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The map label for this gene is sdhA [H]

Identifier: 89897852

GI number: 89897852

Start: 44990

End: 46873

Strand: Direct

Name: sdhA [H]

Synonym: CF0045

Alternate gene names: 89897852

Gene position: 44990-46873 (Clockwise)

Preceding gene: 89897851

Following gene: 89897853

Centisome position: 3.86

GC content: 42.73

Gene sequence:

>1884_bases
ATGGAAGCACAGGGTTGTAGGGTTATTGTCGTTGGCGGAGGGTTAGCAGGATTATCAGCAGCCATGAAGTTGGCAGATTA
TGGTATCGTTGTTGATCTAGTATCGTTGACAAAAGTGAAAAGGTCTCACTCTGTATGTGCGCAGGGGGGAATAAATGCCG
CTCTTAATCTTAAGCATGAAGAAGAAGATTCTCCCTATATACATGCCTATGACACAATAAAAGGTGGGGATTTCCTAGCA
GATCAGCCGCCGGTGTTAGAAATGTGTTTGGCAGCTCCGAGGATTATCCGCATGTTAGATAATTTCGGTTGTCCTTTCAA
CCGCACCCCAAATGGAAATTTGGATGTGCGTAGGTTTGGAGGAACTCTATACCATCGCACGGTATTTTGCGGGGCTTCTA
CAGGTCAACAACTTATGTATACCCTAGATGAACAAGTGCGGCGTCGAGAAAGTCAGGAACGTGTTAATAAATTTGAAAAT
CATGAATTTGTAAGATTAATTACCAATAGTTCAGGAAGAACTTGTGGGATTGTGATGATGAATCTATTCAACAATCGTTT
AGAAGTTCTTAAAGGGGATGCTGTGATCTTTGCTACAGGTGGTCCCGGAGTGATTTTTAAAATGTCTACGAACTCGACAT
TTTGCACAGGAGCTGCCAATGGACGATTGTTCCTTCAGGGAATGACCTATGCCAATCCGGAATTCATACAAATTCATCCT
ACAGCTATACCTGGTATTGATAAACTGCGGCTAATATCCGAGTCTGTGCGTGGAGAGGGAGGACGCGTTTGGGTTCCTGG
AGATTCTTCCAAGACAATTACATTTCCTGACGGCTCTCAACGCCCTTGTGGGAAAACAGGAGAACCCTGGTATTTCCTAG
AAGAGATGTATCCTGCCTATGGGAATTTAGTCAGTCGTGATGTGGGAGCTCGTGCTATTTTACAGGTGTGTGAAGCTGGA
TTAGGAATAGATGGACGCATGGAAGTCTTCTTAGATGTCACCCACTTACCGGCTGCCACACGACATAAATTAGAAGTTGT
TCTTGATATTTATCGAAAATTTACTGGGGAAGATCCTGACAAGGAACCAATGAGAATTTTCCCCGCTGTGCACTATTCTA
TGGGCGGGGCTTGGGTAGATTGGCCCGCAGCAGATGATCCCGATCGTGATAGTCGATACCGCCAGATGACAAATATCCCG
GGATGTTTCAATTGCGGGGAATCAGATTTCCAATATCACGGAGCAAATCGTTTGGGAGCGAATTCTTTATTATCCTGTCT
ATATGCTGGATTAGTTGCTGGAGAAGAGGCTGCTCGTTTTATTACAGCTTTTGGCTCCTGTCCAACAACATCTACGGATT
TTTCGGATGCTCTTCAACAAGAGAAGGAGGTCAATGCTCTTTTACTTTCTAGAAGTGGAGGAGAAAATATCTTCGCATTG
CATGAGGATATTGCCAAAGTTATGGTAAGAAACGTCACTGTAAAACGGAACAACAAAGATCTGAAGTCAACTTTAGAACA
ATTAAAAGAGTTCAGAGAGAGACTTCAAAAGGTTTCTGTGCATGATTCTTCACAATTTGCTAATAAGACTTTCCATTTTG
TACGTCAGATGGGCCCGATGATAGAATTAGCCTTAGCAATTACAAAGGGAGCTTTATTGCGAGATGAGTTTCGTGGTTCT
CATTTTAAAGAGGAATTTCCTAAGCGTGATGATGTGCATTGGTTAAAAACAACATTAGCTTCTTATGCTCCTGAGGAGCC
TGAAATTACTTATAAGCCTGTAGATACACGTCACGTGCAGCCTTCACTGCGAGATTACACAAAATCTTCGACAGCAAAAA
TCGAACTTACCAATGTTCCTGAACTTATTCATCTGCCCATATAA

Upstream 100 bases:

>100_bases
TCTCAAGCTCTTTTACGTAATTTGTGTTATTGTGCCATGGTTGTAGTTGCGGCCATGGGCATTAGTGTGATCTGGAATTT
GTATAGCGTGGCATAAGAGT

Downstream 100 bases:

>100_bases
ATAGAGAGAGGACTATGGATATTCCTGAAACTTTTATATTGAAAATTTACCGAGGAACTCCGGGAAAACAATATTGGGAA
AGTTTTGAATTGGCCTTACA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MEAQGCRVIVVGGGLAGLSAAMKLADYGIVVDLVSLTKVKRSHSVCAQGGINAALNLKHEEEDSPYIHAYDTIKGGDFLA
DQPPVLEMCLAAPRIIRMLDNFGCPFNRTPNGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRRESQERVNKFEN
HEFVRLITNSSGRTCGIVMMNLFNNRLEVLKGDAVIFATGGPGVIFKMSTNSTFCTGAANGRLFLQGMTYANPEFIQIHP
TAIPGIDKLRLISESVRGEGGRVWVPGDSSKTITFPDGSQRPCGKTGEPWYFLEEMYPAYGNLVSRDVGARAILQVCEAG
LGIDGRMEVFLDVTHLPAATRHKLEVVLDIYRKFTGEDPDKEPMRIFPAVHYSMGGAWVDWPAADDPDRDSRYRQMTNIP
GCFNCGESDFQYHGANRLGANSLLSCLYAGLVAGEEAARFITAFGSCPTTSTDFSDALQQEKEVNALLLSRSGGENIFAL
HEDIAKVMVRNVTVKRNNKDLKSTLEQLKEFRERLQKVSVHDSSQFANKTFHFVRQMGPMIELALAITKGALLRDEFRGS
HFKEEFPKRDDVHWLKTTLASYAPEEPEITYKPVDTRHVQPSLRDYTKSSTAKIELTNVPELIHLPI

Sequences:

>Translated_627_residues
MEAQGCRVIVVGGGLAGLSAAMKLADYGIVVDLVSLTKVKRSHSVCAQGGINAALNLKHEEEDSPYIHAYDTIKGGDFLA
DQPPVLEMCLAAPRIIRMLDNFGCPFNRTPNGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRRESQERVNKFEN
HEFVRLITNSSGRTCGIVMMNLFNNRLEVLKGDAVIFATGGPGVIFKMSTNSTFCTGAANGRLFLQGMTYANPEFIQIHP
TAIPGIDKLRLISESVRGEGGRVWVPGDSSKTITFPDGSQRPCGKTGEPWYFLEEMYPAYGNLVSRDVGARAILQVCEAG
LGIDGRMEVFLDVTHLPAATRHKLEVVLDIYRKFTGEDPDKEPMRIFPAVHYSMGGAWVDWPAADDPDRDSRYRQMTNIP
GCFNCGESDFQYHGANRLGANSLLSCLYAGLVAGEEAARFITAFGSCPTTSTDFSDALQQEKEVNALLLSRSGGENIFAL
HEDIAKVMVRNVTVKRNNKDLKSTLEQLKEFRERLQKVSVHDSSQFANKTFHFVRQMGPMIELALAITKGALLRDEFRGS
HFKEEFPKRDDVHWLKTTLASYAPEEPEITYKPVDTRHVQPSLRDYTKSSTAKIELTNVPELIHLPI
>Mature_627_residues
MEAQGCRVIVVGGGLAGLSAAMKLADYGIVVDLVSLTKVKRSHSVCAQGGINAALNLKHEEEDSPYIHAYDTIKGGDFLA
DQPPVLEMCLAAPRIIRMLDNFGCPFNRTPNGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRRESQERVNKFEN
HEFVRLITNSSGRTCGIVMMNLFNNRLEVLKGDAVIFATGGPGVIFKMSTNSTFCTGAANGRLFLQGMTYANPEFIQIHP
TAIPGIDKLRLISESVRGEGGRVWVPGDSSKTITFPDGSQRPCGKTGEPWYFLEEMYPAYGNLVSRDVGARAILQVCEAG
LGIDGRMEVFLDVTHLPAATRHKLEVVLDIYRKFTGEDPDKEPMRIFPAVHYSMGGAWVDWPAADDPDRDSRYRQMTNIP
GCFNCGESDFQYHGANRLGANSLLSCLYAGLVAGEEAARFITAFGSCPTTSTDFSDALQQEKEVNALLLSRSGGENIFAL
HEDIAKVMVRNVTVKRNNKDLKSTLEQLKEFRERLQKVSVHDSSQFANKTFHFVRQMGPMIELALAITKGALLRDEFRGS
HFKEEFPKRDDVHWLKTTLASYAPEEPEITYKPVDTRHVQPSLRDYTKSSTAKIELTNVPELIHLPI

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=628, Percent_Identity=28.8216560509554, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1790597, Length=584, Percent_Identity=30.9931506849315, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1786942, Length=595, Percent_Identity=30.7563025210084, Blast_Score=229, Evalue=6e-61,
Organism=Escherichia coli, GI1788928, Length=581, Percent_Identity=27.5387263339071, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17550100, Length=625, Percent_Identity=28.48, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17505833, Length=632, Percent_Identity=28.006329113924, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71986328, Length=483, Percent_Identity=26.2939958592132, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322701, Length=569, Percent_Identity=30.9314586994728, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322416, Length=569, Percent_Identity=29.8769771528998, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24663005, Length=603, Percent_Identity=29.8507462686567, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17137288, Length=605, Percent_Identity=29.2561983471074, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24655642, Length=605, Percent_Identity=29.2561983471074, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24655647, Length=605, Percent_Identity=29.2561983471074, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 69676; Mature: 69676

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAQGCRVIVVGGGLAGLSAAMKLADYGIVVDLVSLTKVKRSHSVCAQGGINAALNLKHE
CCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
EEDSPYIHAYDTIKGGDFLADQPPVLEMCLAAPRIIRMLDNFGCPFNRTPNGNLDVRRFG
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
GTLYHRTVFCGASTGQQLMYTLDEQVRRRESQERVNKFENHEFVRLITNSSGRTCGIVMM
CEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHH
NLFNNRLEVLKGDAVIFATGGPGVIFKMSTNSTFCTGAANGRLFLQGMTYANPEFIQIHP
HHHCCHHHEEECCEEEEEECCCEEEEEEECCCEEEECCCCCEEEEEECCCCCCCEEEEEC
TAIPGIDKLRLISESVRGEGGRVWVPGDSSKTITFPDGSQRPCGKTGEPWYFLEEMYPAY
CCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHH
GNLVSRDVGARAILQVCEAGLGIDGRMEVFLDVTHLPAATRHKLEVVLDIYRKFTGEDPD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
KEPMRIFPAVHYSMGGAWVDWPAADDPDRDSRYRQMTNIPGCFNCGESDFQYHGANRLGA
CCCCEEEHHHHHHCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCH
NSLLSCLYAGLVAGEEAARFITAFGSCPTTSTDFSDALQQEKEVNALLLSRSGGENIFAL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCEEHH
HEDIAKVMVRNVTVKRNNKDLKSTLEQLKEFRERLQKVSVHDSSQFANKTFHFVRQMGPM
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHH
IELALAITKGALLRDEFRGSHFKEEFPKRDDVHWLKTTLASYAPEEPEITYKPVDTRHVQ
HHHHHHHHHCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCC
PSLRDYTKSSTAKIELTNVPELIHLPI
CHHHHHCCCCCEEEEECCCCCEEECCC
>Mature Secondary Structure
MEAQGCRVIVVGGGLAGLSAAMKLADYGIVVDLVSLTKVKRSHSVCAQGGINAALNLKHE
CCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
EEDSPYIHAYDTIKGGDFLADQPPVLEMCLAAPRIIRMLDNFGCPFNRTPNGNLDVRRFG
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
GTLYHRTVFCGASTGQQLMYTLDEQVRRRESQERVNKFENHEFVRLITNSSGRTCGIVMM
CEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHH
NLFNNRLEVLKGDAVIFATGGPGVIFKMSTNSTFCTGAANGRLFLQGMTYANPEFIQIHP
HHHCCHHHEEECCEEEEEECCCEEEEEEECCCEEEECCCCCEEEEEECCCCCCCEEEEEC
TAIPGIDKLRLISESVRGEGGRVWVPGDSSKTITFPDGSQRPCGKTGEPWYFLEEMYPAY
CCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHH
GNLVSRDVGARAILQVCEAGLGIDGRMEVFLDVTHLPAATRHKLEVVLDIYRKFTGEDPD
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
KEPMRIFPAVHYSMGGAWVDWPAADDPDRDSRYRQMTNIPGCFNCGESDFQYHGANRLGA
CCCCEEEHHHHHHCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCH
NSLLSCLYAGLVAGEEAARFITAFGSCPTTSTDFSDALQQEKEVNALLLSRSGGENIFAL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCEEHH
HEDIAKVMVRNVTVKRNNKDLKSTLEQLKEFRERLQKVSVHDSSQFANKTFHFVRQMGPM
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHH
IELALAITKGALLRDEFRGSHFKEEFPKRDDVHWLKTTLASYAPEEPEITYKPVDTRHVQ
HHHHHHHHHCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCC
PSLRDYTKSSTAKIELTNVPELIHLPI
CHHHHHCCCCCEEEEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]