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The map label for this gene is pth [H]

Identifier: 89898002

GI number: 89898002

Start: 228432

End: 228983

Strand: Direct

Name: pth [H]

Synonym: CF0195

Alternate gene names: 89898002

Gene position: 228432-228983 (Clockwise)

Preceding gene: 89898001

Following gene: 89898003

Centisome position: 19.59

GC content: 42.21

Gene sequence:

>552_bases
ATGACGATGCTGGTTGTTGCCATAGGAAATCCGGGACGTCAATATACATGGACGCGACATAATATAGGGTTTCTATGTGC
AGACAGGCTGCTTCAGGAGTTTTCCGGAGTGCATTTTAAAGAAACTCCGAAATTATTTTCCGATATCGCCAAAGTTGAAT
CTTCCCAAGGGACTGTGATTTTCATTAAACCTAGGACCTACGTCAATCTAAGCGGTAAGGCTGTTTTAGCAGTTAAGGAA
TATTATAATATTGCAACGGATCGTATTCTAGTTCTCGCTGATGACGTGAATCAACCTTTCGGTAAAGTTCGTCTTCGCCA
AAGTGCTGGTGGTGGCGGACACAAAGGGATAAAAAGTATCACACAAAGCTTAGGTTCTAATGATTATTGGCAGTTGCGTT
TGGGTGTCGGTCGACCTCAAAGAGAAGATGTAGAATTGTCAGACTTTGTTCTCGGACAATTTACTGAAGAAGAACAGATT
GGAATACAATCTTTATTTATCGAGGCCTGGGCGTTATTTTCTCAATGGTGTTCCGGGACTCAAACTGCCTAG

Upstream 100 bases:

>100_bases
CAGACAAGAAAATTGTCCGATATTAATATCCCTGCAGGACTTCGTCCTATTACTCCTCTTAAGGAAGTTGTCGTAACAGT
ATCTAGAAGATAATCTAATT

Downstream 100 bases:

>100_bases
GAGATCCCGAAGTAATTTTTATAGACCGGGATATCTTAGGGAAATAAACTACTCTAGCTATGTTTAGGAGTTTTTAATGA
AAGAAAAAACAACCCAACTT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTMLVVAIGNPGRQYTWTRHNIGFLCADRLLQEFSGVHFKETPKLFSDIAKVESSQGTVIFIKPRTYVNLSGKAVLAVKE
YYNIATDRILVLADDVNQPFGKVRLRQSAGGGGHKGIKSITQSLGSNDYWQLRLGVGRPQREDVELSDFVLGQFTEEEQI
GIQSLFIEAWALFSQWCSGTQTA

Sequences:

>Translated_183_residues
MTMLVVAIGNPGRQYTWTRHNIGFLCADRLLQEFSGVHFKETPKLFSDIAKVESSQGTVIFIKPRTYVNLSGKAVLAVKE
YYNIATDRILVLADDVNQPFGKVRLRQSAGGGGHKGIKSITQSLGSNDYWQLRLGVGRPQREDVELSDFVLGQFTEEEQI
GIQSLFIEAWALFSQWCSGTQTA
>Mature_182_residues
TMLVVAIGNPGRQYTWTRHNIGFLCADRLLQEFSGVHFKETPKLFSDIAKVESSQGTVIFIKPRTYVNLSGKAVLAVKEY
YNIATDRILVLADDVNQPFGKVRLRQSAGGGGHKGIKSITQSLGSNDYWQLRLGVGRPQREDVELSDFVLGQFTEEEQIG
IQSLFIEAWALFSQWCSGTQTA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=157, Percent_Identity=26.1146496815287, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI1787455, Length=178, Percent_Identity=36.5168539325843, Blast_Score=91, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321983, Length=188, Percent_Identity=29.2553191489362, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20417; Mature: 20285

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMLVVAIGNPGRQYTWTRHNIGFLCADRLLQEFSGVHFKETPKLFSDIAKVESSQGTVI
CEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEE
FIKPRTYVNLSGKAVLAVKEYYNIATDRILVLADDVNQPFGKVRLRQSAGGGGHKGIKSI
EECCCEEEEECCCEEEEEHHHHHHCCCEEEEEECCCCCCHHHEEEECCCCCCCHHHHHHH
TQSLGSNDYWQLRLGVGRPQREDVELSDFVLGQFTEEEQIGIQSLFIEAWALFSQWCSGT
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QTA
CCC
>Mature Secondary Structure 
TMLVVAIGNPGRQYTWTRHNIGFLCADRLLQEFSGVHFKETPKLFSDIAKVESSQGTVI
EEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEE
FIKPRTYVNLSGKAVLAVKEYYNIATDRILVLADDVNQPFGKVRLRQSAGGGGHKGIKSI
EECCCEEEEECCCEEEEEHHHHHHCCCEEEEEECCCCCCHHHEEEECCCCCCCHHHHHHH
TQSLGSNDYWQLRLGVGRPQREDVELSDFVLGQFTEEEQIGIQSLFIEAWALFSQWCSGT
HHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QTA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA