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The map label for this gene is fabF [H]

Identifier: 89897970

GI number: 89897970

Start: 194372

End: 195622

Strand: Direct

Name: fabF [H]

Synonym: CF0163

Alternate gene names: 89897970

Gene position: 194372-195622 (Clockwise)

Preceding gene: 89897969

Following gene: 89897971

Centisome position: 16.67

GC content: 42.29

Gene sequence:

>1251_bases
ATGAATAAAAAACGTGTAGTAGTCACGGGATTGGGAGTAGTTTCCTGCTTAGGCAATGAAGTAGACACCTTTTATGATAA
TCTGCTCGCTGGTATCAGTGGAGTTCATACAATTACTTCTTTTCCATGCGAAGATTATGCTACCCGTTTCGCTGCTTGGA
TCCCCGAGTTTAATCCCGAGCCTTATTTAGATAAAAAACAAGCACGCAGAGTTGATCCTTTTATTACCTATGCAGTAGTT
GCTGCTAAGAAAGCTATTGCGATGTCTAGATGGGATAAAGACAATCTTCCCGCTGATCCTCTTCGTTGTGGTGTGATCAT
TGGTTCTGGTATGGGTGGGTTGCAGACTTTAGACGAGGGCATGGAACGCCTTATCCAAGGTAATAAAAAACTCTCTCCTT
TCTTTATACCTTACATTATTACTAATATGGCCCCCGCGCTTATTGCTATGGATTTTGGACTGATGGGTCCAAACTATTCT
ATATCCACAGCTTGCGCGACTTCGAATTATTGTATTGATGCTGCTTACCAACATCTTGTTTCTGGGCGTTCTGACATGAT
AGTTTGTGGAGGAACTGAGGCCGCAGTGAACCGTGTTGGATTGGCGGGTTTTATTGCTAATCGTGCTTTATCAGAAAGAA
ACGATGCTCCTCAAGAAGCCTCTCGTCCTTGGGATAGAGATAGAGACGGTTTTGTCATTGGAGAGGGAGCCGGGGTTTTA
GTTTTAGAAACGTTAGAGAATGCTTTGAAGCGAGGTGCTCCGATTTATGCAGAGATACTTGGCTCATACACTACTTGTGA
CGCTTTCCACATCACAGCTCCTAGAGATGATGGAGAGGGAATCACCTCGTGTATTCTTGGGGCTTTAGAAAGTTCTGGAA
TTCCTAAAGAGCGCGTAAATTATATTAATGCTCATGGTACATCAACTCCTTTAGGAGATATATCGGAAGTTTTAGCAGTG
AAAAAAGCTTTCGGTAGTCATGTGAAAAATTTGCGAATGAATTCCACAAAGTCTCTTATAGGTCATTGCCTCGGAGCCGC
TGGAGGAGTCGAAGCTGTTGCAACAATTCAAGCAATTCAAACGGGAAAATTACATCCCACGATTAATTTAGAGAACCCGA
TTGCAGAAATTGATGATTTTGATGTGGTTGCGAATAAGGCTCAGGATTGGGATATTGACGTGGCTATGTCGAATTCTTTT
GGTTTTGGTGGACACAATTCAACGATATTATTCTCGAGGTATATACCCTAA

Upstream 100 bases:

>100_bases
TCTCATCCGTTAGAGAACAATATCGACTGGAAGAGCTGTGGAAGGACGGTTCCATTATTACATCTAAGCTTCTAGCTTCT
TAACGGGGTAGAATAACTTT

Downstream 100 bases:

>100_bases
TTATGATGAAGACTAAGTATGAATACTCTTTTGGTATTATTCCCATAAAGTTTTTTGGTACCCCAGATAAAAGTACACTA
AAAGCTTGTTTTATCTGCCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNKKRVVVTGLGVVSCLGNEVDTFYDNLLAGISGVHTITSFPCEDYATRFAAWIPEFNPEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDKDNLPADPLRCGVIIGSGMGGLQTLDEGMERLIQGNKKLSPFFIPYIITNMAPALIAMDFGLMGPNYS
ISTACATSNYCIDAAYQHLVSGRSDMIVCGGTEAAVNRVGLAGFIANRALSERNDAPQEASRPWDRDRDGFVIGEGAGVL
VLETLENALKRGAPIYAEILGSYTTCDAFHITAPRDDGEGITSCILGALESSGIPKERVNYINAHGTSTPLGDISEVLAV
KKAFGSHVKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINLENPIAEIDDFDVVANKAQDWDIDVAMSNSF
GFGGHNSTILFSRYIP

Sequences:

>Translated_416_residues
MNKKRVVVTGLGVVSCLGNEVDTFYDNLLAGISGVHTITSFPCEDYATRFAAWIPEFNPEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDKDNLPADPLRCGVIIGSGMGGLQTLDEGMERLIQGNKKLSPFFIPYIITNMAPALIAMDFGLMGPNYS
ISTACATSNYCIDAAYQHLVSGRSDMIVCGGTEAAVNRVGLAGFIANRALSERNDAPQEASRPWDRDRDGFVIGEGAGVL
VLETLENALKRGAPIYAEILGSYTTCDAFHITAPRDDGEGITSCILGALESSGIPKERVNYINAHGTSTPLGDISEVLAV
KKAFGSHVKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINLENPIAEIDDFDVVANKAQDWDIDVAMSNSF
GFGGHNSTILFSRYIP
>Mature_416_residues
MNKKRVVVTGLGVVSCLGNEVDTFYDNLLAGISGVHTITSFPCEDYATRFAAWIPEFNPEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDKDNLPADPLRCGVIIGSGMGGLQTLDEGMERLIQGNKKLSPFFIPYIITNMAPALIAMDFGLMGPNYS
ISTACATSNYCIDAAYQHLVSGRSDMIVCGGTEAAVNRVGLAGFIANRALSERNDAPQEASRPWDRDRDGFVIGEGAGVL
VLETLENALKRGAPIYAEILGSYTTCDAFHITAPRDDGEGITSCILGALESSGIPKERVNYINAHGTSTPLGDISEVLAV
KKAFGSHVKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINLENPIAEIDDFDVVANKAQDWDIDVAMSNSF
GFGGHNSTILFSRYIP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=40.625, Blast_Score=297, Evalue=9e-81,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=47.945205479452, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI41872631, Length=432, Percent_Identity=25.6944444444444, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=45.0602409638554, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=36.4734299516908, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=33.2541567695962, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=38.6363636363636, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=413, Percent_Identity=25.4237288135593, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=23.4463276836158, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=36.1990950226244, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=42.2535211267606, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI221330659, Length=360, Percent_Identity=25.5555555555556, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19920632, Length=360, Percent_Identity=25.5555555555556, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=24.3055555555556, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44643; Mature: 44643

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE ; PS00205 TRANSFERRIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKRVVVTGLGVVSCLGNEVDTFYDNLLAGISGVHTITSFPCEDYATRFAAWIPEFNPE
CCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
PYLDKKQARRVDPFITYAVVAAKKAIAMSRWDKDNLPADPLRCGVIIGSGMGGLQTLDEG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
MERLIQGNKKLSPFFIPYIITNMAPALIAMDFGLMGPNYSISTACATSNYCIDAAYQHLV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHH
SGRSDMIVCGGTEAAVNRVGLAGFIANRALSERNDAPQEASRPWDRDRDGFVIGEGAGVL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLETLENALKRGAPIYAEILGSYTTCDAFHITAPRDDGEGITSCILGALESSGIPKERVN
EHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHH
YINAHGTSTPLGDISEVLAVKKAFGSHVKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQ
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINLENPIAEIDDFDVVANKAQDWDIDVAMSNSFGFGGHNSTILFSRYIP
CCCCCCEEECCCCCHHCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MNKKRVVVTGLGVVSCLGNEVDTFYDNLLAGISGVHTITSFPCEDYATRFAAWIPEFNPE
CCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
PYLDKKQARRVDPFITYAVVAAKKAIAMSRWDKDNLPADPLRCGVIIGSGMGGLQTLDEG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
MERLIQGNKKLSPFFIPYIITNMAPALIAMDFGLMGPNYSISTACATSNYCIDAAYQHLV
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHH
SGRSDMIVCGGTEAAVNRVGLAGFIANRALSERNDAPQEASRPWDRDRDGFVIGEGAGVL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLETLENALKRGAPIYAEILGSYTTCDAFHITAPRDDGEGITSCILGALESSGIPKERVN
EHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHH
YINAHGTSTPLGDISEVLAVKKAFGSHVKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQ
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINLENPIAEIDDFDVVANKAQDWDIDVAMSNSFGFGGHNSTILFSRYIP
CCCCCCEEECCCCCHHCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]