTCTAGTTTCA
ATTCCTGTGCATGTTGAAGTTGCTTCAGAATTTCGTTATAGAAGAGCGTATATCGGAAAGAAGACTTTGGCAATTTTAAT
TAGTCAATCTGGGGAAACAGCTGATACTTTAGCTGCGCTAAAGGAGTTCCGCCGTAGACACGTTGCTTGTGTTTTAGGAA
TTTGTAATGTTGAAGAATCCGCGCTAGCTATGGGTGTGGATCATTGCTTATTTTTAGAGGCAGGTATTGAAATTGGCGTT
GCCTCTACGAAAGCTTTCACAGCTCAATTACTTTTACTTATTTTATTCGGGTTAAAACTAGCATCTGTAAAACGAACTTT
GAGTTTAGAAGAACAACGTTCTTGTGGGAAAGGTTTGCTTGAGCTTCCAGTTTTATGTGATCTTCTATTAGCAAATGAAG
GTTTGCGTTCTTGGGCGGATAACTATTGCAATGAAGATAGGTTTATATTTTTAGGACGTCGTCTGATGTATCCTATTTGT
ATGGAAGCCGCATTGAAACTGAAAGAAATTGCATATGTTGAAGCGAACTGTTATCCTGCTGGGGAAATGAAGCACGGGCC
TATTGCTTTAATCAGCAAAGGATCTCTGGTAATTACTTTTTGTGGTGACCCTATTGTCTATGAAAAGATGGTGGGATGTA
TCATGGAGGTAAAAGCTCGGCAAGCTCATGTGATTGCTATAGCTTCAGAATTGCAAGAAGATATTGCTGCTGTTTCGGAC
TTTCACATATATGTTCCGAATAGTCATCCCTTAGTGTCTCCAATTCTTTATGCTGTTGTGGGGCAAATCATGGCCTATAC
CATGGCTTTGAAAAAAGGCAATGAAATAGACCGTCCGAGGAATTTAGCCAAATCTGTAACTGTTGAATAA

Upstream 100 bases:

>100_bases
TTGAGGGCTTAAAGAAGCATCAAGTAGATTCCCTAGCTAAGACCATAGCAGATATTGTTGATTCTGAGCTAGGAGTAGGC
ATTATAGAGTAGGGTAATGT

Downstream 100 bases:

>100_bases
CACAAAAGATTAAGGTTTTATTTCTAAATAACTTTAAATCTGAAATATAAGACAAAATTCGAAAGGTTTGTTATGTCTAG
CAAGGTTTTAGGGGGCTCCC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIFGYLGSKLAIPVVLDGLAKLEYRGYDSAGLAAITSGQLFVRKTIGRVDELRNALETHQIQSSLAIGHTRWATHGVP
TVNNAHPHVDENATCAIVHNGIIENFKELKSLLLSEGISFSSDTDSEVIAQLFAFRYQATGDFVHSFSWTLSQLQGSFSC
GLIHKDHPSVLLCASQESPLIIGLGDQERLIASDTRAFLKYTKNVQALASGELAIVSLGNEVETYNFALKRIQKEVRQVT
YTDADSDKQGYSYYMLKEIYEQPEVFERLLHKYLDPQGYIGEKFLEGFSIEDFDEISIVACGSSYHAGLLAKYIVESLVS
IPVHVEVASEFRYRRAYIGKKTLAILISQSGETADTLAALKEFRRRHVACVLGICNVEESALAMGVDHCLFLEAGIEIGV
ASTKAFTAQLLLLILFGLKLASVKRTLSLEEQRSCGKGLLELPVLCDLLLANEGLRSWADNYCNEDRFIFLGRRLMYPIC
MEAALKLKEIAYVEANCYPAGEMKHGPIALISKGSLVITFCGDPIVYEKMVGCIMEVKARQAHVIAIASELQEDIAAVSD
FHIYVPNSHPLVSPILYAVVGQIMAYTMALKKGNEIDRPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIFGYLGSKLAIPVVLDGLAKLEYRGYDSAGLAAITSGQLFVRKTIGRVDELRNALETHQIQSSLAIGHTRWATHGVP
TVNNAHPHVDENATCAIVHNGIIENFKELKSLLLSEGISFSSDTDSEVIAQLFAFRYQATGDFVHSFSWTLSQLQGSFSC
GLIHKDHPSVLLCASQESPLIIGLGDQERLIASDTRAFLKYTKNVQALASGELAIVSLGNEVETYNFALKRIQKEVRQVT
YTDADSDKQGYSYYMLKEIYEQPEVFERLLHKYLDPQGYIGEKFLEGFSIEDFDEISIVACGSSYHAGLLAKYIVESLVS
IPVHVEVASEFRYRRAYIGKKTLAILISQSGETADTLAALKEFRRRHVACVLGICNVEESALAMGVDHCLFLEAGIEIGV
ASTKAFTAQLLLLILFGLKLASVKRTLSLEEQRSCGKGLLELPVLCDLLLANEGLRSWADNYCNEDRFIFLGRRLMYPIC
MEAALKLKEIAYVEANCYPAGEMKHGPIALISKGSLVITFCGDPIVYEKMVGCIMEVKARQAHVIAIASELQEDIAAVSD
FHIYVPNSHPLVSPILYAVVGQIMAYTMALKKGNEIDRPRNLAKSVTVE
>Mature_609_residues
MCGIFGYLGSKLAIPVVLDGLAKLEYRGYDSAGLAAITSGQLFVRKTIGRVDELRNALETHQIQSSLAIGHTRWATHGVP
TVNNAHPHVDENATCAIVHNGIIENFKELKSLLLSEGISFSSDTDSEVIAQLFAFRYQATGDFVHSFSWTLSQLQGSFSC
GLIHKDHPSVLLCASQESPLIIGLGDQERLIASDTRAFLKYTKNVQALASGELAIVSLGNEVETYNFALKRIQKEVRQVT
YTDADSDKQGYSYYMLKEIYEQPEVFERLLHKYLDPQGYIGEKFLEGFSIEDFDEISIVACGSSYHAGLLAKYIVESLVS
IPVHVEVASEFRYRRAYIGKKTLAILISQSGETADTLAALKEFRRRHVACVLGICNVEESALAMGVDHCLFLEAGIEIGV
ASTKAFTAQLLLLILFGLKLASVKRTLSLEEQRSCGKGLLELPVLCDLLLANEGLRSWADNYCNEDRFIFLGRRLMYPIC
MEAALKLKEIAYVEANCYPAGEMKHGPIALISKGSLVITFCGDPIVYEKMVGCIMEVKARQAHVIAIASELQEDIAAVSD
FHIYVPNSHPLVSPILYAVVGQIMAYTMALKKGNEIDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=696, Percent_Identity=31.4655172413793, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI205277386, Length=695, Percent_Identity=31.6546762589928, Blast_Score=305, Evalue=9e-83,
Organism=Homo sapiens, GI29570798, Length=233, Percent_Identity=28.755364806867, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=39.9030694668821, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1788651, Length=220, Percent_Identity=27.7272727272727, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=438, Percent_Identity=34.0182648401827, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17532899, Length=438, Percent_Identity=33.5616438356164, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17532897, Length=438, Percent_Identity=33.5616438356164, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17554892, Length=245, Percent_Identity=31.8367346938775, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=33.5585585585586, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323731, Length=439, Percent_Identity=26.1958997722096, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=32.6829268292683, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=31.8379160636758, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24659598, Length=202, Percent_Identity=29.7029702970297, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=34.5070422535211, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24659604, Length=177, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67201; Mature: 67201

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFGYLGSKLAIPVVLDGLAKLEYRGYDSAGLAAITSGQLFVRKTIGRVDELRNALET
CCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
HQIQSSLAIGHTRWATHGVPTVNNAHPHVDENATCAIVHNGIIENFKELKSLLLSEGISF
HHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
SSDTDSEVIAQLFAFRYQATGDFVHSFSWTLSQLQGSFSCGLIHKDHPSVLLCASQESPL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECEEECCCCCEEEEECCCCCE
IIGLGDQERLIASDTRAFLKYTKNVQALASGELAIVSLGNEVETYNFALKRIQKEVRQVT
EEECCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEE
YTDADSDKQGYSYYMLKEIYEQPEVFERLLHKYLDPQGYIGEKFLEGFSIEDFDEISIVA
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEE
CGSSYHAGLLAKYIVESLVSIPVHVEVASEFRYRRAYIGKKTLAILISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
KEFRRRHVACVLGICNVEESALAMGVDHCLFLEAGIEIGVASTKAFTAQLLLLILFGLKL
HHHHHHHHHHHEEECCCCHHHHHHCHHHHEEEECCCEEEECCHHHHHHHHHHHHHHHHHH
ASVKRTLSLEEQRSCGKGLLELPVLCDLLLANEGLRSWADNYCNEDRFIFLGRRLMYPIC
HHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECHHHHHHHH
MEAALKLKEIAYVEANCYPAGEMKHGPIALISKGSLVITFCGDPIVYEKMVGCIMEVKAR
HHHHHHHHHHEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHC
QAHVIAIASELQEDIAAVSDFHIYVPNSHPLVSPILYAVVGQIMAYTMALKKGNEIDRPR
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIFGYLGSKLAIPVVLDGLAKLEYRGYDSAGLAAITSGQLFVRKTIGRVDELRNALET
CCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
HQIQSSLAIGHTRWATHGVPTVNNAHPHVDENATCAIVHNGIIENFKELKSLLLSEGISF
HHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
SSDTDSEVIAQLFAFRYQATGDFVHSFSWTLSQLQGSFSCGLIHKDHPSVLLCASQESPL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECEEECCCCCEEEEECCCCCE
IIGLGDQERLIASDTRAFLKYTKNVQALASGELAIVSLGNEVETYNFALKRIQKEVRQVT
EEECCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHEE
YTDADSDKQGYSYYMLKEIYEQPEVFERLLHKYLDPQGYIGEKFLEGFSIEDFDEISIVA
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCEEEEE
CGSSYHAGLLAKYIVESLVSIPVHVEVASEFRYRRAYIGKKTLAILISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
KEFRRRHVACVLGICNVEESALAMGVDHCLFLEAGIEIGVASTKAFTAQLLLLILFGLKL
HHHHHHHHHHHEEECCCCHHHHHHCHHHHEEEECCCEEEECCHHHHHHHHHHHHHHHHHH
ASVKRTLSLEEQRSCGKGLLELPVLCDLLLANEGLRSWADNYCNEDRFIFLGRRLMYPIC
HHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECHHHHHHHH
MEAALKLKEIAYVEANCYPAGEMKHGPIALISKGSLVITFCGDPIVYEKMVGCIMEVKAR
HHHHHHHHHHEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHC
QAHVIAIASELQEDIAAVSDFHIYVPNSHPLVSPILYAVVGQIMAYTMALKKGNEIDRPR
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]